phenprocoumon and Jejunal-Diseases

Spontaneous small-bowel hematomas most commonly involve the jejunum, followed by the ileum and duodenum, and occur in patients who receive excessive anticoagulation with phenprocoumon/warfarin or who have additional risk factors for bleeding. We report three cases of intramural small-bowel hematoma, all complications of treatment with phenprocoumon, which nowadays is used extensively for therapeutic and prophylactic purposes. Diagnosis can be readily attained by sonography and confirmed using computed tomography. Early diagnosis is crucial because most patients can be treated successfully without surgery. Based on this experience and data from the literature, conservative treatment is recommended for intramural intestinal hematomas, when other complications needing laparotomy have been excluded.

Topics: Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Cholangiopancreatography, Endoscopic Retrograde; Duodenal Diseases; Female; Gastrointestinal Hemorrhage; Hematoma; Humans; Image Enhancement; Intestine, Small; Jejunal Diseases; Magnetic Resonance Imaging; Male; Phenprocoumon; Tomography, X-Ray Computed; Ultrasonography