phenprocoumon and Ascites

The diagnosis of pyoderma gangraenosum (PG) was made in a 33-year-old woman with ulcerative (palm-sized) skin changes and pain of the lower leg that had developed over two weeks and was accompanied by fever (39 degrees C). Treatment with prednisolone and azathioprine was initiated. As soon as the medication was reduced new skin changes developed. Two months after onset of the illness she had to be hospitalized because of fever, epigastric pain on pressure and deteriorating general condition. Physical examination provided no significant further information. LABORATORY RESULTS: The differential count demonstrated leucocytosis (15.5 Gpt/l) with a marked monocytosis (25%) as well as anaemia (haemoglobin concentration 5.2 mmol/l). C-reactive protein was elevated (120.20 mg/l). Thromboplastin time was 60%, D-dimer 1000 micrograms/l, thrombin-antithrombin-III complex 9.7 micrograms/l. ADDITIONAL INVESTIGATIONS: Sonography and computed tomography of the upper abdomen revealed splenomegaly, ascites, thrombosis of the portal, splenic and superior mesenteric veins. Bone marrow puncture showed marked increase in blasts (14%) and monocytes (10%).. The findings indicated chronic myelomonocytic leukaemia with PG and the described venous thromboses. The cutaneous changes completely receded on administration of hydroxyurea (1.0 g/d). Other causes of the skin eruption were excluded. Phenprocoumon (INR between 2 and 3) was given in treatment of the thromboses.. When PG is diagnosed, intensive search for an underlying cause must be undertaken, because of its frequent association with serious systemic disease. Only early specific treatment will improve the skin condition.

Topics: Adult; Anti-Inflammatory Agents; Anticoagulants; Antineoplastic Agents; Ascites; Azathioprine; Bone Marrow Cells; Bone Marrow Examination; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Immunosuppressive Agents; Leukemia, Myelomonocytic, Chronic; Mesenteric Veins; Phenprocoumon; Portal Vein; Prednisolone; Pyoderma Gangrenosum; Splenic Vein; Splenomegaly; Tomography, X-Ray Computed; Venous Thrombosis

Topics: Adult; Ascites; Aspirin; Biopsy; Blood Coagulation Tests; Budd-Chiari Syndrome; Combined Modality Therapy; Diagnosis, Differential; Female; Heparin; Hepatomegaly; Humans; Liver; Lymphedema; Phenprocoumon; Splenomegaly; Thrombocythemia, Essential; Thrombophlebitis