phenoxybenzamine has been researched along with Spasm in 16 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Spasm: An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In phenoxybenzamine-treated sections of radial artery, circulating vasoconstrictor agonists may still contribute to the induction of spasm." | 7.72 | Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. ( Chester, MR; Conant, AR; Dihmis, WC; Oo, AY; Shackcloth, MJ; Simpson, AW, 2003) |
| "In phenoxybenzamine-treated sections of radial artery, circulating vasoconstrictor agonists may still contribute to the induction of spasm." | 3.72 | Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators. ( Chester, MR; Conant, AR; Dihmis, WC; Oo, AY; Shackcloth, MJ; Simpson, AW, 2003) |
| "The effect of donor pretreatment with Dibenzyline (phenoxybenzamine) on hepatic arterial vasospasm was studied in a porcine asphyxia model." | 3.67 | Agonal hepatic arterial vasospasm. ( Belzer, FO; D'Alessandro, AM; Kalayoglu, M; Southard, JH; Stratta, RJ, 1989) |
| "Coronary spasm is due to strong contraction of coronary vascular smooth muscle cells which is triggered by an increase of intracellular calcium ions; hyperventilation plus TRIS-buffer infusion induces coronary spasm by decreasing hydrogen ions which antagonize the action of calcium ions." | 1.26 | Pathophysiology and treatment of coronary arterial spasm. ( Yasue, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Conant, AR | 1 |
| Shackcloth, MJ | 1 |
| Oo, AY | 1 |
| Chester, MR | 1 |
| Simpson, AW | 1 |
| Dihmis, WC | 1 |
| ELLIS, PP | 1 |
| LENDE, RA | 1 |
| Yasue, H | 1 |
| De Maeyer, P | 1 |
| Oosterlinck, W | 1 |
| De Sy, W | 1 |
| Fuller, CM | 1 |
| Raizner, AE | 1 |
| Chahine, RA | 1 |
| Nahormek, P | 1 |
| Ishimori, T | 1 |
| Verani, M | 1 |
| Nitishin, A | 1 |
| Mokotoff, D | 1 |
| Luchi, RJ | 1 |
| Taggart, DP | 1 |
| Dipp, M | 1 |
| Mussa, S | 1 |
| Nye, PC | 1 |
| Harrison, WE | 1 |
| Mellor, AJ | 1 |
| Clark, J | 1 |
| Singer, DR | 1 |
| Levene, DL | 1 |
| Freeman, MR | 1 |
| Ricci, DR | 1 |
| Orlick, AE | 1 |
| Cipriano, PR | 1 |
| Guthaner, DF | 1 |
| Harrison, DC | 1 |
| Dhabuwala, CB | 1 |
| Bird, M | 1 |
| Salaman, JR | 1 |
| Raz, S | 1 |
| Smith, RB | 1 |
| D'Alessandro, AM | 1 |
| Stratta, RJ | 1 |
| Southard, JH | 1 |
| Kalayoglu, M | 1 |
| Belzer, FO | 2 |
| Váczy, L | 1 |
| Lenner, A | 1 |
| Molnár, A | 1 |
| Dreikorn, K | 1 |
| Beduhn, D | 1 |
| Hansen, JH | 1 |
| Pryor, JP | 1 |
| Keaveny, TV | 1 |
| Reed, TW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Botulinum Toxin Urethral Sphincter Injection for Dysfunctional Voiding - A Multicenter Study, Randomized, Double-Blind, Placebo Control[NCT01733290] | Phase 2 | 70 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for phenoxybenzamine and Spasm
| Article | Year |
|---|---|
Alpha-adrenoceptor-mediated coronary artery spasm.
Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Exe | 1976 |
15 other studies available for phenoxybenzamine and Spasm
| Article | Year |
|---|---|
Phenoxybenzamine treatment is insufficient to prevent spasm in the radial artery: the effect of other vasodilators.
Topics: Adrenergic alpha-Agonists; Aged; Angiotensin II; Coronary Artery Bypass; Diltiazem; Dose-Response Re | 2003 |
INDUCED SPASM IN THE RETINAL ARTERIOLES OF CATS. II. INFLUENCES OF PHYSICAL FACTORS AND DRUGS.
Topics: Arterioles; Caffeine; Cats; Epinephrine; Histamine; Neostigmine; Niacinamide; Norepinephrine; Papave | 1964 |
Pathophysiology and treatment of coronary arterial spasm.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Atropine; Calcium; Coronary Disease; Coronary Vess | 1980 |
Prevention of vasospasms during extensive renal surgery. An experimental study in rats.
Topics: Animals; Kidney; Male; Mannitol; Papaverine; Perfusion; Phenoxybenzamine; Preoperative Care; Rats; R | 1981 |
Exercise-induced coronary arterial spasm: angiographic demonstration, documentation of ischemia by myocardial scintigraphy and results of pharmacologic intervention.
Topics: Angina Pectoris, Variant; Coronary Disease; Exercise Test; Humans; Indomethacin; Male; Middle Aged; | 1980 |
Phenoxybenzamine prevents spasm in radial artery conduits for coronary artery bypass grafting.
Topics: Coronary Artery Bypass; Humans; Phenoxybenzamine; Radial Artery; Spasm; Vasoconstriction; Vasodilato | 2000 |
Vasodilator pre-treatment of human radial arteries; comparison of effects of phenoxybenzamine vs papaverine on norepinephrine-induced contraction in vitro.
Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Female; Humans; Male; Middle Aged; Papaverine; P | 2001 |
Altered adrenergic activity in coronary arterial spasm: insight into mechanism based on study of coronary hemodynamics and the electrocardiogram.
Topics: Adult; Angina Pectoris, Variant; Arteries; Coronary Disease; Electrocardiography; Ergonovine; Female | 1979 |
Relative importance of warm ischaemia, hypotension, and hypercarbia in producing renal vasospasm.
Topics: Animals; Blood Circulation; Blood Pressure; Female; Hot Temperature; Hypercapnia; Hypotension; Ische | 1979 |
External sphincter spasticity syndrome in female patients.
Topics: Adult; Diazepam; Female; Humans; Male; Methyldopa; Phenoxybenzamine; Spasm; Syndrome; Urethra; Ureth | 1976 |
Agonal hepatic arterial vasospasm.
Topics: Animals; Asphyxia; Blood Flow Velocity; Catecholamines; Disease Models, Animal; Drug Evaluation, Pre | 1989 |
Treatment of pregnancy toxaemia with alpha-blocking agents.
Topics: Adrenergic alpha-Antagonists; Adult; Brain; Capillary Permeability; Eclampsia; Female; Humans; Hyper | 1971 |
[Treatment of renal vasospasm in shock (author's transl)].
Topics: Angiography; Animals; Cadaver; Dogs; Humans; Kidney; Kidney Transplantation; Papaverine; Phenoxybenz | 1973 |
[Muscular blood flow determinations in phenoxybenzamine treated ergotism].
Topics: Adult; Depression, Chemical; Ergotism; Female; Humans; Muscle Contraction; Muscles; Phenoxybenzamine | 1974 |
Improved immediate function of experimental cadaver renal allografts by elimination of agonal vaospasm.
Topics: Animals; Cadaver; Female; Kidney; Kidney Transplantation; Perfusion; Phenoxybenzamine; Renal Artery; | 1971 |