phenoxybenzamine and Shock studies

Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Shock: A pathological condition manifested by failure to perfuse or oxygenate vital organs.

Research Excerpts

Excerpt	Relevance	Reference
"Phenoxybenzamine is a safe and effective vasodilator which usually causes an increase in arterial blood pressure, an increase in cardiac index, an increase in urine output and a decrease in pulmonary artery pressure and central venous pressure in states of severe shock if hypovolemia has been corrected."	7.66	Treatment of severe shock with phenoxybenzamine. ( Hardaway, RM, 1980)
"Seven patients suffering from shock secondary to myocardial infarction were treated with phenoxybenzamine."	7.65	Effects of phenoxybenzamine in shock due to myocardial infarction. ( Riordan, JF; Walters, G, 1969)
" The effects of vasoconstrictor drugs such as methoxamine, phenylephrine, and norepinephrine have been generally unfavorable in shock because of the inhibition of tissue perfusion which results from their use."	4.75	The role of vasoactive agents in shock therapy. ( Ogburn, P, 1976)
" The SMA root was occluded for 60 minutes, after which blood pressure and SMA flow were monitored for one hundred minutes under the administration with fluid infusion of three anti-shock agents; dopamine, phenoxybenzamine and dexamethasone."	3.67	Effects of anti-shock agents on the re-opened superior mesenteric artery flow. ( Akiyama, M; Azuma, K; Hayasaka, H; Mizuma, K; Sasaki, K; Takahashi, K; Totsuka, M, 1984)
"Phenoxybenzamine is a safe and effective vasodilator which usually causes an increase in arterial blood pressure, an increase in cardiac index, an increase in urine output and a decrease in pulmonary artery pressure and central venous pressure in states of severe shock if hypovolemia has been corrected."	3.66	Treatment of severe shock with phenoxybenzamine. ( Hardaway, RM, 1980)
"Seven patients suffering from shock secondary to myocardial infarction were treated with phenoxybenzamine."	3.65	Effects of phenoxybenzamine in shock due to myocardial infarction. ( Riordan, JF; Walters, G, 1969)
"Sixty patients had hypoplastic left heart syndrome."	2.42	Prevention of early sudden circulatory collapse after the Norwood operation. ( Adatia, IT; Ashburn, DA; Burkhart, HM; De Oliveira, NC; Holtby, HM; Khalid, F; Van Arsdell, GS; Williams, WG, 2004)
"A phenoxybenzamine group (n = 6) was identical to the hypovolemic group, except that alpha-adrenergic effects were inhibited with phenoxybenzamine (3 mg/kg)."	1.29	Adrenergic vasoconstriction augments tissue O2 extraction during reductions in O2 delivery. ( Connolly, H; Maginniss, LA; Samsel, RW; Schumacker, PT, 1994)
" Propranolol, in a dosage insufficient to change MABP, decreased both CO and CBF."	1.26	Relationship of cerebral blood flow to cardiac output, mean arterial pressure, blood volume, and alpha and beta blockade in cats. ( Davis, DH; Sundt, TM, 1980)
" We have compared the effects of an angiotensin antagonist (saralasin) and an alpha-adrenergic blocking agent (phenoxybenzamine) in supramaximal dosage on cardiac output, total peripheral resistance, and venous tone in rabbits rendered hypovolemic by restriction of sodium intake, supplemented by a furosemide-induced diuresis 48 h prior to study."	1.26	Cardiovascular responses to blockade of angiotensin and alpha-adrenergic receptors. ( Borucki, LJ; Hollenberg, NK; Levenson, D, 1978)
"Bacteremic shock is second in frequency only to myocardial infarction as a cause of hypotension and death in hospitalized medical patients."	1.24	BACTEREMIC SHOCK--A MEDICAL EMERGENCY. ( CAMERON, DG; DIRKS, JH; RUEDY, J, 1963)

Timeframe	Studies, this research(%)	All Research%
pre-1990	93 (97.89)	18.7374
1990's	1 (1.05)	18.2507
2000's	1 (1.05)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Baez, S	2
Srikantia, SG	1
Burack, B	1
HERSHEY, SG	1
ROVENSTINE, EA	1
RAYNER, RR	1
MACLEAN, LD	1
GRIM, E	1
IAMPIETRO, PF	1
HINSHAW, LB	2
BRAKE, CM	2
PORCIUNCULA, CI	1
CROWELL, JW	3
RUEDY, J	1
DIRKS, JH	1
CAMERON, DG	1
SMITH, EE	2
NICKERSON, M	1
MARSHALL, RJ	1
DARBY, TD	1
POLLOCK, L	1
KJARTANSSON, KB	1
DELIN, NA	1
SCHENK, WG	1
VICK, JA	1
WILSON, RF	4
JABLONSKI, DV	1
THAL, AP	4
SMITH, LL	1
MULLER, W	1
HINSHAW, DB	1
UNAL, M	1
WEBB, WR	2
ASLAMI, A	1
SHARMA, GP	1
EISEMAN, B	1
SUKHNANDEN, R	1
EMERSON, TE	1
WITTMERS, LE	1
FILKINS, JP	1
MURPHY, DL	1
DOTY, JM	1
SMITH, JJ	1
O'NEILL, JA	1
FOSTER, JH	1
LILLEHEI, RC	7
LONGERBEAM, JK	1
BLOCH, JH	3
MANAX, WG	3
FITTS, CT	1
SAWYER, RB	1
ADNER, M	1
LEFER, AM	1
LINTZ, EM	1
SUKHNANDAN, R	1
PIERCE, CH	1
KLASS, AA	1
BERGER, RL	2
NOVOGRADAC, WE	1
BYRNE, JJ	1
ECKENHOFF, JE	1
COOPERMAN, LH	1
De Oliveira, NC	1
Ashburn, DA	1
Khalid, F	1
Burkhart, HM	1
Adatia, IT	1
Holtby, HM	1
Williams, WG	1
Van Arsdell, GS	1
Dietzman, RH	5
Iatrides, E	1
Ryan, TJ	1
Hruza, Z	1
Zweifach, BW	1
Hardaway, RM	3
James, PM	1
Anderson, RW	1
Bredenberg, CE	1
West, RL	1
Davis, DH	1
Sundt, TM	1
Akiyama, M	1
Takahashi, K	1
Azuma, K	1
Sasaki, K	1
Mizuma, K	1
Totsuka, M	1
Hayasaka, H	1
Haglund, U	1
Hellman, A	1
Häggendal, E	1
Häggendal, J	1
Maginniss, LA	1
Connolly, H	1
Samsel, RW	1
Schumacker, PT	1
Ahlquist, RP	1
Kovach, AG	1
El-Etr, AA	1
Glisson, SN	1
Borucki, LJ	1
Levenson, D	1
Hollenberg, NK	1
Korbut, R	1
Ocetkiewicz, A	1
Gryglewski, RJ	1
Ogburn, P	1
Berk, JL	1
Su, JY	1
Mitchell, HM	1
Lyons, GW	1
Litton, A	1
Lewis, CM	1
Weil, MH	1
Williamson, M	1
Nelson, NC	1
Nelson, JL	1
Weldon, WE	1
Vela, AR	1
Huguenard, P	1
Humphrey, EW	1
Lindsay, WG	1
Murphy, WR	1
Schwartz, L	1
Alho, A	1
Moyer, JH	2
Mills, LC	2
Meyer, W	2
Ciesielski, L	1
Bilski, D	1
Chodorowski, R	1
Hermreck, AS	1
Motsay, GJ	2
Schultz, LS	1
Romero, LH	1
Beckman, CB	1
Bivins, BA	1
Madauss, WC	1
Griffen, WO	1
Voegeli, E	1
Grandchamp, A	1
Kabal, J	1
Doyle, TF	1
Orr, KB	1
Freeman, J	1
Halmagyi, DF	2
Dornhorst, AC	1
Markley, K	1
Smallman, E	1
Chandra, P	1
Dave, PK	1
Sarver, EJ	1
Rizzo, J	1
Shoemaker, WC	1
Brown, RS	1
Novelli, GP	1
Zampolini, M	1
Celiberti, A	1
Cortesini, C	1
Pagni, E	1
Haller, JA	1
Gengos, DC	1
Tecklenberg, P	1
Schumer, W	1
Irving, MH	1
Gillett, DJ	1
Varga, D	1
Nagy, S	1
Riordan, JF	1
Walters, G	1
Friedberg, CK	1
Watt, DA	1
Obineche, EN	1
Livingstone, WR	1
Delaney, JP	1
Paritzky, AZ	1
Corday, E	2
Sauer, H	1
Vyden, JK	1
Lang, TW	1
Boszormenyi, E	1
Carvalho, M	1
Gold, H	1
Goldman, A	1
Rosselot, E	1
Fromm, S	1
Goldberg, LI	1
MacCannell, KL	1
McNay, JL	1
Meyer, MB	1
Szabó, G	1
Sátori, O	1
Grandtner, G	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock[NCT03235921]			Phase 2	100 participants (Anticipated)	Interventional	2016-03-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
NEWER AGENTS IN THE TREATMENT OF SHOCK. The Medical clinics of North America, 1964, Volume: 48 Topics: Anaphylaxis; Arrhythmias, Cardiac; Cardiac Tamponade; Catecholamines; Drug Therapy; Endocrinology; G	1964
Prevention of early sudden circulatory collapse after the Norwood operation. Circulation, 2004, Sep-14, Volume: 110, Issue:11 Suppl 1 Topics: Adrenergic alpha-Antagonists; Biomarkers; Cardiopulmonary Bypass; Cardiotonic Agents; Case Managemen	2004
Cerebral hemodynamic and metabolic alterations in hypovolemic shock. Advances in experimental medicine and biology, 1977, Volume: 78 Topics: Afferent Pathways; Animals; Blood Pressure; Brain; Cardiac Output; Deoxyglucose; Electric Stimulatio	1977
Alpha-adrenergic blocking agents. International anesthesiology clinics, 1978,Summer, Volume: 16, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Ergot	1978
The role of vasoactive agents in shock therapy. The Veterinary clinics of North America, 1976, Volume: 6, Issue:2 Topics: Animals; Chlorpromazine; Dog Diseases; Dogs; Dopamine; Isoproterenol; Methoxamine; Norepinephrine; P	1976
[Mechanism of the antishock action of anisodamine (654-2)]. Sheng li ke xue jin zhan [Progress in physiology], 1985, Volume: 16, Issue:4 Topics: Animals; Calcium Channel Blockers; Hypoxia; Intestine, Small; Lysosomes; Mitochondria; Phenoxybenzam	1985
Adrenergic agonists and antagonists in the treatment of hypovolemic shock. Journal of the American Medical Women's Association, 1969, Volume: 24, Issue:12 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A	1969
[Cliniccal aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms]. Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5 Topics: Adult; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; Escherichia	1966
[Clinical aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms]. Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5 Topics: Adult; Aldosterone; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins;	1966
[Use of alpha-adrenergic blockade for the treatment of shock]. Polski przeglad chirurgiczny, 1968, Volume: 40, Issue:6 Topics: Humans; Phenoxybenzamine; Shock	1968
The adrenergic drugs and their use in shock therapy. Current problems in surgery, 1968 Topics: Adolescent; Aged; Blood Pressure; Female; Heart Rate; Humans; Isoproterenol; Male; Metaraminol; Meth	1968

Article	Year
Dibenzyline protection against shock and preservation of hepatic ferritin systems. The American journal of physiology, 1958, Volume: 192, Issue:1 Topics: Ferritins; Humans; Liver; Phenoxybenzamine; Portal System; Shock; Sympatholytics	1958
Intestinal ischemia shock in normal and Dibenzyline-protected dogs. The American journal of physiology, 1961, Volume: 200 Topics: Animals; Dogs; Intestines; Ischemia; Phenoxybenzamine; Shock; Sympatholytics; Vascular Diseases	1961
Intestinal tissue blood flows in experimental shock due to hemorrhage endotoxin, and adrenalin; and in endotoxin shock pretreated with hydrocortisone or dibenzyline. Surgical forum, 1960, Volume: 11 Topics: Antitoxins; Endotoxins; Epinephrine; Hydrocortisone; Intestines; Phenoxybenzamine; Shock; Sympatholy	1960
Effect of an adrenergic blocking agent on vascular alterations associated with endotoxin shock. The American journal of physiology, 1963, Volume: 204 Topics: Adrenergic Antagonists; Blood Pressure; Blood Pressure Determination; Endotoxins; Epinephrine; Pheno	1963
QUANTITATIVE STUDY OF INTESTINAL FLUID LOSS IN IRREVERSIBLE HEMORRHAGIC SHOCK. The American journal of physiology, 1963, Volume: 205 Topics: Animals; Atropine; Body Fluids; Dogs; Hypotension; Intestine, Small; Intestines; Pharmacology; Pheno	1963
BACTEREMIC SHOCK--A MEDICAL EMERGENCY. Canadian Medical Association journal, 1963, Nov-23, Volume: 89 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Emergencies; Humans; Hypotension; Metaraminol; M	1963
OXYGEN DEFICIT AND IRREVERSIBLE HEMORRHAGIC SHOCK. The American journal of physiology, 1964, Volume: 206 Topics: Animals; Digitalis; Digitalis Glycosides; Dogs; Epinephrine; Hypotension; Hypoxia; Metabolism; Norep	1964
VASOCONSTRICTION AND VASODILATATION IN SHOCK. International anesthesiology clinics, 1964, Volume: 2 Topics: Blood Circulation; Blood Pressure; Blood Transfusion; Blood Volume; Dextrans; Humans; Infections; Pa	1964
REGIONAL BLOOD FLOW ALTERATIONS. STUDIES OF CHANGES IN THIS COURSE PRODUCED BY A VASOCONSTRICTOR AND AN ADRENERGIC BLOCKING AGENT DURING READJUSTMENT TO HEMORRHAGIC SHOCK. Archives of surgery (Chicago, Ill. : 1960), 1964, Volume: 89 Topics: Adrenergic Antagonists; Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Dogs; Norep	1964
ENDOTOXIN SHOCK IN THE PRIMATE: TREATMENT WITH PHENOXYBENZAMINE. The Journal of clinical investigation, 1964, Volume: 43 Topics: Animals; Blood Pressure; Endotoxins; Escherichia coli; Haplorhini; Kidney Function Tests; p-Aminohip	1964
THE USAGE OF DIBENZYLINE IN CLINICAL SHOCK. Surgery, 1964, Volume: 56 Topics: Aortic Aneurysm; Biomedical Research; Blood Pressure Determination; Duodenal Ulcer; Geriatrics; Hear	1964
THE MANAGEMENT OF EXPERIMENTAL ENDOTOXIN SHOCK. THE CIRCULATORY EFFECTS OF LEVARTERENOL, HYDROCORTISONE, PHENOXYBENZAMINE HYDROCHLORIDE, AND BLOOD VOLUME EXPANSION. Archives of surgery (Chicago, Ill. : 1960), 1964, Volume: 89 Topics: Blood Circulation; Blood Pressure; Blood Volume; Dextrans; Dogs; Endotoxins; Heart Function Tests; H	1964
METABOLIC RESPONSES TO VARIOUS VASOACTIVE AND CARDIOTONIC AGENTS IN HYPOVOLEMIA. Surgical forum, 1964, Volume: 15 Topics: Angiotensins; Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Determinati	1964
PROTECTIVE EFFECT OF ADENOSINE TRIPHOSPHATE IN EXPERIMENTAL HEMORRHAGIC SHOCK. Surgical forum, 1964, Volume: 15 Topics: Adenine Nucleotides; Adenosine Triphosphate; Heart; Metabolism; Pharmacology; Phenoxybenzamine; Rats	1964
COMBINED USE OF NOREPINEPHRINE AND DIBENZYLINE IN CLINICAL SHOCK. Surgical forum, 1964, Volume: 15 Topics: Norepinephrine; Phenoxybenzamine; Shock	1964
ALTERATION OF VASCULAR RESPONSES TO ENDOTOXIN BY ADRENERGIC BLOCKADE. The American journal of physiology, 1964, Volume: 207 Topics: Adrenergic Agents; Animals; Blood; Blood Pressure; Blood Pressure Determination; Blood Vessels; Dogs	1964
EFFECT OF PHENOXYBENZAMINE ON PHAGOCYTIC ACTIVITY AND SHOCK MORTALITY IN THE RAT. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 116 Topics: Mononuclear Phagocyte System; Phagocytosis; Pharmacology; Phenoxybenzamine; Rats; Research; Shock; S	1964
THE INFLUENCE OF LOW MOLECULAR WEIGHT DEXTRAN ON LETHAL ENDOTOXEMIA. The American surgeon, 1964, Volume: 30 Topics: Aldosterone; Dextrans; Dogs; Endotoxemia; Endotoxins; Erythrocyte Aggregation; Escherichia coli Infe	1964
THE NATURE OF IRREVERSIBLE SHOCK: EXPERIMENTAL AND CLINICAL OBSERVATIONS. Annals of surgery, 1964, Volume: 160 Topics: Blood Flow Velocity; Blood Pressure Determination; Blood Transfusion; Blood Volume Determination; Co	1964
EFFECT OF HEMORRHAGIC HYPOTENSION ON OXYGEN CONSUMPTION OF DOGS. The American journal of physiology, 1964, Volume: 207 Topics: Blood Flow Velocity; Dogs; Epinephrine; Hematocrit; Homeostasis; Hypotension; Metabolism; Oximetry;	1964
THE USE OF DRUGS IN THE TREATMENT OF IRREVERSIBLE VASOCONSTRICTOR SHOCK. The Journal of trauma, 1965, Volume: 5 Topics: Dextrans; Dogs; Heparin; Norepinephrine; Pharmacology; Phenoxybenzamine; Research; Shock; Shock, Hem	1965
MODERN TREATMENT OF HAEMODYNAMIC DISTURBANCES IN SHOCK. Acta anaesthesiologica Scandinavica. Supplementum, 1964, Volume: 15 Topics: Chlorpromazine; Drug Therapy; Hemodynamics; Humans; Hydrocortisone; Phenoxybenzamine; Shock; Therape	1964
PROTECTION AGAINST CARDIOVASCULAR COLLAPSE IN ACUTE ADRENALECTOMY BY AUTONOMIC BLOCKING AGENTS. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 118 Topics: Adrenalectomy; Autonomic Agents; Dogs; Hexamethonium Compounds; Hydrocortisone; Pentolinium Tartrate	1965
THE EFFECT OF ENDOTOXIN AND VASOACTIVE AGENTS ON DIBENZYLINE-PRETREATED LUNGS. Surgery, 1965, Volume: 58 Topics: Animals; Blood; Blood Pressure; Blood Pressure Determination; Bradykinin; Capillary Resistance; Dext	1965
TREATMENT OF EXPERIMENTAL CARDIOGENIC SHOCK. Surgery, 1965, Volume: 58 Topics: Animals; Blood Pressure; Cardiac Output; Coronary Disease; Dextrans; Dogs; Electrocardiography; Hemo	1965
THE TREATMENT OF SUPERIOR MESENTERIC ARTERY OCCLUSION: A REAPPRAISAL. Canadian Medical Association journal, 1965, Aug-14, Volume: 93 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Anticoagulants; Blood Pressure; Diagnosis; Drug	1965
SURGICAL AND CHEMICAL DENERVATION OF ABDOMINAL VISCERA IN IRREVERSIBLE HEMORRHAGIC SHOCK. Annals of surgery, 1965, Volume: 162 Topics: Abdomen; Animals; Autonomic Nerve Block; Blood Circulation; Dogs; Hemodynamics; Mesentery; Pharmacol	1965
THE CLINICAL APPLICATION OF PHENOXYBENZAMINE IN SHOCK AND VASOCONSTRICTIVE STATES. Surgery, gynecology & obstetrics, 1965, Volume: 121 Topics: Blood Pressure; Blood Pressure Determination; Blood Volume; Drug Therapy; Humans; Hypotension; Hypot	1965
Shock: mechanisms and therapy. Canadian Anaesthetists' Society journal, 1967, Volume: 14, Issue:4 Topics: Animals; Chlorpromazine; Digitalis Glycosides; Dogs; Endotoxins; Epinephrine; Equipment and Supplies	1967
The homologous blood reaction of cardiopulmonary bypass: an experimental study on pathogenesis and treatment. The Annals of thoracic surgery, 1967, Volume: 4, Issue:6 Topics: Animals; Ascorbic Acid; Blood Group Incompatibility; Blood Pressure; Blood Volume; Cardiac Output; D	1967
Effect of age on vascular reactivity to catecholamines in rats. Journal of gerontology, 1967, Volume: 22, Issue:4 Topics: Age Factors; Animals; Arteries; Blood Flow Velocity; Blood Pressure; Blood Vessels; Epinephrine; Fem	1967
Intensive study and treatment of shock in man. JAMA, 1967, Mar-13, Volume: 199, Issue:11 Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Blood Pressure; Blood Volume; Electrocardiogra	1967
Relationship of cerebral blood flow to cardiac output, mean arterial pressure, blood volume, and alpha and beta blockade in cats. Journal of neurosurgery, 1980, Volume: 52, Issue:6 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Blood Volume; Br	1980
Effects of anti-shock agents on the re-opened superior mesenteric artery flow. The Japanese journal of surgery, 1984, Volume: 14, Issue:1 Topics: Animals; Blood Flow Velocity; Blood Pressure; Dexamethasone; Dopamine; Intestines; Mesenteric Arteri	1984
Ligation of the adrenal vessels--an incomplete technique to eliminate the plasma adrenaline content in the dog. Acta physiologica Scandinavica, 1981, Volume: 113, Issue:3 Topics: Adrenal Glands; Animals; Blood Vessels; Dogs; Epinephrine; Hemodynamics; Ligation; Methylprednisolon	1981
Treatment of severe shock with phenoxybenzamine. Surgery, gynecology & obstetrics, 1980, Volume: 151, Issue:6 Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Diuresis; Hemodynamics; Humans; Phenoxybenz	1980
Adrenergic vasoconstriction augments tissue O2 extraction during reductions in O2 delivery. Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:4 Topics: Acid-Base Equilibrium; Animals; Blood Gas Analysis; Dogs; Hemodynamics; Hindlimb; Hypoxia; In Vitro	1994
Present state of alpha and beta adrenergic drugs. II. The adrenergic blocking agents. American heart journal, 1976, Volume: 92, Issue:6 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Cardiovascular System; Humans; Neuroblast	1976
Cardiovascular responses to blockade of angiotensin and alpha-adrenergic receptors. The American journal of physiology, 1978, Volume: 235, Issue:3 Topics: Animals; Blood Pressure; Cardiac Output; Female; Phenoxybenzamine; Rabbits; Receptors, Adrenergic; R	1978
The influence of hydrocortisone and indomethacin on the release of prostaglandin-like substances during circulatory shock in cats, which was induced by an intravenous administration of rabbit blood. Pharmacological research communications, 1978, Volume: 10, Issue:4 Topics: Animals; Cats; Drug Interactions; Female; Hydrocortisone; Indomethacin; Male; Phenoxybenzamine; Prop	1978
Use of vasoactive drugs in the treatment of shock. The Surgical clinics of North America, 1975, Volume: 55, Issue:3 Topics: Adrenal Cortex Hormones; Blood Pressure; Calcium; Cardiac Output; Catecholamines; Digitalis Glycosid	1975
The use of adrenergic blocking drugs in hypovolemic shock. Journal of the American Medical Women's Association, 1969, Volume: 24, Issue:6 Topics: Blood Volume; Phenoxybenzamine; Shock	1969
Relation of cardiac work to survival in cardiogenic shock in dogs. JAMA, 1967, Mar-13, Volume: 199, Issue:11 Topics: Angiotensin II; Animals; Blood Pressure; Cardiac Output; Dextrans; Dogs; Electricity; Hemodynamics;	1967
Microvascular effects of vasoactive agents in shock. The British journal of surgery, 1968, Volume: 55, Issue:10 Topics: Aged; Angiotensin II; Animals; Arteries; Blood; Blood Vessels; Cheek; Cricetinae; Epinephrine; Femal	1968
Hemodynamic spectrum of vasopressor and vasodilator drugs. JAMA, 1969, May-26, Volume: 208, Issue:8 Topics: Angiotensin II; Animals; Blood Pressure; Dogs; Epinephrine; Heart Rate; Hemodynamics; Isoproterenol;	1969
Mechanisms of change in thoracic duct lymph flow during hypotensive states. Annals of surgery, 1970, Volume: 171, Issue:6 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspirin; Capillary Permeability;	1970
[Adrenergic receptor drugs in treatment of shock]. Laval medical, 1971, Volume: 42, Issue:7 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Catecholamines; C	1971
Shock lung. International surgery, 1973, Volume: 58, Issue:5 Topics: Adolescent; Adult; Aged; Animals; Disseminated Intravascular Coagulation; Dogs; Female; Heart Failur	1973
Determinants in the measurement of pulmonary extravascular water. Bulletin de la Societe internationale de chirurgie, 1974, Volume: 33, Issue:2 Topics: Airway Resistance; Animals; Arteriovenous Fistula; Blood Volume; Body Water; Cardiac Output; Dogs; E	1974
Effects of vasoactive drugs on lysosomal stability in vitro. Biochemical pharmacology, 1973, Oct-15, Volume: 22, Issue:20 Topics: Acid Phosphatase; Adrenergic alpha-Antagonists; Animals; Cell Fractionation; Cell Membrane; Cell Sur	1973
Vasopressors for treating shock. Postgraduate medicine, 1974, Volume: 56, Issue:2 Topics: Bacteria; Chloramphenicol; Epinephrine; Humans; Isoproterenol; Metaraminol; Methoxamine; Morphine; M	1974
[Drugs in shock treatment]. Der Internist, 1971, Volume: 12, Issue:3 Topics: Adrenal Cortex Hormones; Cardiac Output; Chlorpromazine; Digitalis Glycosides; Humans; Isoproterenol	1971
The pharmacologic approach to the treatment of shock. I. Defining traumatic, septic, and cardiogenic shock. Geriatrics, 1972, Volume: 27, Issue:7 Topics: Adrenal Glands; Cardiac Output; Glucocorticoids; Humans; Infusions, Parenteral; Isoproterenol; Micro	1972
Fat embolism syndrome: a clinical study. Southern medical journal, 1972, Volume: 65, Issue:8 Topics: Abdominal Injuries; Accidents, Traffic; Adult; Age Factors; Blood Transfusion; Craniocerebral Trauma	1972
[The cortical renal ischaemia. The angiographic diagnosis and clinical meaning]. Radiologia clinica et biologica, 1971, Volume: 40, Issue:6 Topics: Adrenal Glands; Angiography; Animals; Dogs; Epinephrine; Humans; Ischemia; Kidney; Kidney Diseases;	1971
The origin of tourniquet shock-induced cardiovascular failure in exogenous hyperthyroidism. Experientia, 1971, Volume: 27, Issue:11 Topics: Animals; Extremities; Heart; Hemodynamics; Hyperthyroidism; Ischemia; Male; Phenoxybenzamine; Rats;	1971
A fatal case of phaeochromocytoma. The Medical journal of Australia, 1969, Nov-01, Volume: 2, Issue:18 Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Humans; Male; Phenoxybenzamine; Pheochromocytoma; Pr	1969
Phenoxybenzamine in the treatment of cardiogenic shock. The Medical journal of Australia, 1969, Dec-06, Volume: 2, Issue:23 Topics: Adult; Aged; Angina Pectoris; Catecholamines; Diabetes Complications; Female; Humans; Male; Middle A	1969
Catecholamines, disseminated intra-vascular coagulation and shock. The Medical journal of Australia, 1970, May-16, Volume: 1, Issue:20 Topics: Animals; Blood Coagulation Disorders; Catecholamines; Heparin; Humans; Phenoxybenzamine; Shock; Thro	1970
The pathogenesis and management of peripheral circulatory failure. Annals of the Royal College of Surgeons of England, 1970, Volume: 46, Issue:3 Topics: Arteries; Blood Pressure; Blood Transfusion; Blood Volume; Cardiac Output; Cardiovascular Diseases;	1970
Protection against burn, tourniquet, and endotoxin shock by purine compounds. The Journal of trauma, 1970, Volume: 10, Issue:7 Topics: Adenosine Triphosphate; Animals; Burns; Histamine; Injections, Intraperitoneal; Mice; Phenoxybenzami	1970
Effect of dipyrone on tourniquet shock. Arzneimittel-Forschung, 1970, Volume: 20, Issue:3 Topics: Aminopyrine; Animals; Arteries; Blood Pressure; Blood Volume; Guanethidine; Hexamethonium Compounds;	1970
Vasopressors and other drugs used in shock. British medical journal, 1970, Sep-26, Volume: 3, Issue:5725 Topics: Blood Volume; Cardiac Output; Central Venous Pressure; Dopamine; Humans; Infusions, Parenteral; Isop	1970
Hemodynamic changes, treatment, and prognosis in clinical shock. Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 102, Issue:1 Topics: Blood Pressure; Cardiac Output; Heart; Hemodynamics; Humans; Liver Cirrhosis; Phenoxybenzamine; Phen	1971
The dilemma of vasopressors and vasodilators in the therapy of shock. Surgery, gynecology & obstetrics, 1971, Volume: 132, Issue:1 Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Chlorpromazine; Heart Rate; Hemodynamics; H	1971
Indications for adrenergic stimulators in shock. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1971, Volume: 4, Issue:4 Topics: Blood Pressure; Blood Volume; Cardiac Output; Carotid Arteries; Central Venous Pressure; Cerebrovasc	1971
[Halothane as an anti-adrenergic drug in the treatment of shock. Experimental hemodynamic study]. Minerva anestesiologica, 1967, Volume: 33, Issue:1 Topics: Animals; Blood Transfusion; Dogs; Halothane; Hemodynamics; Phenoxybenzamine; Propranolol; Shock; Sho	1967
Metabolic alterations in shock. An experimental comparison of three vasoactive drugs with high levels of arterial oxygen tension. The Journal of trauma, 1968, Volume: 8, Issue:2 Topics: Animals; Arteries; Blood Pressure; Cardiac Output; Dogs; Extracorporeal Circulation; Female; Hydroge	1968
Localization of the energy pathway block in shock. Surgery, 1968, Volume: 64, Issue:1 Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Chromatography, Thin Layer; Citric Acid Cycle; Coe	1968
The effect of adrenergic blockade upon shock-induced lacticacidosis in sheep. The British journal of surgery, 1968, Volume: 55, Issue:10 Topics: Acidosis; Animals; Blood Pressure; Epinephrine; Female; Lactates; Male; Phenoxybenzamine; Propranolo	1968
Effect of isoproterenol on cardiac output during alpha adrenergic receptor blockade. Medicina experimentalis : International journal of experimental medicine, 1968, Volume: 18, Issue:1 Topics: Animals; Cardiac Output; Dogs; Isoproterenol; Phenoxybenzamine; Sensory Receptor Cells; Shock; Vasom	1968
Effects of phenoxybenzamine in shock due to myocardial infarction. British medical journal, 1969, Jan-18, Volume: 1, Issue:5637 Topics: Aged; Cardiac Output; Humans; Middle Aged; Myocardial Infarction; Noise; Phenoxybenzamine; Respirati	1969
Current status of the treatment of shock complicating acute myocardial infarction. The Journal of trauma, 1969, Volume: 9, Issue:2 Topics: Digitalis Glycosides; Dopamine; Humans; Hydrocortisone; Hyperbaric Oxygenation; Hypotension; Isoprot	1969
Treating shock. British medical journal, 1969, Feb-22, Volume: 1, Issue:5642 Topics: Humans; Phenoxybenzamine; Pulmonary Edema; Shock	1969
Necrosis of a pheochromocytoma with shock. The New England journal of medicine, 1969, Jun-19, Volume: 280, Issue:25 Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Female; Humans; Hypertension; Hypotension; Necrosis;	1969
Treatment of shock associated with myocardial infarction. The Medical letter on drugs and therapeutics, 1969, Apr-04, Volume: 11, Issue:7 Topics: Albumins; Arrhythmias, Cardiac; Dextrans; Digitalis Glycosides; Dopamine; Heart-Lung Machine; Humans	1969
Pressor agents in cardiogenic shock. The American journal of cardiology, 1969, Volume: 23, Issue:6 Topics: Animals; Anuria; Aortic Valve; Blood Flow Velocity; Blood Pressure; Blood Viscosity; Blood Volume; C	1969
[Special problems in ileus during infancy]. Wiener medizinische Wochenschrift (1946), 1969, Jul-05, Volume: 119, Issue:27 Topics: Adenosine Triphosphate; Dexamethasone; Female; Humans; Infant; Infant, Newborn; Intestinal Obstructi	1969
Reevaluation of the treatment of shock secondary to cardiac infarction. Diseases of the chest, 1969, Volume: 56, Issue:3 Topics: Adrenal Cortex Hormones; Animals; Blood Flow Velocity; Blood Pressure; Blood Volume; Cardiac Output;	1969
Phenoxybenzamine in human shock. Surgery, gynecology & obstetrics, 1969, Volume: 129, Issue:4 Topics: Cardiac Output; Humans; Norepinephrine; Phenoxybenzamine; Shock; Vascular Resistance	1969
Vasodilators in shock--when? Southern medical journal, 1966, Volume: 59, Issue:3 Topics: Humans; Hydralazine; Hydrocortisone; Phenoxybenzamine; Shock; Trimethaphan; Vasodilator Agents	1966
The use of dopamine in the treatment of hypotension and shock after myocardial infarction or cardiac surgery. American heart journal, 1966, Volume: 72, Issue:4 Topics: Cardiac Surgical Procedures; Dopamine; Humans; Hypotension; Mannitol; Myocardial Infarction; Phenoxy	1966
Vasodilator in shock gains laboratory, clinical support. JAMA, 1966, Jun-27, Volume: 196, Issue:13 Topics: Animals; Dogs; Phenoxybenzamine; Shock	1966
Prevention and treatment of shock with corticosteroids. Effect of prednisolone in norepinephrine- and epinephrine-induced shock. Acta medica Academiae Scientiarum Hungaricae, 1966, Volume: 23, Issue:1 Topics: Animals; Dogs; Epinephrine; Norepinephrine; Phenoxybenzamine; Prednisolone; Shock	1966

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