phenoxybenzamine has been researched along with Sepsis in 15 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therefore, the active hyperemia of inflammation may add significantly to demands on circulation." | 1.25 | Septic shock: hemodynamics of endotoxin and inflammation. ( Damewood, CA; Hopkins, RW, 1974) |
| "Bacteremic shock is second in frequency only to myocardial infarction as a cause of hypotension and death in hospitalized medical patients." | 1.24 | BACTEREMIC SHOCK--A MEDICAL EMERGENCY. ( CAMERON, DG; DIRKS, JH; RUEDY, J, 1963) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| RUEDY, J | 1 |
| DIRKS, JH | 1 |
| CAMERON, DG | 1 |
| FRANK, ED | 1 |
| LILLEHEI, RC | 3 |
| LONGERBEAM, JK | 1 |
| BLOCH, JH | 1 |
| MANAX, WG | 1 |
| Anderson, RW | 1 |
| James, PM | 1 |
| Bredenberg, CE | 1 |
| Hardaway, RM | 1 |
| Seneca, H | 1 |
| Fantini, GA | 1 |
| Shiono, S | 1 |
| Bal, BS | 1 |
| Shires, GT | 1 |
| Lambert, HP | 1 |
| Hopkins, RW | 2 |
| Damewood, CA | 1 |
| Lambotte, L | 1 |
| Rocmans, P | 1 |
| Meyer, W | 2 |
| Motsay, GJ | 1 |
| Dietzman, RH | 2 |
| Ersek, RA | 1 |
| Motsay, G | 1 |
| Alho, A | 1 |
| Marston, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock[NCT03235921] | Phase 2 | 100 participants (Anticipated) | Interventional | 2016-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phenoxybenzamine and Sepsis
| Article | Year |
|---|---|
The management of bacteremic shock.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Burns; Catheterization; Cephaloridine; Cephalot | 1969 |
[Cliniccal aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
Topics: Adult; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; Escherichia | 1966 |
[Clinical aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms].
Topics: Adult; Aldosterone; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; | 1966 |
12 other studies available for phenoxybenzamine and Sepsis
| Article | Year |
|---|---|
BACTEREMIC SHOCK--A MEDICAL EMERGENCY.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Emergencies; Humans; Hypotension; Metaraminol; M | 1963 |
SEPTIC SHOCK.
Topics: Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Autonomic Nerve Block; Blood; Blood Volume; | 1964 |
THE NATURE OF IRREVERSIBLE SHOCK: EXPERIMENTAL AND CLINICAL OBSERVATIONS.
Topics: Blood Flow Velocity; Blood Pressure Determination; Blood Transfusion; Blood Volume Determination; Co | 1964 |
Phenoxybenzamine in septic shock.
Topics: Adult; Endometritis; Female; Humans; Male; Peritonitis; Phenoxybenzamine; Pheochromocytoma; Pneumoni | 1967 |
Gram-negative sepsis: part II. Management.
Topics: Acidosis; Adult; Amikacin; Child; Chloramphenicol; Clindamycin; Disseminated Intravascular Coagulati | 1977 |
Adrenergic mechanisms contribute to alterations in regional perfusion during normotensive E. coli bacteremia.
Topics: Animals; Blood Pressure; Escherichia coli Infections; Male; Phenoxybenzamine; Rats; Rats, Inbred Str | 1989 |
Septic shock: hemodynamics of endotoxin and inflammation.
Topics: Animals; Blood Pressure; Blood Volume; Dextrans; Dogs; Endotoxins; Escherichia coli; Hematocrit; Hem | 1974 |
[Toxi-infectious shock].
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Blood Transfusion; Chlorpromazine; Digitalis G | 1973 |
Hemodynamic alterations and results of treatment in patients with gram-negative septic shock.
Topics: Adult; Aged; Ampicillin; Blood Pressure; Blood Transfusion; Cardiac Output; Central Venous Pressure; | 1970 |
Clinical and laboratory experience with gram-negative septic shock.
Topics: Adult; Aged; Animals; Blood Pressure; Capillaries; Capillary Permeability; Cardiac Output; Central V | 1972 |
Gram-negative septicaemia--clinical aspects and physiological management.
Topics: Central Venous Pressure; Dexamethasone; Drainage; Hemorrhage; Humans; Infusions, Parenteral; Isoprot | 1969 |
Septic shock: hemodynamic cost of inflammation.
Topics: Animals; Arteries; Calcium Chloride; Dogs; Hemodynamics; Hindlimb; Hyperemia; Inflammation; Methylpr | 1970 |