phenoxybenzamine has been researched along with Multiple Sclerosis in 6 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dicyclomine hydrochloride was the drug of choice for detrusor hyperreflexia, bethanechol chloride for hypotonicity, dantrolene sodium for somatic dyssynergia and phenoxybenzamine hydrochloride for sympathetic dyssynergia." | 1.26 | Dysfunction of the detrusor and urethra in multiple sclerosis: the role of drug therapy. ( Awad, SA; Fenemore, J; Kiruluta, HG; Wilson, JW, 1982) |
| "Treatment with phenoxybenzamine was found valuable in patients with multiple sclerosis and poor bladder emptying as well as in patients with lower motor neuron bladder paresis." | 1.26 | Alpha-blockers and urethral pressure in neurological patients. ( Nordling, J, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Awad, SA | 1 |
| Wilson, JW | 1 |
| Fenemore, J | 1 |
| Kiruluta, HG | 1 |
| McGuire, EJ | 1 |
| Savastano, JA | 1 |
| Kiesswetter, H | 1 |
| Flamm, J | 1 |
| Hennrich, F | 1 |
| Summer, K | 1 |
| Schober, W | 1 |
| Busse, O | 1 |
| Kronsbein, HJ | 1 |
| Schoenberg, HW | 1 |
| Gutrich, JM | 1 |
| Nordling, J | 1 |
1 review available for phenoxybenzamine and Multiple Sclerosis
| Article | Year |
|---|---|
[Somatic and psychosocial therapy concepts in multiple sclerosis (I)].
Topics: Azathioprine; Benzilates; Butylscopolammonium Bromide; Cyclophosphamide; Dietary Fats; Emepronium; F | 1981 |
5 other studies available for phenoxybenzamine and Multiple Sclerosis
| Article | Year |
|---|---|
Dysfunction of the detrusor and urethra in multiple sclerosis: the role of drug therapy.
Topics: Adult; Bethanechol; Bethanechol Compounds; Dantrolene; Dicyclomine; Drug Evaluation; Female; Humans; | 1982 |
Urodynamic findings and long-term outcome management of patients with multiple sclerosis-induced lower urinary tract dysfunction.
Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Female; Humans; Imipramine; Male; Mandelic Acids; M | 1984 |
[Urological complications in patients with multiple sclerosis (author's transl)].
Topics: Adolescent; Adult; Aged; Baclofen; Electric Stimulation; Emepronium; Female; Humans; Male; Middle Ag | 1980 |
Management of vesical dysfunction in multiple sclerosis.
Topics: Bethanechol Compounds; Diazepam; Humans; Multiple Sclerosis; Phenoxybenzamine; Reflex, Abnormal; Uri | 1980 |
Alpha-blockers and urethral pressure in neurological patients.
Topics: Adrenergic alpha-Antagonists; Female; Humans; Male; Multiple Sclerosis; Paralysis; Phenoxybenzamine; | 1978 |