phenoxybenzamine has been researched along with Leukemia in 2 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "2-Chlorpromazine was shown previously [Syed SK, Christopherson RI and Roufogalis BD (1996) Biochem Mol Biol Int 39: 687-696] to be actively transported into vesicles from multidrug-resistant cells." | 1.30 | Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells. ( Christopherson, RI; Roufogalis, BD; Syed, SK, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Syed, SK | 1 |
| Christopherson, RI | 1 |
| Roufogalis, BD | 1 |
| Mason, AB | 1 |
2 other studies available for phenoxybenzamine and Leukemia
| Article | Year |
|---|---|
Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells.
Topics: Biological Transport; Calcium; Cell Membrane; Chlorpromazine; Colchicine; Drug Resistance, Multiple; | 1998 |
Can adrenergic blockers be leukemogenic?
Topics: Adrenergic alpha-Antagonists; Carcinogens; Leukemia; Phenoxybenzamine; Sympatholytics | 1971 |