Page last updated: 2024-11-02

phenoxybenzamine and Leukemia

phenoxybenzamine has been researched along with Leukemia in 2 studies

Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"2-Chlorpromazine was shown previously [Syed SK, Christopherson RI and Roufogalis BD (1996) Biochem Mol Biol Int 39: 687-696] to be actively transported into vesicles from multidrug-resistant cells."1.30Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells. ( Christopherson, RI; Roufogalis, BD; Syed, SK, 1998)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Syed, SK1
Christopherson, RI1
Roufogalis, BD1
Mason, AB1

Other Studies

2 other studies available for phenoxybenzamine and Leukemia

ArticleYear
Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells.
    British journal of cancer, 1998, Volume: 78, Issue:3

    Topics: Biological Transport; Calcium; Cell Membrane; Chlorpromazine; Colchicine; Drug Resistance, Multiple;

1998
Can adrenergic blockers be leukemogenic?
    The New England journal of medicine, 1971, Jan-28, Volume: 284, Issue:4

    Topics: Adrenergic alpha-Antagonists; Carcinogens; Leukemia; Phenoxybenzamine; Sympatholytics

1971