phenoxybenzamine and Endotoxin Shock studies

Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.

Research Excerpts

Excerpt	Relevance	Reference
"Phenoxybenzamine is a safe and effective vasodilator which usually causes an increase in arterial blood pressure, an increase in cardiac index, an increase in urine output and a decrease in pulmonary artery pressure and central venous pressure in states of severe shock if hypovolemia has been corrected."	7.66	Treatment of severe shock with phenoxybenzamine. ( Hardaway, RM, 1980)
"Phenoxybenzamine is a safe and effective vasodilator which usually causes an increase in arterial blood pressure, an increase in cardiac index, an increase in urine output and a decrease in pulmonary artery pressure and central venous pressure in states of severe shock if hypovolemia has been corrected."	3.66	Treatment of severe shock with phenoxybenzamine. ( Hardaway, RM, 1980)
"Pretreatment with indomethacin alone blunted the endotoxin- (8 mg/kg) induced hypoglycemia."	1.27	The effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia. ( Armstrong, J; Cook, JA; Halushka, PV; Tempel, GE; Wise, WC, 1986)
"Indomethacin post-treatment significantly elevated aortic pressure, cardiac output, and left ventricular isometric tension elevated aortic pressure, cardiac output, and left ventricular isometric tension rise (LVP dp/dt max) following endotoxin administration in the dog."	1.26	The effect of indomethacin and adrenergic receptor blocking agents on rats and canine responses to endotoxin. ( Fujita, T; Goto, F; Otani, E; Yamamuro, M, 1980)
"Therefore, the active hyperemia of inflammation may add significantly to demands on circulation."	1.25	Septic shock: hemodynamics of endotoxin and inflammation. ( Damewood, CA; Hopkins, RW, 1974)
"Bacteremic shock is second in frequency only to myocardial infarction as a cause of hypotension and death in hospitalized medical patients."	1.24	BACTEREMIC SHOCK--A MEDICAL EMERGENCY. ( CAMERON, DG; DIRKS, JH; RUEDY, J, 1963)

Timeframe	Studies, this research(%)	All Research%
pre-1990	90 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
IAMPIETRO, PF	1
HINSHAW, LB	5
BRAKE, CM	2
VICK, JA	3
LAFAVE, J	1
MACLEAN, LD	1
LILLEHEI, RC	10
LONGERBEAM, JK	3
BLOCH, JH	3
RUEDY, J	1
DIRKS, JH	1
CAMERON, DG	1
FRANK, ED	1
MANAX, WG	3
MARSHALL, RJ	1
DARBY, TD	1
KALAS, JP	1
JACOBSON, ED	3
SMITH, LL	1
MULLER, W	1
HINSHAW, DB	1
EMERSON, TE	1
WITTMERS, LE	1
O'NEILL, JA	1
FOSTER, JH	1
SKIRROW, MB	2
MAEGRAITH, BG	2
CHONGSUPHAJAISIDDHI, T	1
FITTS, CT	1
SAWYER, RB	1
MORRIS, JA	1
SMITH, RW	1
ASSALI, NS	2
SUKHNANDAN, R	2
THAL, AP	2
KLASS, AA	1
Anderson, RW	1
James, PM	1
Bredenberg, CE	1
Hardaway, RM	2
Palmerio, C	1
Nahor, A	1
Minton, R	1
Fine, J	1
Kutner, FR	1
Schwartz, SI	1
Adams, JT	1
Dietzman, RH	6
Swan, KG	1
Goto, F	3
Fujita, T	2
Otani, E	2
Yamamuro, M	3
Beller, BK	1
Archer, LT	2
Lane, MM	1
Murray, CK	1
Parker, DE	1
Wosornu, L	1
Hirano, A	1
Ito, H	1
Hosokawa, S	1
Hayase, S	1
Armstrong, J	1
Tempel, GE	1
Cook, JA	1
Wise, WC	1
Halushka, PV	1
Halmagyi, DF	3
Starzecki, B	1
Horner, GJ	1
Clauss, RH	1
Ray, JF	1
Evangelista, BS	1
Green, TJ	1
Gwilt, DJ	1
Brown, TG	1
Müller-Berghaus, G	1
Border, JR	1
Heyden, WC	1
Jacobs, RR	1
Hopkinson, BR	1
Schenk, WG	1
Lambert, HP	1
Nelson, NC	1
Nelson, JL	1
Weldon, WE	1
Vela, AR	1
Kennedy, M	1
Goodman, AH	1
Varga, D	2
Kawarada, Y	2
Wolferth, CC	2
Matsumoto, T	3
Hopkins, RW	5
Damewood, CA	1
Dadkar, VN	1
Dadkar, NK	1
Sheth, UK	1
Ueda, W	1
Yokota, T	1
Hirasawa, M	1
Umezu, S	1
Kosaka, F	1
Rosenbaum, RW	1
Hayes, MF	1
Motsay, GJ	5
Alho, AV	1
Romero, LH	2
Lambotte, L	1
Rocmans, P	1
Monsallier, JF	1
Lagier, G	1
Moyer, JH	2
Mills, LC	2
Meyer, W	2
Anas, P	2
Hardy, JD	2
Fonkalsrud, EW	1
Skjoldborg, H	1
Ersek, RA	1
Shanbour, LL	2
Whitaker, AN	2
McKay, DG	2
Bech-Jansen, P	1
Brinkman, CR	1
Johnson, GH	1
Motsay, G	1
Alho, A	2
Schultz, LS	2
Beckman, CB	1
Knuth, OE	1
Wagenknecht, LV	1
Madsen, PO	1
Suzuki, M	1
Saito, K	1
Hanaoka, H	2
Nozaki, H	1
Saito, T	1
Martin, DS	1
Kurzweg, FT	1
Amor, RL	1
Harvey, R	1
Daigle, L	1
Cattaneo, AD	1
Martinez, JT	1
Fernandez, G	1
Vazquez-Leon, H	1
Masucci, FD	1
Reins, D	1
Marston, A	1
Markley, K	1
Smallman, E	1
Dmochowski, JR	1
Couch, NP	1
Wilson, RF	2
Sarver, EJ	1
Rizzo, J	1
Shoemaker, WC	1
Brown, RS	1
Torsti, P	1
Jaeger, T	1
Lindeman, RD	1
Tung, SH	1
Neely, WA	1
Irving, MH	1
Gillett, DJ	1
Abrams, JS	3
Perlman, R	3
Simeone, FA	3
Sauer, H	1
Ciuchta, HP	1
Manthei, JH	1
Muhm, HY	1
Shumacker, HB	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock[NCT03235921]			Phase 2	100 participants (Anticipated)	Interventional	2016-03-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
NEWER AGENTS IN THE TREATMENT OF SHOCK. The Medical clinics of North America, 1964, Volume: 48 Topics: Anaphylaxis; Arrhythmias, Cardiac; Cardiac Tamponade; Catecholamines; Drug Therapy; Endocrinology; G	1964
Pharmacologic assistance to the failing circulation. Surgery, gynecology & obstetrics, 1968, Volume: 126, Issue:3 Topics: Adenosine Triphosphatases; Aminophylline; Angiotensin II; Blood Gas Analysis; Blood Pressure; Cardia	1968
[On the physiopathology of the consumption coagulopathy]. Bibliotheca haematologica, 1969, Volume: 32 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antigen-Antibody Reactions; Blood Coagulation	1969
The management of bacteremic shock. International anesthesiology clinics, 1969,Winter, Volume: 7, Issue:4 Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Burns; Catheterization; Cephaloridine; Cephalot	1969
[Cliniccal aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms]. Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5 Topics: Adult; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins; Escherichia	1966
[Clinical aspects, pathogenesis and therapy of shock due to sepsis caused by gram-negative organisms]. Schweizerische medizinische Wochenschrift, 1966, Feb-05, Volume: 96, Issue:5 Topics: Adult; Aldosterone; Animals; Blood; Chlorpromazine; Diarrhea; Dogs; Electrocardiography; Endotoxins;	1966
Dopamine in the treatment of shock. Advances in experimental medicine and biology, 1971, Volume: 23, Issue:0 Topics: Animals; Cardiac Output; Dextrans; Disease Models, Animal; Dogs; Dopamine; Drug Therapy, Combination	1971

Article	Year
Effect of an adrenergic blocking agent on vascular alterations associated with endotoxin shock. The American journal of physiology, 1963, Volume: 204 Topics: Adrenergic Antagonists; Blood Pressure; Blood Pressure Determination; Endotoxins; Epinephrine; Pheno	1963
RENAL FAILURE ASSOCIATED WITH ENDOTOXIN SHOCK. Minnesota medicine, 1963, Volume: 46 Topics: Acute Kidney Injury; Animals; Dogs; Endotoxins; Escherichia coli; Hydrocortisone; Metaraminol; Minne	1963
PHYSIOLOGY AND THERAPY OF BACTEREMIC SHOCK. EXPERIMENTAL AND CLINICAL OBSERVATIONS. The American journal of cardiology, 1963, Volume: 12 Topics: Blood Flow Velocity; Blood Pressure Determination; Dogs; Endotoxins; Epinephrine; Escherichia coli;	1963
BACTEREMIC SHOCK--A MEDICAL EMERGENCY. Canadian Medical Association journal, 1963, Nov-23, Volume: 89 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Emergencies; Humans; Hypotension; Metaraminol; M	1963
SEPTIC SHOCK. International anesthesiology clinics, 1964, Volume: 2 Topics: Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Autonomic Nerve Block; Blood; Blood Volume;	1964
THE NATURE OF EXPERIMENTAL IRREVERSIBLE SHOCK WITH ITS CLINICAL APPLICATION. International anesthesiology clinics, 1964, Volume: 2 Topics: Animals; Blood Circulation; Blood Flow Velocity; Blood Transfusion; Blood Volume; Catecholamines; De	1964
ENDOTOXIN SHOCK IN THE PRIMATE: TREATMENT WITH PHENOXYBENZAMINE. The Journal of clinical investigation, 1964, Volume: 43 Topics: Animals; Blood Pressure; Endotoxins; Escherichia coli; Haplorhini; Kidney Function Tests; p-Aminohip	1964
THE EFFECT OF VASOACTIVE ANTAGONISTS IN ENDOTOXIN SHOCK. American heart journal, 1964, Volume: 67 Topics: Animals; Atropine; Blood Circulation; Blood Pressure; Blood Pressure Determination; Chloralose; Cypr	1964
THE MANAGEMENT OF EXPERIMENTAL ENDOTOXIN SHOCK. THE CIRCULATORY EFFECTS OF LEVARTERENOL, HYDROCORTISONE, PHENOXYBENZAMINE HYDROCHLORIDE, AND BLOOD VOLUME EXPANSION. Archives of surgery (Chicago, Ill. : 1960), 1964, Volume: 89 Topics: Blood Circulation; Blood Pressure; Blood Volume; Dextrans; Dogs; Endotoxins; Heart Function Tests; H	1964
ALTERATION OF VASCULAR RESPONSES TO ENDOTOXIN BY ADRENERGIC BLOCKADE. The American journal of physiology, 1964, Volume: 207 Topics: Adrenergic Agents; Animals; Blood; Blood Pressure; Blood Pressure Determination; Blood Vessels; Dogs	1964
THE INFLUENCE OF LOW MOLECULAR WEIGHT DEXTRAN ON LETHAL ENDOTOXEMIA. The American surgeon, 1964, Volume: 30 Topics: Aldosterone; Dextrans; Dogs; Endotoxemia; Endotoxins; Erythrocyte Aggregation; Escherichia coli Infe	1964
THE NATURE OF IRREVERSIBLE SHOCK: EXPERIMENTAL AND CLINICAL OBSERVATIONS. Annals of surgery, 1964, Volume: 160 Topics: Blood Flow Velocity; Blood Pressure Determination; Blood Transfusion; Blood Volume Determination; Co	1964
IS HISTAMINE THE "TRIGGER MECHANISM" OF ENDOTOXIN SHOCK? American heart journal, 1964, Volume: 68 Topics: Endotoxins; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; p-Methoxy-N-methylphenet	1964
THE CIRCULATION IN MALARIA. I. PORTAL ANGIOGRAPHY IN THE NORMAL RABBIT AND MONKEY (MACACA MULATTA). Annals of tropical medicine and parasitology, 1964, Volume: 58 Topics: Acetylcholine; Angiography; Animals; Atropine; Blood Pressure; Epinephrine; Haplorhini; Hemodynamics	1964
THE CIRCULATION IN MALARIA. II. PORTAL ANGIOGRAPHY IN MONKEYS (MACACA MULATTA) INFECTED WITH PLASMODIUM KNOWLESI AND IN SHOCK FOLLOWING MANIPULATION OF THE GUT. Annals of tropical medicine and parasitology, 1964, Volume: 58 Topics: Angiography; Animals; Blood Pressure; Haplorhini; Hemodynamics; Hexamethonium Compounds; Humans; Ile	1964
THE USE OF DRUGS IN THE TREATMENT OF IRREVERSIBLE VASOCONSTRICTOR SHOCK. The Journal of trauma, 1965, Volume: 5 Topics: Dextrans; Dogs; Heparin; Norepinephrine; Pharmacology; Phenoxybenzamine; Research; Shock; Shock, Hem	1965
HEMODYNAMIC ACTION OF VASOPRESSOR AND VASODEPRESSOR AGENTS IN ENDOTOXIN SHOCK. American journal of obstetrics and gynecology, 1965, Feb-15, Volume: 91 Topics: Angiotensins; Blood Circulation; Blood Pressure; Blood Pressure Determination; Cardiac Output; Dogs;	1965
THE EFFECT OF ENDOTOXIN AND VASOACTIVE AGENTS ON DIBENZYLINE-PRETREATED LUNGS. Surgery, 1965, Volume: 58 Topics: Animals; Blood; Blood Pressure; Blood Pressure Determination; Bradykinin; Capillary Resistance; Dext	1965
THE TREATMENT OF SUPERIOR MESENTERIC ARTERY OCCLUSION: A REAPPRAISAL. Canadian Medical Association journal, 1965, Aug-14, Volume: 93 Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Anticoagulants; Blood Pressure; Diagnosis; Drug	1965
Phenoxybenzamine in septic shock. Annals of surgery, 1967, Volume: 165, Issue:3 Topics: Adult; Endometritis; Female; Humans; Male; Peritonitis; Phenoxybenzamine; Pheochromocytoma; Pneumoni	1967
Limitations of antiadrenergic therapy for refractory traumatic shock. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1967, Volume: 124, Issue:2 Topics: Animals; Autonomic Nerve Block; Celiac Plexus; Dogs; Hemodynamics; Phenoxybenzamine; Rabbits; Shock,	1967
The effect of adrenergic blockade on lymph flow in endotoxin shock. Annals of surgery, 1967, Volume: 165, Issue:4 Topics: Animals; Blood Pressure; Blood Volume; Dogs; Lymph; Lymphatic System; Norepinephrine; Phenoxybenzami	1967
Shock: mechanisms and therapy. Canadian Anaesthetists' Society journal, 1967, Volume: 14, Issue:4 Topics: Animals; Chlorpromazine; Digitalis Glycosides; Dogs; Endotoxins; Epinephrine; Equipment and Supplies	1967
Hemodynamics of endotoxin shock in the conscious animal. Surgery, gynecology & obstetrics, 1967, Volume: 125, Issue:5 Topics: Anesthetics; Animals; Blood Flow Velocity; Dogs; Female; Hypertension, Portal; Hypotension; Ischemia	1967
The effect of indomethacin and adrenergic receptor blocking agents on rats and canine responses to endotoxin. Circulatory shock, 1980, Volume: 7, Issue:4 Topics: Animals; Cyclic AMP; Dogs; Endotoxins; Female; Hemodynamics; Indomethacin; Male; Phenoxybenzamine; P	1980
Preventing versus delaying death in shock therapy studies: evaluating "survival". Circulatory shock, 1983, Volume: 11, Issue:4 Topics: Animals; Dexamethasone; Dogs; Endotoxins; Evaluation Studies as Topic; Phenoxybenzamine; Shock, Sept	1983
Treatment of severe shock with phenoxybenzamine. Surgery, gynecology & obstetrics, 1980, Volume: 151, Issue:6 Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Diuresis; Hemodynamics; Humans; Phenoxybenz	1980
[The effect of indomethacin on rat and canine responses to endotoxin (author's transl)]. Masui. The Japanese journal of anesthesiology, 1979, Volume: 28, Issue:2 Topics: Animals; Dogs; Hemodynamics; Indomethacin; Phenoxybenzamine; Prostaglandins; Rats; Shock, Septic	1979
Septic shock. Tropical doctor, 1979, Volume: 9, Issue:2 Topics: Adult; Anti-Bacterial Agents; Blood Coagulation; Digoxin; Drainage; Endotoxins; Female; Fluid Therap	1979
[The effects of indomethacin on rat and canine responses to endotoxin (author's transl)]. Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:4 Topics: Animals; Dogs; Indomethacin; Male; Phenoxybenzamine; Rats; Shock, Septic	1978
[Proceedings: Effective use of phenoxybenzamine in a case of bacterial shock]. Japanese circulation journal, 1975, Volume: 39, Issue:7 Topics: Female; Humans; Middle Aged; Phenoxybenzamine; Shock, Septic	1975
The effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia. Circulatory shock, 1986, Volume: 20, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Indomethacin; Male; Phen	1986
Mechanism and pharmacology of shock due to rattlesnake venom in sheep. Journal of applied physiology, 1965, Volume: 20, Issue:4 Topics: Adrenocorticotropic Hormone; Aldosterone; Animals; Antivenins; Atropine; Blood Pressure; Cardiac Out	1965
An experimental study of current therapeutic approaches to endotoxin shock. Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 180, Issue:1 Topics: Adrenocorticotropic Hormone; Animals; Bicarbonates; Dextrans; Dogs; Drug Synergism; Female; Heparin;	1969
The microcirculatory effects of endotoxin shock as evaluated by effects on interstitial fluid pressure. Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 101, Issue:2 Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Body Fluids; Central Venous Pressure; Disease Models	1970
Mechanisms of change in thoracic duct lymph flow during hypotensive states. Annals of surgery, 1970, Volume: 171, Issue:6 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Aspirin; Capillary Permeability;	1970
Simple and combined adrenergic receptor blockade in canine endotoxinemia. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1971, Volume: 3, Issue:5 Topics: Acid-Base Equilibrium; Adrenal Glands; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; An	1971
Phenoxybenzamine and steroid in renal microcirculation in endotoxin shock. 1. International surgery, 1972, Volume: 57, Issue:1 Topics: Acute Kidney Injury; Angiography; Animals; Dexamethasone; Dogs; Escherichia coli; Female; Ischemia;	1972
Septic shock: hemodynamics of endotoxin and inflammation. American journal of surgery, 1974, Volume: 127, Issue:4 Topics: Animals; Blood Pressure; Blood Volume; Dextrans; Dogs; Endotoxins; Escherichia coli; Hematocrit; Hem	1974
Experimental studies in endotoxin shock in dogs. II. Experimental evaluation of different therapeutic measures in irreversible endotoxin shock. The Indian journal of medical research, 1972, Volume: 60, Issue:6 Topics: Animals; Dextrans; Dogs; Hemodynamics; Phenoxybenzamine; Propranolol; Shock, Septic	1972
[Successful treatment with phenoxybenzamine in severe endotoxic shock]. Masui. The Japanese journal of anesthesiology, 1972, Volume: 21, Issue:12 Topics: Adult; Humans; Male; Phenoxybenzamine; Shock, Septic	1972
Efficacy of steroids in the treatment of septic and cardiogenic shock. Surgery, gynecology & obstetrics, 1973, Volume: 136, Issue:6 Topics: Blood Gas Analysis; Carbon Dioxide; Dexamethasone; Humans; Methylprednisolone; Oxygen; Oxygen Consum	1973
The pulmonary microcirculation in endotoxin-shocked dogs: effect of phenoxybenzamine and methylprednisolone on the precapillary and postcapillary resistances. The Journal of surgical research, 1973, Volume: 14, Issue:5 Topics: Animals; Blood Pressure; Capillary Resistance; Dogs; Endotoxins; Hydrogen-Ion Concentration; Methods	1973
[Toxi-infectious shock]. Acta chirurgica Belgica, 1973, Volume: 72, Issue:3 Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Blood Transfusion; Chlorpromazine; Digitalis G	1973
[Management of a post-transfusion toxic shock]. Revue francaise de transfusion, 1973, Volume: 16, Issue:1 Topics: Animals; Auscultation; Blood Pressure Determination; Diuresis; Dogs; Heart Rate; Hydrocortisone; Iso	1973
Vasopressors for treating shock. Postgraduate medicine, 1974, Volume: 56, Issue:2 Topics: Bacteria; Chloramphenicol; Epinephrine; Humans; Isoproterenol; Metaraminol; Methoxamine; Morphine; M	1974
Effects of vasoactive drugs on oxygen consumption in endotoxin shock. Archives of surgery (Chicago, Ill. : 1960), 1969, Volume: 98, Issue:2 Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Dextrans; Dogs; Escherichia coli; Hematocrit;	1969
Common mechanisms of hypotension in irreversible shock and liver transplantation. Surgery, gynecology & obstetrics, 1969, Volume: 128, Issue:3 Topics: Animals; Chlorpromazine; Dogs; Hydrocortisone; Hypotension; Liver; Liver Transplantation; Phenoxyben	1969
Phenoxybenzamine in the treatment of septic shock. Acta chirurgica Scandinavica, 1968, Volume: 134, Issue:2 Topics: Adult; Aged; Escherichia coli Infections; Female; Humans; Hydrochloric Acid; Male; Middle Aged; Phen	1968
Hemodynamic alterations and results of treatment in patients with gram-negative septic shock. Surgery, 1970, Volume: 67, Issue:4 Topics: Adult; Aged; Ampicillin; Blood Pressure; Blood Transfusion; Cardiac Output; Central Venous Pressure;	1970
[Drugs in shock treatment]. Der Internist, 1971, Volume: 12, Issue:3 Topics: Adrenal Cortex Hormones; Cardiac Output; Chlorpromazine; Digitalis Glycosides; Humans; Isoproterenol	1971
Studies of catecholamine shock. I. Disseminated intravascular coagulation. The American journal of pathology, 1969, Volume: 56, Issue:2 Topics: Aminocaproates; Animals; Blood Coagulation; Blood Coagulation Disorders; Epinephrine; Female; Haplor	1969
Studies of catecholamine shock. II. An experimental model of microangiopathic hemolysis. The American journal of pathology, 1969, Volume: 56, Issue:2 Topics: Aminocaproates; Anemia, Hemolytic; Animals; Blood Coagulation Disorders; Capillaries; Epinephrine; E	1969
Circulatory shock in pregnant sheep. I. Effects of endotoxin on uteroplacental and fetal umbilical circulation. American journal of obstetrics and gynecology, 1972, Apr-15, Volume: 112, Issue:8 Topics: Animals; Arteries; Blood Pressure; Carbon Dioxide; Female; Fetus; Heart Rate; Hemodynamics; Hemoglob	1972
Endotoxin shock. 2. International surgery, 1972, Volume: 57, Issue:2 Topics: Animals; Blood Pressure; Cardiac Output; Dexamethasone; Disease Models, Animal; Dogs; Female; Hemato	1972
Clinical and laboratory experience with gram-negative septic shock. The Journal of reproductive medicine, 1972, Volume: 8, Issue:6 Topics: Adult; Aged; Animals; Blood Pressure; Capillaries; Capillary Permeability; Cardiac Output; Central V	1972
The pharmacologic approach to the treatment of shock. I. Defining traumatic, septic, and cardiogenic shock. Geriatrics, 1972, Volume: 27, Issue:7 Topics: Adrenal Glands; Cardiac Output; Glucocorticoids; Humans; Infusions, Parenteral; Isoproterenol; Micro	1972
The effect of various treatments on renal function during endotoxin shock. An experimental study in dogs. Investigative urology, 1972, Volume: 9, Issue:4 Topics: Animals; Dextrans; Dogs; Female; Glomerular Filtration Rate; Glucocorticoids; Hydrocortisone; Iodine	1972
[Effect of endotoxic shock on blood coagulation]. Masui. The Japanese journal of anesthesiology, 1971, Volume: 20, Issue:10 Topics: Animals; Blood Coagulation; Blood Pressure; Dogs; Endotoxins; Hydrocortisone; Phenoxybenzamine; Shoc	1971
[Effects of endotoxic shock on blood coagulation--with special reference to thrombelastogram]. Masui. The Japanese journal of anesthesiology, 1971, Volume: 20, Issue:12 Topics: Animals; Blood Coagulation; Dogs; Hydrocortisone; Phenoxybenzamine; Shock, Hemorrhagic; Shock, Septi	1971
Multiantagonist and volume therapy for late endotoxin shock. Surgery, 1966, Volume: 60, Issue:2 Topics: Acidosis; Aminocaproates; Animals; Aprotinin; Bicarbonates; Cyproheptadine; Diphenhydramine; Dogs; E	1966
[Various clinical considerations on shock]. Minerva anestesiologica, 1970, Volume: 36, Issue:12 Topics: Animals; Antifibrinolytic Agents; Aprotinin; Disease Models, Animal; Dogs; Glucocorticoids; Humans;	1970
Phenyoxybenzamine in endotoxin shock. The Journal of the Oklahoma State Medical Association, 1966, Volume: 59, Issue:8 Topics: Animals; Dogs; Endotoxins; Escherichia coli; Phenoxybenzamine; Shock, Septic	1966
Gram-negative septicaemia--clinical aspects and physiological management. Proceedings of the Royal Society of Medicine, 1969, Dec-12, Volume: 62, Issue:12 Topics: Central Venous Pressure; Dexamethasone; Drainage; Hemorrhage; Humans; Infusions, Parenteral; Isoprot	1969
Protection against burn, tourniquet, and endotoxin shock by purine compounds. The Journal of trauma, 1970, Volume: 10, Issue:7 Topics: Adenosine Triphosphate; Animals; Burns; Histamine; Injections, Intraperitoneal; Mice; Phenoxybenzami	1970
Septic shock: hemodynamic cost of inflammation. Archives of surgery (Chicago, Ill. : 1960), 1970, Volume: 101, Issue:2 Topics: Animals; Arteries; Calcium Chloride; Dogs; Hemodynamics; Hindlimb; Hyperemia; Inflammation; Methylpr	1970
Skeletal muscle hydrogen ion activity in endotoxin shock. Surgery, gynecology & obstetrics, 1970, Volume: 131, Issue:4 Topics: Acidosis; Animals; Blood; Blood Pressure; Dogs; Endotoxins; Hematocrit; Hydrogen-Ion Concentration;	1970
Hemodynamic changes, treatment, and prognosis in clinical shock. Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 102, Issue:1 Topics: Blood Pressure; Cardiac Output; Heart; Hemodynamics; Humans; Liver Cirrhosis; Phenoxybenzamine; Phen	1971
The dilemma of vasopressors and vasodilators in the therapy of shock. Surgery, gynecology & obstetrics, 1971, Volume: 132, Issue:1 Topics: Blood Pressure; Cardiac Output; Central Venous Pressure; Chlorpromazine; Heart Rate; Hemodynamics; H	1971
[The use of sympathomimetics and sympatholytics in shock]. Duodecim; laaketieteellinen aikakauskirja, 1971, Volume: 87, Issue:4 Topics: Chlorpromazine; Dopamine; Humans; Isoproterenol; Metaraminol; Norepinephrine; Phenoxybenzamine; Phen	1971
Effects of methylprednisolone, phenoxybenzamine, and epinephrine tolerance in canine endotoxin shock: study of isogravimetric capillary pressures in forelimb and intestine. Surgery, 1971, Volume: 70, Issue:2 Topics: Animals; Blood Pressure; Capillary Permeability; Capillary Resistance; Dogs; Epinephrine; Female; Fo	1971
Indications for adrenergic stimulators in shock. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1971, Volume: 4, Issue:4 Topics: Blood Pressure; Blood Volume; Cardiac Output; Carotid Arteries; Central Venous Pressure; Cerebrovasc	1971
Improvement of renal hemodynamics in endotoxin shock with dopamine, phenoxybenzamine and dextran. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 176, Issue:2 Topics: Animals; Blood Pressure; Dextrans; Diuresis; Dogs; Dopamine; Dopamine Antagonists; Drug Antagonism;	1971
Oxygen utilization in experimental shock: survey of some recent studies. The American surgeon, 1968, Volume: 34, Issue:10 Topics: Animals; Blood Circulation; Blood Volume; Cardiac Output; Dogs; Isoproterenol; Norepinephrine; Oxyge	1968
The effect of adrenergic blockade upon shock-induced lacticacidosis in sheep. The British journal of surgery, 1968, Volume: 55, Issue:10 Topics: Acidosis; Animals; Blood Pressure; Epinephrine; Female; Lactates; Male; Phenoxybenzamine; Propranolo	1968
Effect of phenoxybenzamine on endotoxic shock in dogs. I. Hemodynamic changes. The Journal of trauma, 1969, Volume: 9, Issue:7 Topics: Animals; Blood Pressure; Cardiac Output; Cardiac Volume; Dextrans; Dogs; Hematocrit; Hemodynamics; P	1969
Effect of phenoxybenzamine on endotoxic shock in dogs. II. Metabolic changes. The Journal of trauma, 1969, Volume: 9, Issue:7 Topics: Acidosis; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dextrans; Dogs; Hydrogen-Ion C	1969
[Disturbances of the intestinal circulation induced by surgical diseases of infancy and childhood]. Langenbecks Archiv fur Chirurgie, 1969, Volume: 323, Issue:3 Topics: Adenine Nucleotides; Animals; Autonomic Nerve Block; Child; Child, Preschool; Dexamethasone; Female;	1969
Rapid volume expansion and phenoxybenzamine in endotoxin shock. Surgical forum, 1965, Volume: 16 Topics: Animals; Dextrans; Dogs; Endotoxins; Infusions, Parenteral; Phenoxybenzamine; Shock, Septic	1965
Use of isoproterenol and phenoxybenzamine in treatment of endotoxin shock. The Journal of pharmacology and experimental therapeutics, 1965, Volume: 150, Issue:3 Topics: Animals; Dogs; Endotoxins; Hydrocortisone; Isoproterenol; Mortality; Phenoxybenzamine; Shock, Septic	1965
Norepinephrine, dibenzyline and endotoxin shock. The Journal of the Oklahoma State Medical Association, 1966, Volume: 59, Issue:8 Topics: Animals; Dogs; Endotoxins; Hemodynamics; Norepinephrine; Phenoxybenzamine; Shock, Septic	1966
Effects of adrenergic blocking agents on renal blood flow in normovolemia and experimental hypovolemia. Annals of surgery, 1966, Volume: 164, Issue:1 Topics: Animals; Blood Circulation; Blood Flow Velocity; Blood Volume; Dogs; Hydralazine; Kidney; Phenoxyben	1966

phenoxybenzamine and Endotoxin Shock

Research Excerpts

Research

Studies (90)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies