phenoxybenzamine has been researched along with Dysautonomia, Familial in 1 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Dysautonomia, Familial: An autosomal disorder of the peripheral and autonomic nervous systems limited to individuals of Ashkenazic Jewish descent. Clinical manifestations are present at birth and include diminished lacrimation, defective thermoregulation, orthostatic hypotension (HYPOTENSION, ORTHOSTATIC), fixed pupils, excessive SWEATING, loss of pain and temperature sensation, and absent reflexes. Pathologic features include reduced numbers of small diameter peripheral nerve fibers and autonomic ganglion neurons. (From Adams et al., Principles of Neurology, 6th ed, p1348; Nat Genet 1993;4(2):160-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast to the sustained stimulation of ventilation produced by hypoxia in normal subjects, hypoxia either did not change, or decreased, the [unk]V(E)-P(ACo2) slope of dysautonomic patients and phenoxybenzamine-treated goats; CO(2)-free hypoxia produced a fleeting hyperventilation, which was followed by apnea when hypoxia was abruptly relieved." | 3.65 | The effects of abnormal sympathetic nervous function upon the ventilatory response to hypoxia. ( Cherniack, NS; Edelman, NH; Fishman, AP; Lahiri, S; Richards, E, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Edelman, NH | 1 |
| Cherniack, NS | 1 |
| Lahiri, S | 1 |
| Richards, E | 1 |
| Fishman, AP | 1 |
1 other study available for phenoxybenzamine and Dysautonomia, Familial
| Article | Year |
|---|---|
The effects of abnormal sympathetic nervous function upon the ventilatory response to hypoxia.
Topics: Animals; Apnea; Blood Pressure; Central Nervous System; Chemoreceptor Cells; Dysautonomia, Familial; | 1970 |