phenoxybenzamine has been researched along with Disease Models, Animal in 50 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clonidine mydriasis model in rats has been widely applied in preclinical research to characterize alpha(2)-adrenoceptor antagonistic properties of drugs." | 7.73 | Rat clonidine mydriasis model: imidazoline receptors are not involved. ( Koss, MC; Yu, Y, 2005) |
| "The clonidine mydriasis model in rats has been widely applied in preclinical research to characterize alpha(2)-adrenoceptor antagonistic properties of drugs." | 3.73 | Rat clonidine mydriasis model: imidazoline receptors are not involved. ( Koss, MC; Yu, Y, 2005) |
| "The effect of donor pretreatment with Dibenzyline (phenoxybenzamine) on hepatic arterial vasospasm was studied in a porcine asphyxia model." | 3.67 | Agonal hepatic arterial vasospasm. ( Belzer, FO; D'Alessandro, AM; Kalayoglu, M; Southard, JH; Stratta, RJ, 1989) |
| " Intravenous use, however, was ineffective in the dosage with which total systemic alpha adrenergic blockade was obtained." | 1.25 | Effect of phenoxybenzamine on experimental cerebral arterial spasm in cats. ( Handa, H; Handa, J; Koyama, T; Matsuda, M; Yoneda, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (70.00) | 18.7374 |
| 1990's | 2 (4.00) | 18.2507 |
| 2000's | 6 (12.00) | 29.6817 |
| 2010's | 6 (12.00) | 24.3611 |
| 2020's | 1 (2.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Hylin, MJ | 1 |
| Brenneman, MM | 1 |
| Corwin, JV | 1 |
| Palotai, M | 1 |
| Telegdy, G | 2 |
| Tanaka, M | 1 |
| Bagosi, Z | 1 |
| Jászberényi, M | 1 |
| Omori, Y | 1 |
| Nakajima, M | 1 |
| Nishimura, K | 1 |
| Takahashi, E | 1 |
| Arai, T | 1 |
| Akahira, M | 1 |
| Suzuki, T | 1 |
| Kainoh, M | 1 |
| Chang, M | 1 |
| Smith, S | 1 |
| Thorpe, A | 1 |
| Barratt, MJ | 1 |
| Karim, F | 1 |
| Schally, AV | 1 |
| Raasch, W | 1 |
| Jungbluth, B | 1 |
| Schäfer, U | 1 |
| Häuser, W | 1 |
| Dominiak, P | 1 |
| Jain, S | 1 |
| Sharma, R | 1 |
| Yu, Y | 1 |
| Koss, MC | 1 |
| Chung, AW | 1 |
| Rauniyar, P | 1 |
| Luo, H | 1 |
| Hsiang, YN | 1 |
| van Breemen, C | 1 |
| Okon, EB | 1 |
| Martinez, JL | 1 |
| Jensen, RA | 1 |
| McGaugh, JL | 1 |
| Andreas, K | 1 |
| Fischer, HD | 1 |
| Schmidt, J | 1 |
| King, GA | 1 |
| Burnham, WM | 1 |
| Matsui, K | 1 |
| Toyoshima, E | 1 |
| Mano, U | 1 |
| Ando, K | 1 |
| Prinssen, EP | 1 |
| Ellenbroek, BA | 1 |
| Cools, AR | 1 |
| Rudé, MJ | 1 |
| Soucy, DM | 1 |
| Hagedorn, F | 1 |
| Illner, H | 1 |
| Shires, GT | 1 |
| Bunc, G | 2 |
| Kovacic, S | 2 |
| Strnad, S | 2 |
| Borison, RL | 1 |
| Diamond, BI | 1 |
| Whitehill, R | 1 |
| Hakala, MW | 1 |
| Fleming, JS | 1 |
| Buchanan, JO | 1 |
| Buyniski, JP | 1 |
| Kogure, K | 1 |
| Scheinberg, P | 1 |
| Kishikawa, H | 1 |
| Busto, R | 1 |
| Reinmuth, OM | 1 |
| Handa, J | 1 |
| Yoneda, S | 1 |
| Matsuda, M | 1 |
| Koyama, T | 1 |
| Handa, H | 1 |
| Katz, MA | 1 |
| Shear, L | 1 |
| Hough, FS | 1 |
| Gevers, W | 1 |
| D'Alessandro, AM | 1 |
| Stratta, RJ | 1 |
| Southard, JH | 1 |
| Kalayoglu, M | 1 |
| Belzer, FO | 1 |
| Wyllie, RG | 1 |
| Hill, GS | 1 |
| Murray, G | 1 |
| Ramsden, PW | 1 |
| Heptinstall, RH | 1 |
| Kontos, HA | 1 |
| Richardson, DW | 1 |
| Raper, AJ | 1 |
| Patterson, JL | 1 |
| Romero, LH | 1 |
| Motsay, GJ | 1 |
| Beckman, CB | 1 |
| Schultz, LS | 1 |
| Dietzman, RH | 1 |
| Lillehei, RC | 1 |
| Lycke, E | 1 |
| Roos, BE | 1 |
| Border, JR | 1 |
| Heyden, WC | 1 |
| Jacobs, RR | 1 |
| Hopkinson, BR | 1 |
| Schenk, WG | 1 |
| Sjoerdsma, A | 1 |
| Flamm, ES | 1 |
| Yasargil, MG | 1 |
| Ransohoff, J | 1 |
| Eidelberg, EE | 1 |
| Osterholm, JL | 1 |
| Mathews, GJ | 1 |
| Irvin, JD | 1 |
| Calesnick, B | 1 |
| Hedeman, LS | 1 |
| Sil, R | 1 |
| Allen, GS | 1 |
| Gold, LH | 1 |
| Chou, SN | 1 |
| French, LA | 1 |
| Duvoisin, RC | 1 |
| Marsden, CD | 1 |
| Nelson, SR | 1 |
| Cheney, DH | 1 |
| Slogoff, S | 1 |
| Allen, GW | 1 |
| Shanbour, LL | 1 |
| Kawarada, Y | 1 |
| Wolferth, CC | 1 |
| Matsumoto, T | 1 |
| Lozano, JR | 1 |
| Corday, E | 1 |
| Carrasco, HA | 1 |
| Lang, TW | 1 |
| Meerbaum, S | 1 |
| Kobayakawa, T | 1 |
| Cheek, RC | 1 |
| Britt, LG | 1 |
| Ueda, H | 1 |
| Uchida, Y | 1 |
| Ozeki, K | 1 |
| O-Ishi, S | 1 |
| Sakuma, A | 1 |
| Cattaneo, AD | 1 |
| Bell, G | 1 |
| Lister, GD | 1 |
2 reviews available for phenoxybenzamine and Disease Models, Animal
| Article | Year |
|---|---|
Attenuation of experimentally-induced amnesia.
Topics: Adrenocorticotropic Hormone; alpha-Methyltyrosine; Amnesia; Amphetamine; Animals; Anisomycin; Cycloh | 1981 |
Dopamine in the treatment of shock.
Topics: Animals; Cardiac Output; Dextrans; Disease Models, Animal; Dogs; Dopamine; Drug Therapy, Combination | 1971 |
1 trial available for phenoxybenzamine and Disease Models, Animal
| Article | Year |
|---|---|
Catecholamines in hypertension.
Topics: Animals; Catecholamines; Clinical Trials as Topic; Disease Models, Animal; Ganglionic Blockers; Huma | 1970 |
47 other studies available for phenoxybenzamine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Noradrenergic antagonists mitigate amphetamine-induced recovery.
Topics: Adrenergic Antagonists; Amphetamine; Animals; Central Nervous System Stimulants; Cerebral Cortex; Di | 2017 |
Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agent | 2014 |
Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Benzamides; Disease Models, Animal; Glycine Plasma Membrane Transport Proteins; | 2015 |
Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping.
Topics: Administration, Oral; Algorithms; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Fre | 2010 |
Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Bicuculline; Cyproh | 2012 |
Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Antihypertensive Agents; Benzofurans; Binding Sites | 2003 |
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analgesia; Animals; Behavio | 2002 |
Rat clonidine mydriasis model: imidazoline receptors are not involved.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
Pressure distention compared with pharmacologic relaxation in vein grafting upregulates matrix metalloproteinase-2 and -9.
Topics: Animals; Biomarkers; Biopsy, Needle; Blotting, Western; Carotid Stenosis; Dilatation, Pathologic; Di | 2005 |
[Effect of central effective substances on alcohol preference].
Topics: Alcohol Drinking; Alcoholism; Animals; Arecoline; Atropine; Central Nervous System Stimulants; Cypro | 1983 |
Effects of d-amphetamine and apomorphine in a new animal model of petit mal epilepsy.
Topics: Animals; Apomorphine; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 1980 |
[Ataxia in rolling mouse Nagoya and the norepinephrine system--a psychopharmacological study].
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Cerebellar Ataxia; Disease Mod | 1982 |
Combined antagonism of adrenoceptors and dopamine and 5-HT receptors underlies the atypical profile of clozapine.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analysis of Variance; Animals; Benzazepines; Clozapine; Dis | 1994 |
The effect of sympatholytics on uncontrolled hemorrhage.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Disease Models, Animal; Drug The | 1999 |
Sympathetic nervous system exclusion following experimental subarachnoid haemorrhage prevents vasospasm in rabbits.
Topics: Animals; Basilar Artery; Disease Models, Animal; Ganglia, Sympathetic; Ganglionectomy; Phenoxybenzam | 2000 |
Evaluation of functional response of cerebral arteries by a new morphometric technique.
Topics: Adrenergic alpha-Antagonists; Animals; Basilar Artery; Cerebrovascular Circulation; Disease Models, | 2001 |
A new animal model for schizophrenia: interactions with adrenergic mechanisms.
Topics: Animals; Behavior, Animal; Dextroamphetamine; Disease Models, Animal; Ditiocarb; Drug Antagonism; Dr | 1978 |
Arterial hypertension induced by femoral lengthening. A canine model.
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Bone Lengthening; Disease Models, Animal; Dogs; Femur; | 1978 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Mal | 1976 |
Hypothesis for rational therapy in acute stroke.
Topics: Acute Disease; Aminophylline; Animals; Cerebrovascular Disorders; Disease Models, Animal; Drug Evalu | 1976 |
Effect of phenoxybenzamine on experimental cerebral arterial spasm in cats.
Topics: Administration, Topical; Animals; Blood Pressure; Cats; Disease Models, Animal; Female; Injections, | 1975 |
Effects of renal nerves on renal hemodynamics. II. Renal denervation models.
Topics: Animals; Denervation; Disease Models, Animal; Dogs; Ethanol; Female; Glomerular Filtration Rate; Hem | 1975 |
Catecholamine release as mediator of intracellular enzyme activation in ischaemic perfused rat hearts.
Topics: Animals; Catecholamines; Colorimetry; Coronary Disease; Cytoplasm; Depression, Chemical; Disease Mod | 1975 |
Agonal hepatic arterial vasospasm.
Topics: Animals; Asphyxia; Blood Flow Velocity; Catecholamines; Disease Models, Animal; Drug Evaluation, Pre | 1989 |
Experimental papillary necrosis of the kidney. 3. Effects of reserpine and other pharmacologic agents on the lesion.
Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Bromine; Catecholamines; Chlorpromazine; Colorin | 1972 |
Mechanisms of action of hypocapnic alkalosis on limb blood vessels in man and dog.
Topics: Alkalosis; Alkalosis, Respiratory; Animals; Blood Pressure; Carbon Dioxide; Diphenhydramine; Disease | 1972 |
The effects of alpha stimulation and alpha blockade on pulmonary vascular segment resistance in canine cardiogenic shock.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Capillary Resistan | 1974 |
Influence of changes in brain monoamine metabolism on behaviour of herpes simplex-infected mice.
Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Brain; Clonidine; Dihydroxyphenylalanine; Diseas | 1974 |
The microcirculatory effects of endotoxin shock as evaluated by effects on interstitial fluid pressure.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Body Fluids; Central Venous Pressure; Disease Models | 1970 |
Alteration of experimental cerebral vasospasm by adrenergic blockade.
Topics: Adrenergic alpha-Antagonists; Animals; Basilar Artery; Blood Flow Velocity; Blood Pressure; Cats; Di | 1972 |
Cardiovascular response to experimental spinal cord compression.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Blood Pressure; Cardiovascular System; Cats; Disease Models | 1973 |
Chapter 29. Anti-norepinephrine therapy against traumatic hemorrhagic necrosis of the spinal cord: preliminary report.
Topics: Animals; Bretylium Compounds; Cats; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Guan | 1973 |
Studies in experimental spinal cord trauma. 2. Comparison of treatment with steroids, low molecular weight dextran, and catecholamine blockade.
Topics: Animals; Dextrans; Disease Models, Animal; Dogs; Edema; Glucocorticoids; Haloperidol; Hypoxia; Methy | 1974 |
Cerebral arterial spasm. 3. In vivo intracisternal production of spasm by serotonin and blood and its reversal by phenoxybenzamine.
Topics: Animals; Basilar Artery; Cerebral Angiography; Disease Models, Animal; Dogs; Female; Ischemic Attack | 1974 |
Reversal of reserpine-induced bradykinesia by alpha-methyldopa--new light on its modus operandi.
Topics: Animals; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Dose | 1974 |
Effect of drugs on experimental brain edema in mice.
Topics: Acetazolamide; Animals; Brain; Brain Edema; Cortisone; Dextrans; Disease Models, Animal; Hexamethoni | 1974 |
Ketamine-induced stress ulcers in the rat.
Topics: Anesthesia, Intravenous; Animals; Disease Models, Animal; Halothane; Humans; Ketamine; Phenoxybenzam | 1974 |
Endotoxin shock. 2.
Topics: Animals; Blood Pressure; Cardiac Output; Dexamethasone; Disease Models, Animal; Dogs; Female; Hemato | 1972 |
Pharmacodynamic application of L-dopa in cardiogenic shock.
Topics: Animals; Aorta; Blood Pressure; Coronary Circulation; Dihydroxyphenylalanine; Disease Models, Animal | 1972 |
[Experimental study on drugs for the treatment of myocardial infarction].
Topics: Angiography; Animals; Benzyl Compounds; Body Weight; Carboxylic Acids; Dipyridamole; Disease Models, | 1972 |
Nonocclusive mesenteric vascular disease.
Topics: Aged; Animals; Autopsy; Disease Models, Animal; Dogs; Female; Humans; Male; Mesenteric Arteries; Mes | 1971 |
Sympathetic activity in cerebral embolism.
Topics: Animals; Blood Pressure; Catheterization; Disease Models, Animal; Electrodes; Hexamethonium Compound | 1969 |
A model for rat paw edema. II. Analyses on the effect of the antagonists.
Topics: Amino Alcohols; Animals; Anti-Inflammatory Agents; Bradykinin; Bromelains; Carbamates; Carrageenan; | 1970 |
[Various clinical considerations on shock].
Topics: Animals; Antifibrinolytic Agents; Aprotinin; Disease Models, Animal; Dogs; Glucocorticoids; Humans; | 1970 |
The effect of noradrenaline and phenoxybenzamine on the renal response to hemorrhage.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Hemorrhage; Injections, Intravenous; Kidney; | 1970 |