phenoxybenzamine has been researched along with Coronary Disease in 24 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coronary spasm is due to strong contraction of coronary vascular smooth muscle cells which is triggered by an increase of intracellular calcium ions; hyperventilation plus TRIS-buffer infusion induces coronary spasm by decreasing hydrogen ions which antagonize the action of calcium ions." | 1.26 | Pathophysiology and treatment of coronary arterial spasm. ( Yasue, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (95.83) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LILLEHEI, RC | 2 |
| LONGERBEAM, JK | 1 |
| BLOCH, JH | 2 |
| MANAX, WG | 2 |
| PIERCE, CH | 1 |
| Corvera, JS | 1 |
| Morris, CD | 1 |
| Budde, JM | 1 |
| Velez, DA | 1 |
| Puskas, JD | 1 |
| Lattouf, OM | 1 |
| Cooper, WA | 1 |
| Guyton, RA | 1 |
| Vinten-Johansen, J | 1 |
| Rubanyi, G | 1 |
| Ligeti, L | 1 |
| Koller, A | 1 |
| Kovach, AG | 1 |
| Giudicelli, JF | 1 |
| Berdeaux, A | 1 |
| Tato, F | 1 |
| Garnier, M | 1 |
| Buffington, CW | 2 |
| Feigl, EO | 2 |
| Yasue, H | 1 |
| Gorman, MW | 2 |
| Sparks, HV | 2 |
| Fuller, CM | 1 |
| Raizner, AE | 1 |
| Chahine, RA | 1 |
| Nahormek, P | 1 |
| Ishimori, T | 1 |
| Verani, M | 1 |
| Nitishin, A | 1 |
| Mokotoff, D | 1 |
| Luchi, RJ | 1 |
| Levene, DL | 1 |
| Freeman, MR | 1 |
| Chiba, S | 1 |
| Simmons, TW | 1 |
| Levy, MN | 1 |
| Sagar, KB | 1 |
| Hanson, EC | 1 |
| Powell, WJ | 1 |
| Ricci, DR | 1 |
| Orlick, AE | 1 |
| Cipriano, PR | 1 |
| Guthaner, DF | 1 |
| Harrison, DC | 1 |
| Farsang, C | 1 |
| Debreczeni, L | 1 |
| Kerényi, A | 1 |
| Takács, L | 1 |
| Hough, FS | 1 |
| Gevers, W | 1 |
| Ertl, G | 1 |
| Bauer, B | 1 |
| Gaudron, P | 1 |
| Kochsiek, K | 1 |
| Nathan, HJ | 1 |
| Vedernikov, YP | 1 |
| Schwartz, PJ | 1 |
| Vanoli, E | 1 |
| Wangler, RD | 1 |
| DeWitt, DF | 1 |
| Judge, TG | 1 |
| Hanley, HG | 1 |
| Costin, JC | 1 |
| Skinner, NS | 1 |
| Uchida, Y | 1 |
| Ueda, H | 1 |
| Ettinger, PO | 1 |
| Oldewurtel, HA | 1 |
| Sethi, V | 1 |
| Regan, TJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock[NCT03235921] | Phase 2 | 100 participants (Anticipated) | Interventional | 2016-03-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phenoxybenzamine and Coronary Disease
| Article | Year |
|---|---|
Nickel ions and ischemic coronary vasoconstriction.
Topics: Adenosine; Animals; Calcium; Coronary Disease; Hypoxia; Models, Biological; Nickel; Phenoxybenzamine | 1984 |
Vasodilators..
Topics: Adrenergic alpha-Antagonists; Aminophylline; Angina Pectoris; Bradycardia; Bronchial Diseases; Cereb | 1974 |
1 trial available for phenoxybenzamine and Coronary Disease
| Article | Year |
|---|---|
Alpha-adrenoceptor-mediated coronary artery spasm.
Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Clinical Trials as Topic; Coronary Disease; Exe | 1976 |
21 other studies available for phenoxybenzamine and Coronary Disease
| Article | Year |
|---|---|
THE NATURE OF IRREVERSIBLE SHOCK: EXPERIMENTAL AND CLINICAL OBSERVATIONS.
Topics: Blood Flow Velocity; Blood Pressure Determination; Blood Transfusion; Blood Volume Determination; Co | 1964 |
TREATMENT OF EXPERIMENTAL CARDIOGENIC SHOCK.
Topics: Animals; Blood Pressure; Cardiac Output; Coronary Disease; Dextrans; Dogs; Electrocardiography; Hemo | 1965 |
Pretreatment with phenoxybenzamine attenuates the radial artery's vasoconstrictor response to alpha-adrenergic stimuli.
Topics: Adrenergic alpha-Antagonists; Case-Control Studies; Coronary Artery Bypass; Coronary Disease; Female | 2003 |
Left stellate stimulation: regional myocardial flows and ischemic injury in dogs.
Topics: Animals; Atenolol; Coronary Circulation; Coronary Disease; Dogs; Electric Stimulation; Electrocardio | 1980 |
Effect of coronary artery pressure on transmural distribution of adrenergic coronary vasoconstriction in the dog.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Heart; Hear | 1983 |
Pathophysiology and treatment of coronary arterial spasm.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Atropine; Calcium; Coronary Disease; Coronary Vess | 1980 |
Progressive coronary vasoconstriction during relative ischemia in canine myocardium.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Coronary Disease; Dogs; Hemodynamics; Indomethacin; | 1982 |
Exercise-induced coronary arterial spasm: angiographic demonstration, documentation of ischemia by myocardial scintigraphy and results of pharmacologic intervention.
Topics: Angina Pectoris, Variant; Coronary Disease; Exercise Test; Humans; Indomethacin; Male; Middle Aged; | 1980 |
Chronotropic responses to experimental ischemia of the canine sino auricular node.
Topics: Acetylcholine; Action Potentials; Animals; Atrial Function; Atropine; Coronary Disease; Dogs; Heart | 1976 |
Neurogenic coronary vasoconstrictor effects of digitalis during acute global ischemia in dogs.
Topics: Animals; Coronary Circulation; Coronary Disease; Coronary Vessels; Digoxin; Dogs; Phenoxybenzamine; | 1977 |
Altered adrenergic activity in coronary arterial spasm: insight into mechanism based on study of coronary hemodynamics and the electrocardiogram.
Topics: Adult; Angina Pectoris, Variant; Arteries; Coronary Disease; Electrocardiography; Ergonovine; Female | 1979 |
Effect of phenoxybenzamine and propranolol on myocardial reactive hyperaemia in fibrillating canine heart.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; In Vitro Techniques; Phenoxybenzamine; Propra | 1979 |
Catecholamine release as mediator of intracellular enzyme activation in ischaemic perfused rat hearts.
Topics: Animals; Catecholamines; Colorimetry; Coronary Disease; Cytoplasm; Depression, Chemical; Disease Mod | 1975 |
Coronary effects of neuropeptides in dogs: role of cyclooxygenase products as mediators.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Indomethacin; Neuropeptide Y; Neuropeptides; | 1989 |
Adrenergic coronary vasoconstriction during myocardial underperfusion.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Norepinephrine; Phenoxybenzamine; R | 1987 |
Mechanisms of coronary spasm of isolated human epicardial coronary segments excised 3 to 5 hours after sudden death.
Topics: Acetylcholine; Adult; Angina Pectoris; Calcium; Calcium Channel Blockers; Coronary Disease; Coronary | 1986 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem | 1986 |
Progressive vasomotor changes in ischaemic myocardium.
Topics: Adenosine; Animals; Coronary Circulation; Coronary Disease; Dogs; Guinea Pigs; Humans; Indomethacin; | 1985 |
Differential reflex adjustments in cutaneous and muscle vascular beds during experimental coronary artery occlusion.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood Vessels; Constriction; Coronary Disease | 1971 |
Non-uniform blood flow through the ischemic myocardium induced by stellate ganglion stimulation.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Depression, Chemi | 1972 |
Glucose intolerance in cardiac patients without myocardial ischemia and its relation tto cardiac output.
Topics: Adolescent; Adult; Aged; Cardiac Catheterization; Cardiac Output; Cardiomyopathies; Coronary Disease | 1971 |