phenoxybenzamine has been researched along with Brain Injuries in 2 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma." | 1.40 | Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury. ( Kothiwal, A; Poulsen, DJ; Rau, TF; Rhoderick, JF; Rova, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rau, TF | 1 |
| Kothiwal, A | 1 |
| Rova, A | 1 |
| Rhoderick, JF | 1 |
| Poulsen, DJ | 1 |
| Dasgupta, NK | 1 |
2 other studies available for phenoxybenzamine and Brain Injuries
| Article | Year |
|---|---|
Phenoxybenzamine is neuroprotective in a rat model of severe traumatic brain injury.
Topics: Animals; Brain; Brain Injuries; Cell Death; Cell Survival; Cells, Cultured; Chemokine CCL2; Drug Eva | 2014 |
On the mechanism of the pressor response due to propranolol.
Topics: Animals; Blood Pressure; Brain Injuries; Bretylium Compounds; Heart Rate; Hexamethonium Compounds; I | 1968 |