phenoxybenzamine has been researched along with Acute Liver Injury, Drug-Induced in 12 studies
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC." | 1.26 | Effect of various treatments on toxicity of inhaled vinylidene chloride. ( Lee, CC; Minor, JL; Seifter, J; Short, RD; Winston, JM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| HEIMBERG, M | 1 |
| WATKINS, ML | 1 |
| TOOKER, R | 1 |
| RUBENSTEIN, B | 1 |
| RUBINSTEIN, D | 1 |
| Crook, LE | 1 |
| Rees, KR | 1 |
| Varcoe, JS | 1 |
| Short, RD | 1 |
| Winston, JM | 1 |
| Minor, JL | 1 |
| Seifter, J | 1 |
| Lee, CC | 1 |
| Ochi, Y | 1 |
| Yumori, Y | 1 |
| Morioka, A | 1 |
| Miura, K | 1 |
| Tsukamoto, I | 1 |
| Kojo, S | 1 |
| Maling, HM | 1 |
| Highman, B | 1 |
| Williams, MA | 1 |
| Saul, W | 1 |
| Butler, WM | 1 |
| Brodie, BB | 1 |
1 review available for phenoxybenzamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
11 other studies available for phenoxybenzamine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
CARBON TETRACHLORIDE HEPATOTOXICITY: THE DIRECT ACTION OF CCL4 ON THE LIVER.
Topics: Bile; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1964 |
THE EFFECT OF CARBON TETRACHLORIDE ON HEPATIC LIPID METABOLISM.
Topics: Acetates; Alanine Transaminase; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisonin | 1964 |
The effect of adrenalectomy on thioacetamide-induced hepatic necrosis.
Topics: Adrenal Glands; Adrenalectomy; Amides; Animals; Chemical and Drug Induced Liver Injury; Ergotamine; | 1967 |
Effect of various treatments on toxicity of inhaled vinylidene chloride.
Topics: Amino Acids, Sulfur; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Dichloroethylen | 1977 |
Effect of alpha-blockade on liver regeneration after carbon tetrachloride intoxication in the rat.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 1990 |
Reduction by pretreatment with dibenamine of hepatotoxicity induced by carbon tetrachloride, thioacetamide or dimethylnitrosamine.
Topics: Acetamides; Alanine Transaminase; Alcohols; Allyl Compounds; Animals; Benzene Derivatives; Body Temp | 1974 |