Page last updated: 2024-08-18

phenothiazine and Alzheimer Disease

phenothiazine has been researched along with Alzheimer Disease in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Arndt, HD; Gaube, F; Raztsou, I; Robaa, D; Rohrbach, MM; Sager, H; Schätz, B; Schwarthoff, S; Tischer, N; Winckler, T1
Cai, J; Chen, H; Dong, C; Du, Z; Li, L; Li, Y; Meunier, B; Yan, L; Zhang, W1
Chu, JC; Hsin, LW; Hsu, KC; Huang, WJ; Lee, HS; Lin, CH; Lin, TE; Liu, CI; Tseng, HJ; Wang, AH; Wang, HC1
Aksinenko, AY; Aliev, G; Bachurin, SO; Barreto, GE; Boltneva, NP; Grigoriev, VV; Lushchekina, SV; Makhaeva, GF; Serebryakova, OG; Sokolov, VB; Vikhareva, EA1
Cisek, K; Honson, NS; Jensen, JR; Kuret, J1
Akoury, E; Biernat, J; Gajda, M; Mandelkow, E; Pickhardt, M; Zweckstetter, M1
Conrad, S; Darvesh, KV; Darvesh, S; Gomez, G; Martin, E; Mataija, D; McDonald, RS; Walsh, R1

Other Studies

7 other study(ies) available for phenothiazine and Alzheimer Disease

ArticleYear
Evaluation of γ-carboline-phenothiazine conjugates as simultaneous NMDA receptor blockers and cholinesterase inhibitors.
    Bioorganic & medicinal chemistry, 2021, 09-15, Volume: 46

    Topics: Acetylcholinesterase; Alzheimer Disease; Butyrylcholinesterase; Carbolines; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neuroprotective Agents; Phenothiazines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

2021
Development of novel theranostic agents for in vivo amyloid imaging and protective effects on human neuroblastoma cells.
    European journal of medicinal chemistry, 2019, Nov-01, Volume: 181

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Humans; Male; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Optical Imaging; Phenothiazines; Plaque, Amyloid; Protein Aggregation, Pathological; Theranostic Nanomedicine

2019
Synthesis and biological evaluation of phenothiazine derivative-containing hydroxamic acids as potent class II histone deacetylase inhibitors.
    European journal of medicinal chemistry, 2021, Jul-05, Volume: 219

    Topics: Acetylation; Alzheimer Disease; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Drug Design; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Molecular Docking Simulation; Neurites; Neuroprotective Agents; Oxidative Stress; Phenothiazines; Structure-Activity Relationship; Tubulin

2021
Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease.
    Scientific reports, 2015, Aug-18, Volume: 5

    Topics: Alzheimer Disease; Animals; Binding Sites; Butyrylcholinesterase; Carbolines; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Combinations; Drug Design; Enzyme Activation; Humans; Models, Chemical; Molecular Docking Simulation; Phenothiazines; Protein Binding; Receptors, N-Methyl-D-Aspartate; Treatment Outcome

2015
Ligand polarizability contributes to tau fibril binding affinity.
    Bioorganic & medicinal chemistry, 2011, Sep-01, Volume: 19, Issue:17

    Topics: Alzheimer Disease; Benzothiazoles; Binding Sites; Humans; Indoles; Ligands; Oxindoles; Phenothiazines; Protein Binding; tau Proteins; Thiazoles

2011
Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation.
    Angewandte Chemie (International ed. in English), 2013, Mar-18, Volume: 52, Issue:12

    Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Cysteine; Disease Models, Animal; Humans; Magnetic Resonance Spectroscopy; Methylene Blue; Oxidation-Reduction; Phenothiazines; Protein Binding; tau Proteins

2013
Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.
    Bioorganic & medicinal chemistry, 2007, Oct-01, Volume: 15, Issue:19

    Topics: Acetylcholine; Alzheimer Disease; Amides; Amyloid; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Neurotransmitter Agents; Phenothiazines; Structure-Activity Relationship; Substrate Specificity

2007