phenolsulfonphthalein has been researched along with Breast Cancer in 26 studies
Phenolsulfonphthalein: Red dye, pH indicator, and diagnostic aid for determination of renal function. It is used also for studies of the gastrointestinal and other systems.
phenol red : 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of a new antiestrogen, droloxifene (DROL, (E)-alpha-[p-[2-(dimethylamino)ethoxy]-phenyl]-alpha'-ethyl-3- stilbenol), on human breast cancer cells in vitro and in vivo were studied." | 7.68 | The estrogenic and antiestrogenic activities of droloxifene in human breast cancers. ( Kawamura, I; Kohsaka, M; Lacey, E; Manda, T; Mizota, T; Shimomura, K; Tanaka, Y, 1993) |
| "We propose that ER+ breast cancer that has changed to a paracrine growth factor-driven system (from stromal cells or ER- breast cancer cells) is less responsive to gonadal steroids." | 5.28 | Decrease in estradiol-stimulated progesterone receptor production in MCF-7 cells by epidermal growth factor and possible clinical implication for paracrine-regulated breast cancer growth. ( Cormier, EM; Jordan, VC; Wolf, MF, 1989) |
| "Metformin, a Type II diabetic treatment drug, which inhibits transcription of gluconeogenesis genes, has recently been shown to lower the risk of some diabetes-related tumors, including breast cancer." | 3.77 | Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. ( Jung, JW; Kang, KS; Lee, SJ; Park, SB; Seo, MS; Trosko, JE, 2011) |
| "The effects of a new antiestrogen, droloxifene (DROL, (E)-alpha-[p-[2-(dimethylamino)ethoxy]-phenyl]-alpha'-ethyl-3- stilbenol), on human breast cancer cells in vitro and in vivo were studied." | 3.68 | The estrogenic and antiestrogenic activities of droloxifene in human breast cancers. ( Kawamura, I; Kohsaka, M; Lacey, E; Manda, T; Mizota, T; Shimomura, K; Tanaka, Y, 1993) |
| "In order to determine growth effects of the progestin R5020, (promegestone), we have utilized the progesterone-receptor rich human breast cancer cell line T-47D, growing the cells in the absence of the pH indicator phenol red, which has recently been found to be estrogenic." | 3.67 | Progestin effects on growth in the human breast cancer cell line T-47D--possible therapeutic implications. ( Hissom, JR; Moore, MR, 1987) |
| "Hormone receptor-positive breast cancer (HR+ BC) cells depend on estrogen and its receptor, ER." | 1.91 | A New Culture Model for Enhancing Estrogen Responsiveness in HR+ Breast Cancer Cells through Medium Replacement: Presumed Involvement of Autocrine Factors in Estrogen Resistance. ( Jang, SH; Kim, JK; Lim, W; Paek, SH; Seong, JK, 2023) |
| " In the course of other studies, we observed that brief (1- to 4-h) incubations of these cells at 37 C in serum-free medium (Hanks' or Earle's Balanced Salts Solution) could be toxic to MCF-7 cells when the pH was increased above 7." | 1.28 | pH-dependent cytotoxicity of contaminants of phenol red for MCF-7 breast cancer cells. ( Grady, LH; Nonneman, DJ; Rottinghaus, GE; Welshons, WV, 1991) |
| "Human MCF-7 breast cancer cells have been studied to determine their suitability as an autocrine model for the synthesis, secretion and action of insulin-like growth factor-I (IGF-I)." | 1.28 | Insulin-like growth factor-I and its autocrine role in growth of MCF-7 human breast cancer cells in culture. ( Freed, KA; Herington, AC, 1989) |
| "MCF-7 human breast cancer cells in continuous culture respond to the growth promoting activity of prolactin." | 1.28 | Estrogens are not required for prolactin induced growth of MCF-7 human breast cancer cells. ( Vonderhaar, BK, 1989) |
| "We propose that ER+ breast cancer that has changed to a paracrine growth factor-driven system (from stromal cells or ER- breast cancer cells) is less responsive to gonadal steroids." | 1.28 | Decrease in estradiol-stimulated progesterone receptor production in MCF-7 cells by epidermal growth factor and possible clinical implication for paracrine-regulated breast cancer growth. ( Cormier, EM; Jordan, VC; Wolf, MF, 1989) |
| "The human breast cancer cell line MCF-7 responds to estrogens with increased progesterone receptor (PR) levels." | 1.27 | Regulation of progesterone receptor messenger ribonucleic acid and protein levels in MCF-7 cells by estradiol: analysis of estrogen's effect on progesterone receptor synthesis and degradation. ( Greene, GL; Katzenellenbogen, BS; Nardulli, AM; O'Malley, BW, 1988) |
| "We used cell enucleation of two human breast cancer-derived cell lines, MCF-7 and T47D, to determine whether the unoccupied receptors were also nuclear in these cells and to determine whether the weak estrogen phenol red, present in nearly all tissue culture media, affected the distribution of the receptors seen with this technique." | 1.27 | Estrogen receptor distribution in enucleated breast cancer cell lines. ( Cormier, EM; Jordan, VC; Welshons, WV; Williams, PO; Wolf, MF, 1988) |
| "Hence, these breast cancer cells adapt significantly to long-term growth in estrogen-free conditions, an observation that may be relevant to understanding the growth of hormone-responsive human breast cancers in vivo." | 1.27 | Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens. ( Berthois, Y; Katzenellenbogen, BS; Kendra, KL; Norman, MJ, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (65.38) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Jang, SH | 1 |
| Paek, SH | 1 |
| Kim, JK | 1 |
| Seong, JK | 1 |
| Lim, W | 1 |
| Ermler, S | 1 |
| Scholze, M | 1 |
| Kortenkamp, A | 1 |
| Jung, JW | 1 |
| Park, SB | 1 |
| Lee, SJ | 1 |
| Seo, MS | 1 |
| Trosko, JE | 1 |
| Kang, KS | 1 |
| Balcer-Kubiczek, EK | 1 |
| Harrison, GH | 1 |
| Xu, JF | 1 |
| Gutierrez, PL | 1 |
| Borowiec, AS | 1 |
| Hague, F | 1 |
| Harir, N | 1 |
| Guénin, S | 1 |
| Guerineau, F | 1 |
| Gouilleux, F | 1 |
| Roudbaraki, M | 1 |
| Lassoued, K | 1 |
| Ouadid-Ahidouch, H | 1 |
| Lubin, M | 1 |
| Kawamura, I | 1 |
| Mizota, T | 1 |
| Lacey, E | 1 |
| Tanaka, Y | 1 |
| Manda, T | 1 |
| Shimomura, K | 1 |
| Kohsaka, M | 1 |
| Massaad, C | 1 |
| Coumoul, X | 1 |
| Sabbah, M | 1 |
| Garlatti, M | 1 |
| Redeuilh, G | 1 |
| Barouki, R | 1 |
| Grady, LH | 1 |
| Nonneman, DJ | 1 |
| Rottinghaus, GE | 1 |
| Welshons, WV | 3 |
| Freed, KA | 1 |
| Herington, AC | 1 |
| Vonderhaar, BK | 1 |
| Cormier, EM | 2 |
| Wolf, MF | 3 |
| Jordan, VC | 3 |
| Bignon, E | 1 |
| Pons, M | 1 |
| Gilbert, J | 1 |
| Crastes de Paulet, A | 1 |
| Richards, J | 1 |
| Imagawa, W | 1 |
| Balakrishnan, A | 1 |
| Edery, M | 1 |
| Nandi, S | 1 |
| Nardulli, AM | 1 |
| Greene, GL | 1 |
| O'Malley, BW | 1 |
| Katzenellenbogen, BS | 4 |
| Williams, PO | 1 |
| Moore, MR | 2 |
| Hagley, RD | 1 |
| Hissom, JR | 2 |
| Glover, JF | 1 |
| Irwin, JT | 1 |
| Darbre, PD | 1 |
| Murphy, CS | 1 |
| Bindal, RD | 1 |
| Carlson, KE | 1 |
| Katzenellenbogen, JA | 2 |
| Berthois, Y | 2 |
| Kendra, KL | 1 |
| Norman, MJ | 1 |
| Nunez, AM | 1 |
| Jakowlev, S | 1 |
| Briand, JP | 1 |
| Gaire, M | 1 |
| Krust, A | 1 |
| Rio, MC | 1 |
| Chambon, P | 1 |
| Gill, PG | 1 |
| Vignon, F | 1 |
| Bardon, S | 1 |
| Derocq, D | 1 |
| Rochefort, H | 1 |
| Rajendran, KG | 1 |
| Lopez, T | 1 |
| Parikh, I | 1 |
26 other studies available for phenolsulfonphthalein and Breast Cancer
| Article | Year |
|---|---|
A New Culture Model for Enhancing Estrogen Responsiveness in HR+ Breast Cancer Cells through Medium Replacement: Presumed Involvement of Autocrine Factors in Estrogen Resistance.
Topics: Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; MCF-7 Cells; Phenolsulfonphthalei | 2023 |
The sensitivity of the MDA-kb2 cell in vitro assay in detecting anti-androgenic chemicals--identification of sources of variability and estimation of statistical power.
Topics: Androgen Antagonists; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose | 2010 |
Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression.
Topics: Antioxidants; Breast Neoplasms; Cell Proliferation; Estradiol; Female; Flow Cytometry; Humans; Metfo | 2011 |
Coordinate late expression of trefoil peptide genes (pS2/TFF1 and ITF/TFF3) in human breast, colon, and gastric tumor cells exposed to X-rays.
Topics: Apoptosis; Blotting, Northern; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Colony-Forming Un | 2002 |
IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.
Topics: Androstadienes; Astemizole; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Ether-A-Go-Go Po | 2007 |
An impurity in phenol red opens an ion channel in cultured human cells.
Topics: Animals; Breast Neoplasms; Cells, Cultured; Culture Media, Conditioned; Culture Media, Serum-Free; F | 1993 |
The estrogenic and antiestrogenic activities of droloxifene in human breast cancers.
Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Division; Estradiol; Estrogen | 1993 |
Properties of overlapping EREs: synergistic activation of transcription and cooperative binding of ER.
Topics: Base Sequence; Breast Neoplasms; Carcinoma, Hepatocellular; Chlordan; Dimerization; Drug Synergism; | 1998 |
pH-dependent cytotoxicity of contaminants of phenol red for MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Death; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug | 1991 |
Insulin-like growth factor-I and its autocrine role in growth of MCF-7 human breast cancer cells in culture.
Topics: Animals; Antibodies, Monoclonal; Blotting, Northern; Breast Neoplasms; Cell Division; Dexamethasone; | 1989 |
Estrogens are not required for prolactin induced growth of MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Estrogens; Female; Humans; Phenolsulfonphthalein; Placental Lactoge | 1989 |
Decrease in estradiol-stimulated progesterone receptor production in MCF-7 cells by epidermal growth factor and possible clinical implication for paracrine-regulated breast cancer growth.
Topics: Breast Neoplasms; Cell Line; Epidermal Growth Factor; Estradiol; Humans; Kinetics; Phenolsulfonphtha | 1989 |
Analogies and differences in the modulation of progesterone receptor induction and cell proliferation by estrogens and antiestrogens in MCF-7 human breast cancer cells: study with 24 triphenylacrylonitrile derivatives.
Topics: Breast Neoplasms; Cell Division; Cell Line; Estrogen Antagonists; Estrogens; Humans; Phenolsulfonpht | 1988 |
The lack of effect of phenol red or estradiol on the growth response of human, rat, and mouse mammary cells in primary culture.
Topics: Animals; Breast; Breast Neoplasms; Cell Division; Cells, Cultured; Epidermal Growth Factor; Estradio | 1988 |
Regulation of progesterone receptor messenger ribonucleic acid and protein levels in MCF-7 cells by estradiol: analysis of estrogen's effect on progesterone receptor synthesis and degradation.
Topics: Amino Acids; Breast Neoplasms; Carbon Isotopes; Deuterium; Dose-Response Relationship, Drug; Estradi | 1988 |
Estrogen receptor distribution in enucleated breast cancer cell lines.
Topics: Breast Neoplasms; Cell Fractionation; Cell Nucleus; Cycloheximide; Cytoplasm; DNA; Enzyme-Linked Imm | 1988 |
Progestin effects on lactate dehydrogenase and growth in the human breast cancer cell line T47D.
Topics: Breast Neoplasms; Cell Division; Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Phenolsulfonph | 1988 |
Interaction of phenol red with estrogenic and antiestrogenic action on growth of human breast cancer cells ZR-75-1 and T-47-D.
Topics: Breast Neoplasms; Cell Division; Culture Media; Estradiol; Estrogen Antagonists; Estrogens; Humans; | 1988 |
Estrogenic activity of phenol red.
Topics: Animals; Breast Neoplasms; Cell Line; Cells, Cultured; Culture Media; Estrogens; Female; Humans; Phe | 1988 |
Lipophilic impurities, not phenolsulfonphthalein, account for the estrogenic activity in commercial preparations of phenol red.
Topics: Animals; Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Chromatography, High Pres | 1988 |
Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.
Topics: Binding, Competitive; Breast Neoplasms; Cell Cycle; Cell Line; Culture Media; Dose-Response Relation | 1986 |
Progestin effects on growth in the human breast cancer cell line T-47D--possible therapeutic implications.
Topics: Breast Neoplasms; Cell Division; Cell Line; Drug Combinations; Estradiol; Humans; Norpregnadienes; P | 1987 |
Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.
Topics: Breast Neoplasms; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Estrogen Antagon | 1987 |
Characterization of the estrogen-induced pS2 protein secreted by the human breast cancer cell line MCF-7.
Topics: Breast Neoplasms; Cell Line; Estradiol; Female; Humans; Neoplasm Proteins; Phenolsulfonphthalein; Pr | 1987 |
Difference between R5020 and the antiprogestin RU486 in antiproliferative effects on human breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Estradiol; Estrenes; Glucocorticoids; Humans; Mifepristone; Norpreg | 1987 |
Estrogenic effect of phenol red in MCF-7 cells is achieved through activation of estrogen receptor by interacting with a site distinct from the steroid binding site.
Topics: Binding Sites; Breast Neoplasms; Cell Line; Cell Nucleus; Cellulose; Cytosol; DNA; Female; Humans; P | 1987 |