phenolphthalein has been researched along with Thymus Neoplasms in 5 studies
Phenolphthalein: An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.
Thymus Neoplasms: Tumors or cancer of the THYMUS GLAND.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Benzene-induced sarcomas, p-cresidine-induced bladder carcinomas and phenolphthalein-induced thymic lymphomas were allelotyped at the Trp53 locus and chromosome 11 simple sequence length polymorphic (SSLP) loci." | 3.71 | Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice. ( Dunnick, JK; French, JE; Hulla, JE, 2001) |
| "Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in heterozygous p53-deficient female mice at the same dose in a 6-month study." | 3.70 | Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study. ( Hirose, M; Koujitani, T; Mitsumori, K; Nomura, T; Onodera, H; Takagi, H; Usui, T; Yasuhara, K, 2000) |
| "Bisacodyl was negative in the SHE assay." | 1.33 | Phenolphthalein and bisacodyl: assessment of genotoxic and carcinogenic responses in heterozygous p53 (+/-) mice and syrian hamster embryo (SHE) assay. ( Blanchard, KT; Furst, S; Lilly, PD; Majeska, JB; Mennear, JH; Stoll, RE; Stoltz, JH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stoll, RE | 1 |
| Blanchard, KT | 1 |
| Stoltz, JH | 1 |
| Majeska, JB | 1 |
| Furst, S | 1 |
| Lilly, PD | 1 |
| Mennear, JH | 1 |
| Koujitani, T | 1 |
| Yasuhara, K | 1 |
| Usui, T | 1 |
| Nomura, T | 1 |
| Onodera, H | 1 |
| Takagi, H | 1 |
| Hirose, M | 1 |
| Mitsumori, K | 1 |
| Hulla, JE | 3 |
| French, JE | 2 |
| Dunnick, JK | 2 |
5 other studies available for phenolphthalein and Thymus Neoplasms
| Article | Year |
|---|---|
Phenolphthalein and bisacodyl: assessment of genotoxic and carcinogenic responses in heterozygous p53 (+/-) mice and syrian hamster embryo (SHE) assay.
Topics: Animals; Bisacodyl; Carcinogens; Cathartics; Cell Transformation, Neoplastic; Cells, Cultured; Crice | 2006 |
Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.
Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Female; Genes, ras; H | 2000 |
Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice.
Topics: Alleles; Aniline Compounds; Animals; Benzene; Carcinogenicity Tests; Carcinogens; Chromosomes; Cross | 2001 |
Chromosome 11 loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein.
Topics: Animals; DNA Primers; DNA, Neoplasm; Heterozygote; Loss of Heterozygosity; Lymphoma; Mice; Mice, Inb | 2001 |
Chromosome 11 loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein.
Topics: Animals; Female; Heterozygote; Loss of Heterozygosity; Lymphoma; Male; Mice; Mice, Inbred C57BL; Mic | 2001 |