Page last updated: 2024-11-02

phenolphthalein and Lymphoma

phenolphthalein has been researched along with Lymphoma in 8 studies

Phenolphthalein: An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.

Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.

Research Excerpts

ExcerptRelevanceReference
" Benzene-induced sarcomas, p-cresidine-induced bladder carcinomas and phenolphthalein-induced thymic lymphomas were allelotyped at the Trp53 locus and chromosome 11 simple sequence length polymorphic (SSLP) loci."3.71Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice. ( Dunnick, JK; French, JE; Hulla, JE, 2001)
" In this study, exons 3-5 and exon 7 of the Znfn1a1 gene that encode the functional domains of Ikaros were analyzed for point mutations and deletions in murine lymphomas induced by 1,3-butadiene, 2',3'-dideoxycytidine, or phenolphthalein."3.71Point mutations and deletions in the znfn1a1/ikaros gene in chemically induced murine lymphomas. ( Karlsson, A; Söderkvist, P; Zhuang, SM, 2002)
"Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in heterozygous p53-deficient female mice at the same dose in a 6-month study."3.70Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study. ( Hirose, M; Koujitani, T; Mitsumori, K; Nomura, T; Onodera, H; Takagi, H; Usui, T; Yasuhara, K, 2000)
"Bisacodyl was negative in the SHE assay."1.33Phenolphthalein and bisacodyl: assessment of genotoxic and carcinogenic responses in heterozygous p53 (+/-) mice and syrian hamster embryo (SHE) assay. ( Blanchard, KT; Furst, S; Lilly, PD; Majeska, JB; Mennear, JH; Stoll, RE; Stoltz, JH, 2006)
"Analysis of the p-cresidine-induced bladder tumors by cold single-strand conformation polymorphism (SSCP) analysis of exon 4-9 amplicons failed to demonstrate polymorphisms associated with mutations in tumors that retained the p53 wild-type allele."1.31Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent. ( Dunnick, JK; Foley, J; French, JE; Lacks, GD; Mahler, J; Tennant, RW; Tice, RR; Trempus, C, 2001)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (87.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stoll, RE1
Blanchard, KT1
Stoltz, JH1
Majeska, JB1
Furst, S1
Lilly, PD1
Mennear, JH1
Koujitani, T1
Yasuhara, K1
Usui, T1
Nomura, T1
Onodera, H1
Takagi, H1
Hirose, M1
Mitsumori, K1
Hulla, JE3
French, JE3
Dunnick, JK3
Lacks, GD1
Trempus, C1
Foley, J1
Mahler, J1
Tice, RR1
Tennant, RW1
Karlsson, A1
Söderkvist, P1
Zhuang, SM1

Other Studies

8 other studies available for phenolphthalein and Lymphoma

ArticleYear
Phenolphthalein.
    Report on carcinogens : carcinogen profiles, 2011, Volume: 12

    Topics: Animals; Carcinogens; Humans; Indicators and Reagents; Laxatives; Lymphoma; Phenolphthalein

2011
Phenolphthalein and bisacodyl: assessment of genotoxic and carcinogenic responses in heterozygous p53 (+/-) mice and syrian hamster embryo (SHE) assay.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2

    Topics: Animals; Bisacodyl; Carcinogens; Cathartics; Cell Transformation, Neoplastic; Cells, Cultured; Crice

2006
Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.
    Cancer letters, 2000, May-01, Volume: 152, Issue:2

    Topics: Adenoma, Liver Cell; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Female; Genes, ras; H

2000
Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice.
    Carcinogenesis, 2001, Volume: 22, Issue:1

    Topics: Alleles; Aniline Compounds; Animals; Benzene; Carcinogenicity Tests; Carcinogens; Chromosomes; Cross

2001
Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent.
    Carcinogenesis, 2001, Volume: 22, Issue:1

    Topics: Alleles; Aniline Compounds; Animals; Bacterial Proteins; Benzene; Carcinogens; Escherichia coli Prot

2001
Chromosome 11 loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 60, Issue:2

    Topics: Animals; DNA Primers; DNA, Neoplasm; Heterozygote; Loss of Heterozygosity; Lymphoma; Mice; Mice, Inb

2001
Chromosome 11 loss from thymic lymphomas induced in heterozygous Trp53 mice by phenolphthalein.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 64, Issue:2

    Topics: Animals; Female; Heterozygote; Loss of Heterozygosity; Lymphoma; Male; Mice; Mice, Inbred C57BL; Mic

2001
Point mutations and deletions in the znfn1a1/ikaros gene in chemically induced murine lymphomas.
    Cancer research, 2002, May-01, Volume: 62, Issue:9

    Topics: Alleles; Animals; Blotting, Southern; Butadienes; Carcinogens; DNA-Binding Proteins; Gene Deletion;

2002