phenolphthalein has been researched along with Experimental Neoplasms in 6 studies
Phenolphthalein: An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Benzene-induced sarcomas, p-cresidine-induced bladder carcinomas and phenolphthalein-induced thymic lymphomas were allelotyped at the Trp53 locus and chromosome 11 simple sequence length polymorphic (SSLP) loci." | 3.71 | Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice. ( Dunnick, JK; French, JE; Hulla, JE, 2001) |
| "Phenolphthalein has carcinogenic activity, causing malignant lymphomas in B6C3F1 mice at a dietary dose of 3000 ppm in a 2-year carcinogenicity study and in female heterozygous p53-knockout TSG mice (C57BL/6 background) at the same dose in a 6-month study." | 1.32 | Lack of susceptibility of heterozygous p53-knockout CBA and CIEA mice to phenolphthalein in a 6-month carcinogenicity study. ( Hirose, M; Kashida, Y; Mitsumori, K; Okamura, M; Onodera, H; Tamaoki, N; Usui, T; Watanabe, T; Yasuhara, K, 2003) |
| "Analysis of the p-cresidine-induced bladder tumors by cold single-strand conformation polymorphism (SSCP) analysis of exon 4-9 amplicons failed to demonstrate polymorphisms associated with mutations in tumors that retained the p53 wild-type allele." | 1.31 | Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent. ( Dunnick, JK; Foley, J; French, JE; Lacks, GD; Mahler, J; Tennant, RW; Tice, RR; Trempus, C, 2001) |
| "Phenolphthalein has been shown to have estrogenic and clastogenic properties." | 1.29 | Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems. ( Dunnick, JK; Hailey, JR, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okamura, M | 1 |
| Kashida, Y | 1 |
| Watanabe, T | 1 |
| Yasuhara, K | 1 |
| Onodera, H | 1 |
| Hirose, M | 1 |
| Usui, T | 1 |
| Tamaoki, N | 1 |
| Mitsumori, K | 1 |
| Dunnick, JK | 3 |
| Hailey, JR | 1 |
| Hulla, JE | 1 |
| French, JE | 2 |
| Lacks, GD | 1 |
| Trempus, C | 1 |
| Foley, J | 1 |
| Mahler, J | 1 |
| Tice, RR | 1 |
| Tennant, RW | 1 |
| Prival, MJ | 1 |
6 other studies available for phenolphthalein and Experimental Neoplasms
| Article | Year |
|---|---|
Lack of susceptibility of heterozygous p53-knockout CBA and CIEA mice to phenolphthalein in a 6-month carcinogenicity study.
Topics: Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Diet; Dose-Response Relationship, | 2003 |
Phenolphthalein highlights NTP bioassay review.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Female; Male; Mice; Neoplasms, Experimental; Phenolphth | 1996 |
Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems.
Topics: Animals; Body Weight; Cathartics; Female; Hematopoietic System; Kidney Neoplasms; Male; Mice; Neopla | 1996 |
Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice.
Topics: Alleles; Aniline Compounds; Animals; Benzene; Carcinogenicity Tests; Carcinogens; Chromosomes; Cross | 2001 |
Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent.
Topics: Alleles; Aniline Compounds; Animals; Bacterial Proteins; Benzene; Carcinogens; Escherichia coli Prot | 2001 |
Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals.
Topics: Animals; Benzene Derivatives; Carcinogenicity Tests; Carcinogens; Chloroprene; Enzyme Inhibitors; Fe | 2001 |