Page last updated: 2024-10-19

phenol and Kidney Failure, Chronic

phenol has been researched along with Kidney Failure, Chronic in 8 studies

Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, X1
Hao, Y1
Liu, X1
Yu, S1
Zhang, W1
Yang, S1
Yu, Z1
Ren, F1
Eidi, F1
Poor-Reza Gholi, F1
Ostadrahimi, A1
Dalili, N1
Samadian, F1
Barzegari, A1
Calaf, R1
Cerini, C1
Génovésio, C1
Verhaeghe, P1
Jourde-Chiche, N1
Bergé-Lefranc, D1
Gondouin, B1
Dou, L1
Morange, S1
Argilés, A1
Rathelot, P1
Dignat-George, F1
Brunet, P1
Charpiot, P1
Ye, S2
Zhong, H1
Yanamadala, V1
Campese, VM2
Capeillère-Blandin, C1
Gausson, V1
Nguyen, AT1
Descamps-Latscha, B1
Drüeke, T1
Witko-Sarsat, V1
Christiansen, RG1
Klaman, JS1
Ozgur, B1
Gasparović, V1
Kuzmanić, D1
Brod, J1
Radonić, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Renal SympAthetic DenerVation on Chronic HypErtension[NCT01628198]38 participants (Actual)Interventional2011-10-31Terminated (stopped due to recommendation by the study's DSMB due to insufficient data to determine efficacy.)
Renal Sympathetic Denervation for the Management of Chronic Hypertension[NCT01628172]96 participants (Actual)Interventional2011-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Ambulatory Diastolic Blood Pressure

The change in diastolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

InterventionmmHg mean change (Mean)
Renal Denervation Group-5.5

Mean Change in Ambulatory Systolic Blood Pressure

The change in systolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

InterventionmmHg (Mean)
Renal Denervation Group-10.2

Anti-hypertensive Medications

The total number of anti-hypertensive medications at baseline, 6 months, and 12 months (NCT01628198)
Timeframe: Baseline, 6 months, 12 months

Interventionmedications (Mean)
Baseline6 months12 months
Renal Denervation Group5.374.794.64

Blood Urea Nitrogen

A blood urea nitrogen (BUN) test measures the amount of nitrogen in blood that comes from the waste product urea. Urea is made when protein is broken down in the body. Urea is made in the liver and passed out in the urine. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Interventionmg/dL (Mean)
Baseline6 months12 months
Renal Denervation Group20.8222.1523.11

Creatinine

Creatinine measures the level of the waste product in the body. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. High levels of creatinine indicates kidney impairment. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Interventionmg/dl (Mean)
Baseline6 months12 months
Renal Denervation Group1.61.682.03

Office Diastolic BP

Different time points office diastolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Interventionmm Hg (Mean)
Baseline6 months12 months
Renal Denervation Group87.0686.9387.75

Office Systolic BP

Different time points office systolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Interventionmm Hg (Mean)
Baseline6 months12 months
Renal Denervation Group156.86151.19158.45

Renal Aortic Ratio

Renal artery blood flow as measured by Renal Aortic Ratio (RAR) = Peak systolic Velocity renal artery / Peak Systolic Velocity Aorta. A >60% stenosis is reported when there is a >3.5:1 Renal to Aortic Ratio. (NCT01628198)
Timeframe: Baseline and 12 months

Interventionratio (Mean)
Baseline Right RARBaseline Left RAR12 months Right RAR12 months Left RAR
Renal Denervation Group1.381.521.411.52

Renal Artery Dimensions

Dimensions of renal artery, right and left (NCT01628198)
Timeframe: baseline and 12 months

Interventionmm (Mean)
Baseline R KidneyBaseline L Kidney12 months R Kidney12 months L Kidney
Renal Denervation Group11.4311.6811.2611.39

Resistive Index

Renal artery blood flow as measured by Resistive Index. RI = (peak systolic velocity - end diastolic velocity ) / peak systolic velocity. the normal value is ~ 0.60, with 0.70 being around the upper limits of normal (NCT01628198)
Timeframe: Baseline and 12 months

Interventionindex (Mean)
Baseline Right RIBaseline Left RI12 months Right RI12 months Left RI
Renal Denervation Group0.670.720.720.72

Trials

1 trial available for phenol and Kidney Failure, Chronic

ArticleYear
Effect of Lactobacillus Rhamnosus on serum uremic toxins (phenol and P-Cresol) in hemodialysis patients: A double blind randomized clinical trial.
    Clinical nutrition ESPEN, 2018, Volume: 28

    Topics: Cresols; Double-Blind Method; Female; Humans; Kidney Failure, Chronic; Lacticaseibacillus rhamnosus;

2018

Other Studies

7 other studies available for phenol and Kidney Failure, Chronic

ArticleYear
Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol.
    Journal of genetics and genomics = Yi chuan xue bao, 2019, 08-20, Volume: 46, Issue:8

    Topics: Biopsy; Cytokines; Gastrointestinal Microbiome; Humans; Inflammation Mediators; Intestinal Mucosa; K

2019
Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Aug-01, Volume: 879, Issue:23

    Topics: Aged; Chromatography, High Pressure Liquid; Cresols; Female; Humans; Indican; Indoleacetic Acids; Ki

2011
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Respective role of uraemic toxins and myeloperoxidase in the uraemic state.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, Volume: 21, Issue:6

    Topics: Adult; Case-Control Studies; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Oxidation-R

2006
Successful treatment of phenol poisoning with charcoal hemoperfusion.
    Veterinary and human toxicology, 1996, Volume: 38, Issue:1

    Topics: Blood Proteins; Charcoal; Chronic Disease; Female; Hemoperfusion; Humans; Kidney Failure, Chronic; K

1996
Renal afferent impulses, the posterior hypothalamus, and hypertension in rats with chronic renal failure.
    Kidney international, 1997, Volume: 51, Issue:3

    Topics: Afferent Pathways; Angiotensin II; Animals; Blood Pressure; Denervation; Hypertension, Renal; Hypoth

1997
Membranoproliferative glomerulonephritis in a patient with multiple myeloma and phenol intoxication.
    Przeglad lekarski, 1985, Volume: 42, Issue:4

    Topics: Adult; Female; Glomerulonephritis; Humans; Kidney Failure, Chronic; Multiple Myeloma; Phenol; Phenol

1985