phenol has been researched along with Hypertension in 13 studies
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The alteration in the activity of sympathetic or capsaicin-sensitive sensory nerves in the development of phenol-induced hypertension was observed separately in rats." | 7.73 | Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat. ( Cai, WJ; Deng, HW; Deng, PY; Li, D; Li, YJ; Luo, D; Luo, XG; Ye, F; Yu, J; Zhang, JW, 2005) |
| "Previous investigations have demonstrated that capsaicin-sensitive sensory nerves are involved in the development of hypertension in some rat models of hypertension." | 7.72 | Role of calcitonin gene-related peptide in the phenol-induced neurogenic hypertension in rats. ( Cai, WJ; Deng, HW; Deng, PY; Li, YJ; Ye, F, 2004) |
| "Minoxidil (2,4-diamino-6-(piperidin-1'-yl)pyrimidine N(3)-oxide; CASRN 38304-91-5) is a bioactive molecule with several nitrosatable groups widely used as an antihypertensive and antialopecia agent." | 3.77 | Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil. ( Arenas-Valgañón, J; Calle, E; Casado, J; González-Jiménez, M, 2011) |
| "Single injection of small quantities of phenol into the kidney cortex causes hypertension which is mediated by renal afferent sympathetic pathway activation." | 3.75 | Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension. ( Bai, Y; Campese, VM; Jabbari, B; Vaziri, ND; Ye, S, 2009) |
| "Single injection of a small quantity of phenol into the cortex of one kidney in rats results in development of persistent hypertension (HTN) which is thought to be mediated by activation of renal afferent and efferent sympathetic pathways and sodium retention." | 3.74 | Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney. ( Bai, Y; Campese, V; Mortazavi, R; Vaziri, ND; Ye, S, 2007) |
| " The alteration in the activity of sympathetic or capsaicin-sensitive sensory nerves in the development of phenol-induced hypertension was observed separately in rats." | 3.73 | Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat. ( Cai, WJ; Deng, HW; Deng, PY; Li, D; Li, YJ; Luo, D; Luo, XG; Ye, F; Yu, J; Zhang, JW, 2005) |
| "Renal injury-induced by phenol injection activates renal sympathetic afferent pathways, increases norepinephrine release from the posterior hypothalamus, activates renal efferent pathways, and provokes a rapid and persistent hypertension." | 3.72 | Responses of proximal tubule sodium transporters to acute injury-induced hypertension. ( Campese, VM; Leong, PK; McDonough, AA; Yang, LE; Ye, S, 2003) |
| "Renal cortical phenol injection provokes acute sympathetic nervous system-dependent hypertension and a shift of proximal tubule Na(+)/H(+) exchanger isoform 3 (NHE3) and Na(+)-P(i) cotransporter type 2 (NaPi2) to apical microvilli." | 3.72 | Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. ( Campese, VM; Leong, PK; McDonough, AA; Perianayagam, A; Yang, LE; Zhong, H, 2003) |
| "Previous investigations have demonstrated that capsaicin-sensitive sensory nerves are involved in the development of hypertension in some rat models of hypertension." | 3.72 | Role of calcitonin gene-related peptide in the phenol-induced neurogenic hypertension in rats. ( Cai, WJ; Deng, HW; Deng, PY; Li, YJ; Ye, F, 2004) |
| " The final study determined the dose-response relationship for paclitaxel." | 1.40 | Chemical renal denervation in the rat. ( Consigny, PM; Davalian, D; Donn, R; Hu, J; Rieser, M; Stolarik, D, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wei, S | 1 |
| Li, D | 2 |
| Zhang, Y | 2 |
| Su, L | 1 |
| Wang, Q | 1 |
| Yang, D | 1 |
| Yang, Y | 1 |
| Ma, S | 1 |
| Consigny, PM | 1 |
| Davalian, D | 1 |
| Donn, R | 1 |
| Hu, J | 1 |
| Rieser, M | 1 |
| Stolarik, D | 1 |
| Bai, Y | 2 |
| Jabbari, B | 1 |
| Ye, S | 5 |
| Campese, VM | 5 |
| Vaziri, ND | 2 |
| González-Jiménez, M | 1 |
| Arenas-Valgañón, J | 1 |
| Calle, E | 1 |
| Casado, J | 1 |
| Hashikawa-Hobara, N | 1 |
| Hashikawa, N | 1 |
| Zamami, Y | 1 |
| Takatori, S | 1 |
| Kawasaki, H | 1 |
| Zhong, H | 2 |
| Yanamadala, V | 1 |
| Yang, LE | 2 |
| Leong, PK | 2 |
| McDonough, AA | 2 |
| Perianayagam, A | 1 |
| BORSCHEL, W | 1 |
| HARTMANN, F | 1 |
| HEIMSOTH, V | 1 |
| RUGE, W | 1 |
| Deng, PY | 2 |
| Ye, F | 2 |
| Cai, WJ | 2 |
| Deng, HW | 2 |
| Li, YJ | 2 |
| Yu, J | 1 |
| Luo, D | 1 |
| Zhang, JW | 1 |
| Luo, XG | 1 |
| Mortazavi, R | 1 |
| Campese, V | 1 |
| Gamburd, M | 1 |
| Mozayeni, P | 1 |
| Koss, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Renal SympAthetic DenerVation on Chronic HypErtension[NCT01628198] | 38 participants (Actual) | Interventional | 2011-10-31 | Terminated (stopped due to recommendation by the study's DSMB due to insufficient data to determine efficacy.) | |||
| Renal Sympathetic Denervation for the Management of Chronic Hypertension[NCT01628172] | 96 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The change in diastolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months
| Intervention | mmHg mean change (Mean) |
|---|---|
| Renal Denervation Group | -5.5 |
The change in systolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months
| Intervention | mmHg (Mean) |
|---|---|
| Renal Denervation Group | -10.2 |
The total number of anti-hypertensive medications at baseline, 6 months, and 12 months (NCT01628198)
Timeframe: Baseline, 6 months, 12 months
| Intervention | medications (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 5.37 | 4.79 | 4.64 |
A blood urea nitrogen (BUN) test measures the amount of nitrogen in blood that comes from the waste product urea. Urea is made when protein is broken down in the body. Urea is made in the liver and passed out in the urine. (NCT01628198)
Timeframe: baseline, 6 months, 12 months
| Intervention | mg/dL (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 20.82 | 22.15 | 23.11 |
Creatinine measures the level of the waste product in the body. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. High levels of creatinine indicates kidney impairment. (NCT01628198)
Timeframe: baseline, 6 months, 12 months
| Intervention | mg/dl (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 1.6 | 1.68 | 2.03 |
Different time points office diastolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months
| Intervention | mm Hg (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 87.06 | 86.93 | 87.75 |
Different time points office systolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months
| Intervention | mm Hg (Mean) | ||
|---|---|---|---|
| Baseline | 6 months | 12 months | |
| Renal Denervation Group | 156.86 | 151.19 | 158.45 |
Renal artery blood flow as measured by Renal Aortic Ratio (RAR) = Peak systolic Velocity renal artery / Peak Systolic Velocity Aorta. A >60% stenosis is reported when there is a >3.5:1 Renal to Aortic Ratio. (NCT01628198)
Timeframe: Baseline and 12 months
| Intervention | ratio (Mean) | |||
|---|---|---|---|---|
| Baseline Right RAR | Baseline Left RAR | 12 months Right RAR | 12 months Left RAR | |
| Renal Denervation Group | 1.38 | 1.52 | 1.41 | 1.52 |
Dimensions of renal artery, right and left (NCT01628198)
Timeframe: baseline and 12 months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline R Kidney | Baseline L Kidney | 12 months R Kidney | 12 months L Kidney | |
| Renal Denervation Group | 11.43 | 11.68 | 11.26 | 11.39 |
Renal artery blood flow as measured by Resistive Index. RI = (peak systolic velocity - end diastolic velocity ) / peak systolic velocity. the normal value is ~ 0.60, with 0.70 being around the upper limits of normal (NCT01628198)
Timeframe: Baseline and 12 months
| Intervention | index (Mean) | |||
|---|---|---|---|---|
| Baseline Right RI | Baseline Left RI | 12 months Right RI | 12 months Left RI | |
| Renal Denervation Group | 0.67 | 0.72 | 0.72 | 0.72 |
13 other studies available for phenol and Hypertension
| Article | Year |
|---|---|
Perivascular radiofrequency renal denervation lowers blood pressure and ameliorates cardiorenal fibrosis in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Catecholamines; Catheter Ablation; Denervation; Fibrosis; Heart Diseases; H | 2017 |
Chemical renal denervation in the rat.
Topics: Animals; Chromatography, Liquid; Denervation; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension.
Topics: Afferent Pathways; Animals; Blood Pressure; Brain; Disease Models, Animal; Hypertension; Male; NADPH | 2009 |
Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil.
Topics: Alopecia; Animals; Antihypertensive Agents; Chromatography, Liquid; Dimethylnitrosamine; Drug-Relate | 2011 |
The mechanism of calcitonin gene-related peptide-containing nerve innervation.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Fructose; Hypercholesterolemia; Hy | 2012 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An | 2002 |
Responses of proximal tubule sodium transporters to acute injury-induced hypertension.
Topics: Acute Disease; Animals; Denervation; Hypertension; Intracellular Membranes; Kidney; Kidney Diseases; | 2003 |
Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance.
Topics: Animals; Blood Pressure; Chronic Disease; Hypertension; Immunoblotting; Immunohistochemistry; Inject | 2003 |
[URINARY EXCRETION OF PHENYLIC ACID AND INDOLE IN HYPERTENSIONS].
Topics: Body Fluids; Hypertension; Indoles; Phenol; Phenols; Urine | 1964 |
Role of calcitonin gene-related peptide in the phenol-induced neurogenic hypertension in rats.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Ganglia, Spinal; Hypertension; | 2004 |
Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat.
Topics: Animals; Aorta; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; | 2005 |
Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Body Weight; Calmodulin; Caveolin 1; C | 2007 |
A limited renal injury may cause a permanent form of neurogenic hypertension.
Topics: Animals; Blood Pressure; Hypertension; Hypothalamus; Kidney; Male; Norepinephrine; Phenol; Rats; Rat | 1998 |