Page last updated: 2024-10-19

phenol and Disease Models, Animal

phenol has been researched along with Disease Models, Animal in 34 studies

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

ExcerptRelevanceReference
" This study investigated the effects of a topically applied FO preparation (FOP) on phenol-induced ear edema and evaluated the percutaneous penetration of FOP in ear tissue."7.96Fish oil preparation inhibits leukocyte recruitment and bands that characterize inflamed tissue in a model of phenol-induced skin inflammation: percutaneous penetration of a topically applied preparation demonstrated by photoacoustic spectroscopy. ( Ambrósio da Rocha, B; Ames, FQ; Aparecida Bersani-Amado, C; Bracht, L; Kenji Nakamura Cuman, R; Luciano Baesso, M; Oliveira, LA; Parreira de Lima, E; Sato, F; Vizioli de Castro-Hoshino, L, 2020)
"We investigated the antiplatelet and antithrombotic activities of obovatol in rat carotid arterial thrombosis in vivo along with platelet aggregation in vitro and ex vivo."7.77Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation. ( Hong, JT; Kwon, BM; Lee, SH; Lim, Y; Park, ES; Yoo, HS; Yun, YP, 2011)
" The alteration in the activity of sympathetic or capsaicin-sensitive sensory nerves in the development of phenol-induced hypertension was observed separately in rats."7.73Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat. ( Cai, WJ; Deng, HW; Deng, PY; Li, D; Li, YJ; Luo, D; Luo, XG; Ye, F; Yu, J; Zhang, JW, 2005)
" staudtii stem bark, as well as protocatechuic acid and betulinic acid isolated from the bioactive ethyl acetate fraction were evaluated in different mice models of inflammation and pain; furthermore, antioxidant assays were carried out."4.02Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark. ( Ajibesin, K; Akpan, O; Archibong, B; De Leo, M; Eseyin, O; Essien, E; Etukudo, E; Flamini, G; Thomas, P; Udoh, A, 2021)
" This study investigated the effects of a topically applied FO preparation (FOP) on phenol-induced ear edema and evaluated the percutaneous penetration of FOP in ear tissue."3.96Fish oil preparation inhibits leukocyte recruitment and bands that characterize inflamed tissue in a model of phenol-induced skin inflammation: percutaneous penetration of a topically applied preparation demonstrated by photoacoustic spectroscopy. ( Ambrósio da Rocha, B; Ames, FQ; Aparecida Bersani-Amado, C; Bracht, L; Kenji Nakamura Cuman, R; Luciano Baesso, M; Oliveira, LA; Parreira de Lima, E; Sato, F; Vizioli de Castro-Hoshino, L, 2020)
"We investigated the antiplatelet and antithrombotic activities of obovatol in rat carotid arterial thrombosis in vivo along with platelet aggregation in vitro and ex vivo."3.77Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation. ( Hong, JT; Kwon, BM; Lee, SH; Lim, Y; Park, ES; Yoo, HS; Yun, YP, 2011)
"Single injection of small quantities of phenol into the kidney cortex causes hypertension which is mediated by renal afferent sympathetic pathway activation."3.75Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension. ( Bai, Y; Campese, VM; Jabbari, B; Vaziri, ND; Ye, S, 2009)
" The alteration in the activity of sympathetic or capsaicin-sensitive sensory nerves in the development of phenol-induced hypertension was observed separately in rats."3.73Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat. ( Cai, WJ; Deng, HW; Deng, PY; Li, D; Li, YJ; Luo, D; Luo, XG; Ye, F; Yu, J; Zhang, JW, 2005)
"Latex-induced transmural myocardial infarction or epicardial application of phenol interrupts sympathetic fibers innervating myocardium apical to the infarction or to the phenol-painted area."3.67Results of sympathetic denervation in the canine heart: supersensitivity that may be arrhythmogenic. ( Inoue, H; Zipes, DP, 1987)
"Rotenone treatment resulted in motor deficits and TH expression decreases in the nigrostriatal pathway, exhibiting PD-like behavioural motor and neurochemical phenotypes."1.91Brain polar phenol content, behavioural and neurochemical effects of Corinthian currant in a rotenone rat model of Parkinson's disease. ( Chiou, A; Dermon, CR; Fanarioti, E; Karathanos, VT; Karvelas, M; Tsarouchi, M; Vasilakopoulou, PB, 2023)
"Erianin has been reported to inhibit tumor activity by suppressing the expression of integrins."1.72Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction. ( Li, X; Liu, X; Ma, J; Shen, H; Xing, Y; Zeng, L, 2022)
"(AFC) has been widely used in clinical treatment of cervicitis."1.48An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy. ( Feng, Y; He, M; Lei, S; Ouyang, H; Tan, T; Wu, B; Xu, W; Zhang, X, 2018)
" The final study determined the dose-response relationship for paclitaxel."1.40Chemical renal denervation in the rat. ( Consigny, PM; Davalian, D; Donn, R; Hu, J; Rieser, M; Stolarik, D, 2014)
"Sodium morrhuate, P2G, and needlestick control were also investigated after 24 h (n = 4)."1.35Early inflammatory response of knee ligaments to prolotherapy in a rat model. ( Best, TM; Jensen, KT; Patterson, JJ; Rabago, DP; Vanderby, R, 2008)
"Phenol is a chemical agent which has been used for spasticity treatment for a long time."1.33A comparison of the effect of doxorubicin and phenol on the skeletal muscle. May doxorubicin be a new alternative treatment agent for spasticity? ( Alparslan, B; Culhaci, N; Cullu, E; Ozkan, I, 2005)
"Lidocaine and phenol were injected into the sciatic nerves of the rats in Groups 1 and 2, respectively."1.32Free radical-induced damage in experimental peripheral nerve injection injury. ( Apan, A; Kisa, U; Saray, A, 2003)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's2 (5.88)18.2507
2000's10 (29.41)29.6817
2010's14 (41.18)24.3611
2020's7 (20.59)2.80

Authors

AuthorsStudies
Abrams, RPM1
Yasgar, A1
Teramoto, T1
Lee, MH1
Dorjsuren, D1
Eastman, RT1
Malik, N1
Zakharov, AV1
Li, W1
Bachani, M1
Brimacombe, K1
Steiner, JP1
Hall, MD1
Balasubramanian, A1
Jadhav, A1
Padmanabhan, R1
Simeonov, A1
Nath, A1
Zhang, X2
Hu, L1
Xu, S1
Ye, C1
Chen, A1
Li, X1
Liu, X2
Xing, Y1
Zeng, L1
Shen, H1
Ma, J1
Fanarioti, E1
Tsarouchi, M1
Vasilakopoulou, PB1
Chiou, A1
Karvelas, M1
Karathanos, VT1
Dermon, CR1
Xiao, Y1
Li, M1
Wu, Y1
Zhong, K1
Gao, H1
Thomas, P1
Essien, E1
Udoh, A1
Archibong, B1
Akpan, O1
Etukudo, E1
De Leo, M1
Eseyin, O1
Flamini, G1
Ajibesin, K1
Ajayi, AM1
Ologe, MO1
Ben-Azu, B1
Okhale, SE1
Adzu, B1
Ademowo, OG1
Amino, M1
Yoshioka, K1
Tanaka, S1
Kawabe, N1
Kurosawa, H1
Uchida, K1
Oshikiri, S1
Hashida, T1
Kanda, S1
Inokuchi, S1
Ikari, Y1
He, M1
Lei, S1
Wu, B1
Tan, T1
Ouyang, H1
Xu, W1
Feng, Y1
Ames, FQ1
Bracht, L1
Sato, F1
Vizioli de Castro-Hoshino, L1
Ambrósio da Rocha, B1
Oliveira, LA1
Parreira de Lima, E1
Kenji Nakamura Cuman, R1
Luciano Baesso, M1
Aparecida Bersani-Amado, C1
Sukovatykh, BS1
Sukovatykh, MB1
Itinson, AI1
Kniazev, VV1
Colomeu, TC1
Figueiredo, D1
Cazarin, CB1
Schumacher, NS1
Maróstica, MR1
Meletti, LM1
Zollner, RL1
Consigny, PM1
Davalian, D1
Donn, R1
Hu, J1
Rieser, M1
Stolarik, D1
Bae, JY1
Kim, CY1
Kim, HJ1
Park, JH1
Ahn, MJ1
Ahmad, N1
Bhatnagar, S1
Ali, SS1
Dutta, R1
Khan, IA1
Aziz, A1
Bashir, S1
Raza, MA1
Fatima, G1
Ying, Z1
Chen, M1
Xie, X1
Wang, X1
Kherada, N1
Desikan, R1
Mihai, G1
Burns, P1
Sun, Q1
Rajagopalan, S1
Boakes, E1
Marbach, H1
Lynham, S1
Ward, M1
Edgeworth, JD1
Otter, JA1
Bai, Y1
Jabbari, B1
Ye, S3
Campese, VM3
Vaziri, ND1
Ekor, M1
Emerole, GO1
Farombi, EO1
Park, ES1
Lim, Y1
Lee, SH1
Kwon, BM1
Yoo, HS1
Hong, JT1
Yun, YP1
Hashikawa-Hobara, N1
Hashikawa, N1
Zamami, Y1
Takatori, S1
Kawasaki, H1
Zhong, H2
Yanamadala, V1
Szabó, C1
Mabley, JG1
Moeller, SM1
Shimanovich, R1
Pacher, P1
Virag, L1
Soriano, FG1
Van Duzer, JH1
Williams, W1
Salzman, AL1
Groves, JT1
Monteiro-Riviere, NA1
Inman, AO1
Jackson, H1
Dunn, B1
Dimond, S1
Saray, A1
Apan, A1
Kisa, U1
Cullu, E1
Ozkan, I1
Culhaci, N1
Alparslan, B1
Deng, PY1
Yu, J1
Ye, F1
Li, D1
Luo, D1
Cai, WJ1
Zhang, JW1
Luo, XG1
Deng, HW1
Li, YJ1
Yanamadala, S1
Bi, W1
Cai, J1
Liu, S1
Baudy-Floc'h, M1
Bi, L1
Jensen, KT1
Rabago, DP1
Best, TM1
Patterson, JJ1
Vanderby, R1
Zukowski, ML1
Mossie, RD1
Roth, SI1
Giese, S1
McKinney, P1
Carone, FA1
Kanwar, Y1
Inoue, H1
Zipes, DP1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Renal SympAthetic DenerVation on Chronic HypErtension[NCT01628198]38 participants (Actual)Interventional2011-10-31Terminated (stopped due to recommendation by the study's DSMB due to insufficient data to determine efficacy.)
Renal Sympathetic Denervation for the Management of Chronic Hypertension[NCT01628172]96 participants (Actual)Interventional2011-01-31Completed
Demonstration and Comparison of 5% Dextrose Prolotherapy and 15% Dextrose Prolotherapy Efficacy in Lateral Epicondylitis[NCT05066451]26 participants (Actual)Interventional2021-02-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Ambulatory Diastolic Blood Pressure

The change in diastolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

InterventionmmHg mean change (Mean)
Renal Denervation Group-5.5

Mean Change in Ambulatory Systolic Blood Pressure

The change in systolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline. (NCT01628198)
Timeframe: baseline and 6 months

InterventionmmHg (Mean)
Renal Denervation Group-10.2

Anti-hypertensive Medications

The total number of anti-hypertensive medications at baseline, 6 months, and 12 months (NCT01628198)
Timeframe: Baseline, 6 months, 12 months

Interventionmedications (Mean)
Baseline6 months12 months
Renal Denervation Group5.374.794.64

Blood Urea Nitrogen

A blood urea nitrogen (BUN) test measures the amount of nitrogen in blood that comes from the waste product urea. Urea is made when protein is broken down in the body. Urea is made in the liver and passed out in the urine. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Interventionmg/dL (Mean)
Baseline6 months12 months
Renal Denervation Group20.8222.1523.11

Creatinine

Creatinine measures the level of the waste product in the body. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. High levels of creatinine indicates kidney impairment. (NCT01628198)
Timeframe: baseline, 6 months, 12 months

Interventionmg/dl (Mean)
Baseline6 months12 months
Renal Denervation Group1.61.682.03

Office Diastolic BP

Different time points office diastolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Interventionmm Hg (Mean)
Baseline6 months12 months
Renal Denervation Group87.0686.9387.75

Office Systolic BP

Different time points office systolic blood pressure measurements (NCT01628198)
Timeframe: baseline, 6 month, 12 months

Interventionmm Hg (Mean)
Baseline6 months12 months
Renal Denervation Group156.86151.19158.45

Renal Aortic Ratio

Renal artery blood flow as measured by Renal Aortic Ratio (RAR) = Peak systolic Velocity renal artery / Peak Systolic Velocity Aorta. A >60% stenosis is reported when there is a >3.5:1 Renal to Aortic Ratio. (NCT01628198)
Timeframe: Baseline and 12 months

Interventionratio (Mean)
Baseline Right RARBaseline Left RAR12 months Right RAR12 months Left RAR
Renal Denervation Group1.381.521.411.52

Renal Artery Dimensions

Dimensions of renal artery, right and left (NCT01628198)
Timeframe: baseline and 12 months

Interventionmm (Mean)
Baseline R KidneyBaseline L Kidney12 months R Kidney12 months L Kidney
Renal Denervation Group11.4311.6811.2611.39

Resistive Index

Renal artery blood flow as measured by Resistive Index. RI = (peak systolic velocity - end diastolic velocity ) / peak systolic velocity. the normal value is ~ 0.60, with 0.70 being around the upper limits of normal (NCT01628198)
Timeframe: Baseline and 12 months

Interventionindex (Mean)
Baseline Right RIBaseline Left RI12 months Right RI12 months Left RI
Renal Denervation Group0.670.720.720.72

Other Studies

34 other studies available for phenol and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr

2020
Erianin: A Direct NLRP3 Inhibitor With Remarkable Anti-Inflammatory Activity.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Bibenzyls; Diabetes Mellitus, Type 2; Disease M

2021
Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction.
    Investigative ophthalmology & visual science, 2022, 01-03, Volume: 63, Issue:1

    Topics: Animals; Bibenzyls; Cell Movement; Cells, Cultured; Collagen; Disease Models, Animal; Gene Expressio

2022
Brain polar phenol content, behavioural and neurochemical effects of Corinthian currant in a rotenone rat model of Parkinson's disease.
    Nutritional neuroscience, 2023, Volume: 26, Issue:7

    Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dopaminergic Neurons; Neu

2023
Structural Characteristics and Hypolipidemic Activity of Theabrownins from Dark Tea Fermented by Single Species
    Biomolecules, 2020, 01-30, Volume: 10, Issue:2

    Topics: Animals; Aspergillus; Catechin; Disease Models, Animal; Fermentation; Gas Chromatography-Mass Spectr

2020
Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark.
    Journal of ethnopharmacology, 2021, Apr-06, Volume: 269

    Topics: Africa, Western; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Betu

2021
Ocimum gratissimum Linn. Leaf extract inhibits free radical generation and suppressed inflammation in carrageenan-induced inflammation models in rats.
    Journal of basic and clinical physiology and pharmacology, 2017, Nov-27, Volume: 28, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response

2017
Normal
    Pacing and clinical electrophysiology : PACE, 2017, Volume: 40, Issue:10

    Topics: 3-Iodobenzylguanidine; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Heart; Male; Myocardiu

2017
An integrative investigation of the therapeutic mechanism of Ainsliaea fragrans Champ. in cervicitis using liquid chromatography tandem mass spectrometry based on a rat plasma metabolomics strategy.
    Journal of pharmaceutical and biomedical analysis, 2018, Jul-15, Volume: 156

    Topics: Adhesives; Animals; Asteraceae; Biomarkers; Chromatography, High Pressure Liquid; Disease Models, An

2018
Fish oil preparation inhibits leukocyte recruitment and bands that characterize inflamed tissue in a model of phenol-induced skin inflammation: percutaneous penetration of a topically applied preparation demonstrated by photoacoustic spectroscopy.
    Natural product research, 2020, Volume: 34, Issue:16

    Topics: Administration, Topical; Animals; Disease Models, Animal; Ear; Edema; Fish Oils; Inflammation; Leuko

2020
[Chemichal desympathization in the treatment of throphic ulcer in patients with varicose veins of the lower limbs].
    Khirurgiia, 2013, Issue:9

    Topics: Adult; Aged; Animals; Disease Models, Animal; Ethanol; Female; Humans; Lower Extremity; Male; Middle

2013
Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice).
    International immunopharmacology, 2014, Volume: 18, Issue:1

    Topics: Animals; Antioxidants; Cell Movement; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Hyp

2014
Chemical renal denervation in the rat.
    Cardiovascular and interventional radiology, 2014, Volume: 37, Issue:1

    Topics: Animals; Chromatography, Liquid; Denervation; Disease Models, Animal; Dose-Response Relationship, Dr

2014
Differences in the chemical profiles and biological activities of Paeonia lactiflora and Paeonia obovata.
    Journal of medicinal food, 2015, Volume: 18, Issue:2

    Topics: Animals; Biphenyl Compounds; Butylated Hydroxytoluene; Cell Line; Chromatography, High Pressure Liqu

2015
Phytofabrication of bioinduced silver nanoparticles for biomedical applications.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Biomedical Technology; Disease

2015
Dermatological evaluation of counter irritant effect of methanol leaf extract of Rumexvesicarius Linn. in rabbits.
    JPMA. The Journal of the Pakistan Medical Association, 2016, Volume: 66, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Dermatitis, Irritant; Disease Models, Animal; Disinfectants; Dose

2016
Lipoicmethylenedioxyphenol Reduces Experimental Atherosclerosis through Activation of Nrf2 Signaling.
    PloS one, 2016, Volume: 11, Issue:2

    Topics: Animals; Atherosclerosis; Blood Vessels; Chemotaxis, Leukocyte; Disease Models, Animal; Disease Prog

2016
Comparative analysis of phenol-soluble modulin production and Galleria mellonella killing by community-associated and healthcare-associated meticillin-resistant Staphylococcusaureus strains.
    Journal of medical microbiology, 2016, Volume: 65, Issue:12

    Topics: Animals; Bacterial Toxins; Community-Acquired Infections; Cross Infection; Disease Models, Animal; H

2016
Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension.
    American journal of nephrology, 2009, Volume: 29, Issue:5

    Topics: Afferent Pathways; Animals; Blood Pressure; Brain; Disease Models, Animal; Hypertension; Male; NADPH

2009
Phenolic extract of soybean (Glycine max) attenuates cisplatin-induced nephrotoxicity in rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:4

    Topics: 5'-Nucleotidase; Acetylglucosaminidase; Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxi

2010
Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation.
    Journal of atherosclerosis and thrombosis, 2011, Volume: 18, Issue:8

    Topics: Administration, Oral; Animals; Arteries; Biphenyl Compounds; Calcium; Disease Models, Animal; Humans

2011
The mechanism of calcitonin gene-related peptide-containing nerve innervation.
    Journal of pharmacological sciences, 2012, Volume: 119, Issue:2

    Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Fructose; Hypercholesterolemia; Hy

2012
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Renal injury caused by intrarenal injection of phenol increases afferent and efferent renal sympathetic nerve activity.
    American journal of hypertension, 2002, Volume: 15, Issue:8

    Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Clonidine; Denervation; Disease Models, An

2002
Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst.
    Molecular medicine (Cambridge, Mass.), 2002, Volume: 8, Issue:10

    Topics: Animals; Catalysis; Cytoprotection; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Re

2002
Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin.
    Toxicology and industrial health, 2001, Volume: 17, Issue:4

    Topics: Absorption; Animals; Burns, Chemical; Disease Models, Animal; Female; Phenol; Sclerosing Solutions;

2001
Free radical-induced damage in experimental peripheral nerve injection injury.
    Journal of reconstructive microsurgery, 2003, Volume: 19, Issue:6

    Topics: Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Immunohistochemistry; Injury

2003
A comparison of the effect of doxorubicin and phenol on the skeletal muscle. May doxorubicin be a new alternative treatment agent for spasticity?
    Journal of pediatric orthopedics. Part B, 2005, Volume: 14, Issue:2

    Topics: Animals; Biopsy, Needle; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Drug

2005
Interactions of sympathetic nerves with capsaicin-sensitive sensory nerves: neurogenic mechanisms for phenol-induced hypertension in the rat.
    Journal of hypertension, 2005, Volume: 23, Issue:3

    Topics: Animals; Aorta; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal;

2005
Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension.
    Hypertension (Dallas, Tex. : 1979), 2006, Volume: 48, Issue:2

    Topics: Animals; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Hypertension, Renal; Hypothalamus,

2006
Design, synthesis and cardioprotective effect of a new class of dual-acting agents: phenolic tetrahydro-beta-carboline RGD peptidomimetic conjugates.
    Bioorganic & medicinal chemistry, 2007, Nov-15, Volume: 15, Issue:22

    Topics: Animals; Carbolines; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug D

2007
Early inflammatory response of knee ligaments to prolotherapy in a rat model.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2008, Volume: 26, Issue:6

    Topics: Animals; Arthritis; Biomarkers; Disease Models, Animal; Gene Expression; Glucose; Glycerol; Leukosia

2008
Pilot study analysis of the histologic and bacteriologic effects of occlusive dressings in chemosurgical peel using a minipig model.
    Aesthetic plastic surgery, 1993,Winter, Volume: 17, Issue:1

    Topics: Animals; Chemexfoliation; Combined Modality Therapy; Dermabrasion; Disease Models, Animal; Drug Eval

1993
Tubular cell and matrix changes in renal cystic disease.
    Contributions to nephrology, 1993, Volume: 101

    Topics: Animals; Basement Membrane; Biological Transport; Cells, Cultured; Disease Models, Animal; Epitheliu

1993
Results of sympathetic denervation in the canine heart: supersensitivity that may be arrhythmogenic.
    Circulation, 1987, Volume: 75, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Female; Heart; Heart Ventricles; Male;

1987