phenobarbital has been researched along with Uremia in 14 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenytoin assays were evaluated using an additional set of samples from patients with abnormal renal function." | 1.31 | Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer. ( Annesley, TM; Frank, EL; Juenke, J; Roberts, WL; Schwarz, EL, 2002) |
| "1." | 1.25 | The plasma half-life of antipyrine in chromic uraemic and normal subjects. ( Harber, MJ; Maddocks, JL; Wake, CJ, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Frank, EL | 1 |
| Schwarz, EL | 1 |
| Juenke, J | 1 |
| Annesley, TM | 1 |
| Roberts, WL | 1 |
| Reiter, K | 1 |
| Bordoni, V | 1 |
| Dall'Olio, G | 1 |
| Ricatti, MG | 1 |
| Soli, M | 1 |
| Ruperti, S | 1 |
| Soffiati, G | 1 |
| Galloni, E | 1 |
| D'Intini, V | 1 |
| Bellomo, R | 1 |
| Ronco, C | 1 |
| Wilson, TC | 1 |
| Levy, G | 3 |
| Porter, RJ | 1 |
| Layzer, RB | 1 |
| Reidenberg, MM | 1 |
| Bosl, R | 1 |
| Shideman, JR | 1 |
| Meyer, RM | 1 |
| Buselmeier, TJ | 1 |
| von Hartitzsch, B | 1 |
| Kjellstrand, CM | 1 |
| Livingston, S | 1 |
| Berman, W | 1 |
| Pauli, LL | 1 |
| Maddocks, JL | 1 |
| Wake, CJ | 1 |
| Harber, MJ | 1 |
| Danhof, M | 1 |
| Pugh, CB | 1 |
| Hisaoka, M | 1 |
| Alestig, K | 1 |
| Kurata, D | 1 |
| Wilkinson, GR | 1 |
| Hagstam, KE | 1 |
| Larsson, LE | 1 |
| Thysell, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cytokine Adsorption in Severe, Refractory Septic Shock[NCT04910893] | 48 participants (Actual) | Interventional | 2014-11-27 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenobarbital and Uremia
| Article | Year |
|---|---|
Drug metabolism in uremia.
Topics: Acetohexamide; Animals; Antipyrine; Humans; Hydrolysis; Lipid Metabolism; Microsomes, Liver; Oxidati | 1975 |
13 other studies available for phenobarbital and Uremia
| Article | Year |
|---|---|
Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Cross Reactions; Drug Monitori | 2002 |
In vitro removal of therapeutic drugs with a novel adsorbent system.
Topics: Adsorption; Anti-Bacterial Agents; Biocompatible Materials; Carbamazepine; Digoxin; Glycopeptides; H | 2002 |
Kinetics of drug action in disease states. XLIII: Potentiating effect of L-tryptophan on the hypnotic action of phenobarbital and ethanol in rats.
Topics: Animals; Blood Proteins; Brain; Drug Synergism; Ethanol; Female; Hypnotics and Sedatives; Infusions, | 1994 |
Plasma albumin concentration and diphenylhydantoin binding in man.
Topics: Adolescent; Adult; Aged; Aspirin; Blood Protein Electrophoresis; Blood-Brain Barrier; Chromatography | 1975 |
Effects and complications of high efficiency dialysis.
Topics: Barbiturates; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Edema; Headache; Humans; Hypote | 1975 |
Anticonvulsant drug blood levels.
Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi | 1975 |
The plasma half-life of antipyrine in chromic uraemic and normal subjects.
Topics: Administration, Oral; Adolescent; Adult; Antipyrine; Enzyme Induction; Female; Half-Life; Humans; In | 1975 |
Kinetics of drug action in disease states. V. Acute effect of urea infusion on phenobarbital concentrations in rats at onset of loss of righting reflex.
Topics: Animals; Barbiturates; Blood Urea Nitrogen; Brain; Female; Kinetics; Phenobarbital; Postural Balance | 1985 |
Phenytoin and phenobarbital protein binding alterations in a uremic burn patient.
Topics: Burns; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Protein Binding; Seizures; Serum Albumin | 1987 |
Kinetics of drug action in disease states. XIII. Effect of dialyzable component(s) of uremic blood on phenobarbital concentrations in rats at onset of loss of righting reflex.
Topics: Age Factors; Animals; Dialysis; Drug Synergism; Female; Phenobarbital; Postural Balance; Rats; Rats, | 1985 |
Studies on the intestinal excretion of doxycycline.
Topics: Adult; Aged; Bile; Bronchopneumonia; Creatinine; Crohn Disease; Doxycycline; Female; Humans; Infusio | 1974 |
Erythrocyte uptake and plasma binding of diphenylhydantoin.
Topics: Carbon Radioisotopes; Dialysis; Erythrocytes; Ethosuximide; Female; Hematocrit; Humans; Hydroxylatio | 1974 |
Experimental studies on charcoal haemoperfusion in phenobarbital intoxication and uraemia, including histopathologic findings.
Topics: Animals; Brain; Charcoal; Extracorporeal Circulation; Kidney; Liver; Lung; Phenobarbital; Pulmonary | 1966 |