phenobarbital has been researched along with Tuberous Sclerosis in 9 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Tuberous Sclerosis: Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with phenobarbital or phenytoin caused a reduction in seizure frequency, but did not improve EEG background or prevent death." | 1.34 | The natural history and treatment of epilepsy in a murine model of tuberous sclerosis. ( Erbayat-Altay, E; Gutmann, DH; Wong, M; Xu, L; Zeng, LH, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kharoshankaya, L | 1 |
| Murray, DM | 1 |
| Bogue, C | 1 |
| Ahearne, C | 1 |
| Murphy, BP | 1 |
| Boylan, GB | 1 |
| NELSON, CT | 1 |
| Erbayat-Altay, E | 1 |
| Zeng, LH | 1 |
| Xu, L | 1 |
| Gutmann, DH | 1 |
| Wong, M | 1 |
| Dyer, AM | 1 |
| Hill, R | 1 |
| Rowan, RM | 1 |
| Taylor, WO | 1 |
| Pejrone, F | 1 |
| Piccinini, GP | 1 |
| De Maria, F | 1 |
| Buccheri, G | 1 |
| Teotia, M | 1 |
| Teotia, SP | 1 |
| Singh, RK | 1 |
| McNaughton, FL | 1 |
| Rasmussen, T | 1 |
| Martin, AJ | 1 |
| Cree, JE | 1 |
| Nash, FW | 1 |
9 other studies available for phenobarbital and Tuberous Sclerosis
| Article | Year |
|---|---|
Early EEG findings in tuberous sclerosis complex presenting with apneic seizures soon after birth.
Topics: Anticonvulsants; Apnea; Electroencephalography; Humans; Infant, Newborn; Magnetic Resonance Imaging; | 2016 |
CONVULSIONS.
Topics: Black People; Diagnosis, Differential; Epilepsy; Humans; Intellectual Disability; Phenobarbital; Phe | 1964 |
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 2007 |
Case of tuberous sclerosis and haemorrhagic retinopathy (with fundus photographs).
Topics: Adult; Amphetamine; Anemia, Macrocytic; Female; Folic Acid; Fundus Oculi; Humans; Phenobarbital; Phe | 1967 |
[A case of Pringle-Bourneville disease].
Topics: Adult; Carbamazepine; Epilepsy; Epilepsy, Absence; Female; Humans; Phenobarbital; Tuberous Sclerosis | 1981 |
Rickets in tuberous sclerosis from anticonvulsant drugs.
Topics: Adolescent; Anticonvulsants; Child; Humans; Male; Phenobarbital; Phenytoin; Rickets; Tuberous Sclero | 1977 |
Criteria for selection of patients for neurosurgical treatment.
Topics: Adolescent; Age Factors; Child; Electroencephalography; Encephalitis; Epilepsies, Partial; Epilepsy; | 1975 |
The tuberous sclerosis complex.
Topics: Adult; Epilepsy; Female; Fluorescence; Hamartoma; Humans; Intellectual Disability; Intracranial Pres | 1968 |
Tuberous sclerosis with polycystic kidneys.
Topics: Antihypertensive Agents; Electroencephalography; Female; Humans; Infant; Phenobarbital; Pigmentation | 1969 |