phenobarbital has been researched along with Thiamine Deficiency in 8 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Thiamine Deficiency: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
| Excerpt | Relevance | Reference |
|---|---|---|
| " This may due in part to vascular damage, neuroinflammation and neuronal degeneration in the diencephalon, which is seen in animal models of pyrithiamine-enhanced thiamine deficiency." | 3.88 | Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency. ( Bowyer, JF; Hanig, JP; Sarkar, S; Tranter, KM, 2018) |
| "Phenobarbital treatment induced the activities of all drug enzymes and inhibited the lipid peroxidation in either sex during the period of thiamine deficiency." | 1.26 | Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats. ( Galdhar, NR; Pawar, SS, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bowyer, JF | 1 |
| Tranter, KM | 1 |
| Sarkar, S | 1 |
| Hanig, JP | 1 |
| Wade, AE | 1 |
| Evans, JS | 1 |
| Holmes, D | 1 |
| Baker, MT | 1 |
| Onodera, K | 1 |
| Sakurada, S | 1 |
| Ando, R | 1 |
| Takahashi, N | 1 |
| Tadano, T | 1 |
| Kisara, K | 1 |
| Ogura, Y | 1 |
| Galdhar, NR | 1 |
| Pawar, SS | 1 |
| Campbell, TC | 1 |
| Hayes, JR | 1 |
| Kaplan, ML | 1 |
| Murphy, SD | 1 |
| Gilles, FH | 1 |
| VanderWende, C | 1 |
| Johnson, JC | 1 |
| Spoerlein, MT | 1 |
| Luc, NC | 1 |
| Hofmann, H | 1 |
1 review available for phenobarbital and Thiamine Deficiency
| Article | Year |
|---|---|
Role of nutrition in the drug-metabolizing enzyme system.
Topics: Ascorbic Acid Deficiency; Calcium; Carbohydrates; Carcinogens; Catalysis; Chemical and Drug Induced | 1974 |
7 other studies available for phenobarbital and Thiamine Deficiency
| Article | Year |
|---|---|
Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency.
Topics: Animals; Blood Vessels; Calcium-Binding Proteins; CD11b Antigen; Diet; Dizocilpine Maleate; Female; | 2018 |
Influence of dietary thiamin on phenobarbital induction of rat hepatic enzymes responsible for metabolizing drugs and carcinogens.
Topics: Aniline Compounds; Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diet; Diethylnitrosamine; D | 1983 |
[The effect of thiamine deficiency on the actions of drugs affecting the central nervous system in rats (author's transl)].
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Brain; Drug Synergism; Hexobarbital; Hypnotics and | 1980 |
Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats.
Topics: Acetanilides; Aminopyrine; Aniline Compounds; Animals; Biotransformation; Body Weight; Cytochromes; | 1976 |
Modification of acrylamide neuropathy in rats by selected factors.
Topics: Acrylamides; Adrenal Glands; Adrenalectomy; Age Factors; Animals; DDT; Enzyme Induction; Hexobarbita | 1973 |
The effect of thiamine deficiency on the actions of drugs effecting the central nervous system.
Topics: Analgesia; Animals; Appetite; Body Weight; Brain; Chlordiazepoxide; Dextroamphetamine; Lethal Dose 5 | 1973 |
[Experimental studies on the effect of phenylethylbarbituric acid in the rat suffering from thiamine deficiency].
Topics: Animals; Child; Drug Synergism; Humans; Phenobarbital; Rats; Thiamine Deficiency | 1970 |