phenobarbital has been researched along with Suffocation in 11 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study uses a population modeling approach to evaluate and quantify the impact of severity of asphyxia and hypoxic-ischemic encephalopathy (HIE) on the pharmacokinetics of phenobarbital in asphyxiated newborns treated with therapeutic hypothermia." | 8.12 | Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain inter-individual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia. ( Hronová, K; Krekels, EH; Michaličková, D; Pokorná, P; Slanař, O; Tibboel, D; Völler, S, 2022) |
| "Phenobarbital is the first-line treatment of seizures in asphyxiated neonates; however, due to the high pharmacokinetic variability in this population, there is no consensus on the optimal dosage regimen." | 7.88 | Estimation of initial phenobarbital dosing in term neonates with moderate-to-severe hypoxic ischaemic encephalopathy following perinatal asphyxia. ( Hartinger, J; Pokorná, P; Šíma, M; Slanař, O, 2018) |
| "This study characterizes the circulatory changes associated with asphyxia in the newborn monkey and examines the effect of phenobarbital on asphyxia." | 7.65 | The effect of phenobarbital on asphyxia in the newborn monkey. ( Behrman, RE; Fisher, DE; Paton, JB, 1975) |
| "The current study uses a population modeling approach to evaluate and quantify the impact of severity of asphyxia and hypoxic-ischemic encephalopathy (HIE) on the pharmacokinetics of phenobarbital in asphyxiated newborns treated with therapeutic hypothermia." | 4.12 | Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain inter-individual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia. ( Hronová, K; Krekels, EH; Michaličková, D; Pokorná, P; Slanař, O; Tibboel, D; Völler, S, 2022) |
| "Phenobarbital is the first-line treatment of seizures in asphyxiated neonates; however, due to the high pharmacokinetic variability in this population, there is no consensus on the optimal dosage regimen." | 3.88 | Estimation of initial phenobarbital dosing in term neonates with moderate-to-severe hypoxic ischaemic encephalopathy following perinatal asphyxia. ( Hartinger, J; Pokorná, P; Šíma, M; Slanař, O, 2018) |
| " The present study investigated the postmortem brain mRNA and immunohistochemical expressions of matrix metalloproteases (MMPs), claudin5 (CLDN5), and aquaporins (AQPs) in forensic autopsy cases of carbon monoxide (n = 14), METH (n = 21), and phenobarbital (n = 17) intoxication, compared with mechanical asphyxia (n = 15), brain injury (n = 11), non-brain injury (n = 21), and sharp instrument injury (n = 15) cases." | 3.80 | Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication. ( Guan, DW; Ishikawa, T; Maeda, H; Michiue, T; Wang, Q; Zhu, BL, 2014) |
| "The antihypoxic effect of the newly-synthesized hydroxylamine barbiturate HB-7, compared with the effects of phenobarbital and pentobarbital, was studied in experiments on albino mice, using the following models of hypoxia: hypobaric, anoxic, asphyctic and haemic." | 3.67 | Antihypoxic effect of the hydroxylamine derivative HB-7. ( Georgiev, V; Getova, D, 1989) |
| "This study characterizes the circulatory changes associated with asphyxia in the newborn monkey and examines the effect of phenobarbital on asphyxia." | 3.65 | The effect of phenobarbital on asphyxia in the newborn monkey. ( Behrman, RE; Fisher, DE; Paton, JB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Welzel, B | 1 |
| Johne, M | 1 |
| Löscher, W | 1 |
| Pokorná, P | 2 |
| Michaličková, D | 1 |
| Völler, S | 1 |
| Hronová, K | 1 |
| Tibboel, D | 1 |
| Slanař, O | 2 |
| Krekels, EH | 1 |
| Šíma, M | 1 |
| Hartinger, J | 1 |
| Wang, Q | 1 |
| Ishikawa, T | 1 |
| Michiue, T | 1 |
| Zhu, BL | 1 |
| Guan, DW | 1 |
| Maeda, H | 1 |
| Bjerre, I | 1 |
| Hellström-Westas, L | 1 |
| Rosén, I | 1 |
| Svenningsen, N | 1 |
| Gal, P | 1 |
| Boer, HR | 1 |
| Toback, J | 1 |
| Erkan, NV | 1 |
| Cocito, L | 1 |
| Primavera, A | 1 |
| Fisher, DE | 1 |
| Paton, JB | 1 |
| Behrman, RE | 1 |
| Getova, D | 1 |
| Georgiev, V | 1 |
| Carmichael, SW | 1 |
| Nilsson, L | 1 |
11 other studies available for phenobarbital and Suffocation
| Article | Year |
|---|---|
Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia.
Topics: Animals; Anticonvulsants; Asphyxia; Asphyxia Neonatorum; Bumetanide; Epilepsy; Humans; Infant, Newbo | 2023 |
Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain inter-individual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia.
Topics: Adult; Asphyxia; Asphyxia Neonatorum; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, | 2022 |
Estimation of initial phenobarbital dosing in term neonates with moderate-to-severe hypoxic ischaemic encephalopathy following perinatal asphyxia.
Topics: Asphyxia; Female; Gestational Age; Half-Life; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male | 2018 |
Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aquaporin 1; Aquaporin 4; Asphyxia; Brain; Brain Injurie | 2014 |
Monitoring of cerebral function after severe asphyxia in infancy.
Topics: Asphyxia; Asphyxia Neonatorum; Brain; Brain Damage, Chronic; Electroencephalography; Electrophysiolo | 1983 |
Phenobarbital dosing in neonates and asphyxia.
Topics: Asphyxia; Humans; Phenobarbital | 1982 |
Vigabatrin aggravates absences and absence status.
Topics: Adult; Anticonvulsants; Asphyxia; Brain Damage, Chronic; Carbamazepine; Drug Therapy, Combination; E | 1998 |
The effect of phenobarbital on asphyxia in the newborn monkey.
Topics: Adrenal Glands; Animals; Animals, Newborn; Asphyxia; Brain; Cardiac Catheterization; Cardiac Output; | 1975 |
Antihypoxic effect of the hydroxylamine derivative HB-7.
Topics: Animals; Anticonvulsants; Asphyxia; Atmospheric Pressure; Hydroxylamines; Hypoxia; Mice; Pentobarbit | 1989 |
Fluorescence microscopy of the adrenal medulla of the newborn puppy after asphyxia and hypothermia.
Topics: Adrenal Medulla; Anesthesia, General; Anesthesia, Local; Animals; Animals, Newborn; Asphyxia; Borohy | 1974 |
The influence of barbiturate anaesthesia upon the energy state and upon acid-base parameters of the brain in arterial hypotension and in asphyxia.
Topics: Acid-Base Equilibrium; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anest | 1971 |