phenobarbital has been researched along with Stroke in 9 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures." | 7.80 | Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure. ( Albertini, G; De Sarro, G; Gallelli, L; Gratteri, S; Iemolo, F; Manes, MT; Mercuri, NB; Quirino, G; Sanzaro, E; Scaglione, F; Siniscalchi, A, 2014) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 7.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 7.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| " In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures." | 3.80 | Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure. ( Albertini, G; De Sarro, G; Gallelli, L; Gratteri, S; Iemolo, F; Manes, MT; Mercuri, NB; Quirino, G; Sanzaro, E; Scaglione, F; Siniscalchi, A, 2014) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 3.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| " This is the first report of successful utilization of the prepuce as a skin graft to reconstruct a full thickness skin necrosis due to a phenobarbital extravasation to the forefoot of a newborn." | 3.73 | The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn. ( Donatucci, CF; Erdmann, D; Kukies, S; Levin, LS; Schäfer, T; Stokes, TH, 2005) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 3.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy." | 2.82 | Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022) |
| "Perinatal arterial stroke is the most frequent form of cerebral infarction in children." | 1.46 | Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. ( Auvin, S; Baud, O; Bonnin, P; Charriaut-Marlangue, C; Dupuis, N; Enderlin, J; Leger, PL; Morin, L; Perrotte, G, 2017) |
| "Stroke is the major cause of acquired epilepsy in the adult population." | 1.37 | An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. ( Delorenzo, RJ; Deshpande, LS; Ziobro, JM, 2011) |
| "Stroke is the major cause of acquired epilepsy." | 1.31 | Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy". ( DeLorenzo, RJ; Sombati, S; Sun, DA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sortino, V | 1 |
| Praticò, A | 1 |
| Marino, S | 1 |
| Criscione, R | 1 |
| Ruggieri, M | 1 |
| Pisani, F | 1 |
| Falsaperla, R | 1 |
| Barsch Bergqvist, A | 1 |
| Simatou, E | 1 |
| Skiöld, B | 1 |
| Mitha, A | 1 |
| Bolk, J | 1 |
| Soul, JS | 1 |
| Bergin, AM | 1 |
| Stopp, C | 1 |
| Hayes, B | 1 |
| Singh, A | 1 |
| Fortuno, CR | 1 |
| O'Reilly, D | 1 |
| Krishnamoorthy, K | 1 |
| Jensen, FE | 1 |
| Rofeberg, V | 1 |
| Dong, M | 1 |
| Vinks, AA | 1 |
| Wypij, D | 1 |
| Staley, KJ | 1 |
| Siniscalchi, A | 1 |
| Scaglione, F | 1 |
| Sanzaro, E | 1 |
| Iemolo, F | 1 |
| Albertini, G | 1 |
| Quirino, G | 1 |
| Manes, MT | 1 |
| Gratteri, S | 1 |
| Mercuri, NB | 1 |
| De Sarro, G | 1 |
| Gallelli, L | 1 |
| Morin, L | 1 |
| Enderlin, J | 1 |
| Leger, PL | 1 |
| Perrotte, G | 1 |
| Bonnin, P | 1 |
| Dupuis, N | 1 |
| Baud, O | 1 |
| Charriaut-Marlangue, C | 1 |
| Auvin, S | 1 |
| Ziobro, JM | 1 |
| Deshpande, LS | 1 |
| Delorenzo, RJ | 2 |
| Markowitz, GJ | 1 |
| Kadam, SD | 1 |
| Smith, DR | 1 |
| Johnston, MV | 1 |
| Comi, AM | 1 |
| Schäfer, T | 1 |
| Kukies, S | 1 |
| Stokes, TH | 1 |
| Levin, LS | 1 |
| Donatucci, CF | 1 |
| Erdmann, D | 1 |
| Sun, DA | 1 |
| Sombati, S | 1 |
1 review available for phenobarbital and Stroke
| Article | Year |
|---|---|
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review.
Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac | 2022 |
1 trial available for phenobarbital and Stroke
| Article | Year |
|---|---|
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.
Topics: Anticonvulsants; Bumetanide; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; | 2021 |
7 other studies available for phenobarbital and Stroke
| Article | Year |
|---|---|
Term-born infants with a perinatal stroke frequently had seizures and were prescribed anti-seizure medication at discharge.
Topics: Anticonvulsants; Cross-Sectional Studies; Humans; Infant, Newborn; Patient Discharge; Phenobarbital; | 2023 |
Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Levetiracetam; Long QT Syndrome; Male; Mid | 2014 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; | 2017 |
An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Survival; Epilepsy; Ethosuximide; Glutamic Acid; H | 2011 |
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Body Weight; Cognition Disorders; | 2011 |
The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn.
Topics: Anticonvulsants; Circumcision, Male; Foot Injuries; Humans; Infant, Newborn; Infusions, Intravenous; | 2005 |
Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy".
Topics: Action Potentials; Animals; Anticonvulsants; Cell Size; Cell Survival; Cells, Cultured; Dose-Respons | 2001 |