phenobarbital has been researched along with Stevens-Johnson Syndrome in 44 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have demonstrated a strong association between carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and HLA-B*1502 in Han Chinese." | 3.80 | Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China. ( He, XL; Hu, JS; Liu, ZS; Mao, B; Sun, D; Wu, GF; Wu, SH; Xiang, HH; Yu, CH, 2014) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| " Phenytoin, on the other hand, causes gingival hyperplasia in many patients, irreversible hypertrichosis in some patients and lethal reactions, such as Stevens-Johnson syndrome, in a few patients." | 3.66 | Phenobarbital vs. phenytoin for grand mal epilepsy. ( Kramer, II; Livingston, S; Pauli, LL; Pruce, I, 1980) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications." | 1.35 | Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases. ( Banelli, E; Bulzonetti, N; Caiazzo, R; Dionisi, F; Lichtner, M; Musio, D; Parisi, E; Parisi, G; Raffetto, N; Vullo, V, 2009) |
| "Several bullae and erosions were noted on grafted areas 3 weeks later." | 1.28 | Transient intraepidermal bullous reaction after skin graft for toxic epidermal necrolysis. Ultrastructural and immunohistochemical features similar to those of inherited epidermolysis bullosa simplex. ( André, C; Bourgault, I; Chosidow, O; Prost, C; Revuz, J; Villada, G; Wechsler, J, 1991) |
| "The authors report 18 children with toxic epidermal necrolysis (T." | 1.27 | [Toxic epidermal necrolysis in children (Lyell's syndrome). Apropos of 18 cases]. ( Cloup, M; De Frost, Y; Hubert, P; Marsol, P; Richard, P; Roujeau, JC; Teillac, D, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (45.45) | 18.7374 |
| 1990's | 9 (20.45) | 18.2507 |
| 2000's | 10 (22.73) | 29.6817 |
| 2010's | 5 (11.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hosohata, K | 1 |
| Inada, A | 1 |
| Oyama, S | 1 |
| Niinomi, I | 1 |
| Wakabayashi, T | 1 |
| Iwanaga, K | 1 |
| Sun, D | 1 |
| Yu, CH | 1 |
| Liu, ZS | 1 |
| He, XL | 1 |
| Hu, JS | 1 |
| Wu, GF | 1 |
| Mao, B | 1 |
| Wu, SH | 1 |
| Xiang, HH | 1 |
| Kaputu-Kalala-Malu, C | 1 |
| Ntumba-Tshitenge, O | 1 |
| Misson, JP | 1 |
| Ordoñez, L | 1 |
| Salgueiro, E | 1 |
| Jimeno, FJ | 1 |
| Manso, G | 1 |
| Cornelis, I | 1 |
| Vandenabeele, S | 1 |
| Dunon, D | 1 |
| Van Ham, L | 1 |
| Soto, I | 1 |
| Núñez Calvo, ML | 1 |
| Pintos, A | 1 |
| Gómez, R | 1 |
| Alvarez, J | 1 |
| Riu, M | 1 |
| Musio, D | 1 |
| Parisi, E | 1 |
| Dionisi, F | 1 |
| Parisi, G | 1 |
| Caiazzo, R | 1 |
| Bulzonetti, N | 1 |
| Lichtner, M | 1 |
| Raffetto, N | 1 |
| Vullo, V | 1 |
| Banelli, E | 1 |
| Mamishi, S | 1 |
| Fattahi, F | 1 |
| Pourpak, Z | 1 |
| Aghaee, FM | 1 |
| Moinfar, Z | 1 |
| Mohammadi, M | 1 |
| Ashrafi, M | 1 |
| Moin, M | 1 |
| Uzüm, K | 1 |
| Caksen, H | 1 |
| Gündüz, Z | 1 |
| Ustünbaş, HB | 1 |
| Kandemir, O | 1 |
| Vincenzi, B | 1 |
| Santini, D | 1 |
| Grilli, C | 1 |
| La Cesa, A | 1 |
| Dianzani, C | 1 |
| Tonini, G | 1 |
| Mockenhaupt, M | 1 |
| Messenheimer, J | 1 |
| Tennis, P | 1 |
| Schlingmann, J | 1 |
| Kobayashi, A | 1 |
| Yoshita, T | 1 |
| Sugiyama, K | 1 |
| Miyashita, K | 1 |
| Niida, Y | 1 |
| Koizumi, S | 1 |
| Tseng, SC | 1 |
| Ruggiero, A | 1 |
| Buonuomo, PS | 1 |
| Maurizi, P | 1 |
| Cefalo, MG | 1 |
| Cefalo, MP | 1 |
| Corsello, M | 1 |
| Riccardi, R | 1 |
| Iijima, M | 1 |
| Vandvik, IH | 1 |
| Brahams, D | 1 |
| Livingston, S | 1 |
| Pauli, LL | 1 |
| Pruce, I | 1 |
| Kramer, II | 1 |
| Koukoulis, A | 1 |
| Sopeña, B | 1 |
| Muñoz, D | 1 |
| de la Fuente, J | 1 |
| Errani, A | 1 |
| Reggiani, M | 1 |
| Schianchi, S | 1 |
| Staffa, M | 1 |
| Stewart, MG | 1 |
| Duncan, NO | 1 |
| Franklin, DJ | 1 |
| Friedman, EM | 1 |
| Sulek, M | 1 |
| Weltman, E | 1 |
| Salvajoli, JV | 1 |
| Labandeira García, J | 1 |
| Duncan, KO | 1 |
| Tigelaar, RE | 1 |
| Bolognia, JL | 1 |
| Stutts, JT | 1 |
| Washington, K | 1 |
| Barnard, JA | 1 |
| Z'Graggen, WJ | 1 |
| Itin, PH | 1 |
| Conen, D | 1 |
| Taaffe, A | 1 |
| O'Brien, C | 1 |
| Adams, N | 1 |
| Addison, CM | 1 |
| Pollack, MA | 1 |
| Burk, PG | 1 |
| Nathanson, G | 1 |
| Kirby, JD | 1 |
| Darley, CR | 1 |
| Nozicková, M | 1 |
| Danda, J | 1 |
| Hamáková, K | 1 |
| Kraus, Z | 1 |
| Giallorenzi, AF | 1 |
| Goldstein, BH | 1 |
| Deviller, G | 1 |
| Langevin, P | 1 |
| Drouin, M | 1 |
| Lleonart, R | 1 |
| Nomdedeu, J | 1 |
| Sambeat, MA | 1 |
| Bourgault, I | 1 |
| Prost, C | 1 |
| André, C | 1 |
| Villada, G | 1 |
| Wechsler, J | 1 |
| Chosidow, O | 1 |
| Revuz, J | 1 |
| Teillac, D | 1 |
| Marsol, P | 1 |
| Richard, P | 1 |
| Hubert, P | 1 |
| Roujeau, JC | 1 |
| Cloup, M | 1 |
| De Frost, Y | 1 |
| de Rego, JA | 1 |
| Goldstein, DM | 1 |
| Avery, JK | 1 |
| Messaritakis, J | 1 |
| Adams, RM | 1 |
| Farber, EM | 1 |
| Stüttgen, G | 1 |
| Monnat, A | 1 |
| Bell, DR | 1 |
| Adeloye, A | 1 |
| Familusi, JB | 1 |
| Alabi, GO | 1 |
| Latunde Odeku, E | 1 |
| Haraszti, A | 1 |
| Urbán, G | 1 |
1 review available for phenobarbital and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
[Judicial judgment for severe adverse drug reaction (ADR)].
Topics: Clinical Competence; Humans; Indomethacin; Liability, Legal; Malpractice; Phenobarbital; Referral an | 2007 |
43 other studies available for phenobarbital and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Adverse Cutaneous Drug Reactions Associated with Old- and New- Generation Antiepileptic Drugs Using the Japanese Pharmacovigilance Database.
Topics: Anticonvulsants; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Exanthema; Fem | 2019 |
Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China.
Topics: Adolescent; Alleles; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; China; F | 2014 |
[Toxic epidermal necrolysis induced by phenobarbital in a Rwandan child: report of a case].
Topics: Anticonvulsants; Child, Preschool; Humans; Male; Phenobarbital; Rwanda; Stevens-Johnson Syndrome | 2014 |
Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Child; Child, Pr | 2015 |
Presumed phenobarbital-induced Stevens-Johnson syndrome in a 4-year-old female Great Dane.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Female; Phenobarbital; Potassium Compounds; | 2016 |
[Fever and skin lesions in patients treated with phenobarbital].
Topics: Aged; Anticonvulsants; Female; Fever; Humans; Phenobarbital; Skin Diseases; Stevens-Johnson Syndrome | 2008 |
Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases.
Topics: Anticonvulsants; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Mid | 2009 |
Severe cutaneous reactions caused by barbiturates in seven Iranian children.
Topics: Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Humans; Infant; | 2009 |
A fatal case of toxic epidermal necrolysis associated with liver cirrhosis.
Topics: Child; Disease Progression; Dose-Response Relationship, Drug; Emergency Service, Hospital; Fatal Out | 2003 |
Complications of therapy in cancer patients: Case 3. Toxic epidermal necrolysis induced by oral phenobarbital and whole-brain radiotherapy in a breast cancer patient.
Topics: Administration, Oral; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Femal | 2004 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
Amniotic membrane transplantation in acute phase of toxic epidermal necrolysis with severe corneal involvement.
Topics: Acute Disease; Amnion; Cell Count; Child; Conjunctival Diseases; Corneal Diseases; Cryopreservation; | 2006 |
Stevens-Johnson syndrome in children receiving phenobarbital therapy and cranial radiotherapy.
Topics: Anticonvulsants; Brain Neoplasms; Child; Combined Modality Therapy; Cranial Irradiation; Female; Hum | 2007 |
[Toxic epidermal necrolysis. Epidermolysis necroticans combustiforme].
Topics: Child, Preschool; Exanthema; Humans; Male; Phenobarbital; Phenytoin; Stevens-Johnson Syndrome | 1967 |
Medicine and the law. Risk of Stevens-Johnson syndrome due to phenobarbitone too remote to be foreseeable.
Topics: Adult; Humans; Male; Malpractice; Phenobarbital; Stevens-Johnson Syndrome; United Kingdom | 1982 |
Phenobarbital vs. phenytoin for grand mal epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epi | 1980 |
[The Stevens-Johnson syndrome induced by phenobarbital in a patient with Becker's disease].
Topics: Adolescent; Genetic Linkage; Humans; Male; Muscular Dystrophies; Phenobarbital; Psoriasis; Seizures; | 1994 |
Toxic epidermal necrolysis induced by barbiturates and radiotherapy.
Topics: Aged; Humans; Male; Phenobarbital; Radiotherapy; Stevens-Johnson Syndrome | 1994 |
Head and neck manifestations of erythema multiforme in children.
Topics: Adolescent; Anti-Bacterial Agents; Anticonvulsants; Child; Child, Preschool; Conjunctival Diseases; | 1994 |
Stevens-Johnson syndrome resulting from whole-brain irradiation and phenytoin.
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Brain Neoplasms; Combined Modality Therapy; Dexame | 1996 |
[Stevens-Johnson syndrome and fixed drug eruption].
Topics: Diagnosis, Differential; Drug Eruptions; Humans; Hypnotics and Sedatives; Phenobarbital; Stevens-Joh | 1995 |
Stevens-Johnson syndrome limited to multiple sites of radiation therapy in a patient receiving phenobarbital.
Topics: Biopsy; Combined Modality Therapy; Humans; Male; Middle Aged; Phenobarbital; Radiotherapy; Stevens-J | 1999 |
Cholestatic jaundice with skin desquamation in a 12-year-old girl.
Topics: Atropine; Child; Cholestasis; Cryptogenic Organizing Pneumonia; Drug Combinations; Fatal Outcome; Fe | 1999 |
[Progressive, small spotted, confluent erythema with bullae formation and general symptoms. Acute Lyell syndrome].
Topics: Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; S | 2000 |
A case of Stevens-Johnson syndrome associated with the anti-convulsants sulthiame and ethosuximide.
Topics: Adolescent; Epilepsy, Absence; Ethosuximide; Humans; Male; Phenobarbital; Prednisolone; Stevens-John | 1975 |
How to learn from a case where nearly everything went right: making your best better.
Topics: Child, Preschool; Humans; Male; Patient Care Planning; Patient Isolation; Pediatric Nursing; Phenoba | 1978 |
Mucocutaneous eruptions due to antiepileptic drug therapy in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Erythema Multiforme; Female; Humans; Male; | 1979 |
Eruptive melanocytic naevi following severe bullous disease.
Topics: Child; Female; Humans; Male; Nevus, Pigmented; Phenobarbital; Phenytoin; Skin Neoplasms; Stevens-Joh | 1978 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
Acute (toxic) epidermal necrolysis. Report of a case.
Topics: Child, Preschool; Dextroamphetamine; Humans; Male; Mouth Diseases; Mouth Mucosa; Phenobarbital; Phen | 1975 |
[Toxic epidermic necrolysis].
Topics: Child; Female; Humans; Phenobarbital; Seizures; Stevens-Johnson Syndrome | 1975 |
[Stevens-Johnson syndrome induced by tetrabamate in a patient with HIV infection].
Topics: Adult; Barbiturates; Drug Combinations; Female; HIV Seropositivity; Humans; Phenobarbital; Psychotro | 1992 |
Transient intraepidermal bullous reaction after skin graft for toxic epidermal necrolysis. Ultrastructural and immunohistochemical features similar to those of inherited epidermolysis bullosa simplex.
Topics: Blister; Collagen; Epidermis; Epidermolysis Bullosa Acquisita; Epidermolysis Bullosa Simplex; Female | 1991 |
[Toxic epidermal necrolysis in children (Lyell's syndrome). Apropos of 18 cases].
Topics: Child; Child, Preschool; Combined Modality Therapy; Critical Care; Female; Humans; Infant; Male; Oxy | 1987 |
Case report: psychosis with Stevens-Johnson syndrome and toxic epidermal necrolysis.
Topics: Adult; Basal Ganglia; Female; Humans; Phenobarbital; Phenytoin; Psychotic Disorders; Stevens-Johnson | 1985 |
Without a quarterback--you lose!
Topics: Child; Communication; Humans; Male; Phenobarbital; Stevens-Johnson Syndrome | 1985 |
Toxic epidermal necrolysis in children. (Description of 4 cases).
Topics: Child, Preschool; Dermatitis, Exfoliative; Diagnosis, Differential; Epidermolysis Bullosa; Female; H | 1966 |
Treatment dermatitis. 2. Dermatitis medicamentosa.
Topics: Chlortetracycline; Drug Eruptions; Gold; Heparin; Humans; Lichen Planus; Lupus Vulgaris; Phenobarbit | 1969 |
Toxic epidermal necrolysis provoked by barbiturates.
Topics: Adrenal Cortex Hormones; Aged; Endocarditis; Female; Gastrointestinal Hemorrhage; Humans; Phenobarbi | 1973 |
[Comparative study of Lyell's and Stevens-Johnson syndromes: etiologic role of drugs].
Topics: Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Codeine; Female; Humans; Hydant | 1972 |
Drugs for convulsions.
Topics: Adult; Child; Child, Preschool; Diazepam; Humans; Phenobarbital; Phenytoin; Seizures; Stevens-Johnso | 1973 |
Stevens-Johnson syndrome following anticonvulsant therapy in penetrating head injury.
Topics: Adult; Anticonvulsants; Child; Craniocerebral Trauma; Female; Humans; Male; Phenobarbital; Stevens-J | 1971 |
[Fatal Lyell syndrome caused by Meristin].
Topics: Adolescent; Aminopyrine; Female; Humans; Phenobarbital; Stevens-Johnson Syndrome | 1966 |