phenobarbital has been researched along with Status Epilepticus in 206 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous phenobarbital is frequently offered to patients with generalized convulsive status epilepticus (GCSE) in China, but its long-term benefits are unclear." | 9.69 | Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial. ( Chen, W; Huang, H; Jiang, M; Liu, G; Su, Y; Tian, F; Wang, Y; Zhang, Y, 2023) |
| "We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels." | 9.08 | Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998) |
| "In a randomized, nonblinded clinical trial, 36 consecutive patients with generalized convulsive status epilepticus were treated with either combination diazepam and phenytoin (DZ/DPH) or phenobarbital (PB)." | 9.06 | Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. ( Gabor, AJ; Herring, MO; McCurdy, SA; Shaner, DM, 1988) |
| "Despite phenobarbital (PB) being a key component in status epilepticus (SE) treatment algorithms for decades, it has fallen out of favor compared to newer nonsedating medications due to potential for respiratory suppression and prolonged sedation." | 7.88 | Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience. ( Britton, J; Clark, S; Hocker, S, 2018) |
| "To clarify the effect of levetiracetam (LEV) for acute and chronic seizure control in acute encephalitis with refractory, repetitive partial seizures (AERRPS)." | 7.81 | Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase. ( Imamura, A; Maegaki, Y; Maruta, K; Matsunami, K; Narita, A; Nishimura, Y; Ohno, K; Saiki, Y; Saito, Y; Sokota, T; Sugihara, S; Tamasaki, A; Ueda, R, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "To evaluate the efficacy and safety of mega-dose phenobarbital (MDPB; enteral or parenteral phenobarbital >10 mg/kg/day) for treating super-refractory status epilepticus (SRSE; continuous or recurrent status epilepticus for ≥24 hours after the onset of continuous anaesthetic treatment) in adult patients." | 7.81 | Mega-dose phenobarbital therapy for super-refractory status epilepticus. ( Byun, JI; Chu, K; Jeon, D; Jun, JS; Jung, KH; Jung, KY; Kim, TJ; Lee, DY; Lee, HS; Lee, SK; Lee, ST; Lee, WJ; Lim, JA; Moon, J; Sunwoo, JS, 2015) |
| "To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation." | 7.76 | Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital. ( Claeys, S; Daminet, S; de Rooster, H; Gommeren, K; Hamaide, A, 2010) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| "The goal of this study was to investigate the potential protective effects of nimodipine (ND), a calcium channel blocker, on the acute manifestations and long-term behavioral sequalae of experimental status epilepticus (SE)." | 7.72 | Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats. ( Bakkar, N; Carmant, L; Holmes, GL; Liu, Z; Mikati, MA; Stafstrom, CE; Werner, S, 2004) |
| " In the present study, we used a post-status epilepticus model of TLE to examine whether rats with spontaneous recurrent seizures (SRSs) differ in their individual responses to phenobarbital (PB)." | 7.72 | Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus. ( Brandt, C; Löscher, W; Volk, HA, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 7.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 7.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| " It was proposed that the late activity is a model for pharmacoresistant status epilepticus since it was also refractory to phenytoin, carbamazepine, phenobarbital, and midazolam." | 7.70 | Phenytoin, phenobarbital, and midazolam fail to stop status epilepticus-like activity induced by low magnesium in rat entorhinal slices, but can prevent its development. ( Dreier, JP; Heinemann, U; Zhang, CL, 1998) |
| " We report 3 women, aged 20, 20 and 28 and a man aged 24 with psychogenic status epilepticus admitted to an intensive care unit and treated by induction of phenobarbital coma when other antiepileptic medication failed." | 7.70 | [Phenobarbital coma for psychogenic status epilepticus]. ( Kramer, U; Neufeld, MY; Taliansky, A, 2000) |
| "A previously healthy 2 1/2-year-old girl developed status epilepticus followed by cortical blindness during intravenous N-acetylcysteine therapy for paracetamol ingestion." | 7.69 | Status epilepticus following intravenous N-acetylcysteine therapy. ( Hershkovitz, E; Levitas, A; Shorer, Z; Tal, A, 1996) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 7.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Four-year-old, 20-kg girl, diagnosed with idiopathic tonic-clonic epilepsy, who developed AHS to phenobarbital and phenytoin and status epilepticus unresponsive to lorazepam." | 7.68 | Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome. ( Bertz, RJ; Howrie, DL, 1993) |
| "The brain uptake of phenobarbital during prolonged status epilepticus (3 h) was studied in paralyzed, ventilated sheep." | 7.67 | Brain phenobarbital uptake during prolonged status epilepticus. ( Benowitz, NL; Bronstein, J; Copeland, JR; Jacob, P; Simon, RP, 1987) |
| "Brain uptake and blood concentrations of phenobarbital were determined in rats during pentylenetetrazol-induced status epilepticus and compared to nonconvulsing controls." | 7.67 | Influence of the blood-brain pH gradient on brain phenobarbital uptake during status epilepticus. ( Benowitz, N; Copeland, J; Hedlund, R; Simon, RP, 1985) |
| "Phenobarbital has a strong antiseizure effect with remarkably little sedation." | 7.01 | Phenobarbital in Status epilepticus - Rediscovery of an effective drug. ( Trinka, E, 2023) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 6.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 6.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| " However, these medications have several well-known adverse effects." | 6.77 | Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. ( Ashrafi, MR; Bavarian, B; Ghaempanah, M; Khosroshahi, N; Malamiri, RA; Nikkhah, A, 2012) |
| "Midazolam was given 0." | 6.70 | Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome. ( Al Riyami, K; Chacko, A; Javed, H; Koul, R, 2002) |
| " Success of treatment correlated with higher dosing and serum levels." | 5.91 | Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis. ( Dimitriadis, K; Kunst, S; Madlener, M; Madžar, D; Malter, M; Meyer, L; Minnerup, J; Mueller, A; Neumann, B; Pelz, JO; Reindl, C; Rojo, M; Schmidbauer, ML, 2023) |
| "Intravenous phenobarbital is frequently offered to patients with generalized convulsive status epilepticus (GCSE) in China, but its long-term benefits are unclear." | 5.69 | Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial. ( Chen, W; Huang, H; Jiang, M; Liu, G; Su, Y; Tian, F; Wang, Y; Zhang, Y, 2023) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Phenobarbital (PB) was administrated at a very high daily dose up to 80 mg/kg, reaching serum trough level of 250 μg/ml, which was markedly effective to the treatment." | 5.40 | [A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy]. ( Aiba, H; Okumura, Y; Watanabe, S, 2014) |
| " PB dosage ranged 40-140 mg/kg/day (mean: 70 mg/kg/day)." | 5.34 | Very high dose phenobarbital for refractory status epilepticus. ( Arunpongpaisal, S; Auevitchayapat, N; Chaiyakum, A; Jitpimolmard, S; Mayurasakorn, N; Phunikhom, K; Phuttharak, W; Saengsuwan, J; Suko, P; Tiamkao, S; Vannaprasaht, S, 2007) |
| "When phenobarbital (70 mg/kg) was administered 60 min after stimulation, seizures were controlled in 25% of animals (n=4)." | 5.31 | Ketamine controls prolonged status epilepticus. ( Bertram, EH; Borris, DJ; Kapur, J, 2000) |
| "Phenobarbital and MK-801 were superior to phenytoin in suppressing SE and in preventing chronic epilepsy." | 5.31 | Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus. ( Bertram, EH; Prasad, A; Williamson, JM, 2002) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 5.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "Based on low quality evidence, phenobarbital appears to be the most effective agent for seizure cessation within 60 min of administration in patients with benzodiazepine resistant status epilepticus." | 5.22 | Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses. ( Aneja, S; Arya, R; Cunningham, J; Jain, P; Sharma, S, 2022) |
| "This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies." | 5.22 | [Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022) |
| "Phenobarbital is commonly used to treat status epilepticus in resource-poor countries." | 5.10 | Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions. ( Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Otieno, GO, 2003) |
| "We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels." | 5.08 | Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998) |
| "As initial intravenous treatment for overt generalized convulsive status epilepticus, lorazepam is more effective than phenytoin." | 5.08 | A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. ( Calabrese, VP; Colling, C; Collins, JF; Faught, E; Handforth, A; Mamdani, MB; Meyers, PD; Ramsay, RE; Rowan, AJ; Treiman, DM; Uthman, BM; Walton, NY, 1998) |
| "In a randomized, nonblinded clinical trial, 36 consecutive patients with generalized convulsive status epilepticus were treated with either combination diazepam and phenytoin (DZ/DPH) or phenobarbital (PB)." | 5.06 | Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. ( Gabor, AJ; Herring, MO; McCurdy, SA; Shaner, DM, 1988) |
| " Therapeutic coma induction with midazolam, thiopentone, phenobarbitone or propofol is indicated when conventional antiepileptics fail to abort seizure." | 4.98 | High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature. ( Chakrabarty, B; Gulati, S; Jauhari, P; Lodha, R; Sankar, J; Sondhi, V, 2018) |
| "Lorazepam is better than diazepam or phenytoin alone for cessation of seizures and carries a lower risk of continuation of status epilepticus requiring a different drug or general anaesthesia." | 4.84 | Anticonvulsant therapy for status epilepticus. ( Al-Roomi, K; Krishnan, PR; Prasad, K; Sequeira, R, 2007) |
| "Lorazepam is better than diazepam or phenytoin alone for cessation of seizures and carries a lower risk of continuation of status epilepticus requiring a different drug or general anaesthesia." | 4.82 | Anticonvulsant therapy for status epilepticus. ( Al-Roomi, K; Krishnan, PR; Prasad, K; Sequeira, R, 2005) |
| "Despite phenobarbital (PB) being a key component in status epilepticus (SE) treatment algorithms for decades, it has fallen out of favor compared to newer nonsedating medications due to potential for respiratory suppression and prolonged sedation." | 3.88 | Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience. ( Britton, J; Clark, S; Hocker, S, 2018) |
| " Secondary outcome measures included serum phenobarbital concentrations, number of patients progressing from seizures to status epilepticus, and length of hospital stay." | 3.83 | Standardized Treatment of Neonatal Status Epilepticus Improves Outcome. ( Buss, WF; Harris, ML; Lawson, SN; Malloy, KM; Mietzsch, U; Rose, RS, 2016) |
| "To clarify the effect of levetiracetam (LEV) for acute and chronic seizure control in acute encephalitis with refractory, repetitive partial seizures (AERRPS)." | 3.81 | Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase. ( Imamura, A; Maegaki, Y; Maruta, K; Matsunami, K; Narita, A; Nishimura, Y; Ohno, K; Saiki, Y; Saito, Y; Sokota, T; Sugihara, S; Tamasaki, A; Ueda, R, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Status epilepticus in children was characterized by heterogeneous etiology, prolonged duration and commonly good response to midazolam only given in high doses." | 3.81 | Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus. ( Djuric, M; Jankovic, B; Kravljanac, R; Pekmezovic, T, 2015) |
| "To evaluate the efficacy and safety of mega-dose phenobarbital (MDPB; enteral or parenteral phenobarbital >10 mg/kg/day) for treating super-refractory status epilepticus (SRSE; continuous or recurrent status epilepticus for ≥24 hours after the onset of continuous anaesthetic treatment) in adult patients." | 3.81 | Mega-dose phenobarbital therapy for super-refractory status epilepticus. ( Byun, JI; Chu, K; Jeon, D; Jun, JS; Jung, KH; Jung, KY; Kim, TJ; Lee, DY; Lee, HS; Lee, SK; Lee, ST; Lee, WJ; Lim, JA; Moon, J; Sunwoo, JS, 2015) |
| " We tested the hypothesis that status epilepticus (SE) or exposure to phenytoin or phenobarbital affects brain expression of the metabolic enzyme CYP2E1." | 3.80 | Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. ( Boussadia, B; de Bock, F; Ghosh, C; Janigro, D; Marchi, N; Pascussi, JM; Plaud, C; Rousset, MC, 2014) |
| "High-dose phenobarbital (PB) therapy is effective for refractory status epilepticus." | 3.77 | Effectiveness and safety of non-intravenous high-dose phenobarbital therapy for intractable epilepsy during childhood. ( Hamano, S; Ida, H; Kikuchi, K; Koichihara, R; Minamitani, M; Oritsu, T; Tanaka, M, 2011) |
| "To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation." | 3.76 | Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital. ( Claeys, S; Daminet, S; de Rooster, H; Gommeren, K; Hamaide, A, 2010) |
| "Flupirtine appears more effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressing seizures in both the kainic acid and flurothyl models of symptomatic neonatal seizures." | 3.75 | A KCNQ channel opener for experimental neonatal seizures and status epilepticus. ( Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH, 2009) |
| " In the rat pilocarpine model, status epilepticus significantly increased P-glycoprotein expression by 92 to 197% in the hippocampal hilus and granule cell layer as well as the piriform cortex." | 3.75 | Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. ( Bauer, B; Gorter, JA; Hartz, AM; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Unkrüer, B; van Vliet, EA, 2009) |
| "In the present study we examined if rats with PB-resistant seizures are also resistant to phenytoin (PHT), using continuous EEG/video recording of spontaneous seizures." | 3.74 | Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy. ( Bethmann, K; Brandt, C; Löscher, W, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| "The goal of this study was to investigate the potential protective effects of nimodipine (ND), a calcium channel blocker, on the acute manifestations and long-term behavioral sequalae of experimental status epilepticus (SE)." | 3.72 | Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats. ( Bakkar, N; Carmant, L; Holmes, GL; Liu, Z; Mikati, MA; Stafstrom, CE; Werner, S, 2004) |
| " In the present study, we used a post-status epilepticus model of TLE to examine whether rats with spontaneous recurrent seizures (SRSs) differ in their individual responses to phenobarbital (PB)." | 3.72 | Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus. ( Brandt, C; Löscher, W; Volk, HA, 2004) |
| "Rats in experiment 1 received 1% creatine or cyclocreatine chow from age (P) 21-65 days, underwent kainate induced status epilepticus on P35 and were compared, as adults, to kainate alone rats and to normal controls." | 3.72 | Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats. ( Abu Rialy, S; Farhat, F; Francis, E; Geha, G; Kurdit, RM; Lteif, L; Maraashli, W; Mikati, MA; Rahmeh, AA, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 3.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "We observed a young patient with slight mental retardation, suffering from drug-resistant tonic-clonic seizures, who presented a status epilepticus (SE), in two separate periods when valproic acid (VPA) was added to the phenobarbital (PB) already being used in the patient's therapy." | 3.70 | Valproate-induced epileptic tonic status. ( Balducci, A; Capocchi, G; Cecconi, M; Pelli, MA; Picchiarelli, A; Silvestrelli, G; Zampolini, M, 1998) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 3.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| " It was proposed that the late activity is a model for pharmacoresistant status epilepticus since it was also refractory to phenytoin, carbamazepine, phenobarbital, and midazolam." | 3.70 | Phenytoin, phenobarbital, and midazolam fail to stop status epilepticus-like activity induced by low magnesium in rat entorhinal slices, but can prevent its development. ( Dreier, JP; Heinemann, U; Zhang, CL, 1998) |
| " We report 3 women, aged 20, 20 and 28 and a man aged 24 with psychogenic status epilepticus admitted to an intensive care unit and treated by induction of phenobarbital coma when other antiepileptic medication failed." | 3.70 | [Phenobarbital coma for psychogenic status epilepticus]. ( Kramer, U; Neufeld, MY; Taliansky, A, 2000) |
| "We studied the efficacy of the competitive NMDA receptor antagonist CGP 40116 in protecting against seizure-induced neuronal necrosis from lithium-pilocarpine-induced status epilepticus (SE)." | 3.69 | The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. ( Daniels, AH; Fujikawa, DG; Kim, JS, 1994) |
| "Pentobarbital is standard treatment for refractory status epilepticus (SE) and is almost uniformly effective, but the morbidity of treatment and the mortality of refractory SE are high." | 3.69 | Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus. ( Drislane, FW; Krishnamurthy, KB, 1996) |
| "A previously healthy 2 1/2-year-old girl developed status epilepticus followed by cortical blindness during intravenous N-acetylcysteine therapy for paracetamol ingestion." | 3.69 | Status epilepticus following intravenous N-acetylcysteine therapy. ( Hershkovitz, E; Levitas, A; Shorer, Z; Tal, A, 1996) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 3.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Four-year-old, 20-kg girl, diagnosed with idiopathic tonic-clonic epilepsy, who developed AHS to phenobarbital and phenytoin and status epilepticus unresponsive to lorazepam." | 3.68 | Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome. ( Bertz, RJ; Howrie, DL, 1993) |
| "The pharmacokinetic parameters controlling paraldehyde elimination were determined in nine infants infused with paraldehyde at the rate of 150 mg/kg/hr in a 5% solution in 5% dextrose for the treatment of status epilepticus." | 3.67 | Pharmacokinetics of paraldehyde disposition in the neonate. ( Boutwell, WC; Gessner, PK; Giacoia, GP; Zaleska, MM, 1984) |
| "Intravenous phenytoin, phenobarbital, and paraldehyde are effective and safe for the treatment of acute seizures such as status epilepticus." | 3.67 | Pharmacokinetics and clinical use of parenteral phenytoin, phenobarbital, and paraldehyde. ( Ramsay, RE, 1989) |
| "The brain uptake of phenobarbital during prolonged status epilepticus (3 h) was studied in paralyzed, ventilated sheep." | 3.67 | Brain phenobarbital uptake during prolonged status epilepticus. ( Benowitz, NL; Bronstein, J; Copeland, JR; Jacob, P; Simon, RP, 1987) |
| "Brain uptake and blood concentrations of phenobarbital were determined in rats during pentylenetetrazol-induced status epilepticus and compared to nonconvulsing controls." | 3.67 | Influence of the blood-brain pH gradient on brain phenobarbital uptake during status epilepticus. ( Benowitz, N; Copeland, J; Hedlund, R; Simon, RP, 1985) |
| "Phenobarbital has a strong antiseizure effect with remarkably little sedation." | 3.01 | Phenobarbital in Status epilepticus - Rediscovery of an effective drug. ( Trinka, E, 2023) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 2.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 2.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| " However, these medications have several well-known adverse effects." | 2.77 | Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. ( Ashrafi, MR; Bavarian, B; Ghaempanah, M; Khosroshahi, N; Malamiri, RA; Nikkhah, A, 2012) |
| "Midazolam was given 0." | 2.70 | Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome. ( Al Riyami, K; Chacko, A; Javed, H; Koul, R, 2002) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Status epilepticus is defined as epileptic seizure with the duration for over 30 min or clustered seizure without complete recovery of consciousness for 30 min or more." | 2.50 | [Treatment of status epilepticus]. ( Yamanouchi, H, 2014) |
| "Diazepam gel was better than placebo gel in reducing the risk of non-cessation of seizures (RR 0." | 2.50 | Anticonvulsant therapy for status epilepticus. ( Al-Roomi, K; Krishnan, PR; Prasad, M; Sequeira, R, 2014) |
| "The prevalence of epilepsy is high in many areas of Africa." | 2.43 | Epilepsy and mortality in Africa: a review of the literature. ( Diop, AG; Hauser, WA; Hesdorffer, DC; Logroscino, G, 2005) |
| "Status epilepticus is a neurologic emergency associated with high mortality and long-term disability." | 2.42 | New management strategies in the treatment of status epilepticus. ( Manno, EM, 2003) |
| "Status epilepticus is a serious medical emergency that requires prompt and appropriate intervention." | 2.41 | Status epilepticus. ( Fiallos, MR; Hanhan, UA; Orlowski, JP, 2001) |
| "Nonconvulsive status epilepticus is being considered and recognized more often, including in ambulatory patients with a confusional state, after convulsive status epilepticus, and in critically ill patients." | 2.41 | The current state of treatment of status epilepticus. ( Claassen, J; Hirsch, LJ, 2002) |
| "Once SE is controlled, prevention of seizure recurrence should be individualized to each patient." | 2.40 | Management approaches to prolonged seizures and status epilepticus. ( Bleck, TP, 1999) |
| "Convulsive status epilepticus is an emergency that is associated with high morbidity and mortality." | 2.38 | Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. ( , 1993) |
| " In addition to physiologic factors, such as blood pressure and cerebral blood flow, pharmacokinetic principles, including half-life, distribution, elimination, and volume of distribution (with special regard to an agent's lipid-solubility rating), should be applied." | 2.38 | The pharmacokinetics of agents used to treat status epilepticus. ( Browne, TR, 1990) |
| "Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted." | 2.36 | Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983) |
| "Drug treatment of status epilepticus is reviewed." | 2.36 | Drug therapy reviews: drug therapy of status epilepticus. ( Browne, TR, 1978) |
| " Success of treatment correlated with higher dosing and serum levels." | 1.91 | Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis. ( Dimitriadis, K; Kunst, S; Madlener, M; Madžar, D; Malter, M; Meyer, L; Minnerup, J; Mueller, A; Neumann, B; Pelz, JO; Reindl, C; Rojo, M; Schmidbauer, ML, 2023) |
| "Midazolam has become the preferred benzodiazepine in pre- and in-hospital settings, both in children and adults." | 1.91 | Trends and Differences in Status Epilepticus Treatment of Children and Adults Over 10 Years: A Comparative Study of Medical Records (2012-2021) from a University Hospital in Germany. ( Czabanka, M; Kieslich, M; Merker, M; Purwien, L; Ronellenfitsch, MW; Rosenow, F; Schubert-Bast, S; Strzelczyk, A; Willems, LM, 2023) |
| "Midazolam was the first medication administered in 87/100 (87%) instances, mean dose of 0." | 1.72 | Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus. ( Babl, FE; Borland, ML; Dalziel, SR; Emeto, TI; Furyk, JS; George, S; Hearps, SJ; O'Brien, S; Phillips, N; Riney, K; Watt, K; Wilson, C, 2022) |
| "To identify factors associated with low benzodiazepine (BZD) dosing in patients with refractory status epilepticus (RSE) and to assess the impact of BZD treatment variability on seizure cessation." | 1.56 | First-line medication dosing in pediatric refractory status epilepticus. ( Abend, NS; Amengual-Gual, M; Anderson, A; Arya, R; Brenton, JN; Carpenter, JL; Chapman, K; Clark, J; Farias-Moeller, R; Gaillard, WD; Gaínza-Lein, M; Glauser, T; Goldstein, JL; Goodkin, HP; Guerriero, RM; Kapur, K; Lai, YC; Loddenkemper, T; McDonough, TL; Mikati, MA; Morgan, LA; Novotny, EJ; Ostendorf, AP; Payne, ET; Peariso, K; Piantino, J; Riviello, JJ; Sannagowdara, K; Tasker, RC; Tchapyjnikov, D; Topjian, A; Vasquez, A; Wainwright, MS; Wilfong, A; Williams, K, 2020) |
| "Status epilepticus is defined as a state of unrelenting seizure activity." | 1.51 | Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus. ( Akerman, CJ; Burman, RJ; Calin, A; Codadu, NK; Katz, AA; Lee, JH; Newey, SE; Parrish, RR; Raimondo, JV; Selfe, JS; Trevelyan, AJ; van den Berg, M; Wilmshurst, JM; Wright, R, 2019) |
| "Status epilepticus is common in neonates and infants, and is associated with neuronal injury and adverse developmental outcomes." | 1.46 | Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury. ( Niquet, J; Suchomelova, L; Torolira, D; Wasterlain, CG, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Phenobarbital is an old antiepileptic drug used in severe epilepsy." | 1.40 | High phenobarbital clearance during continuous renal replacement therapy: a case report and pharmacokinetic analysis. ( Rosenborg, S; Saraste, L; Wide, K, 2014) |
| "Phenobarbital (PB) was administrated at a very high daily dose up to 80 mg/kg, reaching serum trough level of 250 μg/ml, which was markedly effective to the treatment." | 1.40 | [A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy]. ( Aiba, H; Okumura, Y; Watanabe, S, 2014) |
| "This is the first report of posterior reversible encephalopathy syndrome in a previously healthy child." | 1.39 | Status epilepticus as manifestation of posterior reversible encephalopathy syndrome in a healthy child. ( Cerini, C; Dilillo, D; Fasan, S; Mameli, C; Spiri, D; Zuccotti, GV, 2013) |
| "Their seizures were controlled after an administration of high-dose phenobarbital." | 1.37 | Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures. ( Abe, S; Ikeno, M; Kitamura, T; Komatsu, M; Matsui, K; Okumura, A; Shimizu, T, 2011) |
| "Status epilepticus is a common neurological emergency in childhood and associated with significant morbidity and mortality." | 1.37 | Status epilepticus. ( Gulati, S; Lodha, R; Raj, D, 2011) |
| "The presence of multiple seizures prior to medical treatment has been suggested as a potential predictor of poor outcome." | 1.36 | High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010) |
| " Based on pharmacokinetic studies with bumetanide, which showed extremely rapid elimination and low brain penetration of this drug in rats, bumetanide was administered systemically with different dosing protocols, including continuous intravenous infusion." | 1.36 | Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. ( Brandt, C; Heuchert, N; Löscher, W; Nozadze, M; Rattka, M, 2010) |
| "Absence status was aggravated with carbamazepine and generalised tonic-clonic seizures were not controlled with ethosuximide." | 1.36 | Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status. ( Genton, P; Velizarova, R, 2010) |
| " PB dosage ranged 40-140 mg/kg/day (mean: 70 mg/kg/day)." | 1.34 | Very high dose phenobarbital for refractory status epilepticus. ( Arunpongpaisal, S; Auevitchayapat, N; Chaiyakum, A; Jitpimolmard, S; Mayurasakorn, N; Phunikhom, K; Phuttharak, W; Saengsuwan, J; Suko, P; Tiamkao, S; Vannaprasaht, S, 2007) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "When phenobarbital (70 mg/kg) was administered 60 min after stimulation, seizures were controlled in 25% of animals (n=4)." | 1.31 | Ketamine controls prolonged status epilepticus. ( Bertram, EH; Borris, DJ; Kapur, J, 2000) |
| "Phenobarbital and MK-801 were superior to phenytoin in suppressing SE and in preventing chronic epilepsy." | 1.31 | Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus. ( Bertram, EH; Prasad, A; Williamson, JM, 2002) |
| "Medical records were reviewed for seizure and medication history, diagnostic test results, types of treatment, hospitalization costs, and outcome of hospital visits." | 1.30 | Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995). ( Bateman, SW; Parent, JM, 1999) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 1.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| " Rats receiving phenobarbital had therapeutic concentrations during most of the 24-hour dosing period, but also experienced supratherapeutic peak concentrations." | 1.29 | Phenobarbital modifies seizure-related brain injury in the developing brain. ( Chronopoulos, A; Gatt, A; Holmes, GL; Hyde, P; Liu, Z; Mikati, MA; Stafstrom, CE; Thurber, S; Werner, S, 1994) |
| "Status epilepticus was treated with intravenous infusion of thiamylal sodium." | 1.29 | [A case of adult Reye's syndrome with favorable outcome despite status epilepticus]. ( Arai, M, 1996) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "Status epilepticus is a medical emergency." | 1.27 | Status epilepticus. ( Hall, S, 1983) |
| "Status epilepticus is a medical emergency requiring immediate treatment." | 1.27 | Treatment of status epilepticus in adults. ( Bruni, J, 1983) |
| "Convulsive status epilepticus is a life-threatening disorder." | 1.27 | Status epilepticus. ( Leppik, IE, 1985) |
| "Status epilepticus is a serious emergency that rarely complicates the management of the pregnant patient with seizure disorders." | 1.27 | Status epilepticus in pregnancy. A case report. ( Fougner, AC; Seltzer, VL; Wilson, SJ, 1985) |
| "Status epilepticus is a serious medical emergency requiring immediate and rational therapy." | 1.27 | Status epilepticus. ( Freeman, JM; Vining, EP, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (25.73) | 18.7374 |
| 1990's | 41 (19.90) | 18.2507 |
| 2000's | 51 (24.76) | 29.6817 |
| 2010's | 46 (22.33) | 24.3611 |
| 2020's | 15 (7.28) | 2.80 |
| Authors | Studies |
|---|---|
| Su, Y | 3 |
| Huang, H | 2 |
| Jiang, M | 3 |
| Pan, S | 1 |
| Ding, L | 1 |
| Zhang, L | 1 |
| Jiang, W | 1 |
| Zhuang, X | 1 |
| Furyk, JS | 1 |
| George, S | 1 |
| Phillips, N | 1 |
| Emeto, TI | 1 |
| Watt, K | 1 |
| O'Brien, S | 1 |
| Riney, K | 1 |
| Wilson, C | 1 |
| Hearps, SJ | 1 |
| Borland, ML | 1 |
| Dalziel, SR | 1 |
| Babl, FE | 1 |
| Jain, P | 1 |
| Aneja, S | 1 |
| Cunningham, J | 1 |
| Arya, R | 2 |
| Sharma, S | 1 |
| Soto-Insuga, V | 1 |
| González-Alguacil, E | 1 |
| García-Peñas, JJ | 1 |
| Trinka, E | 4 |
| Kunst, S | 1 |
| Rojo, M | 1 |
| Schmidbauer, ML | 1 |
| Pelz, JO | 1 |
| Mueller, A | 1 |
| Minnerup, J | 1 |
| Meyer, L | 1 |
| Madžar, D | 1 |
| Reindl, C | 1 |
| Madlener, M | 1 |
| Malter, M | 1 |
| Neumann, B | 1 |
| Dimitriadis, K | 1 |
| Leitinger, M | 1 |
| Gaspard, N | 1 |
| Hirsch, LJ | 2 |
| Beniczky, S | 1 |
| Kaplan, PW | 1 |
| Husari, K | 1 |
| Liu, G | 2 |
| Wang, Y | 1 |
| Tian, F | 2 |
| Chen, W | 2 |
| Zhang, Y | 3 |
| Purwien, L | 1 |
| Schubert-Bast, S | 1 |
| Kieslich, M | 1 |
| Ronellenfitsch, MW | 1 |
| Merker, M | 1 |
| Czabanka, M | 1 |
| Willems, LM | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Burman, RJ | 1 |
| Selfe, JS | 1 |
| Lee, JH | 1 |
| van den Berg, M | 1 |
| Calin, A | 1 |
| Codadu, NK | 1 |
| Wright, R | 1 |
| Newey, SE | 1 |
| Parrish, RR | 1 |
| Katz, AA | 1 |
| Wilmshurst, JM | 3 |
| Akerman, CJ | 1 |
| Trevelyan, AJ | 1 |
| Raimondo, JV | 1 |
| McCarren, HS | 1 |
| Eisen, MR | 1 |
| Nguyen, DL | 1 |
| Dubée, PB | 1 |
| Ardinger, CE | 1 |
| Dunn, EN | 1 |
| Haines, KM | 1 |
| Santoro, AN | 1 |
| Bodner, PM | 1 |
| Ondeck, CA | 1 |
| Honnold, CL | 1 |
| McDonough, JH | 1 |
| Beske, PH | 1 |
| McNutt, PM | 1 |
| Ramírez-Zamora, M | 1 |
| Veliz-Martínez, V | 1 |
| Barahona, GE | 1 |
| Mena, ID | 1 |
| Ortez, CI | 1 |
| Nolasco-Tovar, GA | 1 |
| Spampanato, J | 1 |
| Bealer, SL | 1 |
| Smolik, M | 1 |
| Dudek, FE | 1 |
| Vasquez, A | 1 |
| Gaínza-Lein, M | 2 |
| Abend, NS | 1 |
| Amengual-Gual, M | 1 |
| Anderson, A | 1 |
| Brenton, JN | 1 |
| Carpenter, JL | 1 |
| Chapman, K | 1 |
| Clark, J | 1 |
| Farias-Moeller, R | 1 |
| Gaillard, WD | 1 |
| Glauser, T | 1 |
| Goldstein, JL | 1 |
| Goodkin, HP | 1 |
| Guerriero, RM | 1 |
| Kapur, K | 1 |
| Lai, YC | 1 |
| McDonough, TL | 1 |
| Mikati, MA | 4 |
| Morgan, LA | 1 |
| Novotny, EJ | 1 |
| Ostendorf, AP | 1 |
| Payne, ET | 1 |
| Peariso, K | 1 |
| Piantino, J | 1 |
| Riviello, JJ | 1 |
| Sannagowdara, K | 1 |
| Tasker, RC | 1 |
| Tchapyjnikov, D | 1 |
| Topjian, A | 1 |
| Wainwright, MS | 1 |
| Wilfong, A | 1 |
| Williams, K | 1 |
| Loddenkemper, T | 2 |
| Han, EJ | 1 |
| Chuck, CC | 1 |
| Martin, TJ | 1 |
| Madsen, TE | 1 |
| Claassen, J | 2 |
| Reznik, ME | 1 |
| Bertozzi, V | 1 |
| Bonardi, CM | 1 |
| Biscalchin, G | 1 |
| Tona, C | 1 |
| Amigoni, A | 1 |
| Sartori, S | 1 |
| Torolira, D | 1 |
| Suchomelova, L | 1 |
| Wasterlain, CG | 1 |
| Niquet, J | 1 |
| Geoghegan, AR | 1 |
| Webb, D | 1 |
| Gulati, S | 2 |
| Sondhi, V | 1 |
| Chakrabarty, B | 1 |
| Jauhari, P | 1 |
| Lodha, R | 2 |
| Sankar, J | 1 |
| Witcher, RH | 1 |
| Ramirez, MM | 1 |
| Gillinder, L | 1 |
| Lehn, A | 1 |
| Brown, H | 1 |
| Dionisio, S | 1 |
| Chen, J | 1 |
| Xie, L | 1 |
| Hu, Y | 1 |
| Lan, X | 1 |
| Jiang, L | 1 |
| Jędrzejczak, J | 1 |
| Mazurkiewicz-Bełdzińska, M | 1 |
| Szmuda, M | 1 |
| Majkowska-Zwolińska, B | 1 |
| Steinborn, B | 1 |
| Ryglewicz, D | 1 |
| Owczuk, R | 1 |
| Bartkowska-Śniatkowska, A | 1 |
| Widera, E | 1 |
| Rejdak, K | 1 |
| Siemiński, M | 1 |
| Nagańska, E | 1 |
| Hocker, S | 1 |
| Clark, S | 1 |
| Britton, J | 1 |
| Wang, SN | 1 |
| Gu, CP | 1 |
| Liu, GH | 1 |
| Lin, ZZ | 1 |
| Zheng, P | 1 |
| Pan, SY | 1 |
| Liu, ST | 1 |
| Sánchez Fernández, I | 1 |
| Lamb, N | 1 |
| Cagnotti, G | 1 |
| Odore, R | 1 |
| Bertone, I | 1 |
| Corona, C | 1 |
| Dappiano, E | 1 |
| Gardini, G | 1 |
| Iulini, B | 1 |
| Bellino, C | 1 |
| D'Angelo, A | 1 |
| Olivier-Gougenheim, L | 1 |
| Freychet, C | 1 |
| Collardeau-Frachon, S | 1 |
| Roure-Sobas, C | 1 |
| Di Filippo, S | 1 |
| Riva, R | 1 |
| Lega, JC | 1 |
| Belot, A | 1 |
| Mameli, C | 1 |
| Dilillo, D | 1 |
| Spiri, D | 1 |
| Cerini, C | 1 |
| Fasan, S | 1 |
| Zuccotti, GV | 1 |
| Burns, JM | 1 |
| Marino, A | 1 |
| Manno, M | 1 |
| Rhyee, S | 1 |
| Boyer, EW | 1 |
| Muramoto, E | 1 |
| Mizobuchi, M | 1 |
| Sumi, Y | 1 |
| Sako, K | 1 |
| Nihira, A | 1 |
| Takeuchi, A | 1 |
| Nakamura, H | 1 |
| Brigo, F | 1 |
| Igwe, SC | 1 |
| Nardone, R | 1 |
| Tezzon, F | 1 |
| Bongiovanni, LG | 1 |
| Cuff, DE | 1 |
| Bush, WW | 1 |
| Stecker, MM | 2 |
| Williams, DC | 1 |
| Bogdanović, RM | 1 |
| Syvänen, S | 1 |
| Michler, C | 2 |
| Russmann, V | 2 |
| Eriksson, J | 1 |
| Windhorst, AD | 1 |
| Lammertsma, AA | 1 |
| de Lange, EC | 1 |
| Voskuyl, RA | 1 |
| Potschka, H | 3 |
| Yamanouchi, H | 3 |
| Rosenborg, S | 1 |
| Saraste, L | 1 |
| Wide, K | 1 |
| Ueda, R | 1 |
| Saito, Y | 1 |
| Ohno, K | 1 |
| Maruta, K | 1 |
| Matsunami, K | 1 |
| Saiki, Y | 1 |
| Sokota, T | 1 |
| Sugihara, S | 1 |
| Nishimura, Y | 1 |
| Tamasaki, A | 1 |
| Narita, A | 1 |
| Imamura, A | 1 |
| Maegaki, Y | 1 |
| Prasad, M | 1 |
| Krishnan, PR | 3 |
| Sequeira, R | 3 |
| Al-Roomi, K | 3 |
| Boussadia, B | 1 |
| Ghosh, C | 1 |
| Plaud, C | 1 |
| Pascussi, JM | 1 |
| de Bock, F | 1 |
| Rousset, MC | 1 |
| Janigro, D | 1 |
| Marchi, N | 1 |
| Akman, O | 1 |
| Moshé, SL | 1 |
| Galanopoulou, AS | 1 |
| Töllner, K | 3 |
| Brandt, C | 6 |
| Erker, T | 1 |
| Löscher, W | 10 |
| Klee, R | 1 |
| Bröer, S | 1 |
| Watanabe, S | 1 |
| Okumura, Y | 1 |
| Aiba, H | 1 |
| Kravljanac, R | 1 |
| Djuric, M | 1 |
| Jankovic, B | 1 |
| Pekmezovic, T | 1 |
| Cock, HR | 1 |
| Byun, JI | 1 |
| Chu, K | 1 |
| Sunwoo, JS | 1 |
| Moon, J | 1 |
| Kim, TJ | 1 |
| Lim, JA | 1 |
| Jun, JS | 1 |
| Lee, HS | 1 |
| Lee, WJ | 1 |
| Lee, DY | 1 |
| Jeon, D | 1 |
| Lee, ST | 1 |
| Jung, KH | 1 |
| Jung, KY | 1 |
| Lee, SK | 1 |
| Twele, F | 1 |
| Hassanian-Moghaddam, H | 1 |
| Ghadiri, F | 1 |
| Shojaei, M | 1 |
| Zamani, N | 1 |
| Harris, ML | 1 |
| Malloy, KM | 1 |
| Lawson, SN | 1 |
| Rose, RS | 1 |
| Buss, WF | 1 |
| Mietzsch, U | 1 |
| Haenisch, S | 1 |
| von Rüden, EL | 1 |
| Wahmkow, H | 1 |
| Rettenbeck, ML | 1 |
| Bruckmueller, H | 1 |
| Waetzig, V | 1 |
| Cascorbi, I | 1 |
| Ren, G | 1 |
| Chun, B | 1 |
| Ye, H | 1 |
| Gao, D | 1 |
| Gordon-Graham, E | 1 |
| Green, G | 1 |
| Reynolds, L | 1 |
| Blockman, M | 1 |
| Bankstahl, JP | 1 |
| Wanigasinghe, J | 1 |
| Liyanage, UA | 1 |
| Raol, YH | 1 |
| Lapides, DA | 1 |
| Keating, JG | 1 |
| Brooks-Kayal, AR | 1 |
| Cooper, EC | 1 |
| Wang, NC | 1 |
| Good, LB | 1 |
| Marsh, ST | 1 |
| Treiman, DM | 4 |
| Pekcec, A | 1 |
| Unkrüer, B | 1 |
| Schlichtiger, J | 1 |
| Soerensen, J | 1 |
| Hartz, AM | 1 |
| Bauer, B | 1 |
| van Vliet, EA | 1 |
| Gorter, JA | 1 |
| Okumura, A | 1 |
| Komatsu, M | 1 |
| Abe, S | 1 |
| Kitamura, T | 1 |
| Matsui, K | 1 |
| Ikeno, M | 1 |
| Shimizu, T | 1 |
| Nozadze, M | 1 |
| Heuchert, N | 1 |
| Rattka, M | 1 |
| Gommeren, K | 1 |
| Claeys, S | 1 |
| de Rooster, H | 1 |
| Hamaide, A | 1 |
| Daminet, S | 1 |
| Kikuchi, K | 1 |
| Hamano, S | 1 |
| Oritsu, T | 1 |
| Koichihara, R | 1 |
| Tanaka, M | 1 |
| Minamitani, M | 1 |
| Ida, H | 1 |
| Velizarova, R | 1 |
| Genton, P | 1 |
| Raj, D | 1 |
| Otsuka, Y | 1 |
| Malamiri, RA | 1 |
| Ghaempanah, M | 1 |
| Khosroshahi, N | 1 |
| Nikkhah, A | 1 |
| Bavarian, B | 1 |
| Ashrafi, MR | 1 |
| Jones, DM | 1 |
| Esmaeil, N | 1 |
| Maren, S | 1 |
| Macdonald, RL | 1 |
| Sykes, N | 1 |
| Thorns, A | 1 |
| Koul, R | 1 |
| Chacko, A | 1 |
| Javed, H | 1 |
| Al Riyami, K | 1 |
| Fujikawa, Y | 1 |
| Sugai, K | 3 |
| Hanaoka, S | 2 |
| Fukumizu, M | 2 |
| Sasaki, M | 2 |
| Kaga, M | 1 |
| Manno, EM | 1 |
| Toomes, M | 1 |
| Maleck, WH | 1 |
| Koetter, KP | 1 |
| Petroianu, GA | 1 |
| Kokwaro, GO | 1 |
| Ogutu, BR | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
36 reviews available for phenobarbital and Status Epilepticus
| Article | Year |
|---|---|
Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses.
Topics: Adult; Anticonvulsants; Benzodiazepines; Child; Drug Resistance; Humans; Levetiracetam; Network Meta | 2022 |
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; | 2022 |
Phenobarbital in Status epilepticus - Rediscovery of an effective drug.
Topics: Anticonvulsants; Humans; Phenobarbital; Prospective Studies; Retrospective Studies; Status Epileptic | 2023 |
High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Protocols; Coma; Drug Resistance; Fem | 2018 |
Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Cost-Benefit Analysis; Decision Support Techniques; Humans; Lacosa | 2019 |
A common reference-based indirect comparison meta-analysis of intravenous valproate versus intravenous phenobarbitone for convulsive status epilepticus.
Topics: Algorithms; Anticonvulsants; Bias; Humans; Injections, Intravenous; Models, Statistical; Phenobarbit | 2013 |
[Treatment of status epilepticus].
Topics: Anesthesia, General; Diazepam; Drug Administration Routes; Evidence-Based Medicine; Humans; Hypother | 2014 |
Anticonvulsant therapy for status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Injections, Intravenous; Lorazepam; Midazolam; Phenobarbital; Phe | 2014 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
Drug-induced status epilepticus.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Nipecotic Acids; P | 2015 |
What is the relative value of the standard anticonvulsants: Phenytoin and fosphenytoin, phenobarbital, valproate, and levetiracetam?
Topics: Anticonvulsants; Benzodiazepines; Humans; Levetiracetam; Phenobarbital; Phenytoin; Piracetam; Prodru | 2009 |
New management strategies in the treatment of status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Emergency Medical Services; Humans; Phenobarbital; Phenytoin; Stat | 2003 |
Phenobarbital for the treatment of epilepsy in the 21st century: a critical review.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cost-Benefit Analysis; Developing Countries; Drug Costs; E | 2004 |
Status epilepticus: an evidence based guide.
Topics: Anticonvulsants; Chronic Disease; Critical Care; Drug Administration Routes; Emergency Treatment; Ev | 2005 |
Anticonvulsant therapy for status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Phenobarbital; Phenytoin; Randomized Contro | 2005 |
Epilepsy and mortality in Africa: a review of the literature.
Topics: Africa; Anticonvulsants; Cause of Death; Child; Developing Countries; Epilepsy; Humans; Malaria; Mal | 2005 |
[Update on current care guidelines. Prolonged epileptic attack].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; El | 2006 |
Anticonvulsant therapy for status epilepticus.
Topics: Anticonvulsants; Diazepam; Humans; Lorazepam; Midazolam; Phenobarbital; Phenytoin; Randomized Contro | 2007 |
Intensive care unit management of patients with status epilepticus.
Topics: Anesthesia, General; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule | 2007 |
Seizures and seizure-like states in the child: an approach to emergency management.
Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans | 1983 |
Therapy for status epilepticus.
Topics: Acetazolamide; Anesthesia; Anticonvulsants; Barbiturates; Chlormethiazole; Clonazepam; Diazepam; Eth | 1983 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus.
Topics: Benzodiazepines; Humans; Morbidity; Phenobarbital; Phenytoin; Resuscitation; Spinal Puncture; Status | 1993 |
Treatment of status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Diazepam; Humans; Phenobarbital; Phenytoin; Status | 1993 |
Management of status epilepticus.
Topics: Anticonvulsants; Electroencephalography; Humans; Midazolam; Phenobarbital; Practice Guidelines as To | 1998 |
Management approaches to prolonged seizures and status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; | 1999 |
Treatment of status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Humans; Patient Compliance; Phenobarbital; Phenytoin; Pract | 2000 |
Status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Midazola | 2001 |
Treatment of status epilepticus in children.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Humans; Phenobarbital; Phenytoin; Prev | 2001 |
The current state of treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Electroencephalography; Female; GABA Modulators; H | 2002 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
Drug therapy reviews: drug therapy of status epilepticus.
Topics: Anesthesia, General; Diazepam; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil | 1978 |
Status epilepticus. Clinical features, pathophysiology, and treatment.
Topics: Benzodiazepines; Clinical Protocols; Drug Therapy, Combination; Humans; Phenobarbital; Phenytoin; St | 1991 |
The pharmacokinetics of agents used to treat status epilepticus.
Topics: Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular; Lipi | 1990 |
Treatment of status epilepticus.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Child; Humans; Phenobarbital; Phenytoin; Status Epil | 1989 |
[Status epilepticus in childhood].
Topics: Brain; Child; Child, Preschool; Diazepam; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn | 1986 |
11 trials available for phenobarbital and Status Epilepticus
| Article | Year |
|---|---|
Phenobarbital versus valproate for generalized convulsive status epilepticus in adults (2): A multicenter prospective randomized controlled trial in China (China 2-P vs. V).
Topics: Adult; Anticonvulsants; China; Humans; Phenobarbital; Prospective Studies; Status Epilepticus; Valpr | 2021 |
Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial.
Topics: Adult; Anticonvulsants; Diazepam; Follow-Up Studies; Humans; Phenobarbital; Status Epilepticus; Trea | 2023 |
Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures.
Topics: Administration, Intravenous; Administration, Rectal; Animals; Anticonvulsants; Diazepam; Dog Disease | 2019 |
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male | 2016 |
Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; | 2012 |
Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Dose-Response Relationship, Drug; El | 2002 |
Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions.
Topics: Anticonvulsants; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Infusio | 2003 |
Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings.
Topics: Adult; Aged; Barbiturates; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combinati | 1998 |
A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
Topics: Aged; Anticonvulsants; Diazepam; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inj | 1998 |
[Treatment of status epilepticus with clonazepam].
Topics: Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Diazepam; Drug Evaluation; Humans; Phenobar | 1976 |
Treatment of status epilepticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin.
Topics: Adult; Aged; Clinical Trials as Topic; Diazepam; Drug Therapy, Combination; Female; Humans; Male; Mi | 1988 |
159 other studies available for phenobarbital and Status Epilepticus
| Article | Year |
|---|---|
Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Cohort Studies; Female; Humans; Levetirac | 2022 |
Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis.
Topics: Female; Hospital Mortality; Humans; Male; Phenobarbital; Prospective Studies; Retrospective Studies; | 2023 |
Diagnosing nonconvulsive status epilepticus: Defining electroencephalographic and clinical response to diagnostic intravenous antiseizure medication trials.
Topics: Administration, Intravenous; Benzodiazepines; Clinical Trials as Topic; Electroencephalography; Huma | 2023 |
Trends and Differences in Status Epilepticus Treatment of Children and Adults Over 10 Years: A Comparative Study of Medical Records (2012-2021) from a University Hospital in Germany.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Child; Female; Hospitals, Universi | 2023 |
Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Child, Preschool; Diazepam; Drug Resistance; Drug Resista | 2019 |
Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Levetiracetam; Mice; Nerve Agents; Phenobarbital; | 2020 |
[Hemicerebellitis due to chikungunya associated with refractory status epilepticus in the paediatric age].
Topics: Acute Disease; Antibodies, Viral; Anticonvulsants; Attention Deficit and Disruptive Behavior Disorde | 2020 |
Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Dexmedetomidine; Disease Models, Animal; Dose-Response | 2020 |
First-line medication dosing in pediatric refractory status epilepticus.
Topics: Adolescent; Age Factors; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Dose-Response Re | 2020 |
Statewide Emergency Medical Services Protocols for Status Epilepticus Management.
Topics: Administration, Intranasal; Administration, Rectal; Adult; Anticonvulsants; Benzodiazepines; Child; | 2021 |
Efficacy of lacosamide in neonatal-onset super-refractory status epilepticus: a case report.
Topics: Anticonvulsants; Humans; Infant, Newborn; Lacosamide; Phenobarbital; Seizures; Status Epilepticus | 2021 |
Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury.
Topics: Animals; Apoptosis; Brain; Cell Count; Female; Male; Midazolam; Neurons; Phenobarbital; Rats; Status | 2017 |
Successful Treatment With Phenobarbital Following Lactase Supplementation in an Infant With Lactose Intolerance.
Topics: Dietary Supplements; Humans; Infant; Lactase; Lactose; Lactose Intolerance; Pharmaceutic Aids; Pheno | 2017 |
Successful Phenobarbital Desensitization After DRESS Reaction in the Management of Refractory Status Epilepticus.
Topics: Anticonvulsants; Child, Preschool; Desensitization, Immunologic; Drug Hypersensitivity; Drug-Related | 2019 |
Treatment outcomes after the introduction of a new seizure management protocol.
Topics: Adult; Anticonvulsants; Clinical Protocols; Drug-Related Side Effects and Adverse Reactions; Emergen | 2018 |
Nonconvulsive status epilepticus after cessation of convulsive status epilepticus in pediatric intensive care unit patients.
Topics: Administration, Intravenous; Adolescent; Cerebral Cortex; Child; Child, Preschool; Electroencephalog | 2018 |
Convulsive status epilepticus management in adults and children: Report of the Working Group of the Polish Society of Epileptology.
Topics: Adult; Anticonvulsants; Child; Humans; Phenobarbital; Poland; Seizures; Status Epilepticus | 2018 |
Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience.
Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Brain Waves; Electroencephalography; Female; Glasgow | 2018 |
The effectiveness of phenobarbital in patients with refractory status epilepticus undergoing therapeutic plasma exchange.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Female | 2018 |
A quest for Q fever.
Topics: Brain; Child; Doxycycline; Female; Humans; Hydroxychloroquine; Intracranial Aneurysm; Intracranial H | 2019 |
Status epilepticus as manifestation of posterior reversible encephalopathy syndrome in a healthy child.
Topics: Anticonvulsants; Brain; Child; Humans; Magnetic Resonance Imaging; Male; Neurologic Examination; Phe | 2013 |
Status epilepticus in a child secondary to ingestion of skin-lightening cream.
Topics: Anticonvulsants; Ataxia; Eating; Emergencies; Humans; Hydroquinones; Infant; Intubation, Intratrache | 2013 |
[Efficacy of intravenous phenobarbital treatment for status epilepticus].
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Japan; Male; Middle Aged; Phenobarb | 2013 |
Use of continuous electroencephalography for diagnosis and monitoring of treatment of nonconvulsive status epilepticus in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Electroencephalography; Male; Phenobarbital; Status Ep | 2014 |
(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbon Radioisotopes; Carrier Proteins; Chronic Disease; Disease Mo | 2014 |
High phenobarbital clearance during continuous renal replacement therapy: a case report and pharmacokinetic analysis.
Topics: Acute Kidney Injury; Adolescent; Anticonvulsants; Drug Monitoring; Humans; Hyperglycinemia, Nonketot | 2014 |
Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Bromides; Child; Chronic Disease; Encephalitis; F | 2015 |
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Central Nervous | 2014 |
Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to phenobarbital.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Disease | 2015 |
Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.
Topics: Animals; Anticonvulsants; Basolateral Nuclear Complex; Bumetanide; Disease Models, Animal; Drug Syne | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
[A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy].
Topics: Acute Disease; Child; Encephalitis; Humans; Male; Phenobarbital; Seizures; Status Epilepticus; Treat | 2014 |
Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infusions, I | 2015 |
Mega-dose phenobarbital therapy for super-refractory status epilepticus.
Topics: Adolescent; Adult; Anticonvulsants; Drug Resistant Epilepsy; Female; Humans; Intensive Care Units; M | 2015 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Phenobarbital overdose presenting with status epilepticus: A case report.
Topics: Anticonvulsants; Drug Overdose; Humans; Male; Middle Aged; Phenobarbital; Status Epilepticus | 2016 |
Standardized Treatment of Neonatal Status Epilepticus Improves Outcome.
Topics: Anticonvulsants; Critical Care; Female; Guideline Adherence; Humans; Infant, Newborn; Intensive Care | 2016 |
miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Resistant Epilepsy; Dyrk Kinases; Electric St | 2016 |
Access to parenteral phenobarbitone.
Topics: Anticonvulsants; Health Services Accessibility; Humans; Infusions, Parenteral; Phenobarbital; South | 2008 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease | 2008 |
Audit of treatment of convulsive status epilepticus.
Topics: Anticonvulsants; Child; Diazepam; Humans; Midazolam; Paraldehyde; Phenobarbital; Phenytoin; Practice | 2008 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-R | 2009 |
EEG stages predict treatment response in experimental status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Disease Progressio | 2009 |
Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western | 2009 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons | 2010 |
Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures.
Topics: Anticonvulsants; Child; Electroencephalography; Female; Fever; Humans; Phenobarbital; Seizures; Stat | 2011 |
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bumetanide; Cell Count; | 2010 |
Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Liver Diseases; Male; Phenobarbital; Portal Sy | 2010 |
Effectiveness and safety of non-intravenous high-dose phenobarbital therapy for intractable epilepsy during childhood.
Topics: Child; Child, Preschool; Epilepsies, Partial; Female; Humans; Infant; Male; Phenobarbital; Retrospec | 2011 |
Unilateral continuous subclinical paroxysmal activity: an unusual finding in a patient with recurrent absence status.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Diagnosis, Differential; Dose-Response Relationship, D | 2010 |
Status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Clinical Protocols; Fructose; GABA Modulators; Humans; Keta | 2011 |
[Clinical trials of intravenous phenobarbital for the establishment of evidence-based standard treatment for status epilepticus in Japan].
Topics: Evidence-Based Medicine; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Japan; Mal | 2011 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal | 2002 |
Sedative use in the last week of life and the implications for end-of-life decision making.
Topics: Adult; Aged; Anticonvulsants; Decision Making; Delirium; Double Effect Principle; Ethics, Clinical; | 2003 |
[Three cases with severe motor and intellectual disabilities presenting the severest condition caused by prolonged non-convulsive status epilepticus].
Topics: Child, Preschool; Disabled Children; Disease Progression; Electroencephalography; Female; Humans; In | 2003 |
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome.
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pai | 2003 |
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS].
Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate; | 1963 |
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti | 1965 |
Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats.
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Calcium Channel Blockers; Drug Therapy, Comb | 2004 |
Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug R | 2004 |
Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.
Topics: Acute Disease; Aggression; Animals; Anticonvulsants; Creatine; Creatinine; Dietary Supplements; Emot | 2004 |
Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Drug Resis | 2005 |
Withdrawal of parenteral phenobarbitone--implications for resource-poor countries.
Topics: Algorithms; Anticonvulsants; Child; Developing Countries; Drug Industry; Health Services Accessibili | 2005 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
Treatment delay and the risk of prolonged status epilepticus.
Topics: Administration, Rectal; Anticonvulsants; Benzodiazepines; Child, Preschool; Clinical Protocols; Dise | 2005 |
[Management of status epilepticus].
Topics: Adult; Age Factors; Aged; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Diazepam; Dr | 2005 |
Status epilepticus -- a plea for phenobarbitone.
Topics: Anticonvulsants; Drug Industry; Health Services Accessibility; Humans; Organizational Policy; Phenob | 2005 |
Very-high-dose phenobarbital for childhood refractory status epilepticus.
Topics: Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephal | 2006 |
When benzodiazepines fail: how effective is second line therapy for status epilepticus in children?
Topics: Anesthetics; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Diazepam; Dose-Response Rela | 2006 |
I.v. phenobarbitone shock.
Topics: Anticonvulsants; Child; Drug Industry; Humans; Injections, Intravenous; Marketing; Phenobarbital; So | 2006 |
Treatment of status epilepticus in adults: guidelines of the Italian League against Epilepsy.
Topics: Adult; Age Factors; Anesthesia, General; Anticonvulsants; Benzodiazepines; Humans; International Age | 2006 |
Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug R | 2007 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Ga | 2007 |
Pott puffy tumor in a 4-year-old boy presenting in status epilepticus.
Topics: Anti-Bacterial Agents; Anticonvulsants; Child, Preschool; Craniotomy; Drainage; Epidural Abscess; Fr | 2007 |
Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Data Int | 2008 |
[Retrospective study of the usefulness of phenobarbital injection in children].
Topics: Anticonvulsants; Child, Preschool; Humans; Infant; Infant, Newborn; Injections, Intravenous; Phenoba | 2008 |
Very high dose phenobarbital for refractory status epilepticus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Male; Middle Aged; Phen | 2007 |
Lorazepam in therapy for status epilepticus.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Apnea; Drug Therapy, Combination; Humans; Hypotension; Loraz | 1980 |
A monkey model for status epilepticus: carbamazepine and valproate compared to three standard anticonvulsants.
Topics: Aluminum Hydroxide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Macaca mulatta; Male; Phenoba | 1983 |
Barbiturates in the treatment of status epilepticus.
Topics: Anesthesia; Animals; Haplorhini; Humans; Kinetics; Phenobarbital; Status Epilepticus | 1983 |
Tonic status epilepticus presenting as confusional state.
Topics: Adolescent; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Humans; Male; Methylph | 1983 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Statu | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Pharmacologic therapy of seizures in the elderly.
Topics: Aged; Anticonvulsants; Carbamazepine; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Status | 1984 |
Neonatal status epilepticus II: Electroencephalographic aspects.
Topics: Electroencephalography; Follow-Up Studies; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Status | 1984 |
Status epilepticus.
Topics: Diazepam; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1983 |
Pharmacokinetics of paraldehyde disposition in the neonate.
Topics: Female; Humans; Infant, Newborn; Infusions, Parenteral; Kinetics; Male; Metabolic Clearance Rate; Pa | 1984 |
Status epilepticus.
Topics: Anesthesia, General; Child; Child, Preschool; Diazepam; Epilepsies, Myoclonic; Epilepsies, Partial; | 1980 |
Therapy of status epilepticus.
Topics: Anticonvulsants; Diazepam; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; Lorazepam; Paraldehy | 1982 |
Treatment of status epilepticus in adults.
Topics: Acid-Base Equilibrium; Adult; Bicarbonates; Critical Care; Diazepam; Electrocardiography; Electroenc | 1983 |
General principles of treatment: status epilepticus in neonates.
Topics: Diagnosis, Differential; Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital | 1983 |
Efficacy of phenytoin in treatment of status epilepticus.
Topics: Brain; Diazepam; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1983 |
Identification and treatment of status epilepticus.
Topics: Diazepam; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1980 |
Current concepts in neurology: management of status epilepticus.
Topics: Anticonvulsants; Diazepam; Drug Administration Schedule; Humans; Lorazepam; Phenobarbital; Phenytoin | 1982 |
Current treatment of status epilepticus.
Topics: Adult; Anticonvulsants; Child; Diagnosis, Differential; Diazepam; Humans; Hysteria; Injections, Intr | 1981 |
Therapy for status epilepticus.
Topics: Diazepam; Drug Therapy, Combination; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1980 |
[Management of the status epilepticus].
Topics: Anticonvulsants; Humans; Injections, Intravenous; Lidocaine; Phenobarbital; Phenytoin; Status Epilep | 1980 |
The use of felbamate in patients with periodic lateralized epileptiform discharges (PLEDs).
Topics: Anticonvulsants; Dominance, Cerebral; Dose-Response Relationship, Drug; Drug Therapy, Combination; E | 1995 |
A new, non-pharmacologic model of convulsive status epilepticus induced by electrical stimulation: behavioral/electroencephalographic observations and response to phenytoin and phenobarbital.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epi | 1994 |
Prolonged pentobarbital and phenobarbital coma for refractory generalized status epilepticus.
Topics: Adolescent; Coma; Electrocardiography; Humans; Male; Pentobarbital; Phenobarbital; Status Epilepticu | 1995 |
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Electroenc | 1994 |
Mexiletine overdose producing status epilepticus without cardiovascular abnormalities.
Topics: Adult; Blood Pressure; Cardiovascular System; Diazepam; Drug Overdose; Drug Therapy, Combination; El | 1994 |
Acute encephalopathy and status epilepticus associated with human herpes virus 6 infection.
Topics: Comorbidity; Electroencephalography; Encephalitis; Exanthema Subitum; Fever; Herpesviridae Infection | 1994 |
Phenobarbital modifies seizure-related brain injury in the developing brain.
Topics: Aging; Analysis of Variance; Animals; Brain Diseases; Kainic Acid; Male; Phenobarbital; Rats; Rats, | 1994 |
Phenobarbital bolus dose for status epilepticus.
Topics: Humans; Phenobarbital; Status Epilepticus | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female | 1993 |
Effects of long barbiturate anaesthesia on eight children with severe epilepsy.
Topics: Anesthesia, General; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsies | 1993 |
Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Hypersensitivity; Female; Hospitals, Pediatric; Ho | 1993 |
Generalized convulsive status epilepticus.
Topics: Adolescent; Adult; Aged; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy, Generalized | 1996 |
Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus.
Topics: Adult; Anesthetics, Intravenous; Electroencephalography; Humans; Hypotension; Infusions, Intravenous | 1996 |
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; | 1996 |
Status epilepticus following intravenous N-acetylcysteine therapy.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Anticonvulsants; Blindness; Child, Preschoo | 1996 |
[A case of adult Reye's syndrome with favorable outcome despite status epilepticus].
Topics: Adolescent; Anticonvulsants; Humans; Male; Phenobarbital; Reye Syndrome; Status Epilepticus | 1996 |
Nonconvulsive status epilepticus.
Topics: Anticonvulsants; Dizziness; Electroencephalography; Emergency Service, Hospital; Epilepsy, Tonic-Clo | 1997 |
Status epilepticus.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Humans; Infusions, Intravenous; Lorazepam; P | 1998 |
The use of propofol to treat status epilepticus in a nine-month-old female patient.
Topics: Drug Therapy, Combination; Female; Humans; Hypnotics and Sedatives; Infant; Phenobarbital; Propofol; | 1998 |
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; | 1998 |
Valproate-induced epileptic tonic status.
Topics: Adolescent; Ammonia; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epilepsy, T | 1998 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippo | 1998 |
Phenytoin, phenobarbital, and midazolam fail to stop status epilepticus-like activity induced by low magnesium in rat entorhinal slices, but can prevent its development.
Topics: Animals; Anticonvulsants; Carbamazepine; Culture Techniques; Dose-Response Relationship, Drug; Drug | 1998 |
Initial treatment of generalized convulsive status epilepticus.
Topics: Adolescent; Adult; Anticonvulsants; Diazepam; Double-Blind Method; Electroencephalography; Emergenci | 1999 |
Camphor toxicity.
Topics: Anticonvulsants; Antidotes; Camphor; Charcoal; Consumer Product Safety; Diazepam; Female; Humans; In | 1999 |
Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y.
Topics: Acute Disease; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Colchicine; Elect | 1999 |
Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995).
Topics: Animals; Anticonvulsants; Bromides; Cerebrospinal Fluid; Diazepam; Dog Diseases; Dogs; Female; Male; | 1999 |
[Phenobarbital coma for psychogenic status epilepticus].
Topics: Adult; Anticonvulsants; Coma; Female; Humans; Male; Phenobarbital; Psychophysiologic Disorders; Stat | 2000 |
[Treatment of status epilepticus in a developing country].
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; D | 2000 |
Ketamine controls prolonged status epilepticus.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Drug Resistance; Electric Stimulation; Electroencephalogr | 2000 |
Treatment of nonfebrile status epilepticus in Rochester, Minn, from 1965 through 1984.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; D | 2001 |
Infantile status epilepticus in Tunisia. Clinical, etiological and prognostic aspects.
Topics: Anticonvulsants; Central Nervous System Infections; Chi-Square Distribution; Child, Preschool; Clona | 2001 |
[Non-intravenous high-dose phenobarbital therapy for status epilepticus refractory to continuous infusion of midazolam or pentobarbital: report of three cases].
Topics: Adult; Anticonvulsants; Child, Preschool; Electroencephalography; Female; Humans; Infant; Infusions, | 2002 |
Phenobarbital and MK-801, but not phenytoin, improve the long-term outcome of status epilepticus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Chronic Disease; Dizocilpine Maleate; Excitatory Amino A | 2002 |
Use of high dosage phenobarbital in the treatment of neonatal status epilepticus: a preliminary report.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Status Epilepticus | 1979 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1979 |
Medical treatment of epilepsy: Part II.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep | 1978 |
Behavioral analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Clonazepam; Diazepam; Dogs; Electric St | 1979 |
Status epilepticus in pregnancy: effect of phenytoin malabsorption on seizure control.
Topics: Administration, Oral; Adult; Female; Humans; Intestinal Absorption; Phenobarbital; Phenytoin; Postpa | 1978 |
Drug therapy of status epilepticus.
Topics: Acetazolamide; Diazepam; Humans; Lidocaine; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepticu | 1978 |
[Antiepileptic emergency therapy in the adult age].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Phenobarbi | 1978 |
[Status epilepticus].
Topics: Diazepam; Humans; Phenobarbital; Status Epilepticus | 1977 |
Status epilepticus.
Topics: Adult; Amobarbital; Diazepam; Humans; Male; Phenobarbital; Phenytoin; Status Epilepticus | 1976 |
A model of status epilepticus induced by intermittent electrical stimulation of the deep prepyriform cortex in rats.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electro | 1992 |
Report of a case of phenobarbital-induced dystonia.
Topics: Dystonia; Female; Humans; Infant; Phenobarbital; Status Epilepticus | 1992 |
[Effect of anticonvulsants upon experimental limbic seizure status and regional cerebral blood flow in the hippocampus].
Topics: Animals; Anticonvulsants; Cats; Diazepam; Electroencephalography; Hippocampus; Isoxazoles; Phenobarb | 1992 |
[Convulsive status].
Topics: Diazepam; Humans; Lorazepam; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepticus | 1990 |
Status epilepticus following the oral ingestion of cocaine in an infant.
Topics: Cocaine; Diagnosis, Differential; Diazepam; Electroencephalography; Emergencies; Humans; Infant; Mal | 1990 |
The use of free phenytoin levels in averting phenytoin toxicity.
Topics: Adult; Female; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1990 |
Pharmacokinetics and clinical use of parenteral phenytoin, phenobarbital, and paraldehyde.
Topics: Humans; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepticus | 1989 |
Phenobarbital for status.
Topics: Humans; Phenobarbital; Status Epilepticus | 1989 |
[Grand mal seizures and status epilepticus in general practice-- what's to be done?].
Topics: Adult; Aged; Child, Preschool; Clonazepam; Diazepam; Emergencies; Epilepsy, Tonic-Clonic; Family Pra | 1986 |
Epilepsy in infancy.
Topics: Epilepsy; Humans; Infant; Infant, Newborn; Phenobarbital; Status Epilepticus | 1988 |
Very-high-dose phenobarbital for refractory status epilepticus in children.
Topics: Blood Pressure; Child; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Phenobarbi | 1988 |
Phenobarbital for status epilepticus.
Topics: Drug Therapy, Combination; Humans; Phenobarbital; Phenytoin; Status Epilepticus | 1988 |
[Nonconvulsive status epilepticus in relation to phenobarbital poisoning].
Topics: Child; Electroencephalography; Humans; Male; Phenobarbital; Seizures; Status Epilepticus | 1987 |
Brain phenobarbital uptake during prolonged status epilepticus.
Topics: Animals; Bicuculline; Blood; Blood Pressure; Blood-Brain Barrier; Brain; Cerebrovascular Circulation | 1987 |
The electro-encephalogram in the term neonate. Case reports.
Topics: Cerebral Palsy; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Ph | 1986 |
Status epilepticus.
Topics: Adult; Aged; Anticonvulsants; Diazepam; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; | 1985 |
Influence of the blood-brain pH gradient on brain phenobarbital uptake during status epilepticus.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain; Hydrogen-Ion Concentration; Kinetics; Male; Phe | 1985 |
Status epilepticus in pregnancy. A case report.
Topics: Adolescent; Diazepam; Female; Humans; Infusions, Parenteral; Phenobarbital; Phenytoin; Pregnancy; Pr | 1985 |
Status epilepticus.
Topics: Anesthesia, General; Child; Diazepam; Humans; Paraldehyde; Phenobarbital; Phenytoin; Status Epilepti | 1985 |