phenobarbital has been researched along with Seizures in 1210 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "previous studies have shown that phenobarbital (PB) is a effective and safe drug in the treatment of benign convulsions with mild gastroenteritis (CwG), but there is a lack of large sample prospective randomized controlled study of different doses." | 9.51 | Efficacy and safety of phenobarbital for benign convulsions with mild gastroenteritis: A prospective randomized controlled study. ( Chen, H; Chen, Y; Xie, J; Yi, Z; Yu, X; Zha, J; Zhong, J, 2022) |
| "Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures." | 9.41 | Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023) |
| "The study was a multicenter, randomized, blinded, controlled, phase IIb trial investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment for neonatal seizures of any cause." | 9.34 | Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial. ( Arnell, K; Battin, MR; Bridge, R; Davis, SL; Ernstrom, K; Gold, JJ; Haas, RH; Harbert, MJ; Honold, J; Joe, P; Kim, J; Knodel, E; Kuperman, R; Lane, B; Le, NM; Lee, L; Michelson, D; Mower, A; Nespeca, M; Raman, R; Rasmussen, M; Reiner, GE; Rismanchi, N; Sharpe, C; Wang, S, 2020) |
| "Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression." | 9.30 | A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. ( Abdel Baki, SG; Birbeck, GL; Capparelli, EV; Dzinjalamala, FK; Gardiner, JC; Herman, ST; Mallewa, M; Postels, DG; Seydel, KB; Taylor, TE; Toto, NM, 2019) |
| "This study was performed to evaluate the efficacy and safety of intravenous phenobarbital (PB) for benign convulsions with mild gastroenteritis (CwG)." | 9.30 | Efficacy of phenobarbital for benign convulsions with mild gastroenteritis: A randomized, placebo-controlled trial. ( Nakagawa, T; Takami, Y, 2019) |
| "To evaluate the efficacy of Levetiracetam in the management of neonatal seizures." | 9.22 | Efficacy of Levetiracetam in neonatal seizures: a systematic review. ( Hussain, AM; Sharma, D; Sharma, SS, 2022) |
| "To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates." | 9.22 | Efficacy and safety of levetiracetam in the management of seizures in neonates. ( Asadi, F; Moradian, M; Moradian, N; Sedighi, M; Vakiliamini, M, 2016) |
| "Preclinical data suggest that the loop-diuretic bumetanide might be an effective treatment for neonatal seizures." | 9.20 | Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. ( Blennow, M; Boylan, GB; Chiron, C; Cross, JH; de Vries, LS; Hallberg, B; Hellström-Westas, L; Jullien, V; Livingstone, V; Mangum, B; Marlow, N; Murphy, B; Murray, D; Pons, G; Pressler, RM; Rennie, J; Swarte, R; Toet, MC; Vanhatalo, S; Zohar, S, 2015) |
| "To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates." | 9.17 | Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial. ( Chawla, D; Goel, SP; Pathak, G; Pathak, U; Upadhyay, A, 2013) |
| "Nineteen term asphyxiated newborns treated with mild whole body hypothermia, started within 6 h after birth and protracted for 72 h, received phenobarbital for clinical seizures." | 9.15 | Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia. ( Cavallaro, G; Donzelli, G; Favelli, F; Filippi, L; Fiorini, P; Guerrini, R; la Marca, G; Malvagia, S, 2011) |
| "While phenobarbital (PB) is commonly used for the management of seizures in newborns and pediatrics, its administration may accompany acute poisoning." | 9.12 | Acute Phenobarbital Poisoning for the Management of Seizures in Newborns and Children; A Systematic Literature Review. ( Balali-Mood, M; Darchini-Maragheh, E; Ghorani-Azam, A; Riahi-Zanjani, B; Sadeghi, M, 2021) |
| "This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years." | 9.12 | Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. ( Guillet, R; Kwon, J, 2007) |
| "To determine the potential effectiveness of phenytoin (PHT) in preventing early postoperative seizures in patients undergoing craniotomy for supratentorial brain tumors." | 9.10 | Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study. ( De Santis, A; Perucca, E; Sinisi, M; Stocchetti, N; Villani, R, 2002) |
| "Seizures were controlled in 13 of the 30 neonates assigned to receive phenobarbital (43 percent) and 13 of the 29 neonates assigned to receive phenytoin (45 percent; P=1." | 9.09 | Phenobarbital compared with phenytoin for the treatment of neonatal seizures. ( Alvin, J; Armatti, S; Gardiner, JC; Minnigh, B; Painter, MJ; Paneth, N; Scher, MS; Stein, AD; Wang, Z, 1999) |
| "Children with cerebral malaria admitted to one hospital in Kilifi, Kenya, were randomly assigned a single intramuscular dose of phenobarbital (20 mg/kg) or identical placebo." | 9.09 | Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study. ( Crawley, J; Marsh, K; Mithwani, S; Mwangi, I; Ouma, D; Peto, T; Waruiru, C; Watkins, W; Winstanley, P, 2000) |
| "To determine the efficacy of pyridoxine in treating seizures, 90 infants and children with recurrent convulsions primarily due to acute infectious diseases were enrolled in the present study." | 9.08 | Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. ( Bai, AN; Cao, YM; Chui, W; Gao, DY; Ge, ZL; Jiao, FY; Li, HR; Lieu, NS; Liu, SB; Liu, ZY; Takuma, Y; Wu, S; Zhang, XK, 1997) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 8.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the effects of phenobarbitone compared to phenytoin when used as monotherapy in patients with partial onset seizures or generalized tonic-clonic seizures with or without other generalized seizure types." | 8.81 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Taylor, S; Tudur Smith, C; Williamson, PR, 2001) |
| "Although phenobarbital (PB) is commonly used as a first-line antiseizure medication (ASM) for neonatal seizures, in 2015 we chose to replace it with levetiracetam (LEV), a third-generation ASM." | 8.31 | Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. ( Bättig, L; Cserpan, D; Dünner, C; Hagmann, C; Pisani, F; Ramantani, G; Rüegger, A; Schmitt, B, 2023) |
| "To investigate caregivers' assessments of outcome in dogs with idiopathic epilepsy (IE) administered levetiracetam (LEV), zonisamide (ZNS), or phenobarbital (PB) monotherapy." | 8.31 | Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy. ( Gristina, BR; Muñana, KR; Nettifee, JA; Waldron, RJ, 2023) |
| "Phenobarbital (PB) q12h is the most common treatment recommendation for cats with recurrent epileptic seizures." | 8.31 | Once-a-day oral treatment with phenobarbital in cats with presumptive idiopathic epilepsy. ( De Decker, S; Mojarradi, A; Van Meervenne, S, 2023) |
| "Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions." | 8.12 | Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. ( Karbwang, J; Na-Bangchang, K; Rajoli, RKR; Sae-Heng, T; Siccardi, M, 2022) |
| " Bernard-mastiff crossbred dog showed clinical signs of lethargy and anorexia after being administered phenobarbital for the treatment of idiosyncratic seizures." | 8.02 | Pancytopenia secondary to suspected idiosyncratic phenobarbital reaction in a dog. ( Oberholster, O, 2021) |
| "Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult." | 8.02 | Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021) |
| "Bumetanide was suggested as an adjunct to phenobarbital for suppression of neonatal seizures." | 8.02 | A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia. ( Gailus, B; Gericke, B; Johne, M; Käufer, C; Löscher, W; Römermann, K, 2021) |
| "To compare the safety and efficacy of phenobarbital and levetiracetam in a cohort of neonates with seizures following cardiac surgery." | 7.96 | A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates. ( Abend, NS; Gaynor, JW; Licht, DJ; Massey, SL; Naim, MY; Thibault, C; Xiao, R, 2020) |
| "This study aims to compare the neurocognitive outcome in term infants who were treated using phenobarbital (PB) and levetiracetam (LEV) monotherapy for neonatal clinical seizures." | 7.96 | Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures. ( Akbay, S; Akkaya Inal, M; Arican, P; Cavusoglu, D; Gencpinar, P; Mete Atasever, N; Olgac Dundar, N; Tekgul, H, 2020) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 7.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| "Many neonates with hypoxic ischemic encephalopathy and seizures do not respond to the first line antiepileptic drug, phenobarbital." | 7.91 | Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures. ( Dwivedi, D; Holland, K; Kline-Fath, B; Lin, N; Schapiro, M; Venkatesan, C, 2019) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 7.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| "The aim of this study was to evaluate changes in epileptic seizures (ES) frequency and semiology in antiepileptic-medication (AEM)-naïve dogs with idiopathic epilepsy (DIE) after initiation of imepitoin (IMP) or phenobarbital (PB) monotherapy." | 7.91 | Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy. ( Barnett, CR; De Risio, L; Stabile, F; van Dijk, J, 2019) |
| "Neonatal seizures are treated with phenobarbital and prolonged treatment does not prevent postneonatal epilepsy." | 7.88 | Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures. ( Beatty, CW; Gust, J; Hamiwka, L; Natarajan, N, 2018) |
| "Levetiracetam can be a good and safe choice for treatment of neonatal seizures in preterm infants." | 7.88 | Efficacy of levetiracetam for neonatal seizures in preterm infants. ( Han, JY; Lee, IG; Moon, CJ; Sung, IK; Youn, YA, 2018) |
| "Modeling and simulations were used to support body weight-based dose selection for eslicarbazepine acetate (ESL) in pediatric subjects aged 4-17 years with partial-onset seizures." | 7.88 | Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures. ( Blum, D; Fiedler-Kelly, J; Galluppi, G; Hopkins, S; Ludwig, E; Sunkaraneni, S, 2018) |
| "Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epilepsy resistant to a maximum dose of imepitoin." | 7.85 | Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency. ( Bhatti, SFM; Broeckx, BJG; Martlé, V; Royaux, E; Stee, K; Van Ham, L, 2017) |
| "CYT-evoked alterations in the protection provided by some antiepileptic drugs against seizures can be of serious concern for epileptic smokers, who might demonstrate therapeutic failure to lacosamide, levetiracetam, and pregabalin, resulting in possible breakthrough seizure attacks." | 7.85 | Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. ( Florek-Łuszczki, M; Kondrat-Wróbel, MW; Tutka, P; Zaluska, K; Żółkowska, D; Łuszczki, JJ, 2017) |
| "The objective of this study was to determine the efficacy and safety of levetiracetam in treatment of neonatal seizures due to hypoxic ischemic encephalopathy." | 7.85 | Levetiracetam for the Treatment of Seizures in Neonatal Hypoxic Ischemic Encephalopathy. ( Schapiro, M; Thomas, C; Venkatesan, C; Young, S, 2017) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 7.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| "We reviewed data on children (aged<15 years) with focal seizures treated with high-dose phenobarbital (>5 mg/kg/day to maintain a target serum level >40 μg/mL) for at least 6 months." | 7.83 | Efficacy and tolerability of high-dose phenobarbital in children with focal seizures. ( Abe, S; Igarashi, A; Ikeno, M; Nakahara, E; Nakazawa, M; Okumura, A; Shimizu, T; Takasu, M, 2016) |
| " Seizures were controlled with phenobarbital (6 mg/kg IM q 12 h) and propofol CRI (0." | 7.83 | Successful treatment of refractory seizures with phenobarbital, propofol, and medetomidine following congenital portosystemic shunt ligation in a dog. ( Giordano, P; Heidenreich, DC; Kirby, BM, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Background Phenobarbital is the first-line choice for neonatal seizures treatment, despite a response rate of approximately 45%." | 7.83 | Phenobarbital for Neonatal Seizures: Response Rate and Predictors of Refractoriness. ( Mazzotta, S; Pavlidis, E; Pelosi, A; Pisani, F; Seri, S; Spagnoli, C, 2016) |
| "To clarify the effect of levetiracetam (LEV) for acute and chronic seizure control in acute encephalitis with refractory, repetitive partial seizures (AERRPS)." | 7.81 | Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase. ( Imamura, A; Maegaki, Y; Maruta, K; Matsunami, K; Narita, A; Nishimura, Y; Ohno, K; Saiki, Y; Saito, Y; Sokota, T; Sugihara, S; Tamasaki, A; Ueda, R, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "5 wk), 61 phenobarbital doses and 40 seizures were analyzed." | 7.81 | Phenobarbital and neonatal seizures affect cerebral oxygen metabolism: a near-infrared spectroscopy study. ( Barks, JD; Chervin, RD; Plegue, MA; Shellhaas, RA; Sokoloff, MD, 2015) |
| "To determine the percentage of cats with a phenobarbital (PB) concentration between 15 and 45 μg/mL that had a ≥ 50% reduction in the number of seizures and to investigate applicability of the 2011 International League Against Epilepsy (ILAE) classification system in cats." | 7.80 | Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004-2013). ( Barnes Heller, HL; Finnerty, KE; Giovanella, CJ; Lau, VW; Mercier, MN; Rylander, H, 2014) |
| "Pellagra is caused by deficiency of niacin or its precursor tryptophan." | 7.80 | Phenobarbital-induced pellagra resulted in death. ( Aydin, F; Cengiz, N; Onar, MK; Pancar Yuksel, E; Sen, N; Sen, S; Senturk, N, 2014) |
| "Levetiracetam (LEV) and tiagabine (TGB) are utilized for the treatment of seizures, including neonatal seizures." | 7.80 | Profile of anticonvulsant action of levetiracetam, tiagabine and phenobarbital against seizures evoked by DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in neonatal rats. ( Beck, VC; Forcelli, PA; Gutherz, SB; Kulick, CV; Medvedeva, N; Soper, C, 2014) |
| " In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures." | 7.80 | Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure. ( Albertini, G; De Sarro, G; Gallelli, L; Gratteri, S; Iemolo, F; Manes, MT; Mercuri, NB; Quirino, G; Sanzaro, E; Scaglione, F; Siniscalchi, A, 2014) |
| " The most common cause of neonatal seizures is hypoxic encephalopathy, and here we show in an established model of neonatal hypoxia-induced seizures that the NKCC1 inhibitor, bumetanide, in combination with phenobarbital is significantly more effective than phenobarbital alone." | 7.79 | Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. ( Berry, G; Cleary, RT; Huynh, T; Jackson, M; Jensen, FE; Kahle, KT; Li, Y; Manning, SM; Rakhade, SN; Rotenberg, A; Sun, H; Talos, DM, 2013) |
| "In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010." | 7.79 | Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013) |
| "Compare neurodevelopment after levetiracetam (LEV) and phenobarbital (PB) for neonatal seizures." | 7.79 | Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. ( Maitre, NL; Slaughter, JC; Smolinsky, C; Stark, AR, 2013) |
| "We investigated the effectiveness of intravenous injection of phenobarbital (PB) in patients referred to Himeji Red Cross Hospital, Hyogo, Japan, with benign convulsions with mild gastroenteritis (CwG) between November 2009 and June 2011." | 7.78 | [Intravenous injection of phenobarbital for benign convulsions with mild gastroenteritis]. ( Ban, H; Takami, Y, 2012) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 7.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| "This case is the first report of a patient who had phenobarbital (PB) withdrawal seizures after having been seizure-free for 3 years following temporal lobe surgery." | 7.75 | Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism. ( Bidlack, JM; Morris, HH, 2009) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 7.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "Since the survey of practices 15 years ago, child neurologists and neonatologists are reporting less frequent and shorter phenobarbital treatment after resolution of neonatal seizures, although there remains considerable variation in practices." | 7.74 | Prophylactic phenobarbital administration after resolution of neonatal seizures: survey of current practice. ( Guillet, R; Kwon, JM, 2008) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 7.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 7.73 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "An 11-month-old boy with multiple surface anomalies and respiratory distress due to upper airway narrowing developed generalized tonic seizures coinciding with apnea." | 7.73 | [High-dose phenobarbital therapy is effective for the control of intractable tonic seizure with apnea in a case of multiple anomalies syndrome]. ( Hayashi, T; Horio, K; Kubota, M; Mimaki, M; Tomita, S, 2006) |
| "Questionnaires were mailed to owners of 29 dogs under management for suspected or diagnosed idiopathic epilepsy through the clinics of the Small Animal Hospital of the University of Glasgow Veterinary School, using either phenobarbitone or potassium bromide alone or in combination." | 7.73 | Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. ( Anderson, TJ; Chang, Y; Mellor, DJ, 2006) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 7.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "To examine the interactions of allopregnanolone and phenobarbital for the protection against seizures." | 7.71 | Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice. ( Lu, YQ; Yu, R, 2001) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 7.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 7.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions." | 7.69 | Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994) |
| "We evaluated the anticonvulsive effects of phenobarbital (PB) and zonisamide (ZNS) in the EL mouse, a strain that is highly susceptible to seizures." | 7.69 | Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse. ( Akasaki, Y; Nagase, F; Nagatomo, I; Nomaguchi, M; Takigawa, M, 1996) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 7.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 7.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 7.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 7.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 7.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 7.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 7.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children." | 7.68 | Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991) |
| ") of 9 severely asphyxiated newborns, under artificial ventilation, with neonatal seizures resistant to phenobarbital, is reported in this pilot study." | 7.68 | Thiopental efficacy in phenobarbital-resistant neonatal seizures. ( Bonati, M; Celardo, A; De Capitani, E; Marraro, G; Passerini, F; Schieroni, F; Spada, P; Valsecchi, R, 1990) |
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 7.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| "We report four cases of unexpected cocaine intoxication in children manifested by the sudden development of seizures." | 7.67 | Unexpected cocaine intoxication presenting as seizures in children. ( Ernst, AA; Sanders, WM, 1989) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 7.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| "Glutamic acid diethyl ester (GDEE) is a glutamate antagonist which acts preferentially at the quisqualate-sensitive receptor and has been shown to be an effective anticonvulsant in alcohol withdrawal and homocysteine-induced seizures but ineffective in other seizure models." | 7.67 | Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs. ( Freed, WJ; Schwarz, SS, 1986) |
| "We evaluated the efficacy of pretreatment with phenytoin and phenobarbital to prevent seizures in mice given convulsive doses of theophylline." | 7.67 | Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice. ( Blake, KV; Hendeles, L; Massey, KL; Neims, A; Nickerson, D, 1988) |
| "Although phenobarbital is the most widely used drug to control seizures, dosage guidelines are not available for infants of varying gestational ages." | 7.67 | Developmental aspects of phenobarbital dosage requirements in newborn infants with seizures. ( Edwards, RC; Masuoka, T; Nahata, MC, 1988) |
| "To determine the effect of phenobarbital sodium therapy and subependymal intraventricular hemorrhage (SEp-IVH) on the theophylline requirement of premature infants suffering with apnea and seizure activity, we compared three groups of patients as follows: group 1, those with apnea of prematurity (ten patients); group 2, those with apnea and SEp-IVH (ten patients); and group 3, those with apnea, SEp-IVH, and seizure activity for which they were receiving phenobarbital therapy (nine patients)." | 7.67 | Phenobarbital increases the theophylline requirement of premature infants being treated for apnea. ( Gottschalk, SK; Kissling, GE; Schuth, CR; Tran, TH; Yazdani, M, 1987) |
| "Acute exposure to dieldrin (HEOD) causes hyperglycemia and death in the adult rat." | 7.67 | Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats. ( Fox, GR; Virgo, BB, 1986) |
| "The changes in cerebral blood flow (CBF) during and after bicuculline-induced seizures were studied by the radioactive microsphere technique in 12 newborn, urethan-anesthetized piglets, 6 piglets pretreated with phenobarbital (10 mg/kg) and 6 without phenobarbital." | 7.67 | Regional cerebral blood flow during bicuculline-induced seizures in the newborn piglet: effect of phenobarbital. ( Clozel, M; Daval, JL; Dubruc, C; Monin, P; Morselli, PL; Vert, P, 1985) |
| "The onset of clonic seizures induced by 3-mercaptopropionic acid (MP) was associated with an approximately 200% increase of cAMP and a 70% elevation of cGMP in the mouse cerebral cortex." | 7.66 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "Strychnine poisoning results in a predictable and treatable sequence of events involving blockade of the inhibitory neurotransmitter, extensor muscle spasms, seizures, and respiratory paralysis." | 7.66 | Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis. ( Boyd, RE; Brennan, PT; Deng, JF; Rochester, DF; Spyker, DA, 1983) |
| "Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures." | 7.66 | Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels. ( Boer, HR; Erkan, NV; Gal, P; Toback, J; Wells, TJ, 1982) |
| "An apparent case of carbamazepine-induced leukocytosis in a 26-year-old woman is presented." | 7.66 | Carbamazepine-induced leukocytosis. ( Murphy, JE; Springer, PK; Stewart, RB, 1980) |
| "A comparison was made of the effects of chronically administered diazepam and phenobarbital with those of elicited seizures on repeated acquisition learning in 3 prepubertal Papio papio." | 7.66 | Alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital. ( Killam, EK; Weinberger, SB, 1978) |
| " We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures." | 7.66 | Phenobarbital and diphenylhydantoin levels in neonates with seizures. ( MacDonald, H; Painter, MJ; Pippenger, C; Pitlick, W, 1978) |
| "Eight patients developed grand mal seizures during intravenous theophylline therapy." | 7.65 | Theophylline-induced seizures in adults. Correlation with serum concentrations. ( Cohn, WM; Matthay, RA; Neff, TA; Sutton, FD; Weinberger, MM; Zwillich, CW, 1975) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 7.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 6.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| "Five phenobarbital treated dogs were classified as true responders (≥50% reduction in seizures/month) whereas none of the levetiracetam treated dogs fulfilled this criterion." | 6.82 | A single-blinded phenobarbital-controlled trial of levetiracetam as mono-therapy in dogs with newly diagnosed epilepsy. ( Berendt, M; Fredsø, N; Møller, A; Sabers, A; Toft, N, 2016) |
| " However, these medications have several well-known adverse effects." | 6.77 | Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. ( Ashrafi, MR; Bavarian, B; Ghaempanah, M; Khosroshahi, N; Malamiri, RA; Nikkhah, A, 2012) |
| " Success of treatment correlated with higher dosing and serum levels." | 5.91 | Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis. ( Dimitriadis, K; Kunst, S; Madlener, M; Madžar, D; Malter, M; Meyer, L; Minnerup, J; Mueller, A; Neumann, B; Pelz, JO; Reindl, C; Rojo, M; Schmidbauer, ML, 2023) |
| "High neonatal seizure burden is associated with worsened neurodevelopmental outcomes." | 5.72 | Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. ( Knox, A; Limjoco, J; Rajamanickam, V; Verwoerd, C, 2022) |
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 5.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "Cysticercosis is a neglected tropical disease set as health priority by WHO." | 5.56 | [Disseminated cysticercosis affecting the brain, the eye and the skin on a Senegalese patient]. ( Diallo, K; Diallo, M; Dione, MAD; Diop, A; Manga, NM; Wembulua, BS, 2020) |
| "previous studies have shown that phenobarbital (PB) is a effective and safe drug in the treatment of benign convulsions with mild gastroenteritis (CwG), but there is a lack of large sample prospective randomized controlled study of different doses." | 5.51 | Efficacy and safety of phenobarbital for benign convulsions with mild gastroenteritis: A prospective randomized controlled study. ( Chen, H; Chen, Y; Xie, J; Yi, Z; Yu, X; Zha, J; Zhong, J, 2022) |
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 5.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| "Hypoxia-induced seizures (HS) during the neonatal period can also lead to spontaneous seizures in adulthood." | 5.48 | Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. ( Dunn, R; Forcelli, PA; Pak, DTS; Queenan, BN, 2018) |
| "Neonatal seizures have an incidence of 3." | 5.48 | Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12. ( Carter, BM; Kadam, SD; Landers, JR; Sullivan, BJ, 2018) |
| "Seizures are common in term infants with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia." | 5.48 | A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. ( Chanlaw, T; Cho, A; Garg, M; Hussain, SA; Rao, LM; Sankar, R; Zaki, T, 2018) |
| "Treatment with phenobarbital and potassium bromide completely terminated the seizures within 10days." | 5.43 | Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide. ( Itakura, A; Maegaki, Y; Nishimura, Y; Ohno, K; Okazaki, T; Saito, Y; Sejima, H; Yamamoto, T, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "After treatment, convulsions were suppressed and daily life continued, but intellectual impairment and high-level dysfunction remained." | 5.43 | High-dose phenobarbital with intermittent short-acting barbiturates for acute encephalitis with refractory, repetitive partial seizures. ( Endo, W; Haginoya, K; Kitamura, T; Nishio, T; Numata, Y; Ohura, T; Takayanagi, M; Uchida, T, 2016) |
| "Neonatal seizures are commonly associated with hypoxic-ischemic encephalopathy." | 5.42 | Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia. ( Johnston, MV; Kadam, SD; Kang, SK, 2015) |
| "Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures." | 5.41 | Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023) |
| " Phenobarbital versus levetiracetam as first-line ASM in EEG-confirmed neonatal seizures (one trial) Phenobarbital is probably more effective than levetiracetam in achieving seizure control after first loading dose (RR 2." | 5.41 | Anti-seizure medications for neonates with seizures. ( Abiramalatha, T; Brigo, F; Hartmann, H; Pressler, R; Ramaswamy, VV; Thanigainathan, S, 2023) |
| "All the seizure parameters were significantly reduced when phenobarbital (3 mg/kg) was administered prior to the application of the non-effective pattern of LFS." | 5.40 | Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats. ( Asgari, A; Atapour, N; Mirnajafi-Zadeh, J; Moradi, H; Semnanian, S; Shojaei, A, 2014) |
| "Phenobarbital (PB) was administrated at a very high daily dose up to 80 mg/kg, reaching serum trough level of 250 μg/ml, which was markedly effective to the treatment." | 5.40 | [A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy]. ( Aiba, H; Okumura, Y; Watanabe, S, 2014) |
| " The addition of CYP2C19 genotyping to PK models did not improve the dosing strategies in neonates and infants." | 5.38 | Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures. ( Chung, JY; Lee, C; Lee, SM; Lee, YM; Namgung, R; Park, KI; Park, MS, 2012) |
| "The study was a multicenter, randomized, blinded, controlled, phase IIb trial investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment for neonatal seizures of any cause." | 5.34 | Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial. ( Arnell, K; Battin, MR; Bridge, R; Davis, SL; Ernstrom, K; Gold, JJ; Haas, RH; Harbert, MJ; Honold, J; Joe, P; Kim, J; Knodel, E; Kuperman, R; Lane, B; Le, NM; Lee, L; Michelson, D; Mower, A; Nespeca, M; Raman, R; Rasmussen, M; Reiner, GE; Rismanchi, N; Sharpe, C; Wang, S, 2020) |
| "Seizures are commonly associated with hypoxic-ischemic encephalopathy." | 5.31 | Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde. ( Armstrong, DL; Battin, MR, 2001) |
| "Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression." | 5.30 | A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. ( Abdel Baki, SG; Birbeck, GL; Capparelli, EV; Dzinjalamala, FK; Gardiner, JC; Herman, ST; Mallewa, M; Postels, DG; Seydel, KB; Taylor, TE; Toto, NM, 2019) |
| "This study was performed to evaluate the efficacy and safety of intravenous phenobarbital (PB) for benign convulsions with mild gastroenteritis (CwG)." | 5.30 | Efficacy of phenobarbital for benign convulsions with mild gastroenteritis: A randomized, placebo-controlled trial. ( Nakagawa, T; Takami, Y, 2019) |
| "Phenobarbital (PB) has been traditionally used as the first-line treatment for neonatal seizures." | 5.30 | Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience. ( Barbagallo, M; Corsello, G; Falsaperla, R; Mauceri, L; Pavone, P; Pisani, F; Ruggieri, M; Vitaliti, G, 2019) |
| "Electroconvulsive shock (ECS) seizures provide an animal analog of electroconvulsive therapy (ECT)." | 5.30 | Ketamine and phenobarbital do not reduce the evoked-potential enhancement induced by electroconvulsive shock seizures in the rat. ( Burnham, WM; Cottrell, GA; Gombos, Z; Mendonça, A, 1999) |
| "Phenobarbital monotherapy was given to 20 patients with idiopathic generalized epilepsy beginning in childhood but persisting into adulthood." | 5.30 | Phenobarbital still has a role in epilepsy treatment. ( Lerman, P; Lerman-Sagie, T, 1999) |
| "Behavioral characteristics of seizures have age-dependent features, which suggests that effective treatment of seizures may be age-specific as well." | 5.29 | Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures. ( Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J, 1995) |
| " According to these values and assuming phenobarbital serum levels of 20 mg/l to be safe and effective in neonatal seizures, the initial dosing recommended is 2." | 5.29 | Dosage programming of phenobarbital in neonatal seizures. ( Alonso Gonzalez, AC; Dominguez-Gil Hurle, A; Garcia Sanchez, MJ; Monzon Corral, L; Ortega Valin, L; Santos Borbujo, J; Santos Buelga, D, 1993) |
| "Generalized convulsions were easily suppressed in the level of 15-25 micrograms/ml and afterdischarge was totally suppressed in 33% of cats in the level of 35-50 micrograms/ml in the hippocampal-kindled group." | 5.29 | [Different effects of chronically administered phenobarbital on amygdaloid- and hippocampal-kindled seizures in the cat]. ( Sumi, T, 1993) |
| "A lidocaine level was obtained at 4 h post-ingestion and was 0." | 5.28 | Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992) |
| "AOAA also induced clonic convulsions in mice subjected to intracerebroventricular administration of the drug with a CD50 of 0." | 5.28 | Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics. ( Calderazzo-Filho, LS; Cavalheiro, EA; Dziki, M; Turski, WA; Urbanska, E, 1991) |
| "Infants with refractory seizures received additional phenobarbital to a maximum serum concentration of 100 micrograms/mL." | 5.28 | Rapid sequential phenobarbital treatment of neonatal seizures. ( Duchowny, MS; Gal, P; Gilman, JT; Ransom, JL; Weaver, RL, 1989) |
| "Levetiracetam has been introduced for the control of seizures besides phenobarbital as monotherapy in children with epilepsy." | 5.27 | A Randomized Controlled Trial of Phenobarbital and Levetiracetam in Childhood Epilepsy. ( Akhter, S; Akter, N; Fatema, K; Rahman, MM, 2018) |
| "The ED50s to inhibit seizure pattern in EEG were 30." | 5.27 | Effects of certain antiepileptics on cephaloridine- and cefazolin-induced seizures in rats. ( Kamei, C; Sunami, A; Tasaka, K, 1983) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "Enprofylline, 27." | 5.27 | Effects of aminophylline and enprofylline on the protective activity of phenobarbital against amygdala-kindled seizures in rats. ( Czuczwar, SJ; Jäckel, R; Löscher, W, 1987) |
| "A retrospective study of neonatal seizures in a tertiary care neonatal intensive care unit determined a 3." | 5.27 | Efficacy of phenobarbital in neonatal seizures. ( Darwish, HZ; Van Orman, CB, 1985) |
| "Maximal seizures were induced with electroshock via corneal electrodes, and phenytoin anticonvulsant effects were determined by measuring the duration of tonic hindlimb extension (THE) and prevention of the THE." | 5.26 | A comparative study of the effects of phenytoin and phenobarbital on electrically induced maximal seizures in frogs and mice. ( Johnson, SW; Riker, WK, 1982) |
| "A total of 26 neonates with seizures had an EEG while on phenobarbital therapy." | 5.26 | Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. ( Bickford, RB; Coen, RW; Scholl, ML; Staudt, F, 1982) |
| " These recommendations provide initial maintenance dosage guidelines, which should be adjusted according to plasma concentrations and clinical effects." | 5.26 | Phenobarbital maintenance dose requirements in treating neonatal seizures. ( Fischer, JH; Kriel, R; Lockman, LA; Zaske, D, 1981) |
| "Phenytoin was found in higher concentration in gray matter, whereas phenobarbital was equally distributed between gray and white matter." | 5.26 | Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. ( Abern, S; Barmada, M; Carter, G; Painter, MJ; Pippenger, C; Pitlick, W; Wasterlain, C, 1981) |
| " The blood proportional to the dosage per kilogram, and was not related to weight or gestational age." | 5.26 | Phenobarbital dosage for control of neonatal seizures. ( Kriel, R; Lockman, LA; Thompson, T; Virnig, N; Zaske, D, 1979) |
| "Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC." | 5.26 | Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits. ( Consroe, P; Eisenstein, D; Martin, P, 1977) |
| "Of 290 children with an initial febrile convulsion, 216 met Livingston's criteria for a "simple" febrile convulsion and 74 for "epilepsy triggered by fever." | 5.26 | Effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in "simple" febrile convulsions and "epilepsy triggered by fever". ( Wolf, SM, 1977) |
| " For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration." | 5.25 | Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975) |
| "Based on low quality evidence, phenobarbital appears to be the most effective agent for seizure cessation within 60 min of administration in patients with benzodiazepine resistant status epilepticus." | 5.22 | Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses. ( Aneja, S; Arya, R; Cunningham, J; Jain, P; Sharma, S, 2022) |
| "This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies." | 5.22 | [Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022) |
| "To evaluate the efficacy of Levetiracetam in the management of neonatal seizures." | 5.22 | Efficacy of Levetiracetam in neonatal seizures: a systematic review. ( Hussain, AM; Sharma, D; Sharma, SS, 2022) |
| "To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates." | 5.22 | Efficacy and safety of levetiracetam in the management of seizures in neonates. ( Asadi, F; Moradian, M; Moradian, N; Sedighi, M; Vakiliamini, M, 2016) |
| "Seizures are a common cause of neurologic disease, and phenobarbital (PB) is the most commonly used antiepileptic drug." | 5.20 | Therapeutic serum phenobarbital concentrations obtained using chronic transdermal administration of phenobarbital in healthy cats. ( Barnes Heller, HL; Delamaide Gasper, JA; Robertson, M; Trepanier, LA, 2015) |
| "Preclinical data suggest that the loop-diuretic bumetanide might be an effective treatment for neonatal seizures." | 5.20 | Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. ( Blennow, M; Boylan, GB; Chiron, C; Cross, JH; de Vries, LS; Hallberg, B; Hellström-Westas, L; Jullien, V; Livingstone, V; Mangum, B; Marlow, N; Murphy, B; Murray, D; Pons, G; Pressler, RM; Rennie, J; Swarte, R; Toet, MC; Vanhatalo, S; Zohar, S, 2015) |
| "To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates." | 5.17 | Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial. ( Chawla, D; Goel, SP; Pathak, G; Pathak, U; Upadhyay, A, 2013) |
| "Nineteen term asphyxiated newborns treated with mild whole body hypothermia, started within 6 h after birth and protracted for 72 h, received phenobarbital for clinical seizures." | 5.15 | Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia. ( Cavallaro, G; Donzelli, G; Favelli, F; Filippi, L; Fiorini, P; Guerrini, R; la Marca, G; Malvagia, S, 2011) |
| "While phenobarbital (PB) is commonly used for the management of seizures in newborns and pediatrics, its administration may accompany acute poisoning." | 5.12 | Acute Phenobarbital Poisoning for the Management of Seizures in Newborns and Children; A Systematic Literature Review. ( Balali-Mood, M; Darchini-Maragheh, E; Ghorani-Azam, A; Riahi-Zanjani, B; Sadeghi, M, 2021) |
| "This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years." | 5.12 | Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. ( Guillet, R; Kwon, J, 2007) |
| "To study the effect of phenobarbital given within six hours of life to term and near-term asphyxiated neonates, on mortality, neurological abnormality at discharge and seizures." | 5.11 | A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy. ( Kumar, P; Narang, A; Singh, D, 2005) |
| "Phenobarbital is commonly used to treat status epilepticus in resource-poor countries." | 5.10 | Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions. ( Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Otieno, GO, 2003) |
| "To determine the potential effectiveness of phenytoin (PHT) in preventing early postoperative seizures in patients undergoing craniotomy for supratentorial brain tumors." | 5.10 | Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study. ( De Santis, A; Perucca, E; Sinisi, M; Stocchetti, N; Villani, R, 2002) |
| "Seizures were controlled in 13 of the 30 neonates assigned to receive phenobarbital (43 percent) and 13 of the 29 neonates assigned to receive phenytoin (45 percent; P=1." | 5.09 | Phenobarbital compared with phenytoin for the treatment of neonatal seizures. ( Alvin, J; Armatti, S; Gardiner, JC; Minnigh, B; Painter, MJ; Paneth, N; Scher, MS; Stein, AD; Wang, Z, 1999) |
| "Children with cerebral malaria admitted to one hospital in Kilifi, Kenya, were randomly assigned a single intramuscular dose of phenobarbital (20 mg/kg) or identical placebo." | 5.09 | Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study. ( Crawley, J; Marsh, K; Mithwani, S; Mwangi, I; Ouma, D; Peto, T; Waruiru, C; Watkins, W; Winstanley, P, 2000) |
| " The lack of consensus on prophylaxis of early postoperative seizures with phenytoin (PHT) may be due to the different dosages used in several studies, owing to inadequate therapeutic plasma level." | 5.08 | Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels. ( Boselli, L; Levati, A; Savoia, G; Tommasino, C; Zoppi, F, 1996) |
| "To determine the efficacy of pyridoxine in treating seizures, 90 infants and children with recurrent convulsions primarily due to acute infectious diseases were enrolled in the present study." | 5.08 | Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. ( Bai, AN; Cao, YM; Chui, W; Gao, DY; Ge, ZL; Jiao, FY; Li, HR; Lieu, NS; Liu, SB; Liu, ZY; Takuma, Y; Wu, S; Zhang, XK, 1997) |
| "To determine whether 40 mg/kg phenobarbital given to term infants with severe asphyxia would result in a lower incidence of seizures in the newborn period and an improved neurologic outcome." | 5.08 | High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up. ( Daily, DK; Hall, FK; Hall, RT, 1998) |
| "A double blind randomized study has been performed in 17 newborn infants bearing a diagnosis of perinatal asphyxia and treated with phenobarbital (FB) or phenytoin (DPH) to prevent the onset of seizures." | 5.06 | [Preventive treatment of convulsions in perinatal asphyxia]. ( Chunga, F; Durán, JA; Serrano, JS; Valls, A; Vela, F, 1987) |
| "To review the time to treatment failure, remission and first seizure with carbamazepine compared with phenobarbitone when used as monotherapy in people with focal onset seizures (simple or complex focal and secondarily generalised), or generalised onset tonic-clonic seizures (with or without other generalised seizure types)." | 4.98 | Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C, 2018) |
| "To review the time to withdrawal, remission, and first seizure of carbamazepine compared with phenobarbitone when used as monotherapy in people with partial onset seizures (simple or complex partial and secondarily generalised) or generalised onset tonic-clonic seizures (with or without other generalised seizure types)." | 4.93 | Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 4.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "03 mmol/kg for the induction of seizures), produced a significant reduction in the anticonvulsant effects of carbamazepine, phenobarbital, phenytoin, and valproate against maximal electroshock-induced seizures in mice." | 4.84 | [Caffeine and antiepileptic drugs: experimental and clinical data]. ( Błaszczyk, B; Chrościńska-Krawczyk, M; Czuczwar, SJ; Jankiewicz, K, 2007) |
| "No evidence supports AED prophylaxis with phenobarbital, phenytoin, or valproic acid in patients with brain tumors and no history of seizures, regardless of neoplastic type." | 4.82 | Seizure prophylaxis in patients with brain tumors: a meta-analysis. ( Drazkowski, JF; Lyons, MK; Sirven, JI; Wingerchuk, DM; Zimmerman, RS, 2004) |
| "To review the effects of phenobarbitone compared to phenytoin when used as monotherapy in patients with partial onset seizures or generalized tonic-clonic seizures with or without other generalized seizure types." | 4.81 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Taylor, S; Tudur Smith, C; Williamson, PR, 2001) |
| "Although phenobarbital (PB) is commonly used as a first-line antiseizure medication (ASM) for neonatal seizures, in 2015 we chose to replace it with levetiracetam (LEV), a third-generation ASM." | 4.31 | Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. ( Bättig, L; Cserpan, D; Dünner, C; Hagmann, C; Pisani, F; Ramantani, G; Rüegger, A; Schmitt, B, 2023) |
| " The aim of this study was to determine the anticonvulsant profiles of scoparone (a simple coumarin) and borneol (a bicyclic monoterpenoid) when administered separately and in combination, as well as their impact on the antiseizure effects of four classic ASMs (carbamazepine, phenytoin, phenobarbital and valproate) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures." | 4.31 | Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation. ( Bojar, H; Góralczyk, A; Skalicka-Woźniak, K; Łuszczki, JJ, 2023) |
| "To investigate caregivers' assessments of outcome in dogs with idiopathic epilepsy (IE) administered levetiracetam (LEV), zonisamide (ZNS), or phenobarbital (PB) monotherapy." | 4.31 | Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy. ( Gristina, BR; Muñana, KR; Nettifee, JA; Waldron, RJ, 2023) |
| "Phenobarbital (PB) q12h is the most common treatment recommendation for cats with recurrent epileptic seizures." | 4.31 | Once-a-day oral treatment with phenobarbital in cats with presumptive idiopathic epilepsy. ( De Decker, S; Mojarradi, A; Van Meervenne, S, 2023) |
| " This study was aimed at determining the influence of isopimpinellin (ISOP-a coumarin) when administered either separately or in combination with borneol (BOR-a monoterpenoid), on the antiseizure potencies of four classic ASMs (carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and valproate (VPA)) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures." | 4.31 | Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation. ( Bojar, H; Chmielewski, J; Florek-Łuszczki, M; Jankiewicz, K; Skalicka-Woźniak, K; Łuszczki, JJ, 2023) |
| " Experiment 3: ECoG response to anticonvulsant treatment (Phenytoin, Phenobarbital and Diazepam) of seizures induced by association IPDE5 + PTZ." | 4.31 | Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility. ( Azevedo, JEC; de Araujo, DB; de Mello, VJ; Favacho Lopes, DC; Hamoy, AO; Hamoy, M; Martins Rodrigues, JC; Nascimento, CP; Silva, ALMD; Tiago, ACDS; Vieira, LR, 2023) |
| "Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions." | 4.12 | Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. ( Karbwang, J; Na-Bangchang, K; Rajoli, RKR; Sae-Heng, T; Siccardi, M, 2022) |
| ", lacosamide (LCM), levetiracetam (LEV), phenobarbital (PB) and valproate (VPA)) to prevent seizures evoked by the 6-Hz corneal-stimulation-induced seizure model." | 4.12 | Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study. ( Andres-Mach, M; Lemieszek, MK; Raszewski, G; Szala-Rycaj, J; Szewczyk, A; Zagaja, A; Zagaja, M, 2022) |
| "Ganaxolone provided better seizure control than phenobarbital in this perinatal asphyxia model and was neuroprotective for the newborn brain, affording a new therapeutic opportunity for treatment of neonatal seizures." | 4.12 | Ganaxolone versus Phenobarbital for Neonatal Seizure Management. ( Allison, BJ; Bennet, L; Boyd, BJ; Castillo-Melendez, M; Fahey, MC; Hirst, JJ; Hunt, RW; Jenkin, G; Malhotra, A; McDonald, C; Mihelakis, J; Miller, SL; Nitsos, I; Pham, Y; Sutherland, AE; Walker, DW; Wong, F; Yawno, T, 2022) |
| " Bernard-mastiff crossbred dog showed clinical signs of lethargy and anorexia after being administered phenobarbital for the treatment of idiosyncratic seizures." | 4.02 | Pancytopenia secondary to suspected idiosyncratic phenobarbital reaction in a dog. ( Oberholster, O, 2021) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| "Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult." | 4.02 | Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021) |
| "Bumetanide was suggested as an adjunct to phenobarbital for suppression of neonatal seizures." | 4.02 | A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia. ( Gailus, B; Gericke, B; Johne, M; Käufer, C; Löscher, W; Römermann, K, 2021) |
| " In pentylenetetrazole-induced acute seizures only BUM532 combined with a sub-effective dose of PB increased the seizure threshold." | 3.96 | Functional characterization of novel bumetanide derivatives for epilepsy treatment. ( Auer, T; Erker, T; Schreppel, P; Schwarzer, C, 2020) |
| "A recently characterized CD-1 mouse model of phenobarbital (PB)-resistant neonatal ischemic-seizures (i." | 3.96 | Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits. ( Adler, DA; Ammanuel, S; Kadam, SD; Kang, SK, 2020) |
| "Neonatal seizures are difficult to diagnose and, when they are, tradition dictates first line treatment is phenobarbital." | 3.96 | Investigating and managing neonatal seizures in the UK: an explanatory sequential mixed methods approach. ( Alix, JJP; Gossling, L; Hart, AR; Stavroulakis, T, 2020) |
| "To compare the safety and efficacy of phenobarbital and levetiracetam in a cohort of neonates with seizures following cardiac surgery." | 3.96 | A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates. ( Abend, NS; Gaynor, JW; Licht, DJ; Massey, SL; Naim, MY; Thibault, C; Xiao, R, 2020) |
| "This study aims to compare the neurocognitive outcome in term infants who were treated using phenobarbital (PB) and levetiracetam (LEV) monotherapy for neonatal clinical seizures." | 3.96 | Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures. ( Akbay, S; Akkaya Inal, M; Arican, P; Cavusoglu, D; Gencpinar, P; Mete Atasever, N; Olgac Dundar, N; Tekgul, H, 2020) |
| "Patients who were provided Phenobarbital as a treatment and followed-up monthly were enrolled from the Convulsive Epilepsy Control and Management Program in West China." | 3.96 | Long-term seizure, comorbidity and socioeconomic outcomes of patients with convulsive epilepsy in rural West China. ( Chen, D; Deng, Y; He, J; He, YJ; Liu, L; Zhou, D; Zhu, LN, 2020) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 3.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| " As first-line drug phenobarbital was the most common choice, it was used in 79% of cases of acute symptomatic seizures, in 63% of structural epilepsy, in 42% of genetic epilepsies." | 3.91 | Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists. ( Capovilla, G; Consonni, D; De Liso, P; Di Capua, M; Dilena, R; Falsaperla, R; Pisani, F; Pruna, D; Suppiej, A; Vitaliti, G, 2019) |
| "Many neonates with hypoxic ischemic encephalopathy and seizures do not respond to the first line antiepileptic drug, phenobarbital." | 3.91 | Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures. ( Dwivedi, D; Holland, K; Kline-Fath, B; Lin, N; Schapiro, M; Venkatesan, C, 2019) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 3.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| "The aim of this study was to evaluate changes in epileptic seizures (ES) frequency and semiology in antiepileptic-medication (AEM)-naïve dogs with idiopathic epilepsy (DIE) after initiation of imepitoin (IMP) or phenobarbital (PB) monotherapy." | 3.91 | Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy. ( Barnett, CR; De Risio, L; Stabile, F; van Dijk, J, 2019) |
| "Tonic seizures with high-voltage discharges over the contralateral cerebral hemisphere and secondary generalization were successfully treated with phenobarbital." | 3.88 | Cerebellar Infarction: Unusual Manifestation with Facial Palsy, Focal Seizures, and Secondary Generalization. ( Bohner, G; Bührer, C; Dame, C; Mühlbacher, T, 2018) |
| "Neonatal seizures are treated with phenobarbital and prolonged treatment does not prevent postneonatal epilepsy." | 3.88 | Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures. ( Beatty, CW; Gust, J; Hamiwka, L; Natarajan, N, 2018) |
| "Levetiracetam can be a good and safe choice for treatment of neonatal seizures in preterm infants." | 3.88 | Efficacy of levetiracetam for neonatal seizures in preterm infants. ( Han, JY; Lee, IG; Moon, CJ; Sung, IK; Youn, YA, 2018) |
| "Phenobarbital is frequently used in pediatric patients for treatment and prophylaxis of seizures." | 3.88 | Phenobarbital population pharmacokinetics across the pediatric age spectrum. ( Galati, M; Kayyal, SY; Moffett, BS; Placencia, JL; Riviello, JJ; Rodman, EA; Weingarten, MM, 2018) |
| ", phenobarbital [PB], phenytoin [PHT] and pregabalin [PGB]) at the fixed-ratio of 1:1:1, we used a model of tonic-clonic seizures in male albino Swiss mice." | 3.88 | Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis. ( Florek-Luszczki, M; Luszczki, JJ; Mazurkiewicz, LP; Ossowska, G; Szpringer, M; Wlaz, A; Wroblewska-Luczka, P; Zolkowska, D, 2018) |
| "Modeling and simulations were used to support body weight-based dose selection for eslicarbazepine acetate (ESL) in pediatric subjects aged 4-17 years with partial-onset seizures." | 3.88 | Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures. ( Blum, D; Fiedler-Kelly, J; Galluppi, G; Hopkins, S; Ludwig, E; Sunkaraneni, S, 2018) |
| " Clinical trials have shown that mTOR inhibitors such as everolimus reduce seizures in tuberous sclerosis complex patients with intractable epilepsy." | 3.88 | The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy. ( Beaufils, F; Brandt, C; Fabbro, D; Hillmann, P; Löscher, W; Melone, A; Noack, A; Öhler, LA; Rageot, D; Römermann, K; Sele, AM; Wymann, MP, 2018) |
| "Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and NKCC2, has been tested as an adjunct with phenobarbital to suppress seizures." | 3.88 | Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy. ( Brandt, C; Feit, PW; Hampel, P; Kaila, K; Kalesse, M; Kipper, A; Löscher, W; Lykke, K; MacAulay, N; Paavilainen, P; Puskarjov, M; Römermann, K; Seja, P; Spoljaric, I; Toft-Bertelsen, TL; Töllner, K, 2018) |
| " The seizures were controlled by phenobarbital." | 3.88 | [Vomiting associated with weight stagnation and convulsions: urea cycle disorder should be suspected]. ( Abilkacem, R; Agadr, A; Boujrad, S; Hasbaoui, BE, 2018) |
| "We used the database from the Convulsive Epilepsy Control and Management Program in West China, which routinely provides phenobarbital (PB) as a treatment for convulsive epilepsy." | 3.85 | Terminal seizure frequency and its relation to SUDEP. ( Chen, D; Chen, T; Deng, Y; He, J; He, YJ; Liu, L; Si, Y; Zhou, D, 2017) |
| "Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epilepsy resistant to a maximum dose of imepitoin." | 3.85 | Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency. ( Bhatti, SFM; Broeckx, BJG; Martlé, V; Royaux, E; Stee, K; Van Ham, L, 2017) |
| "CYT-evoked alterations in the protection provided by some antiepileptic drugs against seizures can be of serious concern for epileptic smokers, who might demonstrate therapeutic failure to lacosamide, levetiracetam, and pregabalin, resulting in possible breakthrough seizure attacks." | 3.85 | Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. ( Florek-Łuszczki, M; Kondrat-Wróbel, MW; Tutka, P; Zaluska, K; Żółkowska, D; Łuszczki, JJ, 2017) |
| "Infants with seizures were overwhelmingly exposed to phenobarbital, despite a significant increase in levetiracetam exposure." | 3.85 | Changing antiepileptic drug use for seizures in US neonatal intensive care units from 2005 to 2014. ( Ahmad, KA; Ahmad, SF; Bennett, MM; Clark, RH; Desai, SJ; Ng, YT; Tolia, VN, 2017) |
| "The objective of this study was to determine the efficacy and safety of levetiracetam in treatment of neonatal seizures due to hypoxic ischemic encephalopathy." | 3.85 | Levetiracetam for the Treatment of Seizures in Neonatal Hypoxic Ischemic Encephalopathy. ( Schapiro, M; Thomas, C; Venkatesan, C; Young, S, 2017) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 3.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| "A number of acridone-based oxadiazoles 11a-n have been synthesized and evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ)- and maximal electroshock (MES)-induced seizures in mice." | 3.83 | Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1,2,4-oxadiazoles as potential anticonvulsant agents. ( Aghaei, I; Akbarzadeh, T; Emami, S; Faizi, M; Foroumadi, A; Jahani, R; Mahdavi, M; Mohammadi-Khanaposhtani, M; Shabani, M; Shafiee, A; Shamsaei Zafarghandi, N; Sharafi, Z, 2016) |
| "We reviewed data on children (aged<15 years) with focal seizures treated with high-dose phenobarbital (>5 mg/kg/day to maintain a target serum level >40 μg/mL) for at least 6 months." | 3.83 | Efficacy and tolerability of high-dose phenobarbital in children with focal seizures. ( Abe, S; Igarashi, A; Ikeno, M; Nakahara, E; Nakazawa, M; Okumura, A; Shimizu, T; Takasu, M, 2016) |
| " Seizures were controlled with phenobarbital (6 mg/kg IM q 12 h) and propofol CRI (0." | 3.83 | Successful treatment of refractory seizures with phenobarbital, propofol, and medetomidine following congenital portosystemic shunt ligation in a dog. ( Giordano, P; Heidenreich, DC; Kirby, BM, 2016) |
| "Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital." | 3.83 | Mexiletine and its Interactions with Classical Antiepileptic Drugs: An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, KK; Piskorska, B, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Background Phenobarbital is the first-line choice for neonatal seizures treatment, despite a response rate of approximately 45%." | 3.83 | Phenobarbital for Neonatal Seizures: Response Rate and Predictors of Refractoriness. ( Mazzotta, S; Pavlidis, E; Pelosi, A; Pisani, F; Seri, S; Spagnoli, C, 2016) |
| " Secondary outcome measures included serum phenobarbital concentrations, number of patients progressing from seizures to status epilepticus, and length of hospital stay." | 3.83 | Standardized Treatment of Neonatal Status Epilepticus Improves Outcome. ( Buss, WF; Harris, ML; Lawson, SN; Malloy, KM; Mietzsch, U; Rose, RS, 2016) |
| " This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)." | 3.81 | Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015) |
| "To clarify the effect of levetiracetam (LEV) for acute and chronic seizure control in acute encephalitis with refractory, repetitive partial seizures (AERRPS)." | 3.81 | Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase. ( Imamura, A; Maegaki, Y; Maruta, K; Matsunami, K; Narita, A; Nishimura, Y; Ohno, K; Saiki, Y; Saito, Y; Sokota, T; Sugihara, S; Tamasaki, A; Ueda, R, 2015) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "5 wk), 61 phenobarbital doses and 40 seizures were analyzed." | 3.81 | Phenobarbital and neonatal seizures affect cerebral oxygen metabolism: a near-infrared spectroscopy study. ( Barks, JD; Chervin, RD; Plegue, MA; Shellhaas, RA; Sokoloff, MD, 2015) |
| "Status epilepticus in children was characterized by heterogeneous etiology, prolonged duration and commonly good response to midazolam only given in high doses." | 3.81 | Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus. ( Djuric, M; Jankovic, B; Kravljanac, R; Pekmezovic, T, 2015) |
| "To determine the percentage of cats with a phenobarbital (PB) concentration between 15 and 45 μg/mL that had a ≥ 50% reduction in the number of seizures and to investigate applicability of the 2011 International League Against Epilepsy (ILAE) classification system in cats." | 3.80 | Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004-2013). ( Barnes Heller, HL; Finnerty, KE; Giovanella, CJ; Lau, VW; Mercier, MN; Rylander, H, 2014) |
| "Pellagra is caused by deficiency of niacin or its precursor tryptophan." | 3.80 | Phenobarbital-induced pellagra resulted in death. ( Aydin, F; Cengiz, N; Onar, MK; Pancar Yuksel, E; Sen, N; Sen, S; Senturk, N, 2014) |
| "This baby developed persistent electroencephalographic seizures due to massive doses of phenobarbital and midazolam." | 3.80 | Exacerbation of benign familial neonatal epilepsy induced by massive doses of phenobarbital and midazolam. ( Hirose, S; Ihara, Y; Ishii, A; Izumi, T; Maeda, T; Sekiguchi, K; Shimizu, M, 2014) |
| "Phenobarbital is the most commonly utilized drug for the treatment of neonatal seizures." | 3.80 | Brief postnatal exposure to phenobarbital impairs passive avoidance learning and sensorimotor gating in rats. ( Forcelli, PA; Gale, K; Gutherz, SB; Kondratyev, A; Kulick, CV; Soper, C, 2014) |
| "Levetiracetam (LEV) and tiagabine (TGB) are utilized for the treatment of seizures, including neonatal seizures." | 3.80 | Profile of anticonvulsant action of levetiracetam, tiagabine and phenobarbital against seizures evoked by DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in neonatal rats. ( Beck, VC; Forcelli, PA; Gutherz, SB; Kulick, CV; Medvedeva, N; Soper, C, 2014) |
| " In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures." | 3.80 | Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure. ( Albertini, G; De Sarro, G; Gallelli, L; Gratteri, S; Iemolo, F; Manes, MT; Mercuri, NB; Quirino, G; Sanzaro, E; Scaglione, F; Siniscalchi, A, 2014) |
| " The most common cause of neonatal seizures is hypoxic encephalopathy, and here we show in an established model of neonatal hypoxia-induced seizures that the NKCC1 inhibitor, bumetanide, in combination with phenobarbital is significantly more effective than phenobarbital alone." | 3.79 | Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. ( Berry, G; Cleary, RT; Huynh, T; Jackson, M; Jensen, FE; Kahle, KT; Li, Y; Manning, SM; Rakhade, SN; Rotenberg, A; Sun, H; Talos, DM, 2013) |
| "We investigated whether the recommended phenobarbital loading dose of 15-20 mg/kg with maintenance of 3-4 mg/kg/day can safely be administered to very low birth weight preterm newborns with seizures." | 3.79 | Can we safely administer the recommended dose of phenobarbital in very low birth weight infants? ( Akcakus, M; Kalay, S; Oygur, N; Oztekin, O; Tezel, G, 2013) |
| "In a 10-year cohort, a retrospective chart review was conducted for all infants (gestational age ≥ 37 w, age ≤ 28 days) who had received lidocaine as second-line treatment of neonatal seizures prior to treatment with phenobarbital between January 2000 and June 2010." | 3.79 | Efficacy and safety of lidocaine for treatment of neonatal seizures. ( Ågren, J; Flink, R; Hellström-Westas, L; Lundqvist, M; Wickström, R, 2013) |
| "To analyze seizure control, dose adjustments, and other changes of antiepileptic drug (AED) treatment during pregnancy in a large cohort of women with epilepsy entering pregnancy on monotherapy with carbamazepine, lamotrigine, phenobarbital, or valproate." | 3.79 | Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Tomson, T; Vajda, F, 2013) |
| "Compare neurodevelopment after levetiracetam (LEV) and phenobarbital (PB) for neonatal seizures." | 3.79 | Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. ( Maitre, NL; Slaughter, JC; Smolinsky, C; Stark, AR, 2013) |
| "Phenobarbital is the most commonly utilized drug for neonatal seizures." | 3.79 | Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats. ( Duckles, A; Forcelli, PA; Gale, K; Kondratyev, A; Soper, C, 2013) |
| "In spite of its known negative effects on brain development, phenobarbital is the most commonly used drug for neonatal seizures." | 3.79 | Differing attitudes toward phenobarbital use in the neonatal period among neonatologists and child neurologists in Sweden. ( Bartocci, M; Hallberg, B; Wickström, R, 2013) |
| "Phenobarbital is the first-line treatment for neonatal seizures." | 3.79 | Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia. ( Barks, JD; Bhatt-Mehta, V; Dillon, CH; Ng, CM; Shellhaas, RA, 2013) |
| "We investigated the effectiveness of intravenous injection of phenobarbital (PB) in patients referred to Himeji Red Cross Hospital, Hyogo, Japan, with benign convulsions with mild gastroenteritis (CwG) between November 2009 and June 2011." | 3.78 | [Intravenous injection of phenobarbital for benign convulsions with mild gastroenteritis]. ( Ban, H; Takami, Y, 2012) |
| " In addition, the potence of compound 1i against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide, 3-Mercaptopropionic acid, and Bicuculline in the chemical-induced seizure tests suggested that compound 1i displayed broad spectrum activity in several models, and it is likely to have several mechanisms of action including inhibiting voltage-gated ion channels and modulating GABAergic activity." | 3.77 | Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. ( Deng, XQ; Quan, LN; Quan, ZS; Song, MX; Wei, CX, 2011) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 3.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| "05) the onset and reduced the duration of the seizures induced by picrotoxin (5 mg/kg, i." | 3.77 | Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders. ( Adio, O; Fageyinbo, S; Sowemimo, AA, 2011) |
| "Lacosamide ((R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-1) is a low molecular weight anticonvulsant recently introduced in the United States and Europe for adjuvant treatment of partial-onset seizures in adults." | 3.76 | The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide. ( Kohn, H; Morieux, P; Park, KD; Salomé, C; Stables, JP, 2010) |
| "Pre-treatment with GABA (40 mg/kg), diazepam, phenobarbital, AOAA and DABA abolished the appearance of seizures induced by 50 mg/kg (PhSe)₂ in rat pups." | 3.76 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| "We made a microPET evaluation of the effects of tariquidar on the brain kinetics of the P-glycoprotein substrate [(18) F]MPPF in a rat model with spontaneous recurrent seizures, in which it has previously been demonstrated that phenobarbital nonresponders exhibit higher P-glycoprotein expression than do phenobarbital responders." | 3.76 | Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy. ( Bartenstein, P; Bartmann, H; Böning, G; Cumming, P; Fuest, C; Just, T; la Fougere, C; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Wängler, B; Winter, P; Xiong, G, 2010) |
| " injection to mice at doses of 30, 100, and 300 mg/kg body weight synthesized compounds were examined in the maximal electroshock induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice." | 3.75 | Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea. ( Jain, NK; Kashaw, SK; Kashaw, V; Mishra, P; Stables, JP, 2009) |
| "(R)-Lacosamide ((R)-2, (R)-N-benzyl 2-acetamido-3-methoxypropionamide) has recently gained regulatory approval for the treatment of partial-onset seizures in adults." | 3.75 | Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors. ( Cotten, SW; Eyers, C; Gaskell, SJ; Kohn, H; Liu, R; Morieux, P; Park, KD; Reamtong, O; Salomé, C; Stables, JP, 2009) |
| "This case is the first report of a patient who had phenobarbital (PB) withdrawal seizures after having been seizure-free for 3 years following temporal lobe surgery." | 3.75 | Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism. ( Bidlack, JM; Morris, HH, 2009) |
| "Flupirtine appears more effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressing seizures in both the kainic acid and flurothyl models of symptomatic neonatal seizures." | 3.75 | A KCNQ channel opener for experimental neonatal seizures and status epilepticus. ( Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH, 2009) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 3.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| " In the rat pilocarpine model, status epilepticus significantly increased P-glycoprotein expression by 92 to 197% in the hippocampal hilus and granule cell layer as well as the piriform cortex." | 3.75 | Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. ( Bauer, B; Gorter, JA; Hartz, AM; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Unkrüer, B; van Vliet, EA, 2009) |
| "This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis." | 3.75 | Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2009) |
| " Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice." | 3.74 | Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents. ( Al-Eryani, YA; Amin, KM; Rahman, DE, 2008) |
| "Since the survey of practices 15 years ago, child neurologists and neonatologists are reporting less frequent and shorter phenobarbital treatment after resolution of neonatal seizures, although there remains considerable variation in practices." | 3.74 | Prophylactic phenobarbital administration after resolution of neonatal seizures: survey of current practice. ( Guillet, R; Kwon, JM, 2008) |
| "In the present study we examined if rats with PB-resistant seizures are also resistant to phenytoin (PHT), using continuous EEG/video recording of spontaneous seizures." | 3.74 | Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy. ( Bethmann, K; Brandt, C; Löscher, W, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| "Phenobarbital failed to abolish or depress recurrent seizures in 70% of hippocampi." | 3.74 | Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. ( Brumback, AC; Dzhala, VI; Staley, KJ, 2008) |
| "Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45." | 3.74 | The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. ( Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "Some of the more striking expressions of toxicity are the tremors and seizures observed approximately 100 min after exposure of rats to an acutely toxic dose of acrylonitrile (AN)." | 3.73 | Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile. ( Benz, FW; Nerland, DE, 2005) |
| " This is the first report of successful utilization of the prepuce as a skin graft to reconstruct a full thickness skin necrosis due to a phenobarbital extravasation to the forefoot of a newborn." | 3.73 | The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn. ( Donatucci, CF; Erdmann, D; Kukies, S; Levin, LS; Schäfer, T; Stokes, TH, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 3.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 3.73 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "An 11-month-old boy with multiple surface anomalies and respiratory distress due to upper airway narrowing developed generalized tonic seizures coinciding with apnea." | 3.73 | [High-dose phenobarbital therapy is effective for the control of intractable tonic seizure with apnea in a case of multiple anomalies syndrome]. ( Hayashi, T; Horio, K; Kubota, M; Mimaki, M; Tomita, S, 2006) |
| "Questionnaires were mailed to owners of 29 dogs under management for suspected or diagnosed idiopathic epilepsy through the clinics of the Small Animal Hospital of the University of Glasgow Veterinary School, using either phenobarbitone or potassium bromide alone or in combination." | 3.73 | Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. ( Anderson, TJ; Chang, Y; Mellor, DJ, 2006) |
| "The goal of this article was to summarize some of the Neurology Group's discussion on neonatal seizures and their treatment with phenobarbital (PB)." | 3.73 | The newborn drug development initiative workshop: Summary proceedings from the neurology group on neonatal seizures. ( Clancy, RR, 2006) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| "To report a case of loss of seizure control due to hypocalcemia resulting from long-term treatment with phenytoin and phenobarbital." | 3.72 | Loss of seizure control due to anticonvulsant-induced hypocalcemia. ( Al-Busairi, WA; Al-Bustan, MA; Al-Mulla, FA; Ali, FE, 2004) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 3.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| " He manifested apnea during the first 12 hours of life." | 3.72 | Temporal lobe hemorrhage in the full-term neonate presenting as apneic seizures. ( Goodkin, HP; Tramonte, JJ, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| "Rats in experiment 1 received 1% creatine or cyclocreatine chow from age (P) 21-65 days, underwent kainate induced status epilepticus on P35 and were compared, as adults, to kainate alone rats and to normal controls." | 3.72 | Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats. ( Abu Rialy, S; Farhat, F; Francis, E; Geha, G; Kurdit, RM; Lteif, L; Maraashli, W; Mikati, MA; Rahmeh, AA, 2004) |
| "Trimethyltin (TMT) is an organic metal known to induce neuronal degeneration in the hippocampus, and abnormal behavior characterized by seizures, increased aggression and memory deficits." | 3.71 | Neuropeptide Y and somatostatin participate differently in the seizure-generating mechanisms following trimethyltin-induced hippocampal damage. ( Ishikura, N; Kato, N; Minabe, Y; Nishimura, T; Tsunashima, K; Watanabe, Ki, 2002) |
| " The compounds were assayed against seizures induced by maximal electroshock (MES) and pentylenetetrazole (scMet)." | 3.71 | Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines. ( Kishore Gnanasam, S; Leonard, JT; Ramachandran, S; Sivakumar, R, 2002) |
| "To examine the interactions of allopregnanolone and phenobarbital for the protection against seizures." | 3.71 | Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice. ( Lu, YQ; Yu, R, 2001) |
| " Sensitivity to phenobarbital and related anticonvulsants may induce life-threatening leukopenia, thrombocytopenia, and anemia in dogs." | 3.70 | Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants. ( Calvert, C; Jacobs, G; Kaufman, A, 1998) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 3.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "N(G)-nitro-L-arginine (NNA; an inhibitor of nitric oxide synthase) in a dose of 40 mg/kg impaired the protective activity of ethosuximide against the clonic phase of pentylenetetrazol-induced seizures in mice." | 3.70 | N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol. ( Czuczwar, SJ; Kleinrok, Z; Klonowski, P; Tutka, P, 1999) |
| " The present study was conducted to determine if the adenosinergic system and adenosine A1 receptors are involved in the anticonvulsant action of the antiepileptic drugs phenobarbitone and carbamazepine, in pentylenetetrazole (PTZ)-induced seizures in rats." | 3.70 | Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine. ( Gupta, YK; Malhotra, J, 1999) |
| " In the present study, it was evaluated whether circannual rhythms affect the anticonvulsant activity of phenobarbital, carbamazepine, or valproate in two mouse models of generalized seizures, i." | 3.70 | The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures. ( Fiedler, M; Löscher, W, 2000) |
| " The aim of this paper was to investigate antiepileptogenic properties of phenobarbital, focusing on the neurochemical changes associated with repeated seizures induced by low convulsive dose of pentylenetetrazol (PTZ) (60 mg/kg, sc) in mice." | 3.70 | Antiepileptogenic properties of phenobarbital: behavior and neurochemical analysis. ( Elisabetsky, E; Silva Brum, LF, 2000) |
| "Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan-1,2-diol (the injection vehicle for both these anticonvulsants)." | 3.69 | Detection of propan-1,2-diol in neonatal brain by in vivo proton magnetic resonance spectroscopy. ( Burns, SP; Cady, EB; Coutts, GA; Cowan, FM; Iles, RA; Lorek, A; Penrice, J; Reynolds, EO, 1994) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 3.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "The purpose of this investigation was to determine whether paraplegia induced by neoplastic cord compression affects the pharmacodynamics of phenobarbital general anesthesia or of pentylenetetrazol (PTZ)-induced convulsions." | 3.69 | Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression. ( Alfon, J; Hoffman, A; Siegal, T, 1994) |
| " To test the effect of antiepileptic drugs on kindled seizures and kindling-induced learning deficits we injected ethosuximide, dipropylacetate, and phenobarbital prior to each kindling stimulation or after kindling completion, and tested these animals in a shuttle-box paradigm." | 3.69 | Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments. ( Becker, A; Brosz, M; Grecksch, G, 1995) |
| "We evaluated the protective activity (expressed as ED50 values in mg/kg of phenobarbital (PB, 120 min before testing) and valproate (30 min) alone or combined with caffeine in male mice with seizures induced by maximal electroshock (MES)." | 3.69 | Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. ( Borowicz, K; Buszewicz, G; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1996) |
| "We evaluated the anticonvulsive effects of phenobarbital (PB) and zonisamide (ZNS) in the EL mouse, a strain that is highly susceptible to seizures." | 3.69 | Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse. ( Akasaki, Y; Nagase, F; Nagatomo, I; Nomaguchi, M; Takigawa, M, 1996) |
| " Cats that were having cluster seizures or status epilepticus at the time of admission were treated orally with phenobarbital and with constant IV administration of diazepam." | 3.69 | Clinical management and outcome of cats with seizure disorders: 30 cases (1991-1993). ( McDonell, W; Parent, JM; Quesnel, AD, 1997) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 3.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 3.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 3.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 3.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 3.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| " In the strychnine seizure test (mice), ralitoline (5 and 10 mg/kg) prolonged the latency of tonic seizures as well as the survival time." | 3.68 | Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. ( Bodewei, R; Fischer, W; Satzinger, G, 1992) |
| ") potentiated the anticonvulsant properties of phenytoin, phenobarbital and valproate against audiogenic seizures in DBA/2 mice." | 3.68 | Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice. ( De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 3.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "This study evaluated a possible mechanism by which glycine potentiates the activity of anticonvulsant drugs against maximal electroshock seizures in rats." | 3.68 | Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid. ( Peterson, SL, 1991) |
| "This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children." | 3.68 | Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991) |
| "Thirteen treatment failures and ten instances of apnea occurred among the 28 patients treated with benzodiazepine/phenobarbital." | 3.68 | Management of hyponatremic seizures in children with hypertonic saline: a safe and effective strategy. ( Fleischmann, L; Hackbarth, R; Meert, K; Sarnaik, AP, 1991) |
| "The cholinergic agonist pilocarpine triggers sustained limbic seizures in rodents." | 3.68 | Substantia nigra regulates action of antiepileptic drugs. ( Andrews, JS; Bortolotto, ZA; Bressler, K; Calderazzo-Filho, LS; Cavalheiro, EA; Löschmann, PA; Turski, L, 1990) |
| ") of 9 severely asphyxiated newborns, under artificial ventilation, with neonatal seizures resistant to phenobarbital, is reported in this pilot study." | 3.68 | Thiopental efficacy in phenobarbital-resistant neonatal seizures. ( Bonati, M; Celardo, A; De Capitani, E; Marraro, G; Passerini, F; Schieroni, F; Spada, P; Valsecchi, R, 1990) |
| "Sodium phenobarbitone (20 and 70 mg/kg) had a significant anticonvulsant action against pentylenetetrazole-induced seizures, which persisted for 21 days of treatment." | 3.68 | Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal. ( File, SE; Wilks, LJ, 1990) |
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 3.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| "Amoxapine is a second-generation antidepressant that has been reported to cause seizures, severe acidosis, cardiac dysrhythmias, hypotension, renal failure, coma, and cardiorespiratory arrest in poisoning exposures." | 3.68 | Diagnostic pitfalls associated with amoxapine overdose: a case report. ( Greenwood, RS; Hussey, B; Miles, MV, 1990) |
| " The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of 2- and 3-aminobenzanilides. ( Clark, CR; Lin, CM; Sansom, RT, 1986) |
| " The compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test." | 3.67 | Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. ( Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J, 1986) |
| " The compounds were tested in mice against seizures induced by electroshock and metrazole (pentylenetetrazole) and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of some 4-aminobenzanilides. ( Clark, CR; Lin, CM; Norris, GN; Sansom, RT, 1985) |
| " The compounds were tested in mice against seizures induced by electroshock and pentylenetetrazole ( metrazole ) and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of some 4-aminobenzamides. ( Clark, CR; Dockens, RC; Norris, GN; Ravis, WR; Sansom, RT; Wells, MJ, 1984) |
| "The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures." | 3.67 | Glycine potentiates the action of some anticonvulsant drugs in some seizure models. ( Lajtha, A; Toth, E, 1984) |
| "A 2-year-old child with known neurologic impairment developed a dyskinesia soon after starting phenobarbital therapy for seizures." | 3.67 | Phenobarbital-induced dyskinesia in a neurologically-impaired child. ( Wiznitzer, M; Younkin, D, 1984) |
| "Residents of an institution for the developmentally disabled in northwest Ohio receiving anticonvulsant therapy for six months or more with phenobarbital or phenytoin or both were studied for the prevalence of hypocalcemia and elevated alkaline phosphatase level." | 3.67 | Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy. ( Nordlund, DJ; Rodgers, LA; Schmitt, BP, 1984) |
| "The anticonvulsant effect of primidone was determined in gerbils, in which seizures were elicited by a blast of compressed air, over the time range of 30 min to 18 h after oral administration." | 3.67 | Anticonvulsant effect of primidone in the gerbil. Time course and significance of the active metabolites. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1984) |
| " After an extensive search for a fever source, they noted that her temperature responded to pseudoseizures and to phenobarbital." | 3.67 | Possible psychogenic fever of 103.5 degrees F in a patient with borderline personality disorder. ( Elkins, AM; Leighton, LH; McNeil, GN, 1984) |
| "The effect of phenobarbital and pancuronium on cerebral blood flow (CBF) and CBF autoregulation are studied in newborn piglets after chemically induced seizures with bicuculline." | 3.67 | Autoregulation of cerebral blood flow. Effect of phenobarbital and pancuronium in the newborn piglet. ( Hascoet, JM; Monin, P; Vert, P, 1989) |
| "The purpose of the present study was to examine whether doses of phenytoin and phenobarbital that blocked kindled seizures in rats also disrupted operant behavior." | 3.67 | Effects of phenytoin and phenobarbital on schedule-controlled responding and seizure activity in the amygdala-kindled rat. ( Jakubow, J; Poling, A; Renfrey, G; Schlinger, H, 1989) |
| "We report four cases of unexpected cocaine intoxication in children manifested by the sudden development of seizures." | 3.67 | Unexpected cocaine intoxication presenting as seizures in children. ( Ernst, AA; Sanders, WM, 1989) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 3.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| " Fluid restriction and treatment of seizures with phenobarbital are widely used therapies." | 3.67 | Neonatal hypoxic-ischemic encephalopathy: current management practices. ( Donn, SM; Goldstein, GW; Schork, MA, 1988) |
| " Administration of doses established as median therapeutic doses in humans of phenobarbital, valproate and clonazepam to pregnant rats during the last third of gestation produced sexually dimorphic alterations in pentylenetetrazol (PTZ)-induced seizures as well as in non-convulsive (spontaneous alternation and cliff avoidance) behaviors in the offspring." | 3.67 | Prenatal antiepileptic drug exposure alters seizure susceptibility in rats. ( Nandedkar, AK; Sobrian, SK, 1986) |
| "Glutamic acid diethyl ester (GDEE) is a glutamate antagonist which acts preferentially at the quisqualate-sensitive receptor and has been shown to be an effective anticonvulsant in alcohol withdrawal and homocysteine-induced seizures but ineffective in other seizure models." | 3.67 | Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs. ( Freed, WJ; Schwarz, SS, 1986) |
| "We evaluated the efficacy of pretreatment with phenytoin and phenobarbital to prevent seizures in mice given convulsive doses of theophylline." | 3.67 | Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice. ( Blake, KV; Hendeles, L; Massey, KL; Neims, A; Nickerson, D, 1988) |
| "Although phenobarbital is the most widely used drug to control seizures, dosage guidelines are not available for infants of varying gestational ages." | 3.67 | Developmental aspects of phenobarbital dosage requirements in newborn infants with seizures. ( Edwards, RC; Masuoka, T; Nahata, MC, 1988) |
| "We studied 21 patients with complex partial seizures during phenobarbital (PB) or primidone withdrawal." | 3.67 | Seizures during barbiturate withdrawal: relation to blood level. ( Porter, RJ; Raubertas, RF; Theodore, WH, 1987) |
| "As in humans, theophylline intoxication in rabbits causes seizures and death." | 3.67 | Phenobarbital improves survival in theophylline-intoxicated rabbits. ( Goldberg, MJ; Miller, G; Spector, R, 1986) |
| "Baclofen and phenobarbital were tested for anticonvulsant efficacy against limbic seizures produced by i." | 3.67 | Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome. ( Armstrong, DR; Ault, B; Gruenthal, M; Nadler, JV, 1986) |
| "To determine the effect of phenobarbital sodium therapy and subependymal intraventricular hemorrhage (SEp-IVH) on the theophylline requirement of premature infants suffering with apnea and seizure activity, we compared three groups of patients as follows: group 1, those with apnea of prematurity (ten patients); group 2, those with apnea and SEp-IVH (ten patients); and group 3, those with apnea, SEp-IVH, and seizure activity for which they were receiving phenobarbital therapy (nine patients)." | 3.67 | Phenobarbital increases the theophylline requirement of premature infants being treated for apnea. ( Gottschalk, SK; Kissling, GE; Schuth, CR; Tran, TH; Yazdani, M, 1987) |
| " In this model, tonic-clonic seizures are easily elicited by handling and the effects of administration of carbamazepine (CBZ), phenytoin (DPH), phenobarbital (PB), diazepam, valproic acid (VPA) and ethosuximide were quantitatively evaluated." | 3.67 | Seizure control following administration of anticonvulsant drugs in the quaking mouse. ( Abbott, LC; Bennett, GD; Finnell, RH; Taylor, SM, 1985) |
| "Acute exposure to dieldrin (HEOD) causes hyperglycemia and death in the adult rat." | 3.67 | Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats. ( Fox, GR; Virgo, BB, 1986) |
| "We investigated whether chronic administration of guanidinoethane sulfonate, an inhibitor of taurine uptake, could modify the antiepileptic actions of phenobarbital and phenytoin on maximal electroshock seizures in mice." | 3.67 | Modification of the antiepileptic actions of phenobarbital and phenytoin by the taurine transport inhibitor, guanidinoethane sulfonate. ( Fukuda, T; Huxtable, RJ; Izumi, K; Kishita, C; Koja, T; Nakagawa, K; Shimizu, T, 1985) |
| "The conventional loading dose of phenobarbital for newborn infants with hypoxic-ischemic seizures, 20 mg/kg, often fails to control convulsive activity." | 3.67 | Safety of a higher loading dose of phenobarbital in the term newborn. ( Donn, SM; Goldstein, GW; Grasela, TH, 1985) |
| "The changes in cerebral blood flow (CBF) during and after bicuculline-induced seizures were studied by the radioactive microsphere technique in 12 newborn, urethan-anesthetized piglets, 6 piglets pretreated with phenobarbital (10 mg/kg) and 6 without phenobarbital." | 3.67 | Regional cerebral blood flow during bicuculline-induced seizures in the newborn piglet: effect of phenobarbital. ( Clozel, M; Daval, JL; Dubruc, C; Monin, P; Morselli, PL; Vert, P, 1985) |
| "In the present study, we investigated whether administration of guanidinoethane sulfonate, and inhibitor of taurine uptake, worsens electroshock-induced convulsions or modifies the antiepileptic actions of phenobarbital or phenytoin against maximal electroshock seizures in mice." | 3.67 | Reduced taurine contents and modification of anticonvulsive effects of phenobarbital and phenytoin by guanidinoethane sulfonate in mice. ( Fukuda, T; Huxtable, RJ; Izumi, K; Kishita, C; Koja, T; Nakagawa, K; Shimizu, T, 1985) |
| "The combined use of di-n-propylacetate with phenazepam, diazepam, phenobarbital or phenytoin was shown to be followed by reciprocal potentiation of the anticonvulsant activity of the drugs in a variety of experimental epileptic seizures in mice according to the tests of shock and antagonism with corasole and thiosemicarbazide." | 3.66 | [Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin]. ( Kosoĭ, MIu, 1981) |
| "Enuresis is a common problem often treated effectively with imipramine hydrochloride." | 3.66 | Treatment of imipramine overdose in children. ( Cromie, WJ; Greene, AS, 1981) |
| "The onset of clonic seizures induced by 3-mercaptopropionic acid (MP) was associated with an approximately 200% increase of cAMP and a 70% elevation of cGMP in the mouse cerebral cortex." | 3.66 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "Neurotoxicity and protection against maximal electroshock and Metrazol seizures from primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA) were determined in mice for each drug separately and expressed in terms of brain concentrations." | 3.66 | Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice. ( Bourgeois, BF; Dodson, WE; Ferrendelli, JA, 1983) |
| "Neurotoxicity and protection against maximal electroshock (MES) and pentylenetrazol (Metrazol) seizures were determined in mice for various combinations of primidone (PRM), phenobarbital (PB), and phenylethylmalonamide (PEMA)." | 3.66 | Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice. ( Bourgeois, BF; Dodson, WE; Ferrendelli, JA, 1983) |
| "Strychnine poisoning results in a predictable and treatable sequence of events involving blockade of the inhibitory neurotransmitter, extensor muscle spasms, seizures, and respiratory paralysis." | 3.66 | Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis. ( Boyd, RE; Brennan, PT; Deng, JF; Rochester, DF; Spyker, DA, 1983) |
| "Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures." | 3.66 | Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels. ( Boer, HR; Erkan, NV; Gal, P; Toback, J; Wells, TJ, 1982) |
| "An apparent case of carbamazepine-induced leukocytosis in a 26-year-old woman is presented." | 3.66 | Carbamazepine-induced leukocytosis. ( Murphy, JE; Springer, PK; Stewart, RB, 1980) |
| "A comparison was made of the effects of chronically administered diazepam and phenobarbital with those of elicited seizures on repeated acquisition learning in 3 prepubertal Papio papio." | 3.66 | Alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital. ( Killam, EK; Weinberger, SB, 1978) |
| " We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures." | 3.66 | Phenobarbital and diphenylhydantoin levels in neonates with seizures. ( MacDonald, H; Painter, MJ; Pippenger, C; Pitlick, W, 1978) |
| "Phenobarbital pharmacokinetics after intravenous injection were studied in 8 neonates with seizures." | 3.66 | Phenobarbital pharmacokinetics in neonates. ( Painter, M; Pippenger, C; Pitlick, W, 1978) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Eight patients developed grand mal seizures during intravenous theophylline therapy." | 3.65 | Theophylline-induced seizures in adults. Correlation with serum concentrations. ( Cohn, WM; Matthay, RA; Neff, TA; Sutton, FD; Weinberger, MM; Zwillich, CW, 1975) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| "The kindling of amygldaloid and cortical seizures in cats was used to study the prophylactic effects of phenobarbital, phenytoin, ethosuximide, acetazolamide, and dexamethason." | 3.65 | Pharmacological prophylaxis against the development of kindled amygdaloid seizures. ( Kutt, H; Louis, S; Newman, SM; Turner, IM, 1977) |
| "Zoxazolamine paralysis, hexobarbital anesthesia and digitoxin convulsions were diminished in rats by 3 days of pretreatment with pregnenolone-16alpha-carbonitrile (PCN)." | 3.65 | Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine. ( Garg, BD; Kourounakis, P; Kovacs, K; Szabo, S; Tuchweber, B, 1977) |
| "In two children treated for hypoglycemia and convulsions with diazoxide and diphenylhydantoin, therapeutic serum diphenylhydantoin levels were not achieved despite doses of diphenylhydantoin of 17 and 29 mg/kg/day, respectively." | 3.65 | Drug interaction: diazoxide and diphenylhydantoin. ( Blaskovics, ME; Podosin, RL; Roe, TF, 1975) |
| " To test the validity of this primate model, the effects of diphenylhydantoin (DPH), phenobarbital, and primidone on spontaneous seizures evaluated for 8 months with a Latin-Squar experimental design." | 3.65 | Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures. ( DuCharme, LL; Farquhar, JA; Huntsman, BJ; Lockard, JS; Uhlir, V, 1975) |
| "The anticonvulsive properties of orally administered cinnarizine [(E)-1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine], its difluoro derivative flunarizine [(E)-1-(bis-(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-piperazine], diphenylhydantoin and phenobarbital, were studied against maximal metrazol seizures (MMS) in rats and maximal electroshock seizures (MES) in mice." | 3.65 | Anticonvulsive properties of cinnarizine and flunarizine in rats and mice. ( Desmedt, LK; Janssen, PA; Niemegeers, CJ, 1975) |
| ", the maximal electroshock test (MES), and seizures induced by pentylenetetrazol, strychnine and nicotine." | 3.65 | Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs. ( Barry, H; Sofia, RD; Solomon, TA, 1976) |
| " Phenobarbital is usually given as well to prevent grand mal seizures." | 3.64 | Treatment of epilepsy. ( BAILEY, AA, 1963) |
| "Neonatal seizures are one of the most challenging problems for experts across the globe." | 3.11 | Levetiracetam or Phenobarbitone as a First-Line Anticonvulsant in Asphyxiated Term Newborns? An Open-Label, Single-Center, Randomized, Controlled, Pragmatic Trial. ( Deshmukh, L; Joshi, A; Londhe, A; Susnerwala, S, 2022) |
| "Secondary outcomes such as rates of seizures, hospital, and ICU length of stay (LOS), also were included." | 3.01 | Evaluation of phenobarbital based approach in treating patient with alcohol withdrawal syndrome: A systematic review and meta-analysis. ( AlRemeithi, R; Bronstein, D; Kartiko, S; Pourmand, A; Tran, QK, 2023) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 3.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "The long-term administration of phenobarbitone in neonates may be associated with adverse neurological outcome." | 3.01 | Effect of early withdrawal of phenobarbitone on the recurrence of neonatal seizures: An open-label randomized controlled trial. ( Angurana, SK; Jindal, A; Kumar, P; Sundaram, V; Suthar, R, 2021) |
| "Dogs that experienced no additional seizures were defined as responders, whereas those that showed additional seizure activity were classified as nonresponders." | 2.90 | Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures. ( Bellino, C; Bertone, I; Cagnotti, G; Corona, C; D'Angelo, A; Dappiano, E; Gardini, G; Iulini, B; Odore, R, 2019) |
| "Seizures are the main neurological emergency during the neonatal period and are mostly acute and focal." | 2.82 | Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options. ( Bedetti, L; Berardi, A; Casa Muttini, ED; Cavalleri, F; Ferrari, F; Guidotti, I; Lugli, L; Ori, L; Pugliese, M; Roversi, MF; Stefanelli, F, 2022) |
| "Five phenobarbital treated dogs were classified as true responders (≥50% reduction in seizures/month) whereas none of the levetiracetam treated dogs fulfilled this criterion." | 2.82 | A single-blinded phenobarbital-controlled trial of levetiracetam as mono-therapy in dogs with newly diagnosed epilepsy. ( Berendt, M; Fredsø, N; Møller, A; Sabers, A; Toft, N, 2016) |
| "After 12 hours of seizure free period of the initial loading dose of phenobarbitone, one group received IV maintenance therapy and other 'no maintenance' (saline as placebo)." | 2.82 | Effect of Withholding Phenobarbitone Maintenance in Neonatal Seizures: A Randomized Controlled Trial. ( Gupta, P; Saxena, P; Sharma, S; Singh, A; Upadhyay, A; Vishnubatla, S, 2016) |
| "The demographic, seizure details and outcome measures were recorded." | 2.79 | The effect of phenobarbitone on cognition in adult patients with new onset epilepsy: a multi-centric prospective study from India. ( Dutta, A; Jayalakhsmi, S; Mukaddam, Q; Naik, M; Rao, SL; Ravat, S; Satischandra, P; Senapathy, A; Shah, U; Shunmukhi, MS; Sinha, S; Subbakrishna, DK, 2014) |
| " However, these medications have several well-known adverse effects." | 2.77 | Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. ( Ashrafi, MR; Bavarian, B; Ghaempanah, M; Khosroshahi, N; Malamiri, RA; Nikkhah, A, 2012) |
| "Phenobarbital data were collected between 2008 and 2010." | 2.77 | Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: a thermopharmacological approach. ( de Vries, LS; Egberts, AC; Groenendaal, F; Huitema, AD; Rademaker, CM; Toet, MC; van den Broek, MP; van Hasselt, JG; van Straaten, HL, 2012) |
| "57] or adverse effects (RR 4." | 2.72 | Efficacy and Safety of Phenobarbitone as First-Line Treatment for Neonatal Seizure: A Systematic Review and Meta-Analysis. ( Kumar, J; Meena, J; Saini, L; Yadav, J, 2021) |
| "Seizures are common in newborn infants with hypoxic-ischemic encephalopathy and are highly associated with adverse neurodevelopmental outcomes." | 2.72 | Treating Seizures after Hypoxic-Ischemic Encephalopathy-Current Controversies and Future Directions. ( Bennet, L; Cho, KHT; Davidson, JO; Drury, PP; Gunn, AJ; Lear, CA; McDouall, A; Zhou, KQ, 2021) |
| "Seventy patients died (unrelated to seizures) and survival rates were equivalent in both groups (median survival = 6." | 2.71 | Prophylactic anticonvulsants in patients with brain tumour. ( Barnes, P; Brasher, PM; Cairncross, JG; DeAngelis, LM; Forsyth, PA; Fulton, D; Hagen, NA; Stewart, D; Sutherland, G; Weaver, S, 2003) |
| "The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate." | 2.69 | Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999) |
| "Odds for epilepsy were higher among people who had positive family history (O." | 2.69 | A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. ( Chopra, JS; Kaur, P; Sawhney, IM; Singh, A; Suri, G, 1999) |
| "Phenobarbitone does not interfere with LDDS testing regardless of dosage or treatment time." | 2.69 | Effect of phenobarbitone on the low-dose dexamethasone suppression test and the urinary corticoid: creatinine ratio in dogs. ( Church, DB; Foster, SF; Watson, AD, 2000) |
| "Hemodialysis-associated seizure (HAS) is a common complication of hemodialysis." | 2.69 | Potential prophylactic use of benzodiazepines for hemodialysis-associated seizures. ( Mir, S; Sönmez, F; Tütüncüoğlu, S, 2000) |
| " Intramuscular phenobarbitone is well absorbed in children with severe malaria; the optimum prophylactic anticonvulsant dose remains to be determined." | 2.67 | Absorption of intramuscular phenobarbitone in children with severe falciparum malaria. ( Chongsuphajaisiddhi, T; Holloway, P; Kuile, F; Maelankirri, L; Nosten, F; White, NJ, 1992) |
| "The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure appears to vary from 3% to 92% over a five-year period." | 2.66 | Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2020) |
| "Controlling seizures in children approaching death can be difficult, and there is a limited evidence base to guide best practice." | 2.66 | Seizure management in children requiring palliative care: a review of current practice. ( Baba, M; Beringer, A; Harris, N; Mellor, C; Rogers, R; Sharples, P; Taylor, K, 2020) |
| " The dosage was phenobarbitone 3-6 mg/kg per day; sodium valproate 30-60 mg/kg per day." | 2.65 | Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial. ( Bower, B; Ngwane, E, 1980) |
| " Phenobarbital use should be monitored with serum drug levels and modification of recommended dosage regimens considered." | 2.65 | Opiate v CNS depressant therapy in neonatal drug abstinence syndrome. ( Doberczak, TM; Kandall, SR; Korts, DC; Mauer, KR; Strashun, RH, 1983) |
| "Phenobarbital (Luminal) was given to 41 children (aged 11 months to 4 1/2 years) with uncomplicated febrile convulsions." | 2.65 | [Phenobarbital in febrile convulsions of children (author's transl)]. ( Lagenstein, I; Sternowsky, HJ, 1981) |
| "After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year." | 2.64 | Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. ( Knudsen, FU; Vestermark, S, 1978) |
| "Severe recurrent febrile seizures occurred in no children on daily phenobarbital and in 4." | 2.64 | The value of phenobarbital in the child who has had a single febrile seizure: a controlled prospective study. ( Carr, A; Dale, EP; Davidson, S; Davis, DC; Forsythe, A; Goldenberg, ED; Hanson, R; Lulejian, GA; Nelson, MA; Treitman, P; Weinstein, A; Wolf, SM, 1977) |
| "The recurrence rate of febrile convulsions is assessed in 108 children who had had either prolonged or repeated initial fits or had both a positive family history and persisting neurological disorder." | 2.64 | Continuous phrophylcatic anticonvulsants in selected childrens with febrile convulsions. ( Wallace, SJ, 1975) |
| "Postoperative seizures can precipitate the development of epilepsy; seizures are most likely to occur within the first month of cranial surgery." | 2.58 | Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2018) |
| "Neonatal seizures constitute the most frequent presenting neurologic sign encountered in the neonatal intensive care unit." | 2.55 | The use of phenobarbital and other anti-seizure drugs in newborns. ( El-Dib, M; Soul, JS, 2017) |
| "Phenobarbital is an effective and safe anticonvulsant drug introduced in clinical use in 1904." | 2.53 | Clinical Pharmacology of Phenobarbital in Neonates: Effects, Metabolism and Pharmacokinetics. ( Pacifici, GM, 2016) |
| "Seizures are common following perinatal asphyxia and may exacerbate secondary neuronal injury." | 2.53 | Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia. ( Berg, M; Soll, R; Young, L, 2016) |
| "The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT)." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| "Phenobarbital was the drug of first choice, and the use of off-label drugs and treatment times varied." | 2.52 | Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment. ( Ågren, J; Boylan, G; Hellström-Westas, L, 2015) |
| "The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure may vary from 3% to 92% over a five-year period." | 2.52 | Antiepileptic drugs as prophylaxis for post-craniotomy seizures. ( Greenhalgh, J; Marson, AG; Weston, J, 2015) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Current therapeutic options to treat neonatal seizures (i." | 2.49 | Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013) |
| "The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be 15% to 20%; however, the risk of experiencing a seizure may vary from 3% to 92% over a five-year period." | 2.49 | Antiepileptic drugs as prophylaxis for post-craniotomy seizures. ( Greenhalgh, J; Marson, AG; Pulman, J, 2013) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Neonatal seizures are common and often reflect a severe underlying neurologic dysfunction in neonates." | 2.48 | Neonatal seizures: dialogues between clinic and bench. ( Huang, LT; Lai, MC; Tain, YL; Yang, SN, 2012) |
| "The lifetime risk of having epileptic seizures is profoundly increased in patients with cancer: about 20% of all patients with systemic cancer may develop brain metastases." | 2.48 | Epilepsy meets cancer: when, why, and what to do about it? ( Stupp, R; Weller, M; Wick, W, 2012) |
| "The most common medication used to treat neonatal seizures is phenobarbital, although its efficacy has never been demonstrated by a formal, randomized, placebo-controlled drug trial." | 2.43 | Prolonged electroencephalogram monitoring for seizures and their treatment. ( Clancy, RR, 2006) |
| "Neonatal seizures continue to present a diagnostic and therapeutic challenge to paediatricians worldwide, and are a worrying sign for both parents and clinicians alike." | 2.42 | Neonatal seizures and their treatment. ( Boylan, GB; Rennie, JM, 2003) |
| "Falciparum malaria is the most common cause of convulsions in children admitted to hospital in malaria endemic areas." | 2.42 | Management of seizures in children with falciparum malaria. ( Newton, CR; Ogutu, BR, 2004) |
| "Secondary or reperfusion injury is potentially amenable to neuroprotective strategies." | 2.42 | Brain injury in the term infant. ( Perlman, JM, 2004) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Febrile seizures are the most common seizures in childhood and, like all seizures, can be frightening to witness." | 2.41 | Prevention and management of febrile seizures. ( Baumann, RJ, 2001) |
| "Subtle seizures are mild paroxysmal alterations in motor or autonomic activity and are unique to the neonatal period." | 2.41 | Seizures in the newborn. ( Aggarwal, R; Deorari, AK; Paul, VK; Upadhyay, A, 2001) |
| "People with cerebral malaria become unconscious, and often have protracted convulsions." | 2.41 | Routine anticonvulsants for treating cerebral malaria. ( Marson, AG; Meremikwu, M, 2002) |
| "Opinions vary as to which 'neonatal seizures' should be treated and which should not be." | 2.40 | [Neonatal seizures: the beginning and interruption of the treatment]. ( Caballar-Gonzaga, FJ; Dierkes, T; Koenigsberger, MR, 1997) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "Idiopathic epilepsy is one of the most common and treatable neurologic diseases of small animals." | 2.40 | Idiopathic epilepsy. ( Knowles, K, 1998) |
| "Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment." | 2.40 | Antiepileptic drug therapy. ( Podell, M, 1998) |
| "Once SE is controlled, prevention of seizure recurrence should be individualized to each patient." | 2.40 | Management approaches to prolonged seizures and status epilepticus. ( Bleck, TP, 1999) |
| "Malaria is a major problem in children in many parts of Papua New Guinea; it has a high mortality and, if observations from other countries are applicable, significant long-term morbidity." | 2.38 | Malaria in children in Papua New Guinea. ( Vince, JD, 1992) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| "Treatment with phenobarbital (4 mg/kg/day, P." | 2.38 | [Benign familial neonatal convulsion: clinical features of the propositus and comparison with the previously reported cases]. ( Ishikawa, Y; Kibayashi, M; Minami, R; Okabe, M; Tachi, N; Wakai, S, 1990) |
| "Neonatal seizures may be characterized and classified according to their clinical features and presumed pathophysiology." | 2.38 | Consensus and controversy in the clinical management of neonatal seizures. ( Mizrahi, EM, 1989) |
| "It is the recommended drug for the treatment of seizures in term neonates." | 2.37 | [Phenobarbital in newborn infants. Overview]. ( Staudt, F, 1984) |
| "Febrile seizures are common in children." | 2.37 | The child with febrile seizures. ( Wright, SW, 1987) |
| "Febrile seizures are a common problem." | 2.37 | Febrile seizures: emergency department diagnosis and treatment. ( Ater, SB; Bettis, DB, 1985) |
| "Finally, seizure-like nonepileptic disorders were reviewed and differential diagnostic points highlighted." | 2.36 | Seizures and seizure-like states in the child: an approach to emergency management. ( Oppenheimer, EY; Rosman, NP, 1983) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| " In order to rapidly achieve therapeutic levels, it is suggested that a loading dose of 8 to 10 mg per kg be administered for 2 days followed by reduction of dosage to a maintenance level of 5 to 6 mg per kg with frequent monitoring of plasma phenobarbital concentrations." | 2.35 | Phenobarbital plasma levels in neonates. ( Pippenger, CE; Rosen, TS, 1975) |
| " Success of treatment correlated with higher dosing and serum levels." | 1.91 | Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis. ( Dimitriadis, K; Kunst, S; Madlener, M; Madžar, D; Malter, M; Meyer, L; Minnerup, J; Mueller, A; Neumann, B; Pelz, JO; Reindl, C; Rojo, M; Schmidbauer, ML, 2023) |
| "There was no incidence of delirium tremens or seizures and no difference in intubation rates ( p = 0." | 1.91 | Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients. ( Dorfman, JD; Forni, A; Kip, LM; Li, I, 2023) |
| "Phenobarbital was the primary initial antiseizure medication for both groups (90%), and both groups had similarly high rates of incomplete response to initial antiseizure medication administration (66% vs 68%, P = ." | 1.72 | Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study. ( Abend, NS; Bonifacio, S; Chang, T; Chu, C; Cilio, MR; Glass, HC; Lemmon, ME; Massey, SL; McCulloch, CE; Shellhaas, RA; Soul, JS; Thomas, C; Wusthoff, CJ; Xiao, R, 2022) |
| "High neonatal seizure burden is associated with worsened neurodevelopmental outcomes." | 1.72 | Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. ( Knox, A; Limjoco, J; Rajamanickam, V; Verwoerd, C, 2022) |
| "Midazolam was the first medication administered in 87/100 (87%) instances, mean dose of 0." | 1.72 | Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus. ( Babl, FE; Borland, ML; Dalziel, SR; Emeto, TI; Furyk, JS; George, S; Hearps, SJ; O'Brien, S; Phillips, N; Riney, K; Watt, K; Wilson, C, 2022) |
| "Sixty-seven dogs (13." | 1.72 | Approach to initial management of canine generalised epileptic seizures in primary-care veterinary practices in the United Kingdom. ( Garosi, L; Green, M; Lowrie, M; McConnell, K; Singleton, D, 2022) |
| "Caffeine is a psychoactive substance used worldwide." | 1.72 | Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats. ( Araújo, DB; Azevedo, JEC; Barbas, LAL; da Silva, ALM; Hamoy, AO; Hamoy, M; Lopes, DCF; Lopez, MEC; Mello, VJ; Nascimento, CP; Pereira, RG; Rodrigues, SF; Vieira, LR, 2022) |
| "Male accounted for 51." | 1.72 | Electroencephalographic Findings, Antiepileptic Drugs and Risk Factors of 433 Individuals Referred to a Tertiary Care Hospital in Ethiopia. ( Amare, A; Ayele, BA; Belay, HD; Gebrewold, MA; Gelan, YD; Gugssa, SA; Hagos, T; Kifelew, S; Mengesha, AT; Moges, A; Negash, HA; Oda, DM; Tsehayneh, F; Yifru, YM; Zewde, YZ, 2022) |
| "Since arrhythmia often accompanies seizures, patients suffering from epilepsy are frequently co-treated with antiepileptic and antiarrhythmic drugs." | 1.72 | Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, K, 2022) |
| "Neonatal seizures are significant cause of neonatal mortality and morbidity." | 1.72 | Prevalence and predictors of adverse outcomes in neonatal seizures. ( Aggarwal, A; Banerjee, BD; Batra, P; Famra, K, 2022) |
| " The drug-drug interactions, which may occur among currently available AEDs, are the principal criterion taken by physicians when prescribing the AED combination to the patients." | 1.62 | Polygonogram with isobolographic synergy for three-drug combinations of phenobarbital with second-generation antiepileptic drugs in the tonic-clonic seizure model in mice. ( Florek-Łuszczki, M; Jankiewicz, M; Kominek, M; Kozińska, J; Plewa, Z; Podgórska, D; Żółkowska, D; Łuszczki, JJ, 2021) |
| "Protective (antiseizure) effects of 4-butyl-5-[(4-chloro-2-methylphenoxy)-methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) and acute neurotoxic effects were determined in the tonic-clonic seizure model and rotarod test in mice." | 1.62 | Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice. ( Drabik, M; Florek-Łuszczki, M; Głuszak, M; Jankiewicz, M; Kozińska, J; Plech, T; Plewa, Z; Wróblewska-Łuczka, P; Łuszczki, JJ, 2021) |
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 1.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "Under lamotrigine, seizure aggravation was observed in 15 patients (two patients during levetiracetam, one patient during zonisamide, none during phenobarbital and valproic acid)." | 1.62 | Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy. ( Beier, CP; Gesche, J; Hjalgrim, H; Rubboli, G, 2021) |
| "Epilepsy was induced by pilocarpine, which was shown to produce long-lasting increases in NKCC1 in the hippocampus, whereas MEST did not alter NKCC1 mRNA in this region." | 1.62 | Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice. ( Gailus, B; Gericke, B; Hampel, P; Johne, M; Kaczmarek, E; Löscher, W; Römermann, K, 2021) |
| "Spontaneous recurrent seizures (SRS) in TLE can present after a latent period following a neurological insult (traumatic brain injury, SE event, viral infection, etc." | 1.62 | Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital. ( Barker-Haliski, M; Knox, K; Koneval, Z; Metcalf, C; White, HS; Wilcox, KS; Zierath, D, 2021) |
| " Similar dose-related responses were seen following the week-long dosing protocol for carbamazepine, phenobarbital, and phenytoin, and these responses were associated with drug levels that were in the human therapeutic range." | 1.62 | Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency. ( Bertram, EH; Edelbroek, P, 2021) |
| "Cysticercosis is a neglected tropical disease set as health priority by WHO." | 1.56 | [Disseminated cysticercosis affecting the brain, the eye and the skin on a Senegalese patient]. ( Diallo, K; Diallo, M; Dione, MAD; Diop, A; Manga, NM; Wembulua, BS, 2020) |
| "Phenobarbital was the antiepileptic drug most commonly prescribed in 76." | 1.51 | Clinical presentation of epilepsy in six villages in an onchocerciasis endemic area in Mahenge, Tanzania. ( Bhwana, D; Colebunders, R; Dekker, MC; Kakorozya, A; Makunde, WH; Matuja, W; Mmbando, BP; Mnacho, M; Weckhuysen, S, 2019) |
| "Initially, the prolonged seizures ceased after systemic midazolam treatment and were thought to be fever associated." | 1.51 | Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report. ( Hornei, B; Jacobsen, S; Jenke, AC; Koukou, G; Niendorf, S; Schlump, JU, 2019) |
| "After an episode of clonic seizures on day 11, phenobarbitone was administered intravenously at a loading dose of 20 mg/kg followed by maintenance doses of 6 mg/kg per day in 2 divided doses for 5 days." | 1.51 | Persistent Muscle Twitching With Phenobarbitone in a Preterm Neonate-Lack of Response or Manifestation of Toxicity? ( Dudeja, S; Dutta, S; Krishnamurthy, B; Pattanaik, S, 2019) |
| "Electrically-induced tonic-clonic seizures were experimentally evoked in adult male albino Swiss mice." | 1.51 | New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model. ( Gut-Lepiech, A; Karwan, S; Kondrat-Wróbel, MW; Marzeda, P; Plech, T; Wróblewska-Łuczka, P; Łuszczki, JJ, 2019) |
| "He had seizures since the newborn period and he had been treated with phenobarbital but there was no favorable response to therapy." | 1.51 | Mild hypotonia and recurrent seizures in an 8-month-old boy: Questions. ( Alan, B; Ceylaner, S; Kasapkara, CS; Kurt, ANÇ; Nergız, ME; Özlü, SG; Yılmaz, S, 2019) |
| "Survivors of neonatal seizures are at risk for developmental delay, epilepsy, and further neurological comorbidities." | 1.51 | Neurodevelopmental outcomes at 9-14 months gestational age after treatment of neonatal seizures due to brain injury. ( Brady, J; Cabassa Miskimen, AC; Ghosh, S; Kang, PB; Robinson, MA; Weiss, M; Zou, B, 2019) |
| "However, seizures are not typical and the majority of them were seizure-free." | 1.51 | A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019) |
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 1.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| " At 42 h of age, the serum PB concentration was in the toxic range at 131 mg/L." | 1.48 | The Use of Peritoneal Dialysis in Phenobarbitone Toxicity in a Critically Unwell Neonate. ( Graudins, A; Johnstone, LM; Le Page, AK; Roehr, CC; Stewart, AE, 2018) |
| "Hypoxia-induced seizures (HS) during the neonatal period can also lead to spontaneous seizures in adulthood." | 1.48 | Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. ( Dunn, R; Forcelli, PA; Pak, DTS; Queenan, BN, 2018) |
| "Seizures are present in over 90% of infants and children with Wolf-Hirschhorn syndrome (WHS)." | 1.48 | A survey of antiepileptic drug responses identifies drugs with potential efficacy for seizure control in Wolf-Hirschhorn syndrome. ( Battaglia, A; Carey, JC; Ho, KS; Lortz, A; Markham, LM; Newcomb, T; Olson, LM; Sheng, X; Twede, H; Wassman, ER; Weng, C, 2018) |
| "Epilepsy is a serious neurological disease affecting about 1% of people worldwide (65 million)." | 1.48 | Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model. ( Kondrat-Wróbel, MW; Łuszczki, JJ, 2018) |
| "Neonatal seizures have an incidence of 3." | 1.48 | Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12. ( Carter, BM; Kadam, SD; Landers, JR; Sullivan, BJ, 2018) |
| "Neonatal seizures are harmful to the developing brain and are associated with mortality and long-term neurological comorbidities." | 1.48 | Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model. ( Carter, BM; Kadam, SD; Kharod, SC, 2018) |
| "Cunaniol-induced seizures displayed a cyclic development of electrocorticographic seizures, presenting interictal-like spike and ictal period, which correlates to the behavioral observations and is in line with acute seizures induced by pentylenetetrazole." | 1.48 | Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. ( Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF, 2018) |
| "Seizures are common in term infants with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia." | 1.48 | A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. ( Chanlaw, T; Cho, A; Garg, M; Hussain, SA; Rao, LM; Sankar, R; Zaki, T, 2018) |
| "Phenobarbital was the most common initial medication for all gestational age groups, and failure to respond to an initial loading dose was 63% in both preterm and term neonates." | 1.46 | Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. ( Abend, NS; Bonifacio, SL; Chang, T; Chu, CJ; Cilio, MR; Glass, HC; Massey, SL; Shellhaas, RA; Soul, JS; Tsuchida, TN; Wusthoff, CJ, 2017) |
| "Mild encephalopathy/encephalitis with a reversible splenial (MERS) lesion is a clinic-radiological entity." | 1.46 | Mild encephalopathy/encephalitis with a reversible splenial lesion (MERS): A report of five neonatal cases. ( Baralc, S; Chen, L; Chen, WH; Liu, ZS; Sun, D; Wang, J; Xia, YP, 2017) |
| "Flupirtine is a KCNQ potassium channel opener." | 1.46 | Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy. ( Raol, YH; Sampath, D; Valdez, R; White, AM, 2017) |
| "When phenobarbital was administered every eight hours, 9/10 dogs experienced improvement in seizure frequency and 8/10 dogs maintained seizure freedom for a period three times longer than the longest interictal interval period previously recorded." | 1.46 | Phenobarbital administration every eight hours: improvement of seizure management in idiopathic epileptic dogs with decreased phenobarbital elimination half-life. ( Barnett, CR; De Risio, L; Stabile, F, 2017) |
| "Treatment with phenobarbital and potassium bromide completely terminated the seizures within 10days." | 1.43 | Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide. ( Itakura, A; Maegaki, Y; Nishimura, Y; Ohno, K; Okazaki, T; Saito, Y; Sejima, H; Yamamoto, T, 2016) |
| " Type I isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to analyze the 3-drug combination." | 1.43 | Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model. ( Luszczki, JJ, 2016) |
| "Electroconvulsions were evoked in Albino Swiss mice by a current delivered via ear-clip electrodes." | 1.43 | The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice. ( Barczyński, B; Czuczwar, SJ; Świąder, K; Świąder, MJ; Tomaszewski, M, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "The maximum seizure burden evaluated 1 h before each phenobarbitone dose (T-1) was compared to seizure burden in periods of increasing duration after each phenobarbitone dose had been administered (T+1, T+2 to seizure offset)." | 1.43 | Short-Term Effects of Phenobarbitone on Electrographic Seizures in Neonates. ( Boylan, GB; Livingstone, V; Low, E; Mathieson, SR; Rennie, JM; Ryan, AC; Stevenson, NJ, 2016) |
| "After treatment, convulsions were suppressed and daily life continued, but intellectual impairment and high-level dysfunction remained." | 1.43 | High-dose phenobarbital with intermittent short-acting barbiturates for acute encephalitis with refractory, repetitive partial seizures. ( Endo, W; Haginoya, K; Kitamura, T; Nishio, T; Numata, Y; Ohura, T; Takayanagi, M; Uchida, T, 2016) |
| "electrographic seizure detection; secondary outcome: use of maintenance antiseizure medications, discharge antiseizure medications, and cumulative burden for each antiseizure medication defined as total mg/kg during hospital stay." | 1.43 | Implementation of a Neurocritical Care Program: Improved Seizure Detection and Decreased Antiseizure Medication at Discharge in Neonates With Hypoxic-Ischemic Encephalopathy. ( Bashir, RA; Bello-Espinosa, L; Buchhalter, J; Espinoza, L; Irvine, L; Mohammad, K; Vayalthrikkovil, S, 2016) |
| "After adjustment for seizure burden, neonates managed during the Neonatal Neurocritical Care Service era, on average, received 30 mg/kg less cumulative phenobarbital (95% confidence interval 15-46 mg/kg) and were on maintenance 5 fewer days (95% confidence interval 3-8 days) than those who were treated prior to implementation of the service." | 1.42 | Neonatal Neurocritical Care Service Is Associated With Decreased Administration of Seizure Medication. ( Bonifacio, SL; Glass, HC; Kuzniewicz, MW; McCulloch, CE; Wietstock, SO, 2015) |
| "In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects." | 1.42 | Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (25 mA, 500 V, 50 Hz, 0." | 1.42 | Effect of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of classical antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Florek-Luszczki, M; Glensk, M; Glowniak, K; Luszczki, JJ; Pyrka, D; Skalicka-Wozniak, K; Zagaja, M, 2015) |
| "Seizures are common during the neonatal period, often due to hypoxic-ischemic encephalopathy and may contribute to acute brain injury and the subsequent development of cognitive deficits and childhood epilepsy." | 1.42 | Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice. ( Boylan, GB; Dunleavy, M; Henshall, DC; Jimenez-Mateos, EM; Rodriguez-Alvarez, N; Waddington, JL, 2015) |
| "Neonatal seizures are commonly associated with hypoxic-ischemic encephalopathy." | 1.42 | Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia. ( Johnston, MV; Kadam, SD; Kang, SK, 2015) |
| "All the seizure parameters were significantly reduced when phenobarbital (3 mg/kg) was administered prior to the application of the non-effective pattern of LFS." | 1.40 | Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats. ( Asgari, A; Atapour, N; Mirnajafi-Zadeh, J; Moradi, H; Semnanian, S; Shojaei, A, 2014) |
| " A low dosage of phenobarbital caused a significant increase of the generalized seizure threshold in the L-701,324 pre-treated group, whereas it did not exert a comparable effect in animals that received vehicle during the massive kindling phase." | 1.40 | Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model. ( Aronica, E; Gorter, J; Potschka, H; Salvamoser, JD; Soerensen, J; van Vliet, EA; Zellinger, C, 2014) |
| "Four uncommon cases of canine distemper (CD) were diagnosed in vaccinated adult dogs." | 1.40 | Uncommon acute neurologic presentation of canine distemper in 4 adult dogs. ( Carletti, BE; de las Mulas, JM; Galán, A; Gamito, A; Guisado, A; Martín, EM; Pérez, J, 2014) |
| "The convulsive seizure started with crying and coughing followed by opisthotonus, flexion of upper extremities, extension of lower extremities, and generalized jerks in extremities." | 1.40 | Neonatal eating epilepsy: 50-year follow-up. ( Schmidt, D; Sillanpää, M, 2014) |
| "The seizures were confirmed using amplitude-integrated electroencephalography, and other possible causes of neonatal seizures were excluded." | 1.40 | Myoclonic seizures in a preterm baby: is this a presentation of venlafaxine withdrawal? ( Ansary, A; Ibhanesebhor, S; Manjunatha, C, 2014) |
| "Phenobarbital (PB) was administrated at a very high daily dose up to 80 mg/kg, reaching serum trough level of 250 μg/ml, which was markedly effective to the treatment." | 1.40 | [A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy]. ( Aiba, H; Okumura, Y; Watanabe, S, 2014) |
| "A device capable of detecting seizures and alerting caregivers would be a major advance for epilepsy management, and could be used to guide early intervention and prevent seizure-related injuries." | 1.39 | Feasibility study of a caregiver seizure alert system in canine epilepsy. ( Cloyd, JC; Coles, LD; Higgins, J; Leyde, K; Litt, B; Mavoori, J; Michael, B; Patterson, EE; Sheffield, WD; Vite, C; Worrell, GA, 2013) |
| "Recently, seizures in dogs have been proposed as a translational platform for human therapeutic trials on new epilepsy treatments." | 1.39 | The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs. ( Hoffmann, K; Löscher, W; Potschka, H; Töllner, K; Twele, F, 2013) |
| "Among those with Idiopathic Generalized Epilepsy (46%), generalized tonic clonic seizure was encountered in 74% and absence seizure was observed in 13%." | 1.39 | Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital. ( Chowdhury, AH; Chowdhury, RN; Ghose, SK; Habib, M; Haque, B; Hasan, AT; Hoque, A; Khan, SU; Mohammad, QD; Mondal, BA; Rahman, KM, 2013) |
| "Seizures were treated with sodium valproate (n = 11), phenobarbital (n = 3), diazepam (n = 2), lamotrigine (n = 1), and carbamazepine (n = 1)." | 1.39 | Prevalence of seizures in children infected with human immunodeficiency virus. ( Eley, B; Petersen, R; Samia, P; Walker, KG; Wilmshurst, JM, 2013) |
| "In animal convulsion models, some anticonvulsants have been found to suppress oxidative reactions associated with convulsions." | 1.38 | Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. ( Arai, Y; Higuchi, H; Maeda, S; Miyawaki, T; Shimada, M; Tomoyasu, Y, 2012) |
| "In the three dogs with porencephaly, there was unilateral incomplete loss of the parietal lobe and one dog had additional partial loss of the temporal and frontal lobes." | 1.38 | Porencephaly and hydranencephaly in six dogs. ( Behr, S; Davies, ES; de Lahunta, A; Garosi, L; Jull, P; Summers, B; Syme, H; Volk, HA, 2012) |
| "During drug development, seizure threshold tests are widely used to identify potential proconvulsant activity of investigational drugs." | 1.38 | Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. ( Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W, 2012) |
| " The addition of CYP2C19 genotyping to PK models did not improve the dosing strategies in neonates and infants." | 1.38 | Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures. ( Chung, JY; Lee, C; Lee, SM; Lee, YM; Namgung, R; Park, KI; Park, MS, 2012) |
| "He developed electrographic seizures for the first time during the warming phase, which continued in the hours after rewarming." | 1.38 | Recooling for rebound seizures after rewarming in neonatal encephalopathy. ( Kendall, GS; Mathieson, S; Meek, J; Rennie, JM, 2012) |
| "One dog exhibited increased seizure activity due to a compounded, flavored phenobarbital solution that deteriorated before the expiration date provided by the compounder." | 1.38 | Compounding errors in 2 dogs receiving anticonvulsants. ( Adams, C; McConkey, SE; Walker, S, 2012) |
| "Their seizures were controlled after an administration of high-dose phenobarbital." | 1.37 | Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures. ( Abe, S; Ikeno, M; Kitamura, T; Komatsu, M; Matsui, K; Okumura, A; Shimizu, T, 2011) |
| "On VPA 1000 mg/d, the seizure frequency decreased significantly." | 1.37 | Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome. ( Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R, 2011) |
| "The presence of multiple seizures prior to medical treatment has been suggested as a potential predictor of poor outcome." | 1.36 | High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010) |
| "In the neonatal period, seizures rank among the most common neurological symptoms, often indicating an underlying serious neurological condition." | 1.36 | Approach to seizures in the neonatal period: a European perspective. ( Alberola, A; Blennow, M; Boronat, N; de Vries, LS; Greisen, G; Steggerda, S; Vento, M, 2010) |
| "Sex, age, familial history, type of seizures and AED treatment were noted and EEG monitoring, MRI and CT scanning, and developmental and psychomotor evolution were investigated." | 1.36 | Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy? ( Caraballo, R; Cersósimo, R; Flesler, S; Sakr, D, 2010) |
| "Subtle seizures are the commonest type of seizures occurring in the neonatal period." | 1.36 | Management of neonatal seizures. ( Agarwal, R; Deorari, A; Paul, VK; Sankar, JM, 2010) |
| "The aggravation of habitual seizures and interictal discharges indicate ENM." | 1.35 | A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. ( Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y, 2009) |
| " Outcome did not depend on duration of barbiturate therapy, dosage or serum concentration, co-medication, reduction rate, degree of intellectual disability, or epilepsy syndrome." | 1.35 | Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability. ( Bocchicchio, M; Hauser, I; Horstmann, V; Huber, B; Jokeit, G; May, T; Meinert, T; Robertson, E; Schorlemmer, H; Schulz, L; Seidel, M; Wagner, W, 2009) |
| "Treatment with phenobarbital resulted in substantial improvement in the number of seizure episodes, however fine seizure-like movement continued in both of the hands, feet and in the tongue until the five-month follow-up." | 1.35 | Prenatal diagnosis of fetal seizure: a case report. ( Huh, CY; Jung, E; Lee, BY, 2008) |
| "Neonatal seizures are one of the most common neurological disorders in infants." | 1.35 | Neonatal seizures: treatment and treatment variability in 31 United States pediatric hospitals. ( Blume, HK; Christakis, DA; Garrison, MM, 2009) |
| "Benign familial neonatal convulsions are a rare, autosomal-dominant form of neonatal epileptic syndrome." | 1.35 | Benign familial neonatal convulsions: novel mutation in a newborn. ( Chen, JY; Chen, YJ; Lee, IC; Su, PH; Yu, JS, 2009) |
| "Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest." | 1.35 | Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. ( Augustine, G; Bacskai, BJ; Dzhala, VI; Feng, G; Glykys, J; Kuchibhotla, KV; Kuner, T; Staley, KJ, 2009) |
| "A cat with a history of seizures and clinical suspicion of forebrain disorder underwent a brain magnetic resonance imaging." | 1.35 | Toxoplasma gondii brain granuloma in a cat: diagnosis using cytology from an intraoperative sample and sequential magnetic resonance imaging. ( Baroni, M; De Lorenzi, D; Falzone, C; Mandara, MT, 2008) |
| "The clinical diagnosis of incontinentia pigmenti (stage 1) was secured by histopathology." | 1.35 | Therapy resistant neonatal seizures, linear vesicular rash, and unusually early neuroradiological changes: incontinentia pigmenti: a case report, literature review and insight into pathogenesis. ( Gardiner, J; Kaczala, GW; Messer, MA; Poskitt, KJ; Prendiville, JS; Senger, C, 2008) |
| "To describe the dose-concentration relationship of a continuous intravenous infusion of valproic acid (VPA) in pediatric patients when a dosing protocol is used." | 1.34 | Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients. ( Baumann, RJ; Cook, AM; Farzam, F; Kuhn, RJ; Lewis, DA; Taylor, LM, 2007) |
| "High amplitude with high frequency EMG seizure was observed in parallel with the appearance of tonic extensor (TE) seizure and an intimate relationship was observed between the two parameters." | 1.34 | Effects of certain antiepileptics on behavioral and electromyographic seizure patterns induced by maximal electroshock in mice. ( Ago, J; Ishikawa, T; Kamei, C; Matsumoto, N; Murakami, A; Takechi, K, 2007) |
| " The effect of SNP was tested alone and in combination with phenobarbitone (PB), the GABA potentiating antiepileptic drug, against picrotoxin (PCT) (5 mg/kg)-induced convulsions in rats." | 1.33 | Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats. ( Ekambaram, P; Paul, V, 2005) |
| "Very few respondents used pyridoxine to treat recurrent seizures that were historically linked to perinatal asphyxia and hypoxic-ischaemic encephalopathy." | 1.33 | Drug treatment of neonatal seizures by neonatologists and paediatric neurologists. ( Barr, P; Carmo, KB, 2005) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| " Linear regression analysis of dose-response relationship between the doses of 2-PMPA and their corresponding threshold values allowed the calculation of threshold increasing dose by 20% (TID20), which was 109." | 1.33 | 2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Luszczki, JJ; Mohamed, M, 2006) |
| " The proposed study could provide the first concrete evidence of treatment efficacy because (1) it examines a homogeneous patient population, (2) the recognition and quantification of seizures rests solely on the gold standard of seizure detection (EEG), and (3) the dosing of phenobarbital is matched specifically to the phenobarbital-binding characteristics of the individual treated." | 1.33 | Summary proceedings from the neurology group on neonatal seizures. ( Clancy, RR, 2006) |
| "But, in audiogenic seizures (brainstem tonic-clonic seizures), the anticonvulsant activity of these nuclei is still controversial." | 1.33 | EEG wavelet analyses of the striatum-substantia nigra pars reticulata-superior colliculus circuitry: audiogenic seizures and anticonvulsant drug administration in Wistar audiogenic rats (War strain). ( de Oliveira, JA; Garcia-Cairasco, N; Rodrigues, MC; Rossetti, F, 2006) |
| "As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up." | 1.33 | Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? ( Bianchi, MC; Crisanti, AF; Del Giudice, E; Imperati, F; Romano, A; Titomanlio, L; Tosetti, M; Varrone, A, 2006) |
| "Seizures were observed between 2 and 15 h of age in all of them." | 1.32 | Hypoxic ischemic encephalopathy associated with neonatal seizures without other neurological abnormalities. ( Hayakawa, F; Kato, T; Kuno, K; Okumura, A; Sato, Y; Watanabe, K, 2003) |
| "There were 73 children with seizures, 80% of whom had a greater than 50% reduction in seizure frequency following the start of simple anticonvulsant medication." | 1.32 | A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children. ( Allen, S; Burton, KJ, 2003) |
| "The temporal course of the seizures and the use of antiepileptic drugs were investigated in each episode." | 1.32 | Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis. ( Negoro, T; Okumura, A; Uemura, N; Watanabe, K, 2004) |
| " Hence, in the present study, its (100 and 200 mg/kg) action was tested alone and in combination with phenobarbitone (20 mg/kg) and diazepam (0." | 1.32 | Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats. ( Ekambaram, P; Paul, V, 2003) |
| " Investigations ruled out an infectious etiology; an adverse event following phenobarbital administration was considered." | 1.32 | Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. ( Bavdekar, SB; Gogtay, NJ; Kantharia, V; Kshirsagar, NA; Muranjan, MN, 2004) |
| "An erroneous diagnosis of seizure lead to phenobarbital overdose and the change of aEEG voltage and pattern assisted in a prompt diagnosis." | 1.32 | The influence of phenobarbital overdose on aEEG recording. ( Shany, E, 2004) |
| "Cefoselis (50 microg/animal)-induced convulsions were prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0." | 1.31 | Intracerebroventricular injection of the antibiotic cefoselis produces convulsion in mice via inhibition of GABA receptors. ( Matsuoka, N; Mochizuki, Y; Mutoh, S; Sugimoto, M; Terai, T; Uchida, I; Yamazaki, S, 2002) |
| " Pharmacokinetic studies involved administering phenobarbital (15 mg/kg [6." | 1.31 | Effects of diet on pharmacokinetics of phenobarbital in healthy dogs. ( Fettman, MJ; Greco, DS; Maguire, PJ; Ogilvie, GK; Smith, MO; Turner, AS; Walton, JA, 2000) |
| " In these patients SHS developed during the first 7 months of therapy and regressed after PB discontinuation or, in 2 cases, after dosage reduction." | 1.31 | Shoulder-hand syndrome in neurosurgical patients treated with barbiturates. A long term evaluation. ( Bello, L; Ceccarelli, G; Cesana, BM; De Santis, A; Spagnoli, D; Villani, RM, 2000) |
| "However, the attenuation of severe seizures by a single PRA, PHEN, DZP, or PHB cotreatment was accompanied by a decrease in the brain COCA concentration." | 1.31 | Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity. ( Fukui, Y; Hayase, T; Yamamoto, K; Yamamoto, Y, 2000) |
| "2) prevented tonic-clonic convulsions and significantly enhanced survival of the mutant mice." | 1.31 | Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. ( Bottiglieri, T; Burlingame, TG; Diaz-Arrastia, R; Froestl, W; Gibson, KM; Grompe, M; Gupta, M; Hogema, BM; Jakobs, C; Schutgens, RB; Senephansiri, H; Snead, OC; Taylor, M, 2001) |
| "Seizures are commonly associated with hypoxic-ischemic encephalopathy." | 1.31 | Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde. ( Armstrong, DL; Battin, MR, 2001) |
| "Seizures were categorised as EEG seizure discharges only (electrographic), or as EEG seizure discharges with accompanying clinical manifestations (electroclinical)." | 1.31 | Phenobarbitone, neonatal seizures, and video-EEG. ( Binnie, CD; Boylan, GB; Morton, M; Pressler, RM; Rennie, JM; Wilson, G, 2002) |
| " Further detailed pharmacokinetic studies of irinotecan in patients receiving concomitant therapy with enzyme-inducing anticonvulsants are required so that rational dosing recommendations can be provided for this patient population." | 1.31 | Influence of phenytoin on the disposition of irinotecan: a case report. ( Berg, S; Bernstein, M; Blaney, SM; Cherrick, I; Kuttesch, N; Murry, DJ; Salama, V, 2002) |
| "Tonic-clonic seizures have not been reported as a manifestation of this condition." | 1.31 | An unusual presentation of fifth-day fits in the newborn. ( Boylan, GB; Guerra, MP; Rennie, JM; Wilson, GA, 2002) |
| "Prodromal phase and aura were present in the majority of the dogs with generalised seizures." | 1.30 | Clinical, epidemiological and treatment results of idiopathic epilepsy in 54 labrador retrievers: a long-term study. ( Faissler, D; Heynold, Y; Jaggy, A; Steffen, F, 1997) |
| " For comparison of drug potencies, doses increasing seizure thresholds by 20 or 50% were calculated from dose-response curves." | 1.30 | Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models. ( Krupp, E; Löscher, W, 1998) |
| "Phenobarbital was maintained for 3 weeks to 6 months (mean 11 weeks)." | 1.30 | Outcome of neonatal stroke in full-term infants without significant birth asphyxia. ( Camfield, PR; Jan, MM, 1998) |
| " From our experience, careful and individual dosing of fosphenytoin in this age group can be considered." | 1.30 | Fosphenytoin in infants. ( Caviness, VS; Krishnamoorthy, KS; Soman, TB; Takeoka, M, 1998) |
| "These were presence of seizures, grading of encephalopathy and neurobehavioural assessment at discharge from the hospital." | 1.30 | Clinical predictors of outcome in hypoxic ischaemic encephalopathy in term neonates. ( Aggarwal, P; Barve, S; Bhave, S; Chaudhari, S; Pandit, A, 1998) |
| "This report characterizes seizures in a novel genetic model of developmental epilepsy, the Flathead (FH) rat." | 1.30 | Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. ( D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR, 1999) |
| " A maintenance dose of 5 mg/kg/d provided a peak concentration of 19." | 1.30 | Phenobarbital dosing and pharmacokinetics in a neonate receiving extracorporeal membrane oxygenation. ( Buck, ML; Elliott, ES, 1999) |
| "No further seizures occurred." | 1.30 | The use of phenobarbitone in the management of agitation and seizures at the end of life. ( Kurowska, A; Stirling, LC; Tookman, A, 1999) |
| "After a control recording period, seizures were induced by subcortical penicillin G injections." | 1.30 | Effects of experimental cortical seizures on respiratory motor nerve activities in piglets. ( Bartlett, D; Darnall, R; Knuth, SL; Terndrup, TE, 1999) |
| "Electroconvulsive shock (ECS) seizures provide an animal analog of electroconvulsive therapy (ECT)." | 1.30 | Ketamine and phenobarbital do not reduce the evoked-potential enhancement induced by electroconvulsive shock seizures in the rat. ( Burnham, WM; Cottrell, GA; Gombos, Z; Mendonça, A, 1999) |
| "Medical records were reviewed for seizure and medication history, diagnostic test results, types of treatment, hospitalization costs, and outcome of hospital visits." | 1.30 | Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995). ( Bateman, SW; Parent, JM, 1999) |
| "Phenobarbital monotherapy was given to 20 patients with idiopathic generalized epilepsy beginning in childhood but persisting into adulthood." | 1.30 | Phenobarbital still has a role in epilepsy treatment. ( Lerman, P; Lerman-Sagie, T, 1999) |
| "Seizures were generally frequent, with limited electrographic spread." | 1.29 | Spatial and temporal characteristics of neonatal seizures. ( Bye, AM; Flanagan, D, 1995) |
| "Behavioral characteristics of seizures have age-dependent features, which suggests that effective treatment of seizures may be age-specific as well." | 1.29 | Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures. ( Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J, 1995) |
| "The effects of AEDS on seizures of the tremor rat showed profiles similar to those observed in human absence seizures and also in absence-like seizures of SER." | 1.29 | Effect of antiepileptic drugs on absence-like seizures in the tremor rat. ( Amano, T; Fujita, Y; Hanaya, R; Matsubayashi, H; Sasa, M; Serikawa, T; Ujihara, H; Uozumi, T, 1995) |
| " Rats receiving phenobarbital had therapeutic concentrations during most of the 24-hour dosing period, but also experienced supratherapeutic peak concentrations." | 1.29 | Phenobarbital modifies seizure-related brain injury in the developing brain. ( Chronopoulos, A; Gatt, A; Holmes, GL; Hyde, P; Liu, Z; Mikati, MA; Stafstrom, CE; Thurber, S; Werner, S, 1994) |
| " Differential effects on the pharmacodynamic parameters were seen." | 1.29 | Characterization of the pharmacodynamics of several antiepileptic drugs in a direct cortical stimulation model of anticonvulsant effect in the rat. ( Danhof, M; Hoogerkamp, A; Vis, PW; Voskuyl, RA, 1994) |
| " According to these values and assuming phenobarbital serum levels of 20 mg/l to be safe and effective in neonatal seizures, the initial dosing recommended is 2." | 1.29 | Dosage programming of phenobarbital in neonatal seizures. ( Alonso Gonzalez, AC; Dominguez-Gil Hurle, A; Garcia Sanchez, MJ; Monzon Corral, L; Ortega Valin, L; Santos Borbujo, J; Santos Buelga, D, 1993) |
| "Since repeated seizures and a number of pharmacological agents are known to alter the onset and duration of seizure activity, a relationship between the changes in excitability and the onset of the seizure activity was tested using MK-801, ketamine, bicuculline, diazepam, phenobarbital, baclofen and repeated seizures." | 1.29 | Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus. ( Stringer, JL, 1993) |
| "Generalized convulsions were easily suppressed in the level of 15-25 micrograms/ml and afterdischarge was totally suppressed in 33% of cats in the level of 35-50 micrograms/ml in the hippocampal-kindled group." | 1.29 | [Different effects of chronically administered phenobarbital on amygdaloid- and hippocampal-kindled seizures in the cat]. ( Sumi, T, 1993) |
| "The long-term use of anticonvulsant medication to prevent postoperative seizures in patients with aneurysms has been accepted medical practice for many years." | 1.29 | Short-term perioperative anticonvulsant prophylaxis for the surgical treatment of low-risk patients with intracranial aneurysms. ( Baker, CJ; Prestigiacomo, CJ; Solomon, RA, 1995) |
| "Two protocols were used: assessment of seizures immediately after the completion of the kindling procedure and after the 2-week postkindling PTX-free period, as compared with acute PTX seizures." | 1.29 | Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models. ( Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS, 1996) |
| "Measurement of incidence of neonatal seizures and evaluation of the therapeutic strategy used." | 1.29 | [Treatment of convulsions in newborn infants]. ( Baarsma, R; Fischer, K, 1996) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| "The presence of convulsions before admission or at any time in the illness, coma on admission, and a history of illness of more than 3 days duration prior to admission were strongly associated with death." | 1.28 | Purulent meningitis in children: outcome using a standard management regimen with chloramphenicol. ( Tefuarani, N; Vince, JD, 1992) |
| "Benign Familial Neonatal Seizures (BFNS) occur in normal newborns without perinatal neurological damage or metabolic abnormalities in the setting of a positive family history for neonatal seizures." | 1.28 | Benign Familial Neonatal Seizures. ( Dworsky, ME; Raispis, T, 1992) |
| "As phenobarbital treatment did not protect against neuronal damage in CA3 or other regions of the hippocampus, the circuitry of the dentate gyrus was implicated as a locus of cellular alterations that influenced the development of kindling." | 1.28 | Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital. ( Cavazos, J; Golarai, G; Sutula, T, 1992) |
| "Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable." | 1.28 | Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992) |
| "To report unusually high theophylline dosing requirements in a smoker receiving concomitant therapy with phenytoin and phenobarbital." | 1.28 | Massive theophylline dosing in a heavy smoker receiving both phenytoin and phenobarbital. ( Basile, SA; Cury, JD; Nicholson, JP, 1992) |
| "A lidocaine level was obtained at 4 h post-ingestion and was 0." | 1.28 | Rapid onset of seizures following aspiration of viscous lidocaine. ( Garrettson, LK; McGee, EB, 1992) |
| "The kindled-convulsion model was used to assess the development of tolerance and cross tolerance to the anticonvulsant effects of antiepileptic drugs." | 1.28 | Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine. ( Hudda, MM; Kim, CK; Pinel, JP; Wong, DJ; Yung, A, 1992) |
| "The development of withdrawal seizures depended on repeated episodes of withdrawal, whereas repeated alcohol intoxication per se did not explain the development of seizures." | 1.28 | Convulsive behaviour during alcohol dependence: discrimination between the role of intoxication and withdrawal. ( Clemmesen, L; Hemmingsen, R; Ulrichsen, J, 1992) |
| "We report a patient with a seizure disorder on anticonvulsant therapy, who developed systemic reactive histiocytosis." | 1.28 | Reactive lymphohistiocytosis with recurrence in the optic chiasm. ( Galetta, SL; Hicks, DG; Oberholtzer, JC; Plock, G; Raps, EC; Stadtmauer, EA, 1991) |
| "AOAA also induced clonic convulsions in mice subjected to intracerebroventricular administration of the drug with a CD50 of 0." | 1.28 | Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics. ( Calderazzo-Filho, LS; Cavalheiro, EA; Dziki, M; Turski, WA; Urbanska, E, 1991) |
| "There was a greater risk of recurrence among girls." | 1.28 | [Factors influencing the effectiveness of preventive treatment of febrile convulsions]. ( Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL, 1989) |
| "When phenobarbital was infused about 2." | 1.28 | Kinetics of drug action in disease states. XXXVII. Effects of acute fluid overload and water deprivation on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline in rats. ( Levy, G; Zhi, JG, 1989) |
| "The relationships between the convulsions induced by the local anesthetic procaine and monoamines in the spinal cord were investigated in rats." | 1.28 | Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats. ( Kawaguchi, M; Sawaki, K, 1989) |
| "Infants with refractory seizures received additional phenobarbital to a maximum serum concentration of 100 micrograms/mL." | 1.28 | Rapid sequential phenobarbital treatment of neonatal seizures. ( Duchowny, MS; Gal, P; Gilman, JT; Ransom, JL; Weaver, RL, 1989) |
| " The pharmacokinetics of phenobarbital were studied in a separate set of rats (elimination half-life 11 +/- 2 hr)." | 1.28 | Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats. ( Danhof, M; Dingemanse, J; van Bree, JB, 1989) |
| "The acute effects of seizures were also studied in both S/D rats and audiogenic seizure rats." | 1.27 | Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain. ( Laird, H; Mimaki, T; Yabuuchi, H; Yamamura, HI, 1984) |
| "We think this decline is caused by seizures since phenobarbital pretreatment prevented the appearance of limbic seizures and blocked the receptor decline." | 1.27 | Benzodiazepine receptor declines in hippocampal formation following limbic seizures. ( Dasheiff, RM; Fanelli, RJ; Kraus, VM; McNamara, JO, 1983) |
| "Compared to the preconvulsion group, the total free amino acid level increased in the ACTH group clearly." | 1.27 | Amino acid metabolism in the brain with convulsive disorders. Part 2: The effects of anticonvulsants on convulsions and free amino acid patterns in the brain of El mouse. ( Honda, T, 1984) |
| " The principal pharmacokinetic parameters of guanfacine were greatly altered, with extended biotransformation and a decrease in the half-life compared to the values observed in other cases of severe renal insufficiency." | 1.27 | Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure. ( Comoy, E; Fillastre, JP; Godin, M; Guerret, M; Kiechel, JR; Lavene, D, 1983) |
| "When phenobarbital was administered for several days, a strong induction of hepatic microsomal enzymes occurred." | 1.27 | Anticonvulsant potency of common antiepileptic drugs in the gerbil. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "Sixty-three infants with neonatal seizures were studied in terms of etiology, seizure type, electroencephalograms, and outcome." | 1.27 | Neonatal seizures: a reappraisal. ( Nogen, AG, 1984) |
| "The ED50s to inhibit seizure pattern in EEG were 30." | 1.27 | Effects of certain antiepileptics on cephaloridine- and cefazolin-induced seizures in rats. ( Kamei, C; Sunami, A; Tasaka, K, 1983) |
| "A rat model of phenobarbital tolerance and physical dependence has been developed based on the 'maximally tolerable, chronically equivalent' dosing paradigm." | 1.27 | Phenobarbital tolerance and physical dependence: chronically equivalent dosing model. ( Boisse, NR; Gay, MH; Guarino, JJ; Ryan, GP, 1983) |
| "Neonatal cerebral infarction is infrequently reported in the living newborn and is usually associated with perinatal risk factors, trauma, and asphyxia." | 1.27 | 'Idiopathic' neonatal cerebral infarction. ( Gerber, GJ; Mantovani, JF, 1984) |
| "During this period, partial seizures occurred." | 1.27 | Decreased phenytoin level during antineoplastic therapy: a case report. ( Albani, F; Baruzzi, A; Bollini, C; Bollini, P; Cacciari, L; Ida, N; Riva, R, 1983) |
| " Patients receiving anticonvulsant medication must make no change in drug dosage without medical guidance because of the risk of this catastrophic consequence." | 1.27 | Anticonvulsants and neurogenic pulmonary edema. ( Mandel, S; Paschall, R, 1983) |
| "However, ethosuximide must act against generalized absence seizures and against pentylenetetrazol-induced seizures by a third, as yet unknown, mechanism." | 1.27 | Anticonvulsant drug mechanisms of action. ( Macdonald, RL; McLean, MJ; Skerritt, JH, 1985) |
| "Pretreatment with phenytoin, which is thought to bind to the inactivation gates of sodium, had no effect on the effects produced by lindane or kainic acid." | 1.27 | The effects of lindane, DDT, and chlordecone on avoidance responding and seizure activity. ( McLamb, RL; Shaw, S; Tilson, HA, 1987) |
| "After large numbers of pretreatment seizures (40, 100), drug response was actually enhanced." | 1.27 | The effect of repeated seizures on anticonvulsant drug response in the kindling model. ( Burnham, WM; Mace, JA, 1987) |
| "The results show that aminophylline convulsions are relatively resistant to antiepileptic drugs and suggest that antagonists of excitatory transmission are potential antiaminophylline drugs." | 1.27 | Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A, 1987) |
| "Pentobarbital was also effective against bicuculline whereas only hypnotic doses of phenobarbital provided some protection against bicuculline- (8 mg/kg, IP) induced convulsions." | 1.27 | Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats. ( Mehta, AK; Ticku, MK, 1988) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| " In the case of diazepam, clonazepam, ethosuximide or trimethadione, the TE/TF ratio was decreased dose-dependently, but the slope of the dose-response regression line was less steep than that obtained by the administration of PB, PNT, CBZ, VPA or primidone." | 1.27 | [The correlation between concentrations of anticonvulsive drugs in the brain and various parameters of maximal electroshock seizures in mice]. ( Kishita, C, 1986) |
| "The threshold of the generalized clonic convulsions induced by intravenous infusion of pentylenetetrazol (PTZ) was significantly increased by the intraperitoneal administration of noradrenaline (NA) neurotoxin, 6-hydroxydopamine, which produced no changes in the levels of catecholamines in discrete areas of rat brain, but the effect was accompanied by spinal depletion of NA." | 1.27 | A possible role for spinal noradrenaline in the mechanisms of 6-hydroxydopamine against pentylenetetrazol induced convulsions in rats. ( Abed, WT, 1988) |
| " Purely additive interactions were found for the anticonvulsant effect when valproate was combined with carbamazepine as well as with phenobarbital." | 1.27 | Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital. ( Bourgeois, BF, 1988) |
| "Seizures were classified as subtle, multifocal clonic, generalized tonic, focal clonic, and myoclonic." | 1.27 | Seizures in the neonatal intensive care unit of the 1980s. Types, Etiologies, Timing. ( Calciolari, G; Perlman, JM; Volpe, JJ, 1988) |
| "Five neonates treated with PB alone for seizures were studied." | 1.27 | Development of phenobarbital glucosidation in the human neonate. ( Bhargava, VO; Garrettson, LK, 1988) |
| "Enprofylline, 27." | 1.27 | Effects of aminophylline and enprofylline on the protective activity of phenobarbital against amygdala-kindled seizures in rats. ( Czuczwar, SJ; Jäckel, R; Löscher, W, 1987) |
| "To characterize and classify neonatal seizures, we studied 349 neonates, using a portable, cribside EEG/polygraphic/video monitoring system." | 1.27 | Characterization and classification of neonatal seizures. ( Kellaway, P; Mizrahi, EM, 1987) |
| "The ability of sulfhydryl compounds to provide protection against the acute toxicity of codeinone, a toxic metabolite of codeine, was investigated in mice." | 1.27 | Effects of glutathione and phenobarbital on the toxicity of codeinone. ( Inoue, K; Nagamatsu, K; Terao, T; Toki, S, 1986) |
| "Bicyclic phosphorus esters (BCP) originating from the combustion of fire-retardant polyurethane foam containing phosphorus are highly toxic compounds and potent antagonists of GABA-ergic receptors." | 1.27 | [Effect of diazepam and phenobarbital on the acute toxicity of bicyclic organophosphorus esters]. ( Emilianowicz, J; Smok, W, 1986) |
| "The effects of pregnancy on seizure excitability as well as antiepileptic drug disposition and efficacy were studied in the mouse during late gestation." | 1.27 | Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse. ( Kuhnz, W; Löscher, W; Nau, H, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "Paraldehyde was given as a 200 mg/kg IV bolus followed by an infusion of 16 mg/kg/h (10 cases), or as a 400 mg/kg bolus (4 cases)." | 1.27 | Intravenous paraldehyde for seizure control in newborn infants. ( Butt, W; Koren, G; MacLeod, SM; Mayer, J; Pape, K; Rajchgot, P; Whyte, H, 1986) |
| "EEG seizures were recorded in seven patients, five of whom had experienced clinical seizures in the 24 hours prior to cassette EEG recording." | 1.27 | Cassette electroencephalography in the evaluation of neonatal seizures. ( Bridgers, SL; Ebersole, JS; Ehrenkranz, RA; Ment, LR; Silva, CG, 1986) |
| "A case of infantile seizures of unusual etiology and presentation is described." | 1.27 | Infantile seizures caused by voluntary water intoxication. ( Gold, I; Koenigsberg, M, 1986) |
| "Phenobarbital pretreatment prevented the convulsions and pulmonary damage produced by a 50 mg/kg i." | 1.27 | The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat. ( Hanzlik, RP; Hogberg, K; Penney, DA; Traiger, GJ, 1985) |
| "A retrospective study of neonatal seizures in a tertiary care neonatal intensive care unit determined a 3." | 1.27 | Efficacy of phenobarbital in neonatal seizures. ( Darwish, HZ; Van Orman, CB, 1985) |
| "Sixty-three children with seizure disorders receiving phenobarbital and/or diphenylhydantoin for more than 12 months had liver function tests evaluated." | 1.26 | The effects of phenobarbital and diphenylhydantoin on liver function and morphology. ( Aiges, HW; Daum, F; Kahn, E; Olson, M; Teichberg, S, 1980) |
| "Clonic seizures occurred in all treatment groups, whether tonic seizures preceded them or not, but their duration was longer in the DPH and PHB groups than in the BZDP groups." | 1.26 | Comparative assessment of the anticonvulsant activity of some benzodiazepines, phenobarbitone and diphenylhydantoin against maximal electroshock seizures in rats: a time-distribution study. ( Banerjee, U; Yeoh, PN, 1981) |
| " Thus in adequate dosage both phenobarbitone and valproic acid were significantly better than no treatment in preventing febrile convulsions (p less than 0." | 1.26 | Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone. ( Smith, JA; Wallace, SJ, 1980) |
| "This syndrome consists of sustained seizures, resembling amygdaloid kindled seizures, and acute destruction of neural elements in limbic brain regions (amygdala, olfactory cortex, hippocampus, lateral septum and several thalamic nuclei)." | 1.26 | Only certain anticonvulsants protect against kainate neurotoxicity. ( Fuller, TA; Olney, JW, 1981) |
| "Eleven preschool children with febrile convulsions or epilepsy were started on phenobarbital." | 1.26 | Influence of phenobarbital on the psychomotor development and behaviour in preschool children with convulsions. ( Barlach-Christoffersen, M; Hellström, B, 1980) |
| "Maximal seizures were induced with electroshock via corneal electrodes, and phenytoin anticonvulsant effects were determined by measuring the duration of tonic hindlimb extension (THE) and prevention of the THE." | 1.26 | A comparative study of the effects of phenytoin and phenobarbital on electrically induced maximal seizures in frogs and mice. ( Johnson, SW; Riker, WK, 1982) |
| "A total of 26 neonates with seizures had an EEG while on phenobarbital therapy." | 1.26 | Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. ( Bickford, RB; Coen, RW; Scholl, ML; Staudt, F, 1982) |
| "Phenobarbital was the initial drug of choice and phenytoin usually the second drug." | 1.26 | Neonatal seizures: a survey of current practice. ( Boer, HR; Gal, P, 1982) |
| "In order to find the optimal dosage schedule of phenobarbitone for neonatal convulsions, four groups of patients were studied." | 1.26 | Phenobarbitone dosage in neonatal convulsions. ( Goldsmith, R; Ouvrier, RA, 1982) |
| " These recommendations provide initial maintenance dosage guidelines, which should be adjusted according to plasma concentrations and clinical effects." | 1.26 | Phenobarbital maintenance dose requirements in treating neonatal seizures. ( Fischer, JH; Kriel, R; Lockman, LA; Zaske, D, 1981) |
| "Phenytoin was found in higher concentration in gray matter, whereas phenobarbital was equally distributed between gray and white matter." | 1.26 | Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. ( Abern, S; Barmada, M; Carter, G; Painter, MJ; Pippenger, C; Pitlick, W; Wasterlain, C, 1981) |
| "Prominal reduced the severity of convulsions in pp'DDT-treated animals." | 1.26 | A possible neurochemical basis of the central stimulatory effects of pp'DDT. ( Jaffery, FN; Matin, MA; Siddiqui, RA, 1981) |
| "Most had had a convulsion before admission." | 1.26 | Dexamethasone in the treatment of hypernatraemic dehydration. ( Haque, KN, 1981) |
| "However, the seizure rate of NB mice was three times higher than controls (37%, p less than 0." | 1.26 | Audiogenic seizures and neuronal deficits following early exposure to barbiturate. ( Bergman, A; Shafer, R; Tabakoff, B; Yanai, J; Yedwab, G, 1981) |
| "The effects of long term, low dosage anticonvulsant drug therapy on the vitamin D and folacin status of young children was studied." | 1.26 | Folic acid and vitamin D status of young children receiving minimal anticonvulsant drug therapy. ( Bailey, LB; Enneking-Ivey, O; Gawley, L; Hananian, J; Hurd, R, 1981) |
| "Febrile convulsions occur in 3." | 1.26 | Febrile convulsions. ( Curry, HB, 1980) |
| " In order to test the validity of FEAD as an absence seizure model, the present experiments determined dose-response relationships for the suppression of FEAD by six antiepileptic drugs with established clinical profiles." | 1.26 | Flash-evoked afterdischarge in rat as a model of the absence seizure: dose-response studies with therapeutic drugs. ( Burnham, WM; King, GA; Livingston, KE, 1980) |
| "22 patients with severe preeclampsia-eclampsia were treated in our Intensive Care Unit from 1972 to 1978." | 1.26 | [Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)]. ( Larsen, R; Radke, J; Turner, E, 1980) |
| " The authors draw attention to the fact that there was a concomitant improvement in the behaviour of some patients and a diminution of maintainence dosage in relation to a previously published trial." | 1.26 | [Re-evaluation of barbexaclone in 20 epileptic patients]. ( de Lima, JM; Fernandes, I; Oliveira, C, 1978) |
| "For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s." | 1.26 | Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse. ( Blake, GJ; Gilbert, MB; Raines, A; Richardson, B, 1979) |
| "Tonic seizures consisted of flexion--extension sequences; co-contraction of antagonistic muscles was the rule." | 1.26 | Motor and electrical signs of epileptiform activity induced by penicillin in the spinal cords of decapitate cats. ( Lothman, EW; Somjen, GG, 1976) |
| "Phenobarbital was effective in diminishing the frequency of GHB-induced myoclonic jerks only when given prior to administration of GHB." | 1.26 | Gamma hydroxybutyrate in the monkey. III. Effect of intravenous anticonvulsant drugs. ( Snead, OC, 1978) |
| "The treatment with phenobarbital, diphenylhydantoin and carbamazepine for 7 days decreased the basal cAMP values in CSF and partly inhibited the rise after the convulsions." | 1.26 | Effect of convulsions and anticonvulsive drugs on cerebrospinal fluid cyclic AMP in rabbits. ( Myllylä, VV, 1976) |
| "In a certain percentage of patients seizures are abolished or diminish in frequency only on attaining such a serum level." | 1.26 | [The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)]. ( Deisenhammer, E; Sommer, R, 1979) |
| " The plasma level/dosage ratio has been found to have a highly significant correlation with the age of the patient both for dosage in mg/kg and in mg/m2." | 1.26 | Correlation between age and plasma level/dosage ratio for phenobarbital in infants and children. ( Nino, LM; Principi, N; Rossi, LN, 1979) |
| " The half-life of PB is twice that of PRM and PEMA." | 1.26 | Single-dose pharmacokinetics and anticonvulsant efficacy of primidone in mice. ( Friel, PN; Leal, KW; Rapport, RL; Wilensky, AJ, 1979) |
| "Type II (tonic) seizures are invariably associated with profound transient bradycardia, recovery from which begins about the time the tonic seizure phase ends." | 1.26 | Changes in heart rate associated with high-pressure convulsions in rodents. ( Beaver, RW; Brauer, RW; Fuquay, J, 1979) |
| "Phenytoin was in effective for most withdrawal signs and some signs were made worse." | 1.26 | Evaluation of anticonvulsants in barbiturate withdrawal. ( Boisse, NR; Okamoto, M; Rosenberg, HC, 1977) |
| " The blood proportional to the dosage per kilogram, and was not related to weight or gestational age." | 1.26 | Phenobarbital dosage for control of neonatal seizures. ( Kriel, R; Lockman, LA; Thompson, T; Virnig, N; Zaske, D, 1979) |
| "Phenytoin and diazepam were maximally effective at concentrations of 20 microgram/ml and 3-4 microgram/ml, respectively, in good agreement with their effective concentrations in clinical practice." | 1.26 | The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs. ( Hoffer, BJ; Oliver, AP; Wyatt, RJ, 1977) |
| "Comparison of the PD50 from clonic seizure at the peak-effect hours revealed that the benzodiazepines were 16 to 96 times more potent than phenobarbitone on a molar basis, while phenobarbitone itself was 12 to 26 times more potent than ethosuximide and trimethadione." | 1.26 | The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats. ( Banerjee, U; Yeoh, PN, 1977) |
| "The risk of another febrile convulsion is approximately 30%." | 1.26 | Continuous phenobarbital treatment after a 'simple febril convulsion'. ( Pollack, MA, 1978) |
| "Generalized EEG seizures were induced in acute, conscious New Zealand albino rabbits with intravenous pentylenetetrazol (PTZ) (10 or 15 mg/kg) or electrical stimulation of the frontal cerebral cortex (ELEC) (50 Hz, 1 msec pulse duration, 2 sec train duration, 4." | 1.26 | Elevation of seizure thresholds: a comparison of cerebellar stimulation, phenobarbital, and diphenylhydantoin. ( Brockman, WH; Strain, GM; Van Meter, WG, 1978) |
| "n-DPA proved to be most active against convulsions induced by picrotoxin (ED50 200 mg/kg orally), which might indicate a role of the elevation of the central levels of gamma-aminobutyric acid in the anticonvulsant effect of the drug." | 1.26 | Di-n-propylacetic acid--profile of anticonvulsant activity in mice. ( Frey, HH; Löscher, W, 1976) |
| "Cannabidiol was effective in blocking convulsions when given concurrently with, but not prior to delta9THC." | 1.26 | Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits. ( Consroe, P; Eisenstein, D; Martin, P, 1977) |
| "During seizure activity there was a calcium dependent increase in ACh efflux which was related to increase EEG activity and clonic muscle movements." | 1.26 | Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release. ( Gardner, CR; Webster, RA, 1977) |
| "Of 290 children with an initial febrile convulsion, 216 met Livingston's criteria for a "simple" febrile convulsion and 74 for "epilepsy triggered by fever." | 1.26 | Effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in "simple" febrile convulsions and "epilepsy triggered by fever". ( Wolf, SM, 1977) |
| " Principal features of the complex results include: double peaks in the time course of convulsion thresholds (Pc); an early peak and a shoulder in the time course of pressures reversing anesthesia (Pa); far steeper dose-response curves for Pa than for Pc; selectively greater anticonvulsant effect for phenobarbital than for the other barbiturates; and enhancement of Pa with simultaneous depression of Pc by reserpine in phenobarbital-pretreated mice." | 1.26 | Interaction of central nervous system effects of high pressures with barbiturates. ( Beaver, RW; Brauer, RW; Lahser, S, 1977) |
| "When premidication is needed or when convulsions occur after Amipaque examinations, combined diazepam and phenobarbital therapy ought to be instituted in order to achieve the best control of epileptic reactions." | 1.26 | Potentiation of Amipaque epileptogenic activity by neuroleptics. ( Brucher, JM; Gonsette, RE, 1977) |
| "Generalized motor seizures and myoclonic jerks were the predominant convulsive manifestations." | 1.26 | Neonatal seizures associated with narcotic withdrawal. ( Herzlinger, RA; Kandall, SR; Vaughan, HG, 1977) |
| "In these tests latency to convulsions and lethality associated with electroshock were more sensitive to THC." | 1.26 | Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice. ( Barry, H; Sofia, RD, 1977) |
| "Drug-induced systemic lupus erythematosus (SLE)-like syndromes in children are most commonly associated with the administration of ethosuximide, diphenylhydantoin, and trimethadione." | 1.26 | Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants. ( Fishman, L; Hanson, V; Singsen, BH, 1976) |
| "Simple febrile convulsions occur in otherwise normal children, aged six months to five years, with extracranial infection." | 1.26 | Simple febrile convulsions. ( Mendelsohn, J; Rosen, P; Tomlanovich, MC, 1976) |
| "Benign febrile convulsions occur early in the course of fever of extracranial origin in children six months to five years old." | 1.25 | Febrile seizures in children. ( Henderson, BM; Levi, JS, 1975) |
| " For the often seriously ill infants with convulsions it is therefore difficult to construct rational maintenance dose schedules, and optimal dosage must be based on repeated determinations of the plasma concentration." | 1.25 | Plasma concentrations of phenobarbital in the treatment of seizures in newborns. ( Jalling, B, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 652 (53.88) | 18.7374 |
| 1990's | 146 (12.07) | 18.2507 |
| 2000's | 141 (11.65) | 29.6817 |
| 2010's | 197 (16.28) | 24.3611 |
| 2020's | 74 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Edafiogho, IO | 2 |
| Hinko, CN | 2 |
| Chang, H | 1 |
| Moore, JA | 2 |
| Mulzac, D | 1 |
| Nicholson, JM | 1 |
| Scott, KR | 1 |
| Tomczuk, BE | 1 |
| Taylor, CR | 1 |
| Moses, LM | 1 |
| Sutherland, DB | 1 |
| Lo, YS | 1 |
| Johnson, DN | 1 |
| Kinnier, WB | 1 |
| Kilpatrick, BF | 1 |
| Kohn, H | 15 |
| Sawhney, KN | 2 |
| LeGall, P | 1 |
| Robertson, DW | 2 |
| Leander, JD | 2 |
| Wolfe, JF | 1 |
| Rathman, TL | 1 |
| Sleevi, MC | 1 |
| Campbell, JA | 1 |
| Greenwood, TD | 1 |
| Wall, GM | 1 |
| Baker, JK | 1 |
| Kadaba, PK | 1 |
| Chapleo, CB | 1 |
| Myers, PL | 1 |
| Smith, AC | 1 |
| Tulloch, IF | 1 |
| Turner, S | 1 |
| Walter, DS | 1 |
| Clark, CR | 3 |
| Lin, CM | 2 |
| Sansom, RT | 3 |
| Conley, JD | 1 |
| Hallot, A | 1 |
| Brodin, R | 1 |
| Merlier, J | 1 |
| Brochard, J | 1 |
| Chambon, JP | 1 |
| Biziere, K | 1 |
| Norris, GN | 2 |
| Wells, MJ | 1 |
| Dockens, RC | 1 |
| Ravis, WR | 1 |
| Bardel, P | 1 |
| Farrar, VA | 1 |
| Ciechanowicz-Rutkowska, M | 1 |
| Grochowski, J | 1 |
| Serda, P | 1 |
| Pilati, T | 1 |
| Filippini, G | 1 |
| el-Assadi, A | 1 |
| Ucar, H | 1 |
| Van derpoorten, K | 1 |
| Cacciaguerra, S | 1 |
| Spampinato, S | 1 |
| Stables, JP | 12 |
| Depovere, P | 1 |
| Isa, M | 1 |
| Masereel, B | 1 |
| Delarge, J | 1 |
| Poupaert, JH | 1 |
| Andurkar, SV | 1 |
| Béguin, C | 1 |
| LeTiran, A | 2 |
| Xie, ZF | 1 |
| Chai, KY | 1 |
| Piao, HR | 1 |
| Kwak, KC | 1 |
| Quan, ZS | 3 |
| Yogeeswari, P | 2 |
| Sriram, D | 2 |
| Thirumurugan, R | 1 |
| Raghavendran, JV | 1 |
| Sudhan, K | 1 |
| Pavana, RK | 1 |
| Stables, J | 1 |
| Patel, HJ | 1 |
| Sarra, J | 1 |
| Caruso, F | 1 |
| Rossi, M | 1 |
| Doshi, U | 1 |
| Stephani, RA | 2 |
| Sahitya, P | 1 |
| Ragavendran, JV | 1 |
| Ranganadh, V | 1 |
| Azam, F | 1 |
| Alkskas, IA | 1 |
| Khokra, SL | 1 |
| Prakash, O | 1 |
| Amin, KM | 2 |
| Rahman, DE | 1 |
| Al-Eryani, YA | 1 |
| Kashaw, SK | 1 |
| Kashaw, V | 1 |
| Mishra, P | 1 |
| Jain, NK | 1 |
| Park, KD | 3 |
| Morieux, P | 3 |
| Salomé, C | 7 |
| Cotten, SW | 1 |
| Reamtong, O | 1 |
| Eyers, C | 1 |
| Gaskell, SJ | 1 |
| Liu, R | 1 |
| Salomé-Grosjean, E | 4 |
| Swendiman, R | 1 |
| DeMarco, E | 1 |
| Guan, LP | 1 |
| Sui, X | 1 |
| Deng, XQ | 2 |
| Quan, YC | 1 |
| He, X | 3 |
| Zhong, M | 3 |
| Zhang, T | 3 |
| Wu, W | 2 |
| Wu, Z | 3 |
| Yang, J | 2 |
| Xiao, Y | 3 |
| Pan, Y | 2 |
| Qiu, G | 2 |
| Hu, X | 3 |
| Quan, LN | 1 |
| Song, MX | 1 |
| Wei, CX | 1 |
| King, AM | 4 |
| Dinsmore, J | 2 |
| De Ryck, M | 4 |
| Kaminski, R | 4 |
| Valade, A | 3 |
| Dawidowski, M | 2 |
| Herold, F | 1 |
| Chodkowski, A | 1 |
| Kleps, J | 1 |
| Szulczyk, P | 1 |
| Wilczek, M | 1 |
| Aboul-Enein, MN | 1 |
| El-Azzouny, AA | 1 |
| Attia, MI | 1 |
| Maklad, YA | 1 |
| Abdel-Rehim, M | 1 |
| El-Behairy, MF | 1 |
| Guo, H | 1 |
| Sadarangani, IR | 1 |
| Bhatia, S | 1 |
| Amarante, D | 1 |
| Lengyel, I | 1 |
| Baruah, PK | 1 |
| Provins, L | 1 |
| Chońska, J | 1 |
| Mika, W | 1 |
| Turło, J | 1 |
| Kumari, S | 1 |
| Mishra, CB | 1 |
| Tiwari, M | 1 |
| Torregrosa, R | 1 |
| Yang, XF | 1 |
| Dustrude, ET | 1 |
| Cummins, TR | 1 |
| Khanna, R | 1 |
| Edayadulla, N | 1 |
| Ramesh, P | 1 |
| Kuder, K | 1 |
| Łażewska, D | 1 |
| Latacz, G | 1 |
| Schwed, JS | 1 |
| Karcz, T | 1 |
| Stark, H | 1 |
| Karolak-Wojciechowska, J | 1 |
| Kieć-Kononowicz, K | 1 |
| Mohammadi-Khanaposhtani, M | 1 |
| Shabani, M | 1 |
| Faizi, M | 1 |
| Aghaei, I | 1 |
| Jahani, R | 1 |
| Sharafi, Z | 1 |
| Shamsaei Zafarghandi, N | 1 |
| Mahdavi, M | 1 |
| Akbarzadeh, T | 1 |
| Emami, S | 1 |
| Shafiee, A | 1 |
| Foroumadi, A | 1 |
| Grover, G | 1 |
| Nath, R | 1 |
| Bhatia, R | 1 |
| Akhtar, MJ | 1 |
| Massey, SL | 3 |
| Glass, HC | 4 |
| Shellhaas, RA | 4 |
| Bonifacio, S | 1 |
| Chang, T | 2 |
| Chu, C | 2 |
| Cilio, MR | 2 |
| Lemmon, ME | 1 |
| McCulloch, CE | 2 |
| Soul, JS | 4 |
| Thomas, C | 2 |
| Wusthoff, CJ | 2 |
| Xiao, R | 2 |
| Abend, NS | 3 |
| Sae-Heng, T | 1 |
| Rajoli, RKR | 1 |
| Siccardi, M | 1 |
| Karbwang, J | 1 |
| Na-Bangchang, K | 1 |
| Oberholster, O | 1 |
| Verwoerd, C | 1 |
| Limjoco, J | 1 |
| Rajamanickam, V | 1 |
| Knox, A | 1 |
| Kale, A | 1 |
| Kakde, R | 1 |
| Pawar, S | 1 |
| Jagtap, V | 1 |
| Dorugade, R | 1 |
| Zagaja, M | 3 |
| Zagaja, A | 1 |
| Szala-Rycaj, J | 1 |
| Szewczyk, A | 1 |
| Lemieszek, MK | 1 |
| Raszewski, G | 2 |
| Andres-Mach, M | 4 |
| Furyk, JS | 1 |
| George, S | 1 |
| Phillips, N | 1 |
| Emeto, TI | 1 |
| Watt, K | 1 |
| O'Brien, S | 1 |
| Riney, K | 1 |
| Wilson, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Safety and Feasibility Study of Enteral Levetiracetam vs. Phenobarbital for Seizure Control in Pediatric Cerebral Malaria[NCT01982812] | Phase 2 | 44 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| A Dose-Escalation, Safety And Feasibility Study Of Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria[NCT01660672] | Phase 1/Phase 2 | 7 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| The EAGLET Project: EEG vs aEEG to Improve the Diagnosis of neonataL Seizures and Epilepsy - a Randomised Trial[NCT05079971] | 140 participants (Anticipated) | Interventional | 2023-07-01 | Recruiting | |||
| Effectiveness of Combined Levetiracetam and Midazolam in Treatment of Generalized Convulsive Status Epilepticus in Children[NCT04926844] | Phase 2 | 144 participants (Actual) | Interventional | 2021-06-20 | Completed | ||
| Big Data Construction and Biological Etiological Epidemiology Study of Children Epilepsy in China[NCT02969213] | 10,000 participants (Anticipated) | Observational | 2016-11-30 | Not yet recruiting | |||
| NEMO1: An Open Label Exploratory Dose Finding and Pharmacokinetic Clinical Trial of Bumetanide for the Treatment of Neonatal Seizure Using Medication Off-patent[NCT01434225] | Phase 1/Phase 2 | 14 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676] | 12 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| Pilot Study of Bumetanide for Newborn Seizures: A Phase I Study of Pharmacokinetics and Safety of Bumetanide for Neonatal Seizures[NCT00830531] | Phase 1 | 43 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| Measurement of Risperidone and 9-Hydroxyrisperidone in Plasma and Saliva[NCT00395499] | 19 participants | Observational | 2001-05-31 | Completed | |||
| Protecting Brains and Saving Futures - the PBSF Protocol: a Prospective Multicenter and Observational Study on the Use of Telemedicine for Neurocritical Care in High-risk Newborns in Brazil.[NCT03786497] | 2,268 participants (Anticipated) | Observational [Patient Registry] | 2021-01-01 | Not yet recruiting | |||
| Randomized, Double Blind, Placebo Controlled, Parallel Design Phase II b Study of Safety and Efficacy of MGCND00EP1 as an Add on Treatment in Children and Adolescents With Resistant Epilepsies[NCT04406948] | Phase 2 | 103 participants (Anticipated) | Interventional | 2023-08-31 | Not yet recruiting | ||
| Strengthening Families Program Online for Teens and Families[NCT04214327] | 480 participants (Anticipated) | Interventional | 2022-12-15 | Active, not recruiting | |||
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The mean time in hours from admission until the subject reaches Blantyre Coma Scale of greater than or equal to 4. Participants who died are excluded from this analysis.~The Blantyre Coma Score has ranges from 0-5 based upon the a sum of the following 3 domains- Eye movement~1 - Watches or follows 0 - Fails to watch or follow~Best motor response 2 - Localizes painful stimulus 1 - Withdraws limb from painful stimulus 0 - No response or inappropriate response~Best verbal response 2 - Cries appropriately with pain, or, if verbal, speaks~1 - Moan or abnormal cry with pain 0 - No vocal response to pain" (NCT01982812)
Timeframe: 7 days
| Intervention | hours of coma from admission (Mean) |
|---|---|
| Oral Levetiracetam | 35.4 |
| Comparison Group | 34.6 |
Comparing LVT to standard AED the number of minutes spent in seizure per cEEG in the 72 hours after treatment allocation. (NCT01982812)
Timeframe: 72 hours
| Intervention | minutes with seizure (Mean) |
|---|---|
| Oral Levetiracetam | 165.2 |
| Comparison Group | 464.8 |
Additional AEDs required (including for breakthrough seizures in LVT group) during admission for seizure control (yes/no) (NCT01982812)
Timeframe: 7 days
| Intervention | Participants requiring additional AEDs (Number) |
|---|---|
| Oral Levetiracetam | 18 |
| Comparison Group | 18 |
"Neurologic outcome in 3 categories--~Neurologically intact at discharge~Neurologic sequelae at discharge--specifically new sensory or motor deficits, ongoing seizures, or behavioral abnormalities based upon a physician examination at discharge~Died during admission, never discharged" (NCT01982812)
Timeframe: 7 days
| Intervention | participants (Number) | ||
|---|---|---|---|
| Neurologically intact at discharge | Neurologic sequelae at discharge | Died during admission | |
| Comparison Group | 14 | 2 | 5 |
| Oral Levetiracetam | 19 | 3 | 1 |
Number of subjects free of seizure at 24 hours after initiation of treatment (NCT01660672)
Timeframe: 24 hours
| Intervention | individuals (Number) |
|---|---|
| LEVETIRACETAM | 7 |
Mean time from admission to a BCS score greater than or equal to 4. The BCS (Blantyre Coma Scale) is a 0-5 scale measuring motor response, verbal response and eye movement assessing the severity of coma in children with cerebral malaria. Lower scores correspond to more profound coma. (NCT01660672)
Timeframe: 7 days
| Intervention | hours (Mean) |
|---|---|
| LEVETIRACETAM | 35.3 |
Number of participants who required AEDS during admission(including for breakthrough seizures in the LVT group) during admission. (NCT01660672)
Timeframe: 7 days
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 6 |
Number of participants with neurologic sequelae at discharge (NCT01660672)
Timeframe: day 7
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 2 |
Pre-enrollment exposure to phenobarbitone may impact LVT efficacy, and analysis base on this characteristic will be evaluated. (NCT01660672)
Timeframe: 0 hour
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 3 |
Retinopathy status may impact LVT efficacy and subject status will be analyzed based on this characteristic. (NCT01660672)
Timeframe: Upon admission
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 4 |
Range of plasma LVT concentrations will be determined through HPLC method at eight timepoints post administration to evaluate LVT absorption and elimination in pediatric CM. (NCT01660672)
Timeframe: 72 hours
| Intervention | mcg/ml (Mean) |
|---|---|
| LEVETIRACETAM | 35 |
Toxicity including vomiting, aspiration, complications related to the NGT, laboratory parameters at 24 hours and 1 week post LVT administration, and an overall acute case fatality rate significantly above the consistent historical ward average for CM. Pk studies to evaluate LVT absorption and elimination in pediatric CM. (NCT01660672)
Timeframe: 1 week
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 0 |
94 reviews available for phenobarbital and Seizures
| Article | Year |
|---|---|
Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants.
Topics: Animals; Anticonvulsants; Heterocyclic Compounds; Humans; Molecular Structure; Seizures; Structure-A | 2020 |
Importance of Pharmacophore in Designing Anticonvulsant Agents.
Topics: Anticonvulsants; Electroshock; Humans; Pharmacophore; Phenobarbital; Seizures | 2023 |
Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Disease | 2022 |
Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses.
Topics: Adult; Anticonvulsants; Benzodiazepines; Child; Drug Resistance; Humans; Levetiracetam; Network Meta | 2022 |
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; | 2022 |
KCNQ2-Related Epilepsy: Genotype-Phenotype Relationship with Tailored Antiseizure Medication (ASM)-A Systematic Review.
Topics: Child; Epilepsy, Benign Neonatal; Genotype; Humans; Infant, Newborn; KCNQ2 Potassium Channel; Mutati | 2023 |
Evaluation of phenobarbital based approach in treating patient with alcohol withdrawal syndrome: A systematic review and meta-analysis.
Topics: Adult; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Prospective Studies; Retrospective Studie | 2023 |
Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies.
Topics: Aminoglycosides; Animals; Anticonvulsants; Bumetanide; Epilepsy; Hearing Loss; Humans; Infant; Infan | 2023 |
Anti-seizure medications for neonates with seizures.
Topics: Adolescent; Adult; Child; Epilepsy; Humans; Infant; Infant, Newborn; Levetiracetam; Phenobarbital; P | 2023 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt | 2020 |
Efficacy of Levetiracetam in neonatal seizures: a systematic review.
Topics: Adult; Anticonvulsants; Child; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Pira | 2022 |
Acute Phenobarbital Poisoning for the Management of Seizures in Newborns and Children; A Systematic Literature Review.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy, Generalized; Humans; Infant; Infant, | 2021 |
Efficacy and Safety of Phenobarbitone as First-Line Treatment for Neonatal Seizure: A Systematic Review and Meta-Analysis.
Topics: Anticonvulsants; Carbamazepine; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Seizures | 2021 |
Treating Seizures after Hypoxic-Ischemic Encephalopathy-Current Controversies and Future Directions.
Topics: Animals; Anticonvulsants; Brain; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Phenobarbita | 2021 |
Seizure management in children requiring palliative care: a review of current practice.
Topics: Anticonvulsants; Child; Child, Preschool; England; Female; Humans; Infant; Infusions, Intravenous; M | 2020 |
The use of phenobarbital and other anti-seizure drugs in newborns.
Topics: Anticonvulsants; Fructose; Humans; Hypothermia, Induced; Infant, Newborn; Lidocaine; Midazolam; Phen | 2017 |
Feline Epilepsy.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Epilepsy; Levetiracetam; Phenobarbital; Piracetam; Pro | 2018 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt | 2018 |
Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2018 |
Treatment of neonatal seizures.
Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo | 2013 |
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; I | 2013 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized | 2013 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment.
Topics: Anticonvulsants; Electroencephalography; Humans; Infant, Newborn; Phenobarbital; Seizures | 2015 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized | 2015 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
Question 1: Phenobarbital for preventing mortality and morbidity in full-term newborns with perinatal asphyxia in a resource-poor setting.
Topics: Asphyxia Neonatorum; Humans; Hypnotics and Sedatives; Hypoxia-Ischemia, Brain; Infant, Newborn; Morb | 2015 |
Clinical Pharmacology of Phenobarbital in Neonates: Effects, Metabolism and Pharmacokinetics.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Male; Pharmacolo | 2016 |
Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Barbiturates; Humans; Infant; Infant, Newborn; Infant, Prematu | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec | 2016 |
Carbamazepine versus phenobarbitone monotherapy for epilepsy: an individual participant data review.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, | 2016 |
[Problems in the diagnosis and treatment of neonatal seizures].
Topics: Anticonvulsants; Electroencephalography; Humans; Infant, Newborn; Infusions, Intravenous; Phenobarbi | 2008 |
Preventing and treating posttraumatic seizures: the human experience.
Topics: Animals; Anticonvulsants; Brain Injuries; Drug Evaluation, Preclinical; Drug Therapy, Combination; E | 2009 |
Neonatal seizures: dialogues between clinic and bench.
Topics: Animals; Anticonvulsants; Brain; Humans; Infant, Newborn; Phenobarbital; Seizures; Translational Res | 2012 |
Epilepsy meets cancer: when, why, and what to do about it?
Topics: Animals; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Causality; Comorbidity; Drug Inter | 2012 |
Neonatal seizures and their treatment.
Topics: Anticonvulsants; Brain; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Neuronal Plas | 2003 |
Glucose transporter type1 (GLUT-1) deficiency.
Topics: Anticonvulsants; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Caffeine; Central Nervous System | 2003 |
Management of seizures in children with falciparum malaria.
Topics: Anticonvulsants; Child; Diazepam; Emergency Treatment; Humans; Malaria, Cerebral; Malaria, Falciparu | 2004 |
Seizure prophylaxis in patients with brain tumors: a meta-analysis.
Topics: Anticonvulsants; Brain Neoplasms; Comorbidity; Confidence Intervals; Dose-Response Relationship, Dru | 2004 |
Brain injury in the term infant.
Topics: Cell Death; Cerebral Infarction; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Hypoxia-Isch | 2004 |
Prolonged electroencephalogram monitoring for seizures and their treatment.
Topics: Anticonvulsants; Electroencephalography; Humans; Infant, Newborn; Monitoring, Physiologic; Phenobarb | 2006 |
[Caffeine and antiepileptic drugs: experimental and clinical data].
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactio | 2007 |
Post-resuscitation strategies to avoid ongoing injury following intrapartum hypoxia-ischemia.
Topics: Anticonvulsants; Blood Pressure; Female; Fetal Hypoxia; Fluid Therapy; Humans; Hyperglycemia; Hypogl | 2008 |
Genetic factors in drug neuroteratogenicity.
Topics: Acoustic Stimulation; Agonistic Behavior; Animals; Animals, Newborn; Behavior, Animal; Cerebellum; D | 1983 |
[Indications for phenobarbital in neonatal pathology].
Topics: Asphyxia Neonatorum; Cerebral Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases; Jaundi | 1983 |
[Phenobarbital in newborn infants. Overview].
Topics: Asphyxia Neonatorum; Brain Injuries; Cerebral Hemorrhage; Electroencephalography; Half-Life; Humans; | 1984 |
Seizures and seizure-like states in the child: an approach to emergency management.
Topics: Anesthesia, General; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Emergencies; Humans | 1983 |
Advances in pediatric pharmacology and toxicology.
Topics: Animals; Anti-Bacterial Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Biological A | 1983 |
Sodium valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Kinetics; Phenobarbital; Seizures; Structu | 1980 |
Valproic acid: interactions with phenytoin and phenobarbital.
Topics: Binding, Competitive; Drug Interactions; Half-Life; Humans; Kinetics; Phenobarbital; Phenytoin; Prot | 1982 |
Phenobarbital: proposed mechanisms of antiepileptic action.
Topics: Animals; Anticonvulsants; Electroencephalography; Electrophysiology; Humans; Membranes; Phenobarbita | 1980 |
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
[Neonatal seizures: the beginning and interruption of the treatment].
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Humans; Phenobarbital; Seizures; Treatment Outcome | 1997 |
Role of the ketogenic diet in children with intractable seizures.
Topics: Acetazolamide; Anticonvulsants; Avitaminosis; Child; Child, Preschool; Dehydration; Food-Drug Intera | 1998 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
Idiopathic epilepsy.
Topics: Age Factors; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Diagnosis, Differential; Dog Di | 1998 |
Antiepileptic drug therapy.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid | 1998 |
Management approaches to prolonged seizures and status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Drug Administration Schedule; Drug Therapy, Combination; | 1999 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
Prevention and management of febrile seizures.
Topics: Anticonvulsants; Child, Preschool; Humans; Incidence; Infant; Phenobarbital; Randomized Controlled T | 2001 |
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenobarbital; Phenytoin; Rando | 2001 |
Seizures in the newborn.
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Electroencephalography; Humans; Infant, Newborn; Neonata | 2001 |
Routine anticonvulsants for treating cerebral malaria.
Topics: Anticonvulsants; Humans; Malaria, Cerebral; Phenobarbital; Randomized Controlled Trials as Topic; Se | 2002 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Aci | 1975 |
Febrile seizures: the treatment controversy.
Topics: Child; Epilepsy; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Recurrence; Seizures; Se | 1979 |
Febrile convulsions: diagnosis, treatment, and prognosis.
Topics: Child; Epilepsy; Humans; Infant; Intellectual Disability; Intelligence; Meningitis; Phenobarbital; P | 1979 |
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; | 1979 |
[Prevention of recurrences and of epilepsy in febrile convulsions. Protocol of the Pediatric Clinic of the Florence and preliminary results].
Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Management of seizure disorders: selected aspects. Part I.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Child; Chromatography, Gas; Chromatography, | 1976 |
Phenobarbital plasma levels in neonates.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Phenobarbital; Pilot Projects; Sei | 1975 |
Neonatal seizures and their treatment.
Topics: Anticonvulsants; Diazepam; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 1975 |
Malaria in children in Papua New Guinea.
Topics: Antimalarials; Cause of Death; Child; Child Welfare; Child, Preschool; Clinical Protocols; Communica | 1992 |
Rational use of antiepileptic drug levels.
Topics: Carbamazepine; Half-Life; Humans; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1992 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
[Benign familial neonatal convulsion: clinical features of the propositus and comparison with the previously reported cases].
Topics: Adult; Child; Electroencephalography; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma | 1990 |
Camphor ingestion.
Topics: Administration, Oral; Camphor; Child, Preschool; Gastric Lavage; Humans; Male; Phenobarbital; Seizur | 1989 |
Consensus and controversy in the clinical management of neonatal seizures.
Topics: Electroencephalography; Humans; Infant, Newborn; Phenobarbital; Prognosis; Seizures | 1989 |
The child with febrile seizures.
Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Fever; Humans; Infant; Phenobarbital; Prognosis | 1987 |
[Eclamptic fits: etiologic mechanisms, clinical aspects and therapy].
Topics: Animals; Calcium Gluconate; Cardiac Catheterization; Critical Care; Diazepam; Dogs; Eclampsia; Elect | 1986 |
Febrile seizures: emergency department diagnosis and treatment.
Topics: Blood Cell Count; Blood Glucose; Child, Preschool; Counseling; Diagnosis, Differential; Diazepam; Dr | 1985 |
Seizures which are not epilepsy.
Topics: Child, Preschool; Epilepsies, Partial; Fever; Humans; Hypocalcemia; Hypoglycemia; Infant; Infant, Ne | 1985 |
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc | 1973 |
Anticonvulsants, folic acid, and epilepsy.
Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Ep | 1973 |
The child who convulses with fever.
Topics: Age Factors; Analgesics; Brain Injuries; Central Nervous System Diseases; Child; Child Behavior; Chi | 1974 |
[Epilepsy in children].
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Fever; Humans; Infant; | 1974 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che | 1973 |
Neonatal Seizures.
Topics: Birth Injuries; Calcium; Congenital Abnormalities; Glucose; Humans; Hypocalcemia; Hypoglycemia; Infa | 1973 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
Anticonvulsant drugs. II. Clinical pharmacological and therapeutic aspects.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Cerebellum; Drug Interact | 1972 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; El | 1969 |
Treatment of organophosphorus and chlorinated hydrocarbon insecticide intoxications.
Topics: Atropine; Cerebral Hemorrhage; Cholinesterase Inhibitors; Diagnosis, Differential; Gastroenteritis; | 1971 |
69 trials available for phenobarbital and Seizures
| Article | Year |
|---|---|
Levetiracetam or Phenobarbitone as a First-Line Anticonvulsant in Asphyxiated Term Newborns? An Open-Label, Single-Center, Randomized, Controlled, Pragmatic Trial.
Topics: Adult; Anticonvulsants; Child; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; | 2022 |
Efficacy and safety of phenobarbital for benign convulsions with mild gastroenteritis: A prospective randomized controlled study.
Topics: Child; Gastroenteritis; Humans; Incidence; Infant; Phenobarbital; Prospective Studies; Seizures | 2022 |
Comparison between Phenobarbitone and Levetiracetam as the initial anticonvulsant in preterm neonatal seizures - a pilot randomized control trial in developing country setup.
Topics: Anticonvulsants; Developing Countries; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 2023 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
The effect of acidic beverage versus mineral water on the change in serum phenobarbital concentrations: a randomized clinical trial on children with seizure.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Citrus sinensis; Female; Fruit and Vegetable J | 2021 |
Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy, Benign Neonatal; F | 2020 |
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.
Topics: Anticonvulsants; Bumetanide; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; | 2021 |
Effect of early withdrawal of phenobarbitone on the recurrence of neonatal seizures: An open-label randomized controlled trial.
Topics: Anticonvulsants; Child; Epilepsy; Humans; India; Infant, Newborn; Phenobarbital; Seizures | 2021 |
A Randomized Controlled Trial of Phenobarbital and Levetiracetam in Childhood Epilepsy.
Topics: Adolescent; Anticonvulsants; Bangladesh; Child; Child, Preschool; Cognition; Drug Monitoring; Epilep | 2018 |
Efficacy of phenobarbital for benign convulsions with mild gastroenteritis: A randomized, placebo-controlled trial.
Topics: Administration, Intravenous; Anticonvulsants; Child, Preschool; Female; Gastroenteritis; Humans; Inf | 2019 |
Open-label clinical trial of rectally administered levetiracetam as supplemental treatment in dogs with cluster seizures.
Topics: Administration, Intravenous; Administration, Rectal; Animals; Anticonvulsants; Diazepam; Dog Disease | 2019 |
Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience.
Topics: Anticonvulsants; Female; Humans; Infant, Newborn; Italy; Levetiracetam; Male; Neurodevelopmental Dis | 2019 |
Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial.
Topics: Anticonvulsants; Electroencephalography; Female; Humans; India; Infant, Newborn; Infant, Newborn, Di | 2013 |
The effect of phenobarbitone on cognition in adult patients with new onset epilepsy: a multi-centric prospective study from India.
Topics: Adult; Anticonvulsants; Cognition; Epilepsy; Female; Humans; India; Male; Neuropsychological Tests; | 2014 |
Therapeutic serum phenobarbital concentrations obtained using chronic transdermal administration of phenobarbital in healthy cats.
Topics: Administration, Cutaneous; Animals; Anticonvulsants; Biological Availability; Cat Diseases; Cats; Ph | 2015 |
Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.
Topics: Bumetanide; Drug Administration Schedule; Drug Synergism; Early Termination of Clinical Trials; Feas | 2015 |
A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Blood Glucose; Bromides; Cross-Over Studies; Diet, | 2015 |
A single-blinded phenobarbital-controlled trial of levetiracetam as mono-therapy in dogs with newly diagnosed epilepsy.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Levetiracetam; Male; Phenobarbital; | 2016 |
Efficacy and safety of levetiracetam in the management of seizures in neonates.
Topics: Anticonvulsants; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Iran; Levetiracetam; Ma | 2016 |
Effect of Withholding Phenobarbitone Maintenance in Neonatal Seizures: A Randomized Controlled Trial.
Topics: Anticonvulsants; Double-Blind Method; Female; Humans; India; Infant, Newborn; Infant, Newborn, Disea | 2016 |
Phenobarbital or potassium bromide as an add-on antiepileptic drug for the management of canine idiopathic epilepsy refractory to imepitoin.
Topics: Animals; Anticonvulsants; Belgium; Bromides; Dog Diseases; Dogs; Epilepsy; Imidazoles; Phenobarbital | 2017 |
Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Body Temperature; Humans; Hypothermia, Induced; Hypoxia-Ischem | 2011 |
Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; | 2012 |
Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: a thermopharmacological approach.
Topics: Anticonvulsants; Asphyxia Neonatorum; Drug Administration Schedule; Electroencephalography; Fluoresc | 2012 |
Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Chi-Square Distribution; Chromat | 2012 |
Prophylactic anticonvulsants in patients with brain tumour.
Topics: Anticonvulsants; Brain Neoplasms; Disease Progression; Female; Humans; Incidence; Male; Middle Aged; | 2003 |
Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions.
Topics: Anticonvulsants; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Infusio | 2003 |
Phenytoin and phenobarbital stable isotope studies in neonates.
Topics: Anticonvulsants; Carbon Isotopes; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Infant; In | 2003 |
Midazolam in neonatal seizures with no response to phenobarbital.
Topics: Age Factors; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Resistance; Electroencep | 2005 |
A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy.
Topics: Anticonvulsants; Female; Free Radicals; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Nerv | 2005 |
Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis.
Topics: Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; Epilepsy, Benign Neonatal; Fem | 2007 |
Historical perspective on the choice of antiepileptic drugs for the treatment of seizures in adults.
Topics: Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; History, 20th Century; Hu | 1983 |
Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infant; Male; Phenobarbital; Random A | 1980 |
Opiate v CNS depressant therapy in neonatal drug abstinence syndrome.
Topics: Adult; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenobarbital; Prospective Studies | 1983 |
Once-daily dosing with phenobarbital in children with seizure disorders.
Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Male; Phe | 1981 |
The first febrile seizure--antipyretic instruction plus either phenobarbital or placebo to prevent recurrence.
Topics: Child, Preschool; Double-Blind Method; Female; Humans; Infant; Male; Phenobarbital; Placebos; Seizur | 1980 |
[Phenobarbital in febrile convulsions of children (author's transl)].
Topics: Administration, Oral; Child, Preschool; Humans; Infant; Injections, Intramuscular; Phenobarbital; Se | 1981 |
Neonatal phenobarbital and phenytoin binding profiles.
Topics: Birth Weight; Female; Gestational Age; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; Prot | 1994 |
[Gamma-vinyl-GABA: first experiences in Italy. II].
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; | 1994 |
Peri-operative prophylaxis with phenytoin: dosage and therapeutic plasma levels.
Topics: Adult; Aged; Anticonvulsants; Cefazolin; Dexamethasone; Drug Interactions; Drug Therapy, Combination | 1996 |
Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children.
Topics: Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combinatio | 1997 |
High-dose phenobarbital therapy in term newborn infants with severe perinatal asphyxia: a randomized, prospective study with three-year follow-up.
Topics: Anticonvulsants; Asphyxia Neonatorum; Follow-Up Studies; Humans; Infant, Newborn; Phenobarbital; Pro | 1998 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human | 1999 |
A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Craniocerebral Trauma; Developmenta | 1999 |
Phenobarbital compared with phenytoin for the treatment of neonatal seizures.
Topics: Anticonvulsants; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Male; Phenobarbital; Ph | 1999 |
Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study.
Topics: Adolescent; Animals; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Infusions, In | 2000 |
Effect of phenobarbitone on the low-dose dexamethasone suppression test and the urinary corticoid: creatinine ratio in dogs.
Topics: Adrenal Cortex Function Tests; Adrenal Cortex Hormones; Animals; Anticonvulsants; Creatinine; Dexame | 2000 |
Effects of phenobarbitone on serum biochemical tests in dogs.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Bilirubin; Blood Chemical Anal | 2000 |
Potential prophylactic use of benzodiazepines for hemodialysis-associated seizures.
Topics: Adolescent; Anticonvulsants; Blood Pressure; Child; Diazepam; Female; Humans; Male; Phenobarbital; R | 2000 |
Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cerebellar Neoplasms; Craniotomy; Female; H | 2002 |
[Prevention of febrile convulsions with diazepam or phenemal. A prospective controlled study].
Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Humans; Infant; Phenobarbital; Prospect | 1978 |
Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study.
Topics: Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Phenobarbital; P | 1978 |
A comparison of phenobarbitone and primidone in the control of seizures in chronic epilepsy [proceedings].
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Epilepsy; Humans; Middle Aged; Phenobarbital | 1979 |
The value of phenobarbital in the child who has had a single febrile seizure: a controlled prospective study.
Topics: Child, Preschool; Female; Humans; Infant; Male; Patient Compliance; Phenobarbital; Prospective Studi | 1977 |
Continuous phrophylcatic anticonvulsants in selected childrens with febrile convulsions.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Female; Fever; Follow-Up Studies; Humans; Infant; | 1975 |
A controlled study of profylactic long-term treatment of febrile convulsions with phenobarbital.
Topics: Child, Preschool; Clinical Trials as Topic; Fever; Follow-Up Studies; Humans; Infant; Phenobarbital; | 1975 |
Failure of phenobarbitone to prevent febrile convulsions.
Topics: Child, Preschool; Female; Fever; Humans; Infant; Male; Phenobarbital; Seizures; Time Factors | 1976 |
Absorption of intramuscular phenobarbitone in children with severe falciparum malaria.
Topics: Absorption; Child; Child, Preschool; Humans; Infant; Injections, Intramuscular; Malaria, Falciparum; | 1992 |
Analysis of clinical trials by treatment actually received: is it really an option?
Topics: Child, Preschool; Cognition; Data Interpretation, Statistical; Humans; Infant; Intelligence Tests; L | 1991 |
Single dose phenobarbitone prevents convulsions in cerebral malaria.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Clinical Trials as Topic; Double-Blind Method; Femal | 1988 |
[Preventive treatment of convulsions in perinatal asphyxia].
Topics: Asphyxia Neonatorum; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phen | 1987 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
Proceedings: Comparisons of phenobarbitone, magnesium sulphate, and calcium gluconate in treatment of neonatal hypocalcaemic convulsions.
Topics: Administration, Oral; Calcium; Clinical Trials as Topic; Gluconates; Humans; Hypocalcemia; Infant, N | 1974 |
Successful prophylaxis of febrile convulsions with phenobarbital.
Topics: Age Factors; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Female; Fever; Follow-Up S | 1972 |
New aspects of the chemothrapy of bilharziasis with Ambilhar (Niridazole).
Topics: Adolescent; Adult; Africa; Brazil; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, | 1974 |
Studies on convulsive disorders in young children. II. Intermittent phenobarbital prophylaxis and recurrence of febrile convulsions.
Topics: Child, Preschool; Clinical Trials as Topic; Female; Fever; Humans; Infant; Male; Phenobarbital; Prob | 1971 |
Treatment of alcohol withdrawal syndromes.
Topics: Chloral Hydrate; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Drug Synergism; Ethanol; Huma | 1971 |
Studies on prophylactic treatment of febrile convulsions in children. Is it feasible to inhibit attacks by giving drugs at the first sign of fever or infection?
Topics: Age Factors; Anticonvulsants; Child, Preschool; Electroencephalography; Female; Fever; Humans; Infan | 1970 |
1049 other studies available for phenobarbital and Seizures
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of enaminones.
Topics: Amines; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electric Stimulation; Kindling, Neur | 1992 |
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cereb | 1991 |
Preparation and anticonvulsant activity of a series of functionalized alpha-heteroatom-substituted amino acids.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male | 1991 |
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; | 1990 |
Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype gamma-aminobutyric acid prodrug to lactam and gamma-aminobutyric acid type metabolites.
Topics: Amino Acids; Animals; Baclofen; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure | 1989 |
Triazolines. 14. 1,2,3-Triazolines and triazoles, a new class of anticonvulsants. Drug design and structure-activity relationships.
Topics: Animals; Anticonvulsants; Electroshock; Mice; Seizures; Structure-Activity Relationship; Triazoles | 1988 |
Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 3. Guanidines.
Topics: Animals; Chemical Phenomena; Chemistry; Electroshock; Guanidines; Mice; Pentylenetetrazole; Rats; Se | 1987 |
Anticonvulsant activity of 2- and 3-aminobenzanilides.
Topics: Anilides; Aniline Compounds; Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; | 1986 |
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizur | 1987 |
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 1986 |
Anticonvulsant activity of some 4-aminobenzanilides.
Topics: Anilides; Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Male; | 1985 |
Anticonvulsant activity of some 4-aminobenzamides.
Topics: Animals; Anticonvulsants; Benzamides; Bicuculline; Electroshock; Male; Mice; Pentylenetetrazole; Sei | 1984 |
Synthesis and anticonvulsant activities of alpha-heterocyclic alpha-acetamido-N-benzylacetamide derivatives.
Topics: Acetamides; Animals; Anticonvulsants; Benzeneacetamides; Benzyl Compounds; Furans; Heterocyclic Comp | 1993 |
Synthesis and CLOGP correlation of imidooxy anticonvulsants.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Electrosh | 1993 |
Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives.
Topics: Animals; Anticonvulsants; Electric Stimulation; Injections, Intraperitoneal; Male; Mice; Oxazoles; R | 1998 |
Synthesis and structural studies of aza analogues of functionalized amino acids: new anticonvulsant agents.
Topics: Animals; Anticonvulsants; Aza Compounds; Crystallography, X-Ray; Electroshock; Magnetic Resonance Sp | 2001 |
Design and evaluation of affinity labels of functionalized amino acid anticonvulsants.
Topics: Affinity Labels; Amino Acids; Animals; Anticonvulsants; Electroshock; Isothiocyanates; Mice; Radioli | 2002 |
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizure | 2005 |
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver | 2005 |
Synthesis and anticonvulsant activity of new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones.
Topics: Animals; Anticonvulsants; Benzofurans; Imidazolidines; Mice; Molecular Structure; Pentylenetetrazole | 2006 |
Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Chemistry, Pharmaceutical; Drug Design; Ethanol; gamm | 2007 |
Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Brain Chemistry; Glutathione Peroxidase; Malondialdehyde; Mice; Motor Acti | 2009 |
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Male; | 2008 |
Synthesis, anticonvulsant and CNS depressant activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-phenyl/ethyl-4H-quinazolin-3-yl)-urea.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Depressants; Male; Mice; Molecula | 2009 |
Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors.
Topics: Acetamides; Animals; Anticonvulsants; Brain; In Vitro Techniques; Intercellular Signaling Peptides a | 2009 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus | 2010 |
Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2010 |
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
Topics: Acetamides; Alanine; Amides; Amino Acids; Animals; Anticonvulsants; Benzylamines; Drug Evaluation, P | 2010 |
The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.
Topics: Acetamides; Animals; Anticonvulsants; Electroshock; Hydrophobic and Hydrophilic Interactions; Lacosa | 2010 |
Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives.
Topics: Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Hydantoins; Mice; | 2010 |
Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Electroshock; Isoniazid; Mice; Pent | 2011 |
Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Convulsants; Electroshock; Formaldehyde; Male; Mi | 2011 |
Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Butyrates; Male; Mice; Neuralgia; Pain Measuremen | 2011 |
Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide.
Topics: Aminobutyrates; Animals; Anticonvulsants; Male; Mice; Rats; Rats, Sprague-Dawley; Seizures; Solubili | 2011 |
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.
Topics: Animals; Anticonvulsants; Diketopiperazines; Electroshock; Epilepsy; Humans; Male; Mice; Models, Mol | 2011 |
Design and synthesis of novel stiripentol analogues as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Dioxolanes; Drug Design; Hand Strength; Male; Mice; Seizures; Stereoisomer | 2012 |
Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones.
Topics: Animals; Anticonvulsants; Biological Assay; Electroshock; Heptanes; Magnetic Resonance Spectroscopy; | 2012 |
Synthesis, resolution and anticonvulsant activity of chiral N-1'-ethyl,N-3'-(1-phenylethyl)-(R,S)-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-trione diastereomers.
Topics: Animals; Anticonvulsants; Benzofurans; Humans; Imidazolidines; Mice; Pentylenetetrazole; Seizures; S | 2012 |
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclini | 2012 |
Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Hydrazines; Male; Mice; Motor Activity; R | 2012 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; | 2015 |
Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Topics: Acetamides; Administration, Oral; Amides; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; El | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Resp | 2015 |
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Humans; Ligands; Male; Mic | 2016 |
Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1,2,4-oxadiazoles as potential anticonvulsant agents.
Topics: Acridines; Acridones; Animals; Anticonvulsants; Electroshock; Mice; Molecular Docking Simulation; Ox | 2016 |
Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Monitoring, Physiologic; | 2022 |
Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adolescent; Adult; Anticonvulsants; Antimalarials; Area Under | 2022 |
Pancytopenia secondary to suspected idiosyncratic phenobarbital reaction in a dog.
Topics: Animals; Dog Diseases; Dogs; Male; Pancytopenia; Phenobarbital; Seizures | 2021 |
Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2022 |
Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2022 |
Status Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Cohort Studies; Female; Humans; Levetirac | 2022 |
Approach to initial management of canine generalised epileptic seizures in primary-care veterinary practices in the United Kingdom.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Phenobarbital; Seizures | 2022 |
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Disease Models, Animal; Epilepsy; H | 2022 |
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
Topics: Animals; Anticonvulsants; Caffeine; Diazepam; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Ra | 2022 |
Electroencephalographic Findings, Antiepileptic Drugs and Risk Factors of 433 Individuals Referred to a Tertiary Care Hospital in Ethiopia.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Craniocerebral Trauma; Electroencephalography; Epilepsy; Et | 2022 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Topics: Animals; Anticonvulsants; Brain; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug | 2023 |
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2023 |
Genetic Expression of CYP2B6 Gene in Phenobarbitone Responder and Non- responder Neonates.
Topics: Anticonvulsants; Cytochrome P-450 CYP2B6; Humans; Infant, Newborn; Phenobarbital; Seizures | 2023 |
Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy.
Topics: Animals; Anticonvulsants; Caregivers; Dog Diseases; Dogs; Epilepsy; Humans; Levetiracetam; Phenobarb | 2023 |
Phenobarbital in super-refractory status epilepticus (PIRATE): A retrospective, multicenter analysis.
Topics: Female; Hospital Mortality; Humans; Male; Phenobarbital; Prospective Studies; Retrospective Studies; | 2023 |
Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia.
Topics: Animals; Anticonvulsants; Asphyxia; Asphyxia Neonatorum; Bumetanide; Epilepsy; Humans; Infant, Newbo | 2023 |
Evaluation of phenobarbital for prevention of alcohol withdrawal in trauma patients.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Humans; Phenobarbital; Retrospectiv | 2023 |
Once-a-day oral treatment with phenobarbital in cats with presumptive idiopathic epilepsy.
Topics: Animals; Cat Diseases; Cats; Epilepsy; Phenobarbital; Prospective Studies; Quality of Life; Retrospe | 2023 |
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2023 |
Unmasking hidden risks: The surprising link between PDE5 inhibitors and seizure susceptibility.
Topics: Animals; Anticonvulsants; Diazepam; Humans; Male; Pentylenetetrazole; Phenobarbital; Phosphodiestera | 2023 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Anima | 2020 |
Levetiracetam in Neonatal seizures.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Piracetam; Seizures | 2019 |
Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippoca | 2020 |
Clinical presentation of epilepsy in six villages in an onchocerciasis endemic area in Mahenge, Tanzania.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Neurologists; Onchocerciasis; Phenobarbital; | 2019 |
Human astrovirus infection associated with encephalitis in an immunocompetent child: a case report.
Topics: Anticonvulsants; Astroviridae Infections; Diarrhea; Encephalitis; Feces; Female; Gastroenteritis; Hu | 2019 |
Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits.
Topics: Animals; Anticonvulsants; Azepines; Benzamides; Disease Models, Animal; Dose-Response Relationship, | 2020 |
Treatment of Neonatal Seizures: Levetiracetam vs Phenobarbitone.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2019 |
Treatment of Neonatal Seizures: Levetiracetam vs Phenobarbitone: Author's Reply.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2019 |
Levetiracetam is Still Not a First-line Treatment in Neonatal Seizures.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2020 |
Levetiracetam is Still Not a First-line Treatment in Neonatal Seizures: Author's Reply.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2020 |
Investigating and managing neonatal seizures in the UK: an explanatory sequential mixed methods approach.
Topics: Anticonvulsants; Attitude of Health Personnel; Diagnostic Techniques and Procedures; Electroencephal | 2020 |
Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal | 2020 |
A retrospective comparison of phenobarbital and levetiracetam for the treatment of seizures following cardiac surgery in neonates.
Topics: Anticonvulsants; Cardiac Surgical Procedures; Female; Humans; Infant, Newborn; Levetiracetam; Male; | 2020 |
Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Infant; Infant, Newborn; Levetiracetam; Phenobarbital; Sei | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; | 2020 |
Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital.
Topics: Anticonvulsants; Child, Preschool; Cohort Studies; Female; Humans; Infant; Infant, Newborn; Infant, | 2021 |
Polygonogram with isobolographic synergy for three-drug combinations of phenobarbital with second-generation antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anticonvulsants; Brain; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy, | 2021 |
Long-term seizure, comorbidity and socioeconomic outcomes of patients with convulsive epilepsy in rural West China.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; China; Comorbidity; Epilepsy; Female; H | 2020 |
Pharmacokinetics, tolerability, and clinical effectiveness of perampanel in Japanese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Drug T | 2020 |
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Male; Mice; Muscle Strength; Phenobarbital; | 2021 |
[Disseminated cysticercosis affecting the brain, the eye and the skin on a Senegalese patient].
Topics: Aged; Albendazole; Brain; Cysticercosis; Diagnosis, Differential; Eye; Eye Infections, Parasitic; Fe | 2020 |
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Bumetanide; Disease Models, Animal; | 2021 |
Severe cortical damage associated with COVID-19 case report.
Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo | 2021 |
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epileps | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Drug Therapy, Combination; Epilepsy; Female; Mice; Phenobarbit | 2021 |
Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details.
Topics: Animals; Anticonvulsants; Bumetanide; Epilepsy; Humans; Midazolam; Phenobarbital; Prohibitins; Seizu | 2021 |
Comparative efficacy of levetiracetam to phenobarbital in the treatment of neonatal seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2021 |
A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Benzylamines; Brain; Bumetanide; Do | 2021 |
Comparison of efficacy and safety of levetiracetam and phenobarbitone in neonatal seizure.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Piracetam; Seizure | 2022 |
Prevalence and predictors of adverse outcomes in neonatal seizures.
Topics: Female; Humans; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; | 2022 |
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Cost of Illness; Disease Models, Animal; Drug Co | 2021 |
Efficacy of lacosamide in neonatal-onset super-refractory status epilepticus: a case report.
Topics: Anticonvulsants; Humans; Infant, Newborn; Lacosamide; Phenobarbital; Seizures; Status Epilepticus | 2021 |
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceut | 2021 |
Terminal seizure frequency and its relation to SUDEP.
Topics: Adult; Anticonvulsants; China; Death, Sudden; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mid | 2017 |
Seizures in Preterm Neonates: A Multicenter Observational Cohort Study.
Topics: Anticonvulsants; Brain; Electroencephalography; Female; Gestational Age; Humans; Hypoxia-Ischemia, B | 2017 |
Mild encephalopathy/encephalitis with a reversible splenial lesion (MERS): A report of five neonatal cases.
Topics: Brain Diseases; Cefoperazone; Corpus Callosum; Electroencephalography; Encephalitis; Hospitalization | 2017 |
Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Disease P | 2017 |
Cerebellar Infarction: Unusual Manifestation with Facial Palsy, Focal Seizures, and Secondary Generalization.
Topics: Cerebral Infarction; Cerebrum; Cesarean Section; Electroencephalography; Facial Paralysis; Humans; I | 2018 |
The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain Injuries; Disease Models, Animal | 2018 |
The Use of Peritoneal Dialysis in Phenobarbitone Toxicity in a Critically Unwell Neonate.
Topics: Anticonvulsants; Female; Humans; Infant; Infant, Newborn; Peritoneal Dialysis; Phenobarbital; Poison | 2018 |
Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Female; | 2017 |
Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Hypoxia; Levetiracetam; M | 2018 |
Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures.
Topics: Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Infant, Newborn; Male; Phenobarbital; | 2018 |
A survey of antiepileptic drug responses identifies drugs with potential efficacy for seizure control in Wolf-Hirschhorn syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clobazam; Female; Humans | 2018 |
Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epileps | 2018 |
Efficacy of levetiracetam for neonatal seizures in preterm infants.
Topics: Anticonvulsants; Birth Weight; Brain; Female; Gestational Age; Humans; Infant, Newborn; Infant, Prem | 2018 |
Phenobarbital population pharmacokinetics across the pediatric age spectrum.
Topics: Administration, Oral; Adolescent; Age Factors; Child; Child, Preschool; Dose-Response Relationship, | 2018 |
Convulsive status epilepticus management in adults and children: Report of the Working Group of the Polish Society of Epileptology.
Topics: Adult; Anticonvulsants; Child; Humans; Phenobarbital; Poland; Seizures; Status Epilepticus | 2018 |
Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; Drug Synergism; Drug Th | 2018 |
Modeling and simulations to support dose selection for eslicarbazepine acetate therapy in pediatric patients with partial-onset seizures.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dibenzazepines; Dose-Response Relationship, Dr | 2018 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; E | 2018 |
The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Azabicyclo Compounds; Blood-Brain Barrier; Catalysis; Electroshock; Enzyme | 2018 |
Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalo | 2018 |
Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; K Cl- Cotransporters; Mal | 2018 |
Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy.
Topics: Animals; Anticonvulsants; Benzylamines; Brain; Bumetanide; Drug Evaluation, Preclinical; Drug Synerg | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pen | 2018 |
A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy.
Topics: Anticonvulsants; Electroencephalography; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Bra | 2018 |
Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Androgens; Androsterone; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2019 |
Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Mo | 2019 |
Persistent Muscle Twitching With Phenobarbitone in a Preterm Neonate-Lack of Response or Manifestation of Toxicity?
Topics: Anticonvulsants; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Muscles; Phe | 2019 |
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 2019 |
Mild hypotonia and recurrent seizures in an 8-month-old boy: Questions.
Topics: Calcium; Humans; Hypocalcemia; Infant; Magnesium; Male; Muscle Hypotonia; Phenobarbital; Seizures; T | 2019 |
Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant, | 2019 |
Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures.
Topics: Anticonvulsants; Brain; Electroencephalography; Female; Humans; Hypoxia-Ischemia, Brain; Infant, New | 2019 |
A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Male; Phenobarbital; | 2019 |
[Vomiting associated with weight stagnation and convulsions: urea cycle disorder should be suspected].
Topics: Adolescent; Anticonvulsants; Body Weight; Failure to Thrive; Female; Headache; Humans; Hyperammonemi | 2018 |
Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy.
Topics: Animals; Anticonvulsants; Cohort Studies; Dog Diseases; Dogs; Epilepsy; Imidazoles; Phenobarbital; P | 2019 |
Neurodevelopmental outcomes at 9-14 months gestational age after treatment of neonatal seizures due to brain injury.
Topics: Anticonvulsants; Brain Injuries; Case-Control Studies; Developmental Disabilities; Female; Gestation | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam | 2019 |
Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Bumetanide; CA1 Region, Hippoca | 2013 |
Can we safely administer the recommended dose of phenobarbital in very low birth weight infants?
Topics: Age Factors; Dose-Response Relationship, Drug; Electroencephalography; Female; Gestational Age; Huma | 2013 |
Status epilepticus in a child secondary to ingestion of skin-lightening cream.
Topics: Anticonvulsants; Ataxia; Eating; Emergencies; Humans; Hydroquinones; Infant; Intubation, Intratrache | 2013 |
Efficacy and safety of lidocaine for treatment of neonatal seizures.
Topics: Cohort Studies; Electroencephalography; Female; Follow-Up Studies; Gestational Age; Humans; Infant, | 2013 |
Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Lamotrigine; Phenobarbital; Pregnancy; Pregnancy Com | 2013 |
Feasibility study of a caregiver seizure alert system in canine epilepsy.
Topics: Algorithms; Animals; Anticonvulsants; Caregivers; Chromatography, High Pressure Liquid; Clinical Ala | 2013 |
Anticonvulsants for neonates: high time we were seized of the matter.
Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures | 2013 |
Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures.
Topics: Anticonvulsants; Child Development; Child, Preschool; Cohort Studies; Gestational Age; Humans; Infan | 2013 |
The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs.
Topics: Animals; Anticonvulsants; Carbolines; Dogs; Dose-Response Relationship, Drug; Drug Partial Agonism; | 2013 |
Melatonin potentiates the anticonvulsant action of phenobarbital in neonatal rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Drug T | 2013 |
Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital.
Topics: Adolescent; Adult; Anticonvulsants; Bangladesh; Carbamazepine; Child; Drug Combinations; Epilepsies, | 2013 |
Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004-2013).
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Phenobarbital; Seizures | 2014 |
Neonatal seizures: continued debate on phenobarbitone versus phenytoin.
Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures | 2013 |
Phenobarbital-induced pellagra resulted in death.
Topics: Adult; Anticonvulsants; Dermatitis; Fatal Outcome; Female; Humans; Niacin; Pellagra; Phenobarbital; | 2014 |
Reply: To PMID 23502660.
Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures | 2013 |
Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Combined Modality Therapy; Deep Brain Stimulation; Disease Model | 2014 |
Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Behavior, Animal; | 2014 |
Uncommon acute neurologic presentation of canine distemper in 4 adult dogs.
Topics: Animals; Anticonvulsants; Central Nervous System Viral Diseases; Diazepam; Distemper; Distemper Viru | 2014 |
Neonatal eating epilepsy: 50-year follow-up.
Topics: Anticonvulsants; Diagnosis, Differential; Eating; Female; Follow-Up Studies; Humans; Infant, Newborn | 2014 |
Myoclonic seizures in a preterm baby: is this a presentation of venlafaxine withdrawal?
Topics: Antidepressive Agents; Cyclohexanols; Electroencephalography; Female; Humans; Infant, Newborn; Infan | 2014 |
Optimal estimation for regression models on τ-year survival probability.
Topics: Biometry; Computer Simulation; Humans; Kaplan-Meier Estimate; Logistic Models; Phenobarbital; Random | 2015 |
Exacerbation of benign familial neonatal epilepsy induced by massive doses of phenobarbital and midazolam.
Topics: Electroencephalography; Epilepsy, Benign Neonatal; Female; GABA Modulators; Humans; Midazolam; Pheno | 2014 |
Brief postnatal exposure to phenobarbital impairs passive avoidance learning and sensorimotor gating in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cocaine; Female; Male; Memory; Phenobarbital; Rats; Se | 2014 |
Effect of levetiracetam in acute encephalitis with refractory, repetitive partial seizures during acute and chronic phase.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Bromides; Child; Chronic Disease; Encephalitis; F | 2015 |
Anticonvulsant treatment associated with intractable hypocalcaemia in a female child with hypoparathyroidism.
Topics: Anticonvulsants; Drug Interactions; Female; Humans; Hydroxycholecalciferols; Hypercalcemia; Hypocalc | 2015 |
Profile of anticonvulsant action of levetiracetam, tiagabine and phenobarbital against seizures evoked by DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in neonatal rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Carbolines; Levetiracetam; Male; Nipecotic Acids; Phenob | 2014 |
Neonatal Neurocritical Care Service Is Associated With Decreased Administration of Seizure Medication.
Topics: Cohort Studies; Electroencephalography; Female; Humans; Hypnotics and Sedatives; Hypothermia, Induce | 2015 |
Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Levetiracetam; Long QT Syndrome; Male; Mid | 2014 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod | 2015 |
Levetiracetam as a possible cause of secondary graft failure after allogenic hematopoietic stem cell transplantation.
Topics: Adolescent; Anticonvulsants; Blood Cell Count; Graft Rejection; Hematopoietic Stem Cell Transplantat | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
[A case of acute encephalitis with refractory repetitive partial seizures successfully controlled by very-high-dose phenobarbital therapy found in a boy].
Topics: Acute Disease; Child; Encephalitis; Humans; Male; Phenobarbital; Seizures; Status Epilepticus; Treat | 2014 |
In vivo evaluation of anticonvulsant and antioxidant effects of phenobarbital microemulsion for transdermal administration in pilocarpine seizure rat model.
Topics: Administration, Cutaneous; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Emulsions | 2015 |
Montelukast potentiates the anticonvulsant effect of phenobarbital in mice: an isobolographic analysis.
Topics: Acetates; Animals; Anticonvulsants; Convulsants; Cyclopropanes; Dose-Response Relationship, Drug; Dr | 2015 |
Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzhydryl Compounds; Brain; Carbamazepine; Central Ne | 2015 |
Bumetanide for treatment of seizures in neonates.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Phenobarbital and neonatal seizures affect cerebral oxygen metabolism: a near-infrared spectroscopy study.
Topics: Anticonvulsants; Brain; Electroencephalography; Female; Humans; Infant, Newborn; Infant, Newborn, Di | 2015 |
Epilepsy: Neonatal seizures still lack safe and effective treatment.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
What is your diagnosis? Liver aspirate from a hypoglycemic dog.
Topics: Abdomen; Animals; Anticonvulsants; Biopsy, Fine-Needle; Dog Diseases; Dogs; Euthanasia, Animal; Hypo | 2015 |
Effect of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of classical antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Male; Methoxsalen; Mice; Phen | 2015 |
Etiology, clinical course and response to the treatment of status epilepticus in children: A 16-year single-center experience based on 602 episodes of status epilepticus.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Infusions, I | 2015 |
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonid | 2015 |
Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Anxiety; Behavior, Animal; Cerebral Cortex; Electroencep | 2015 |
Magnetic resonance imaging and computed tomography findings of Dyke-Davidoff-Masson-like syndrome in a cat.
Topics: Animals; Anticonvulsants; Brain; Brain Diseases; Brain Injuries; Cat Diseases; Cats; Female; Magneti | 2015 |
Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Azepines; Benzamides; Brain; Brain Ischemia; Brain-Deriv | 2015 |
Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Design; Male; Mice; Molecular Structur | 2015 |
Efficacy and tolerability of high-dose phenobarbital in children with focal seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Male; Phenobarbital; Retrospective Studies | 2016 |
Bumetanide for neonatal seizures-back from the cotside.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Successful treatment of refractory seizures with phenobarbital, propofol, and medetomidine following congenital portosystemic shunt ligation in a dog.
Topics: Animals; Anticonvulsants; Diagnosis, Differential; Dog Diseases; Dogs; Drug Therapy, Combination; Ma | 2016 |
Mexiletine and its Interactions with Classical Antiepileptic Drugs: An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Electroshock; | 2016 |
Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide.
Topics: Anticonvulsants; Brain; Bromides; Chromosome Deletion; Chromosomes, Human, Pair 4; Comparative Genom | 2016 |
Montelukast reduces seizures in pentylenetetrazol-kindled mice.
Topics: Acetates; Animals; Anticonvulsants; Blotting, Western; Convulsants; Cyclopropanes; Kindling, Neurolo | 2016 |
Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Co | 2016 |
The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cimetidine; Drug Interactions; Electroshock; Male; M | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Lissencephaly in an adult Australian Kelpie.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Dog Diseases; Dogs; Lissencephaly; Magnetic Resonance Ima | 2016 |
Short-Term Effects of Phenobarbitone on Electrographic Seizures in Neonates.
Topics: Anticonvulsants; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Monitor | 2016 |
Low-frequency electrical stimulation enhances the effectiveness of phenobarbital on GABAergic currents in hippocampal slices of kindled rats.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Combined Modality Therapy; Disease Models, Animal | 2016 |
High-dose phenobarbital with intermittent short-acting barbiturates for acute encephalitis with refractory, repetitive partial seizures.
Topics: Acute Disease; Anticonvulsants; Barbiturates; Child; Dose-Response Relationship, Drug; Drug Administ | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Phenobarbital for Neonatal Seizures: Response Rate and Predictors of Refractoriness.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Electroencephalography; Female; Humans; Infant, Newborn; I | 2016 |
Of Phenobarbital for Neonatal Seizures: Response Rate and Refractoriness Predictors.
Topics: Anticonvulsants; Electroencephalography; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Phenobarb | 2016 |
Early EEG findings in tuberous sclerosis complex presenting with apneic seizures soon after birth.
Topics: Anticonvulsants; Apnea; Electroencephalography; Humans; Infant, Newborn; Magnetic Resonance Imaging; | 2016 |
Standardized Treatment of Neonatal Status Epilepticus Improves Outcome.
Topics: Anticonvulsants; Critical Care; Female; Guideline Adherence; Humans; Infant, Newborn; Intensive Care | 2016 |
Implementation of a Neurocritical Care Program: Improved Seizure Detection and Decreased Antiseizure Medication at Discharge in Neonates With Hypoxic-Ischemic Encephalopathy.
Topics: Anticonvulsants; Brain; Cost of Illness; Electroencephalography; Female; Humans; Hypothermia, Induce | 2016 |
Serum Phenobarbitone Levels in Neonates with Seizures: Some Clarifications.
Topics: Anticonvulsants; Humans; Infant, Newborn; Phenobarbital; Seizures | 2016 |
Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Alkaloids; Animals; Anticonvulsants; Azocines; Dose-Response Relationship, Drug; Electroshock; Levet | 2017 |
Changing antiepileptic drug use for seizures in US neonatal intensive care units from 2005 to 2014.
Topics: Anticonvulsants; Child; Drug Utilization; Female; Humans; Infant; Infant, Newborn; Intensive Care Un | 2017 |
Levetiracetam for the Treatment of Seizures in Neonatal Hypoxic Ischemic Encephalopathy.
Topics: Adult; Anticonvulsants; Female; Follow-Up Studies; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B | 2017 |
New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2017 |
Phenobarbital administration every eight hours: improvement of seizure management in idiopathic epileptic dogs with decreased phenobarbital elimination half-life.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Drug Administration Schedule; Epilepsy, Generalized; F | 2017 |
Factor VII deficiency associated with valproate treatment.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Factor VII; Factor VII Deficiency; Follo | 2008 |
Synthesis of DL-fluorobenzenamides as anticonvulsants.
Topics: Animals; Anticonvulsants; Benzamides; Convulsants; Indicators and Reagents; Male; Mice; Pentylenetet | 2008 |
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam; | 2009 |
Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism.
Topics: Anticonvulsants; Data Collection; Female; Humans; Lamotrigine; Levetiracetam; Middle Aged; Phenobarb | 2009 |
Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability.
Topics: Anticonvulsants; Barbiturates; Cognition; Drug Therapy, Combination; Epilepsy; Humans; Intellectual | 2009 |
Prophylactic phenobarbital administration after resolution of neonatal seizures: survey of current practice.
Topics: Anticonvulsants; Attitude of Health Personnel; Clinical Competence; Dose-Response Relationship, Drug | 2008 |
Gardales and seizures.
Topics: Animals; Chelidonium; Coleoptera; Humans; Phenobarbital; Seizures | 1947 |
Anticonvulsant actions of trimethadione-phenobarbital and trimethadione-diphenylhydantoin combinations.
Topics: Anticonvulsants; Humans; Phenobarbital; Phenytoin; Seizures; Trimethadione | 1948 |
Prenatal diagnosis of fetal seizure: a case report.
Topics: Female; Fetal Diseases; Humans; Infant, Newborn; Karyotyping; Magnetic Resonance Imaging; Male; Phen | 2008 |
Neonatal seizures: treatment and treatment variability in 31 United States pediatric hospitals.
Topics: Analysis of Variance; Anticonvulsants; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Lo | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-R | 2009 |
Benign familial neonatal convulsions: novel mutation in a newborn.
Topics: Amino Acid Sequence; Anticonvulsants; Brain; Diagnosis, Differential; DNA Mutational Analysis; Echoc | 2009 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Trans | 2009 |
N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Brain; Carbamazepine; Dose-Response Relationship, Drug; | 2009 |
Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western | 2009 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons | 2010 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug T | 2009 |
Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.
Topics: Amygdala; Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Chlorides; Female; gamma-Aminobuty | 2009 |
Reflections: neurology and the humanities: reflections for October.
Topics: Anti-HIV Agents; Anticonvulsants; Drug Combinations; Drug Interactions; Female; HIV Infections; Huma | 2009 |
Congenital hypoplasia of the Internal Carotid Artery.
Topics: Apgar Score; Carotid Artery, Internal; Cerebral Angiography; Follow-Up Studies; Humans; Imaging, Thr | 2009 |
A case of drug-induced hypersensitivity syndrome-like symptoms following HHV-6 encephalopathy.
Topics: Anticonvulsants; Brain Diseases, Metabolic; Diagnosis, Differential; Drug Hypersensitivity; Eosinoph | 2010 |
Approach to seizures in the neonatal period: a European perspective.
Topics: Anticonvulsants; Europe; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures | 2010 |
Amplitude-integrated electroencephalography in patients with acute encephalopathy with refractory, repetitive partial seizures.
Topics: Anticonvulsants; Child; Electroencephalography; Female; Fever; Humans; Phenobarbital; Seizures; Stat | 2011 |
Comparative anticonvulsant actions of isopropyl alcohol, diphenylhydantoin, phenobarbital and tridione.
Topics: 1-Propanol; 2-Propanol; Anticonvulsants; Humans; Phenobarbital; Phenytoin; Propanols; Seizures; Trim | 1947 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose | 2010 |
Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbon | 2010 |
Epileptiform seizures revealing neurocysticercosis: report of two clinical cases in Libreville, Gabon.
Topics: Adrenal Cortex Hormones; Adult; Albendazole; Animals; Antibodies, Helminth; Anticestodal Agents; Fem | 2010 |
Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy?
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child, Preschool; Drug Therapy, Combination; Electroen | 2010 |
Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, | 2010 |
Management of neonatal seizures.
Topics: Anticonvulsants; Benzodiazepines; Electroencephalography; Epilepsies, Myoclonic; Humans; Hypocalcemi | 2010 |
Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Cannabinoid Receptor Agonists; Carbamaze | 2011 |
Vitamin D deficiency rickets mimicking pseudohypoparathyroidism.
Topics: Anticonvulsants; Calcium; Diagnosis, Differential; Humans; Infant; Male; Phenobarbital; Phosphates; | 2010 |
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; H | 2011 |
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Body Weight; Cognition Disorders; | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cl | 2011 |
[Neonatal seizures revealing incontinentia pigmenti].
Topics: Anticonvulsants; Consanguinity; Diagnosis, Differential; Female; Humans; Incontinentia Pigmenti; Inf | 2011 |
Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Hippocam | 2012 |
Synthesis and biological evaluation of some novel quinoxaline derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Indicators and Reagents; Ma | 2011 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; | 2011 |
Porencephaly and hydranencephaly in six dogs.
Topics: Animals; Cerebellar Diseases; Cerebellum; Dog Diseases; Dogs; Female; Hydranencephaly; Male; Phenoba | 2012 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; | 2012 |
Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Female; Genotype; Humans; Infant; Infant, N | 2012 |
Prevalence of seizures in children infected with human immunodeficiency virus.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Female; HIV Infections; Humans; Male; Pheno | 2013 |
Recooling for rebound seizures after rewarming in neonatal encephalopathy.
Topics: Anticonvulsants; Combined Modality Therapy; Electroencephalography; Humans; Hypothermia, Induced; Hy | 2012 |
Differing attitudes toward phenobarbital use in the neonatal period among neonatologists and child neurologists in Sweden.
Topics: Anticonvulsants; Attitude of Health Personnel; Humans; Infant, Newborn; Neurology; Phenobarbital; Ph | 2013 |
Compounding errors in 2 dogs receiving anticonvulsants.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Compounding; Male; Medication Errors; P | 2012 |
[Intravenous injection of phenobarbital for benign convulsions with mild gastroenteritis].
Topics: Child, Preschool; Epilepsy; Female; Gastroenteritis; Humans; Infant; Injections, Intravenous; Male; | 2012 |
Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia.
Topics: Age Factors; Anticonvulsants; Body Temperature; Body Weight; Female; Humans; Hypothermia, Induced; H | 2013 |
Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Elec | 2002 |
Intracerebroventricular injection of the antibiotic cefoselis produces convulsion in mice via inhibition of GABA receptors.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Bicuculline; Carbamazepine; Ceftizoxime; Dizocilpin | 2002 |
Neuropeptide Y and somatostatin participate differently in the seizure-generating mechanisms following trimethyltin-induced hippocampal damage.
Topics: Animals; Anticonvulsants; Benzoxazines; Cell Count; Coloring Agents; Hippocampus; Immunohistochemist | 2002 |
Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines.
Topics: Amphetamine; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epinephr | 2002 |
A fatal case of toxic epidermal necrolysis associated with liver cirrhosis.
Topics: Child; Disease Progression; Dose-Response Relationship, Drug; Emergency Service, Hospital; Fatal Out | 2003 |
Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning.
Topics: Animals; Behavior, Animal; Cues; Excitatory Amino Acid Agonists; GABA Modulators; Kainic Acid; Learn | 2000 |
The effect of N-nitro-L-arginine methyl ester posttreatment on the anticonvulsant effect of phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Drug Synergism; Male; NG-Nitroarginine Methyl Ester; Phenobarbit | 2003 |
Hypoxic ischemic encephalopathy associated with neonatal seizures without other neurological abnormalities.
Topics: Anticonvulsants; Brain; Electroencephalography; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Ma | 2003 |
A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Developmental Disabilities; Fem | 2003 |
[Effects of phenobarbital, acylureas and diphenylhydantoin on coma during electric epileptic crisis in guinea pig. II..].
Topics: Anticonvulsants; Barbiturates; Coma; Electricity; Epilepsy; Guinea Pigs; Phenobarbital; Phenytoin; S | 1953 |
Electroencephalographic studies, induced seizures, and their modification by phenobarbital, dilantin, and phenurone, in the salamanders, Triturus viridescens and Ambystoma tigrinum.
Topics: Ambystoma; Animals; Anticonvulsants; Barbiturates; Benzeneacetamides; Electroencephalography; Humans | 1954 |
Effects of variations in stimulus intensity on maximal electroshock seizure pattern, recovery time, and anticonvulsant potency of phenobarbital in mice.
Topics: Animals; Anticonvulsants; Electricity; Electroshock; Mice; Phenobarbital; Seizures | 1956 |
[Comparative action of products, numbers 3277 R.P., 4560 R.P., 4909 R.P. and of phenobarbital on convulsions induced by strychnine, picrotoxin, cocaine, cafeine and amphetamine].
Topics: Amphetamine; Amphetamines; Chlorpromazine; Cocaine; Histamine H1 Antagonists; Phenobarbital; Phenoth | 1956 |
[Comparative action of products, numbers 3277 R.P., 4560 R.P., 4909 R.P. and of phenobarbital on convulsions induced by strychnine, picrotoxin, cocaine, cafeine and amphetamine].
Topics: Amphetamine; Amphetamines; Chlorpromazine; Cocaine; Histamine H1 Antagonists; Phenobarbital; Phenoth | 1956 |
[Comparative action of products, numbers 3277 R.P., 4560 R.P., 4909 R.P. and of phenobarbital on convulsions induced by strychnine, picrotoxin, cocaine, cafeine and amphetamine].
Topics: Amphetamine; Amphetamines; Chlorpromazine; Cocaine; Histamine H1 Antagonists; Phenobarbital; Phenoth | 1956 |
[Comparative action of products, numbers 3277 R.P., 4560 R.P., 4909 R.P. and of phenobarbital on convulsions induced by strychnine, picrotoxin, cocaine, cafeine and amphetamine].
Topics: Amphetamine; Amphetamines; Chlorpromazine; Cocaine; Histamine H1 Antagonists; Phenobarbital; Phenoth | 1956 |
The difference in action on normal and convulsive cortical activity between a local anaesthetic (lidocaine) and barbiturates.
Topics: Anesthesia, Local; Anesthetics, Local; Barbiturates; Lidocaine; Pentobarbital; Phenobarbital; Seizur | 1956 |
[Therapy of convulsive states in the newborn].
Topics: Child; Chlorpromazine; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Se | 1957 |
[Effect of chloropromazine and reserpine and their comparison with phenobarbital in pentazole shock in mice].
Topics: Animals; Chlorpromazine; Mice; Phenobarbital; Reserpine; Seizures; Shock | 1958 |
The emergency treatment of convulsions in childhood.
Topics: Child; Emergency Treatment; Humans; Infant; Paraldehyde; Phenobarbital; Seizures | 1958 |
Effect of-anticonvulsant drugs on cortical and subcortical seizure discharges in cats.
Topics: Animals; Anticonvulsants; Cats; Epilepsy; Humans; Hydantoins; Phenobarbital; Seizures | 1960 |
[Clinical experiences of trinuride on epilepsy].
Topics: Anticonvulsants; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Seizures | 1962 |
Convulsions in childhood.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Humans; Phenobarbital; Phenytoin; Seizures | 1963 |
Treatment of epilepsy.
Topics: Acetazolamide; Anticonvulsants; Automatism; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1963 |
Effects of autonomic agents, alone and in combination with antiepileptic drugs, on electroshock seizures in rats.
Topics: Animals; Anticonvulsants; Atropine; Autonomic Agents; Electroshock; Methacholine Compounds; Neostigm | 1963 |
Effect of drugs on EST in various endocrine deficient states.
Topics: Adrenalectomy; Diphenhydramine; Ephedrine; Hydantoins; Hypophysectomy; Lysergic Acid Diethylamide; M | 1963 |
PHARMACOLOGICAL PROPERTIES OF PENTAERYTHRITOL DERIVATIVES. II.MONOBENZALPENTAERYTHRITOL, A COMPOUND STIMULATING THE CENTRAL NERVOUS SYSTEM.
Topics: Cats; Central Nervous System Stimulants; Mephenesin; Mice; Pentylenetetrazole; Pharmacology; Phenoba | 1962 |
CONTRASTING BEHAVIORAL, PHARMACOLOGICAL, NEUROPHYSIOLOGICAL, AND BIOCHEMICAL PROFILES OF C57 B1/6 AND SC-I STRAINS OF MICE.
Topics: Adrenal Glands; Aggression; Animals; Avoidance Learning; Behavior, Animal; Chlorpromazine; Mice; Neu | 1963 |
A SIMPLE METHOD TO MEASURE CENTRAL CHOLINOLYTIC ACTIVITY.
Topics: Anticonvulsants; Atropine; Carbachol; Cholinergic Antagonists; Methantheline; Mice; Pharmacology; Ph | 1963 |
A PROPOSED COMMON MECHANISM OF ACTION FOR GENERAL AND LOCAL ANAESTHETICS IN THE CENTRAL NERVOUS SYSTEM.
Topics: Action Potentials; Anesthesia, Local; Anesthetics, Local; Animals; Cats; Central Nervous System; Cer | 1963 |
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol | 1963 |
THE INHIBITION OF NICOTINE-INDUCED CONVULSIONS IN THE RAT.
Topics: Anesthetics; Anesthetics, Local; Anticonvulsants; Nicotine; Pharmacology; Phenobarbital; Procaine; R | 1963 |
[THE MECHANISM OF ACTION OF L-1-CYCLOHEXYL-2-METHYLAMINOPROPAN-5,5-PHENYLETHYLBARBITURATE AND ITS SUITABILITY AS AN ANTIEPILEPTIC. COMPARATIVE STUDIES WITH PHENOBARBITAL].
Topics: Animals; Anticonvulsants; Barbiturates; Mice; Phenobarbital; Rats; Research; Seizures | 1963 |
THE INFANT WITH EPILEPSY.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific | 1963 |
DOSAGE OF PHENYTOIN AND PHENOBARBITAL IN CHILDREN.
Topics: Blood Chemical Analysis; Child; Epilepsy; Fever; Humans; Phenobarbital; Phenytoin; Seizures | 1963 |
CONVULSIONS.
Topics: Black People; Diagnosis, Differential; Epilepsy; Humans; Intellectual Disability; Phenobarbital; Phe | 1964 |
[CONVULSIONS IN CHILDREN. (1)].
Topics: Adolescent; Child; Chloral Hydrate; Fever; Humans; Infant; Infant, Newborn; Opium; Phenobarbital; Se | 1964 |
STIMULANT ACTION OF PYRIDYL DERIVATIVES OF BENZODIOXANS AND BENZODIOXEPANS.
Topics: Animals; Anticonvulsants; Atropine; Bemegride; Central Nervous System Agents; Central Nervous System | 1963 |
ANTIMALARIALS AND OTHER ANTICONVULSANT DRUGS: PREDICTIVE VALIDITY OF LABORATORY TESTS.
Topics: Animals; Anticonvulsants; Antimalarials; Chloroquine; Electric Stimulation; Hydroxychloroquine; Mice | 1964 |
TOXAEMIA OF PREGNANCY.
Topics: Albuminuria; Amobarbital; Blood Pressure; Edema; Female; Humans; Labor, Induced; Morphine; Paraldehy | 1964 |
DIAGNOSIS AND TREATMENT: MANAGEMENT OF THE CHILD WHO HAS HAD ONE CONVULSION.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Disease Management; Fever; Humans; Infant; Phenobar | 1964 |
PSYCHOMOTOR VARIANT TYPE OF SEIZURE DISCHARGE.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1963 |
NEUROLOGICAL SYNDROMES OF SYSTEMIC LUPUS ERYTHEMATOSUS.
Topics: Adolescent; Anticonvulsants; Autoimmune Diseases; Blood Proteins; Cerebral Cortex; Cerebrospinal Flu | 1964 |
[ACCIDENTAL INH POISONING IN A 2-YEAR-OLD GIRL].
Topics: Drug-Related Side Effects and Adverse Reactions; Infant; Isoniazid; Phenobarbital; Seizures; Toxicol | 1964 |
CONTROL OF THE NEUROMUSCULAR AND CONVULSIVE MANIFESTATIONS OF SEVERE SYSTEMIC TETANUS: CASE REPORT WITH A NEW DRUG, VALIUM (DIAZEPAM).
Topics: Amobarbital; Child; Diazepam; Diphenhydramine; Humans; Neurologic Manifestations; Penicillins; Pheno | 1964 |
CONVULSIONS IN INFANCY AND CHILDHOOD.
Topics: Anticonvulsants; Child; Electroencephalography; Encephalitis; Epilepsy; Epilepsy, Absence; Epilepsy, | 1963 |
[CONVULSIONS IN CHILDREN (3)].
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Bromides; Child; Electroence | 1964 |
SEIZURES INDUCED BY MOVEMENT: A FORM OF REFLEX EPILEPSY.
Topics: Adolescent; Athetosis; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Epilep | 1964 |
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep | 1964 |
REPORT ON THE ANTI-EPILEPTIC ACTION OF TEGRETOL.
Topics: Acetazolamide; Adolescent; Anticonvulsants; Biomedical Research; Carbamazepine; Child; Chlordiazepox | 1964 |
ZARONTIN (ETHOSUXIMIDE) IN THE TREATMENT OF PETIT MAL AND RELATED DISORDERS.
Topics: Adolescent; Anticonvulsants; Biomedical Research; Child; Denmark; Drug Therapy; Epilepsy; Epilepsy, | 1964 |
BORIC ACID POISONING: REPORT OF 11 CASES.
Topics: Acidosis; Anti-Bacterial Agents; Borates; Boric Acids; Color Perception Tests; Dehydration; Diarrhea | 1964 |
ENCEPHALITIS FOLLOWING MODIFIED MEASLES.
Topics: Child; Diphenhydramine; Drug Therapy; Electroencephalography; Encephalitis; Encephalomyelitis, Acute | 1964 |
[INHIBITION OF ELECTROCONVULSION BY THE KAVA-PYRONES DIHYDROMETHYSTICIN AND DIHYDROKAVAIN].
Topics: Anticonvulsants; Chlorpromazine; Kava; Mice; Pharmacology; Phenobarbital; Phenytoin; Primidone; Pyro | 1964 |
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF PHENYL-SUBSTITUTED BIURETS.
Topics: Atropine; Biuret; Chemistry, Pharmaceutical; Gastric Juice; Meprobamate; Mice; Nicotine; Pentylenete | 1963 |
ACUTE MUSHROOM POISONING: TREATMENT WITH CURARE AND INTERMITTENT POSITIVE PRESSURE RESPIRATION.
Topics: Agaricales; Atropine; Child; Curare; Drug Therapy; Edema; Gastric Lavage; Mushroom Poisoning; Neosti | 1964 |
[EFFECT AND INDICATION OF A NEW ANTIEPILEPTIC DRUG].
Topics: Anticonvulsants; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tempor | 1964 |
[THE PROSTRATION SYNDROME. SERIOUS DANGER OF DRUG THERAPY IN EPILEPSY].
Topics: Adolescent; Anticonvulsants; Chlorpromazine; Down Syndrome; Drug Therapy; Electroencephalography; Ep | 1964 |
[TREATMENT OF PATIENTS WITH EPILEPSY WITH FREQUENT PETIT MAL SEIZURES].
Topics: Anticonvulsants; Caffeine; Drug Therapy; Epilepsy; Epilepsy, Absence; Humans; Phenobarbital; Seizure | 1964 |
[CONVULSION CAUSED BY TELODRIN POISONING].
Topics: Drug Therapy; Electroencephalography; Insecticides; Phenobarbital; Poisoning; Seizures; Thioctic Aci | 1964 |
A STATE PROGRAM TO CONTROL PHENYLKETONURIA.
Topics: Adolescent; Blood; Child; Diet; Diet Therapy; Genetics, Medical; Humans; Infant; Intellectual Disabi | 1964 |
COMPARATIVE NEUROTOXICITY AND ANTIPENTYLENETETRAZOL ACTIVITY OF SOME PIPERIDINEDIONES.
Topics: Bemegride; Glutethimide; Hypnotics and Sedatives; Mice; Pentylenetetrazole; Pharmacology; Phenobarbi | 1964 |
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology; | 1964 |
HINTS ON SEIZURE MANAGEMENT.
Topics: Anticonvulsants; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Hu | 1964 |
THE ABSENCE OF ANTICONVULSANT PROPERTIES OF QUINACRINE AND CHLOROQUINE IN MICE.
Topics: Anticonvulsants; Chloroquine; Mice; Pentylenetetrazole; Pharmacology; Phenobarbital; Quinacrine; Res | 1964 |
ALTERATIONS IN THE ACTIVITY OF PENTOTHAL, PHENOBARBITAL, PENTYLENETETRAZOL, AND STRYCHNINE BY CHOLINESTERASE INHIBITORS.
Topics: Acetylcholine; Anesthesia; Atropine; Cholinesterase Inhibitors; Isoflurophate; Mice; Neostigmine; Pe | 1964 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, | 1964 |
BEHAVIOR DISORDERS OF CHILDREN WITH CEREBRAL DYSRHYTHMIAS; SUCCESSFUL TREATMENT OF SUBCONVULSIVE DYSRHYTHMIA WITH ANTICONVULSANTS.
Topics: Acetazolamide; Amphetamine; Amphetamines; Anticonvulsants; Child; Child Behavior Disorders; Conduct | 1964 |
[POSSIBILITIES OF COMBINED ANTICONVULSANT TREATMENT IN CHRONIC SEIZURES].
Topics: Adolescent; Anticonvulsants; Child; Drug Therapy; Epilepsy; Humans; Infant; Infant, Newborn; Phenoba | 1964 |
POSSIBLE IDIOSYNCRASY TO BELLADONNA, PHENOBARBITOL, OR PAREGORIC.
Topics: Atropa belladonna; Diarrhea; Diarrhea, Infantile; Drug Therapy; Gastrointestinal Agents; Humans; Inf | 1965 |
NOCTURNAL EPILEPSY AND HYPOGLYCAEMIA.
Topics: Anticonvulsants; Child; Circadian Rhythm; Delayed-Action Preparations; Drug Therapy; Electroencephal | 1964 |
TEMPORAL LOBE EPILEPSY: A CLINICAL STUDY OF 47 CASES.
Topics: Adolescent; Biomedical Research; Birth Injuries; Depression; Depressive Disorder; Diagnosis, Differe | 1964 |
CHILD CARE IN GENERAL PRACTICE. CONVULSIONS IN INFANCY AND CHILDHOOD. II.
Topics: Acetazolamide; Anticonvulsants; Bromides; Child; Child Care; Chloral Hydrate; Diagnosis; Drug Therap | 1965 |
CERTAIN PHARMACOLOGICAL PROPERTIES OF 3-ETHYL-2-METHYL-2-PHENYLSUCCINIMIDE.
Topics: Anticonvulsants; Mental Disorders; Meprobamate; Mice; Pentylenetetrazole; Peptic Ulcer; Pharmacology | 1964 |
STUDY OF THE EFFECTS OF MORPHINE AND NALORPHINE.
Topics: Animals; Body Temperature Regulation; Chlordiazepoxide; Chlorpromazine; Electroshock; Ether; Guinea | 1964 |
[THE REPRODUCTION OF AUDIOGENIC CONVULSIONS AFTER THE PRELIMINARY ADMINISTRATION OF PYRAMIDONE TO ANIMALS].
Topics: Acetazolamide; Aminopyrine; Anticonvulsants; Antipyrine; Epilepsy, Reflex; Mice; Pharmacology; Pheno | 1964 |
[TOXICITY STUDIES WITH AMITRIPTYLINE. THERAPEUTIC GUIDE LINES FROM EXPERIMENTAL STUDIES].
Topics: Amitriptyline; Chlordiazepoxide; Dogs; Electrocardiography; Mice; Parasympathomimetics; Pharmacology | 1965 |
TOLERANCE TO ANTICONVULSANT DRUGS.
Topics: Anticonvulsants; Drug Tolerance; Electroshock; Ethosuximide; Metabolism; Mice; Phenobarbital; Phenyt | 1965 |
EFFECTS OF CORTICAL SPREADING DEPRESSION AND DRUGS UPON AUDIOGENIC SEIZURES IN RATS.
Topics: Brain; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Epilepsy; Epilepsy, Reflex | 1965 |
THE EFFECT OF PERIODIC CONVULSIONS INDUCED BY 1,1-DIMETHYLHYDRAZINE ON THE GLYCOGEN OF RAT BRAIN.
Topics: Brain; Brain Chemistry; Dimethylhydrazines; Glycogen; Hydrazines; Pharmacology; Phenobarbital; Phosp | 1965 |
A critical evaluation of therapy of febrile seizures.
Topics: Child; Fever; Humans; Hydantoins; Infant; Phenobarbital; Seizures; Seizures, Febrile | 1960 |
Effect of lidocaine and procaine on the electroshock seizure threshold, with a comparison of the effects of phenytoin and phenobarbital.
Topics: Convulsive Therapy; Electroconvulsive Therapy; Electroshock; Humans; Hydantoins; Lidocaine; Phenobar | 1960 |
[Molecular structure and anticonvulsive power. Effect of gardenal, metabromogardenal and sodium bromide on audiogenic crisis of the white rat].
Topics: Animals; Barbital; Bromides; Molecular Structure; Phenobarbital; Rats; Seizures; Sodium Compounds | 1950 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
Efficacy of antiepileptic drugs in patients with benign convulsions with mild gastroenteritis.
Topics: Anesthetics, Local; Anticonvulsants; Bromazepam; Child, Preschool; Diazepam; Female; Gastroenteritis | 2004 |
Loss of seizure control due to anticonvulsant-induced hypocalcemia.
Topics: Adult; Anticonvulsants; Humans; Hypocalcemia; Male; Phenobarbital; Phenytoin; Seizures; Vitamin D De | 2004 |
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
Topics: Animals; Anticonvulsants; Cilastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2004 |
Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electro | 2004 |
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phe | 2003 |
Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment.
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Female; Humans; Lymphocyte Count; Lymphocytes; Phenob | 2004 |
Temporal lobe hemorrhage in the full-term neonate presenting as apneic seizures.
Topics: Adult; Apnea; Cerebral Hemorrhage; Electroencephalography; Female; Humans; Infant, Newborn; Magnetic | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
The effect of L-arginine on the memory impairing action of phenobarbitone in rats that convulsed after the injection of picrotoxin.
Topics: Animals; Arginine; Male; Memory Disorders; Nitric Oxide; Phenobarbital; Picrotoxin; Rats; Rats, Wist | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
The influence of phenobarbital overdose on aEEG recording.
Topics: Diagnostic Errors; Drug Overdose; Electroencephalography; Humans; Hypnotics and Sedatives; Infant, N | 2004 |
Complications of therapy in cancer patients: Case 3. Toxic epidermal necrolysis induced by oral phenobarbital and whole-brain radiotherapy in a breast cancer patient.
Topics: Administration, Oral; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Femal | 2004 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Ma | 2004 |
Synthesis and pharmacological evaluation of some DL-dichlorophenyl alcohol amides anticonvulsants.
Topics: Amides; Animals; Anticonvulsants; Convulsants; Hydrocarbons, Chlorinated; Magnetic Resonance Spectro | 2004 |
Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.
Topics: Acute Disease; Aggression; Animals; Anticonvulsants; Creatine; Creatinine; Dietary Supplements; Emot | 2004 |
Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; gamma-Aminobutyric Acid; Male; | 2005 |
Drug-induced hypersensitivity syndrome due to anticonvulsants in a two-year-old boy.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Drug Eruptions; Humans; Male; Phenobarbi | 2004 |
Hepatic failure in a child with anti-epileptic hypersensitivity syndrome.
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Humans; Immunoglobulins, Intravenous; Liver Failure, | 2005 |
Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile.
Topics: Acrylonitrile; Animals; Anticonvulsants; Carcinogens; Central Nervous System Depressants; Cyanides; | 2005 |
The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn.
Topics: Anticonvulsants; Circumcision, Male; Foot Injuries; Humans; Infant, Newborn; Infusions, Intravenous; | 2005 |
Drug treatment of neonatal seizures by neonatologists and paediatric neurologists.
Topics: Anticonvulsants; Benzodiazepines; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, Newborn, | 2005 |
Animal behavior case of the month. Behavioral seizures.
Topics: Aggression; Analgesics, Opioid; Animals; Anticonvulsants; Behavior, Animal; Butorphanol; Cat Disease | 2005 |
Toxicological and pharmacological effects of D-arginine.
Topics: Adrenergic beta-Antagonists; Animals; Arginine; Autonomic Nervous System; Behavior, Animal; Betameth | 2005 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Ther | 2005 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
NKCC1 transporter facilitates seizures in the developing brain.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Cerebral Cortex; Diuretics; Electroencephalo | 2005 |
Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent.
Topics: Amines; Animals; Anticonvulsants; Bromides; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Dog | 2005 |
Phenobarbital for convulsive epilepsy at primary care level.
Topics: Anticonvulsants; Humans; Phenobarbital; Primary Health Care; Seizures | 2006 |
2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Carbamazepine; Dose-Response Relationship, Dr | 2006 |
Neuropharmacological effects of deltamethrin in rats.
Topics: Animals; Ataxia; Brain; Female; gamma-Aminobutyric Acid; Insecticides; Male; Molecular Structure; Ni | 2006 |
Summary proceedings from the neurology group on neonatal seizures.
Topics: Anticonvulsants; Clinical Trials as Topic; Electroencephalography; GABA Modulators; Humans; Infant, | 2006 |
The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; | 2006 |
[High-dose phenobarbital therapy is effective for the control of intractable tonic seizure with apnea in a case of multiple anomalies syndrome].
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Cough; Humans; Infant, Newborn; Male; Phenobarbital | 2006 |
Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Phenoba | 2006 |
The newborn drug development initiative workshop: Summary proceedings from the neurology group on neonatal seizures.
Topics: Anticonvulsants; Drug Design; Electroencephalography; Humans; Infant, Newborn; Phenobarbital; Random | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
EEG wavelet analyses of the striatum-substantia nigra pars reticulata-superior colliculus circuitry: audiogenic seizures and anticonvulsant drug administration in Wistar audiogenic rats (War strain).
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Corpus Striatum; Electrodes, Impla | 2006 |
Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment?
Topics: Adolescent; Anticonvulsants; Attention; Brain; Carbamazepine; Cerebral Cortex; Cognition; Epilepsies | 2006 |
Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug R | 2007 |
Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combinatio | 2007 |
Assessing developmental outcomes in children from Kilifi, Kenya, following prophylaxis for seizures in cerebral malaria.
Topics: Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Female; Humans; Infant; Keny | 2007 |
Effects of certain antiepileptics on behavioral and electromyographic seizure patterns induced by maximal electroshock in mice.
Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Dose-Response Relat | 2007 |
Chronically administered fluoxetine enhances the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Drug Synergis | 2007 |
Interactions between two enantiomers of losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model--an isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Electroshock; | 2007 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Ga | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Cholecalciferol; Disease Models, Animal | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Car | 2007 |
Neonatal seizures: multicenter variability in current treatment practices.
Topics: Anticonvulsants; Consensus; Electroencephalography; Female; Humans; Infant, Newborn; Intensive Care, | 2007 |
Toxoplasma gondii brain granuloma in a cat: diagnosis using cytology from an intraoperative sample and sequential magnetic resonance imaging.
Topics: Animals; Cat Diseases; Cats; Clindamycin; Fatal Outcome; Granuloma; Magnetic Resonance Imaging; Male | 2008 |
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.
Topics: Animals; Anticonvulsants; Bumetanide; Chloride Channels; Chlorides; Drug Synergism; Drug Therapy, Co | 2008 |
Therapy resistant neonatal seizures, linear vesicular rash, and unusually early neuroradiological changes: incontinentia pigmenti: a case report, literature review and insight into pathogenesis.
Topics: Anticonvulsants; Exanthema; Female; Humans; Incontinentia Pigmenti; Infant, Newborn; Phenobarbital; | 2008 |
Magnetic resonance imaging and computed tomography appearance of chronic subdural haematoma in a dog.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Hematoma, Subdural, Chronic; Magnetic Resonanc | 2008 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; | 2008 |
Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model.
Topics: Agmatine; Animals; Anticonvulsants; Avoidance Learning; Drug Interactions; Drug Synergism; Electrosh | 2008 |
Effects of convulsants on energy reserves in the cerebral cortex.
Topics: Animals; Centrifugation; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Electroshock; Freezi | 1967 |
A comparison of the effects of phenobarbital and pentobarbital on motor cortical threshold and righting reflex response in the cat.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Electrophysiology; Injections, Intraperitoneal; Inj | 1967 |
Thioridazine in the treatment of mentally retarded children. (A four-year retroactive evaluation).
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child Behavior Disorders; Child, Preschool; Evaluat | 1967 |
Pharmacological properties of the isopropyl ester of o-sulfamoyl-benzoic acid.
Topics: Animals; Behavior, Animal; Benzoates; Carbamates; Carisoprodol; Chlordiazepoxide; Chlormezanone; Chl | 1967 |
Case of tuberous sclerosis and haemorrhagic retinopathy (with fundus photographs).
Topics: Adult; Amphetamine; Anemia, Macrocytic; Female; Folic Acid; Fundus Oculi; Humans; Phenobarbital; Phe | 1967 |
A comparison of the convulsant activity of procaine and pentylenetetrazol.
Topics: Animals; Anticonvulsants; Chlorpromazine; Dibenzylchlorethamine; Female; Hydroxybutyrates; Mice; Pen | 1967 |
Serum creatine phosphokinase activity in epilepsy. Clinical and experimental studies.
Topics: Animals; Child; Creatine Kinase; Electroshock; Epilepsy; Female; Gallamine Triethiodide; Humans; Mal | 1967 |
A comparison of the anticonvulsant properties of l-propylhexedrine, phenobarbital and a salt-like complex of l-propylhexedrine and phenobarbital in mice and rats.
Topics: Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Electroshock; Male; Mice; Pentylenetetrazo | 1967 |
Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain.
Topics: Acoustic Stimulation; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Cerebral Cortex; Flunitr | 1984 |
The effects of phenobarbital and diphenylhydantoin on liver function and morphology.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Enzym | 1980 |
Anticonvulsive properties of 5-allyl-(beta-hydroxy)propyl-N-phenylbarbituric acid and the corresponding lactone.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Barbiturates; Convulsants; Electroshock; Furans; Lethal D | 1980 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Th | 1981 |
Aminophylline seizures in the rat.
Topics: Aminophylline; Animals; Diazepam; Male; Phenobarbital; Phenytoin; Rats; Seizures | 1981 |
Enhancement of drug withdrawal convulsion by combinations of phenobarbital and antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Drug Combinations; Drug Tolerance; Humans; Male; Ph | 1981 |
Comparative assessment of the anticonvulsant activity of some benzodiazepines, phenobarbitone and diphenylhydantoin against maximal electroshock seizures in rats: a time-distribution study.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Electroshock; Female; Male; Phenobar | 1981 |
The effects of convulsant and anticonvulsant drugs on the release of radiolabeled GABA, glutamate, noradrenaline, serotonin and acetylcholine from rat cortical slices.
Topics: Acetylcholine; Animals; Anticonvulsants; Cerebral Cortex; Culture Techniques; Diazepam; gamma-Aminob | 1982 |
An improved method for perfusion of the isolated brain of the rat-influence of perfusion conditions and application of analeptic and anticonvulsant drugs.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain; Central Nervous System Stimulants; Lactates | 1983 |
Effects of excitatory amino-acid antagonists on the anticonvulsant action of phenobarbital or diphenylhydantoin in mice.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Anticonvulsants; Drug Interac | 1984 |
Cumulative after-discharge as the principal factor in the acquisition of kindled seizures.
Topics: Animals; Brain; Diazepam; Male; Phenobarbital; Propranolol; Rats; Seizures | 1981 |
[Antiepileptic effects of complex therapy with vitamins and anticonvulsant preparations (experimental findings)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Therapy, Com | 1982 |
Effect of dopaminergic and GABA-ergic drugs given alone or in combination on the anticonvulsant action of phenobarbital and diphenylhydantoin in the electroshock test in mice.
Topics: Amantadine; Aminooxyacetic Acid; Amphetamine; Animals; Apomorphine; Baclofen; Dopamine; Electroshock | 1980 |
Treatment of imipramine overdose in children.
Topics: Adult; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Preschool; Coma; Diazepam; Drug Administrat | 1981 |
Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Cerebral Cortex; Cyclic AMP; Cyclic GMP; gamma-A | 1980 |
Benzodiazepine receptor declines in hippocampal formation following limbic seizures.
Topics: Afferent Pathways; Animals; Diazepam; Dominance, Cerebral; Flunitrazepam; Hippocampus; Limbic System | 1983 |
Amino acid metabolism in the brain with convulsive disorders. Part 2: The effects of anticonvulsants on convulsions and free amino acid patterns in the brain of El mouse.
Topics: Adrenocorticotropic Hormone; Amino Acids; Animals; Anticonvulsants; Brain; Mice; Mice, Inbred Strain | 1984 |
Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure.
Topics: Female; Guanfacine; Guanidines; Humans; Hypertension; Kidney Failure, Chronic; Kinetics; Middle Aged | 1983 |
Febrile convulsions.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Fever; Humans; Infant; Male; Phenobarbital; Rec | 1983 |
Anticonvulsant potency of common antiepileptic drugs in the gerbil.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Female; Gerbillinae; Male; Phenobar | 1983 |
Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.
Topics: Animals; Carnitine; Fasting; Male; Mice; Mice, Inbred Strains; Nervous System; Phenobarbital; Proadi | 1984 |
Pharmacologic therapy of seizures in the elderly.
Topics: Aged; Anticonvulsants; Carbamazepine; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Status | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Dr | 1984 |
[Central depressive action of propranolol (author's transl)].
Topics: Animals; Central Nervous System Depressants; Female; Male; Mice; Phenobarbital; Phenytoin; Propranol | 1981 |
Neonatal seizures: a reappraisal.
Topics: Age Factors; Anticonvulsants; Electroencephalography; Female; Humans; Hypoxia; Infant, Newborn; Isch | 1984 |
Primidone therapy in refractory neonatal seizures.
Topics: Drug Therapy, Combination; Female; Humans; Infant; Male; Phenobarbital; Phenytoin; Primidone; Seizur | 1984 |
Splenic hemorrhage in a neonate of a mother on anticonvulsant therapy.
Topics: Female; Hemorrhage; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Co | 1984 |
Phenobarbital-induced dyskinesia in a neurologically-impaired child.
Topics: Child, Preschool; Dyskinesia, Drug-Induced; Humans; Male; Phenobarbital; Seizures | 1984 |
Study of blood-brain tissue [H+] gradient during respiratory alkalosis and experimental seizures in newborn piglets. Effect on phenobarbital distribution.
Topics: Alkalosis, Respiratory; Animals; Animals, Newborn; Blood Gas Analysis; Blood-Brain Barrier; Hydrogen | 1984 |
Vitamin K-dependent proteins and anticonvulsant medication.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Calcium-Binding Proteins; Child; Child, Preschool; Drug I | 1983 |
Effects of certain antiepileptics on cephaloridine- and cefazolin-induced seizures in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cefazolin; Cephaloridine; Diazepam; Electroencephalograp | 1983 |
[Effects of barbexaclone on the electroencephalogram, motor activity and experimental convulsions].
Topics: Animals; Anticonvulsants; Blood Pressure; Electroencephalography; Male; Mice; Mice, Inbred Strains; | 1983 |
An EEG investigation on the effects of phencyclidine on pentylentetrazol convulsions in rats and rabbits.
Topics: Animals; Electroencephalography; Male; Pentylenetetrazole; Phencyclidine; Phenobarbital; Rabbits; Ra | 1983 |
Criteria for discontinuing neonatal seizure therapy: a long-term appraisal.
Topics: Anticonvulsants; Benzodiazepines; Drug Therapy, Combination; Electroencephalography; Female; Follow- | 1983 |
Primidone, phenobarbital, and PEMA: I. Seizure protection, neurotoxicity, and therapeutic index of individual compounds in mice.
Topics: Animals; Bicuculline; Brain; Brain Chemistry; Electroshock; Female; Malonates; Mice; Mice, Inbred St | 1983 |
Primidone, phenobarbital, and PEMA: II. Seizure protection, neurotoxicity, and therapeutic index of varying combinations in mice.
Topics: Animals; Brain; Brain Chemistry; Drug Synergism; Drug Therapy, Combination; Electroshock; Female; Ma | 1983 |
A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.
Topics: Adult; Aged; Anticonvulsants; Behavior; Carbamazepine; Clinical Trials as Topic; Double-Blind Method | 1983 |
Carbamazepine in prophylaxis of febrile seizures in phenobarbital failures.
Topics: Carbamazepine; Child, Preschool; Fever; Humans; Infant; Phenobarbital; Seizures | 1983 |
Phenobarbital tolerance and physical dependence: chronically equivalent dosing model.
Topics: Animals; Central Nervous System; Drug Tolerance; Humans; Male; Phenobarbital; Rats; Rats, Inbred Str | 1983 |
'Idiopathic' neonatal cerebral infarction.
Topics: Adult; Cerebral Angiography; Cerebral Arteries; Cerebral Infarction; Electrocardiography; Female; Fo | 1984 |
Distribution of phenobarbital in serum, brain and other organs from pediatric patients.
Topics: Body Fluids; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; I | 1984 |
Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Calcium; Child; Female; Humans; Hypocalcemia; Male; Middle | 1984 |
Herbal teas and water intoxication in a young child.
Topics: Beverages; Female; Fluid Therapy; Humans; Hyponatremia; Infant; Magnoliopsida; Phenobarbital; Seizur | 1984 |
Anticonvulsant effect of primidone in the gerbil. Time course and significance of the active metabolites.
Topics: Administration, Oral; Animals; Brain; Chromatography, Gas; Gerbillinae; Phenobarbital; Phenylethylma | 1984 |
Possible psychogenic fever of 103.5 degrees F in a patient with borderline personality disorder.
Topics: Adult; Body Temperature; Borderline Personality Disorder; Electroencephalography; Factitious Disorde | 1984 |
Hypertension, vascular headaches, and seizures after carotid endarterectomy. Case report and therapeutic considerations.
Topics: Carotid Arteries; Endarterectomy; Female; Humans; Hypertension; Middle Aged; Phenobarbital; Prazosin | 1984 |
Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.
Topics: Child, Preschool; Female; Humans; Infant; Male; Phenobarbital; Recurrence; Seizures; Seizures, Febri | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child; Humans; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Infant; Phenobarbital; Seizures; Seizur | 1980 |
Valproic acid.
Topics: Adult; Drug Therapy, Combination; Humans; Male; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1980 |
Prevention of simple febrile convulsions.
Topics: Child; Humans; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions.
Topics: Humans; Infant; Infant, Newborn; Phenobarbital; Recurrence; Seizures; Seizures, Febrile; Valproic Ac | 1980 |
Consensus statement. Febrile seizures: long-term management of children with fever-associated seizures.
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Fever; Humans; Infant; Long-Term Care; National Institu | 1980 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se | 1981 |
Febrile convulsions: long-term treatment.
Topics: Anticonvulsants; Child; Child, Preschool; Humans; Infant; Phenobarbital; Prognosis; Recurrence; Seiz | 1981 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; | 1981 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Pheny | 1981 |
Effect of anticonvulsant drugs on kainic acid-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ethosuximide; Guinea Pigs; Hippocampus; | 1982 |
Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepa | 1982 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
Decreased phenytoin level during antineoplastic therapy: a case report.
Topics: Antineoplastic Agents; Brain Neoplasms; Carmustine; Drug Interactions; Drug Therapy, Combination; Hu | 1983 |
General principles of treatment: status epilepticus in neonates.
Topics: Diagnosis, Differential; Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital | 1983 |
Phenobarbital dosage for neonatal seizures.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Phenobarbital; Seizures | 1983 |
Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis.
Topics: Acidosis; Adult; Body Temperature; Creatine Kinase; Female; Fever; Glycine; Humans; Hydrogen-Ion Con | 1983 |
The effects of doxapram, diazepam, phenobarbital and pentylenetetrazol on suprathreshold and threshold stimulations in amygdaloid kindled rats.
Topics: Amygdala; Animals; Diazepam; Doxapram; Kindling, Neurologic; Male; Pentylenetetrazole; Phenobarbital | 1983 |
Neurologic aspects and treatment of La Crosse encephalitis.
Topics: Brain Edema; Child; Encephalitis, Arbovirus; Encephalitis, California; Humans; Phenobarbital; Phenyt | 1983 |
Anticonvulsants and neurogenic pulmonary edema.
Topics: Adult; Humans; Male; Patient Compliance; Phenobarbital; Phenytoin; Pulmonary Edema; Seizures | 1983 |
Effect of restraint stress on anticonvulsant actions of phenobarbitone & diphenylhydantoin in rats.
Topics: Animals; Anticonvulsants; Humans; Male; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Restra | 1982 |
Phenobarbital and phenytoin in neonatal seizures.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Phenytoin; Seizures | 1982 |
Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels.
Topics: Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures | 1982 |
Influence of phenobarbital on the psychomotor development and behaviour in preschool children with convulsions.
Topics: Child; Child Behavior; Child Development; Child, Preschool; Female; Humans; Male; Motor Activity; Ph | 1980 |
Lidocaine metabolism and toxicity: a laboratory experiment for dental students.
Topics: Anesthesia, Dental; Anesthesiology; Animals; Carbon Tetrachloride; Lidocaine; Liver; Male; Phenobarb | 1980 |
A comparative study of the effects of phenytoin and phenobarbital on electrically induced maximal seizures in frogs and mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Female; Hindlimb; Humans; | 1982 |
[Our experience with intensive therapy of some cases of infantile encephalitis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Coma; Dexamethasone; Encephalitis; | 1981 |
Dose-dependent effects of taurine on convulsions induced by hypoxia in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Hypoxia, Brain; Male; Phenobarbital; Rats; Rats, Inbred S | 1980 |
Dilantin toxicity in a preterm infant: persistent bradycardia and lethargy.
Topics: Bradycardia; Dose-Response Relationship, Drug; Heart; Humans; Infant, Newborn; Infant, Premature, Di | 1982 |
Early discontinuation of anticonvulsants after neonatal seizures: a preliminary report.
Topics: Child Development; Female; Follow-Up Studies; Growth; Humans; Infant, Newborn; Infant, Newborn, Dise | 1982 |
Les torsades des pointes.
Topics: Adolescent; Diagnosis, Differential; Electrocardiography; Female; Heart Ventricles; Humans; Pacemake | 1982 |
Brain-orientated intensive care treatment in severe neonatal asphyxia. Effects of phenobarbitone protection.
Topics: Asphyxia Neonatorum; Blood Transfusion; Brain Damage, Chronic; Brain Edema; Critical Care; Humans; I | 1982 |
Diazepam withdrawal seizures.
Topics: Adult; Diazepam; Female; Humans; Male; Phenobarbital; Seizures; Substance Withdrawal Syndrome | 1982 |
Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG.
Topics: Electroencephalography; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Prematur | 1982 |
Maternal anticonvulsant therapy and hemorrhagic disease of the newborn.
Topics: Adult; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1982 |
Neonatal seizures: a survey of current practice.
Topics: Blood Glucose; Calcium; Diagnosis, Differential; Dose-Response Relationship, Drug; Electrolytes; Eva | 1982 |
Anticonvulsant action of phenobarbital, diazepam, carbamazepine, and diphenylhydantoin in the electroshock test in mice after lesion of hippocampal pyramidal cells with intracerebroventricular kainic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Electroshock; Hippocampus; Injections, Intraventr | 1982 |
Seizure intensity in the Mongolian gerbil after prolonged phenobarbital administration.
Topics: Animals; Dose-Response Relationship, Drug; Gerbillinae; Phenobarbital; Seizures; Time Factors | 1982 |
Phenobarbitone dosage in neonatal convulsions.
Topics: Drug Administration Schedule; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Sei | 1982 |
[Drug distribution during convulsive seizure in comparison with narcosis].
Topics: Adipose Tissue; Animals; Antipyrine; Brain; Female; Liver; Pentylenetetrazole; Phenobarbital; Rats; | 1980 |
Barbiturate physical dependence in mice: effects on body temperature regulation.
Topics: Animals; Barbiturates; Behavior, Animal; Body Temperature Regulation; Humans; Male; Mice; Mice, Inbr | 1981 |
Phenobarbital maintenance dose requirements in treating neonatal seizures.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Phenobarbital; Seizures | 1981 |
Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution.
Topics: Brain; Drug Therapy, Combination; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phe | 1981 |
A possible neurochemical basis of the central stimulatory effects of pp'DDT.
Topics: Acetylcholine; Aminooxyacetic Acid; Ammonia; Animals; Central Nervous System; Corpus Striatum; DDT; | 1981 |
Antagonism of intrastriatal and intravenous kainic acid by 1-nuciferine: comparison with various anticonvulsants and GABAmimetics.
Topics: Animals; Aporphines; Baclofen; Behavior, Animal; Choline O-Acetyltransferase; Corpus Striatum; Diaze | 1980 |
Prophylaxis against febrile convulsions with phenobarbital. A 3-year prospective investigation.
Topics: Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Male; Phenobarbital; Prospective | 1981 |
Dexamethasone in the treatment of hypernatraemic dehydration.
Topics: Blood Glucose; Calcium; Dehydration; Dexamethasone; Humans; Hypernatremia; Infant; Phenobarbital; Se | 1981 |
A study on serum concentration of phenobarbital in epileptic children and children with febrile convulsions.
Topics: Child; Epilepsy; Humans; Phenobarbital; Seizures; Seizures, Febrile | 1980 |
The anticonvulsant properties of melatonin on kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Melatonin; Naloxone; Penty | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Male; Pentylenetetrazole; Phenob | 1981 |
Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles.
Topics: Animals; Anticonvulsants; Female; Imidazoles; Male; Mice; Phenobarbital; Phenytoin; Seizures; Struct | 1981 |
Audiogenic seizures and neuronal deficits following early exposure to barbiturate.
Topics: Acoustic Stimulation; Animals; Animals, Newborn; Barbiturates; Female; Fetus; Hippocampus; Male; Mic | 1981 |
Folic acid and vitamin D status of young children receiving minimal anticonvulsant drug therapy.
Topics: Alkaline Phosphatase; Calcium; Child, Preschool; Female; Folic Acid; Hematocrit; Humans; Male; Nutri | 1981 |
Febrile convulsions.
Topics: Child, Preschool; Epilepsy; Humans; Infant; Male; Phenobarbital; Prognosis; Seizures; Seizures, Febr | 1980 |
The development of tolerance to the anticonvulsant effect of phenobarbital in mice.
Topics: Animals; Brain Chemistry; Drug Tolerance; Electroshock; Mice; Phenobarbital; Seizures | 1980 |
Changes of hippocampal Met-enkephalin content after recurrent motor seizures.
Topics: Animals; Endorphins; Enkephalins; Functional Laterality; Hippocampus; Kainic Acid; Male; Phenobarbit | 1980 |
Carbamazepine-induced leukocytosis.
Topics: Adult; Carbamazepine; Female; Humans; Leukocytosis; Neutrophils; Phenobarbital; Phenytoin; Seizures | 1980 |
The first year of life. Convulsions in the older infant.
Topics: Diazepam; First Aid; Humans; Hyaluronoglucosaminidase; Infant; Paraldehyde; Phenobarbital; Seizures; | 1980 |
[A study of effects on antiepileptic drugs upon the hippocampal afterdischarge (author's transl)].
Topics: Animals; Anticonvulsants; Carbamazepine; Cats; Electric Stimulation; Female; Hippocampus; Male; Phen | 1980 |
Once daily doses of phenobarbital in children.
Topics: Child; Child, Preschool; Drug Administration Schedule; Evaluation Studies as Topic; Female; Humans; | 1980 |
[Effect of phenobarbital on metrazol convulsions during ontogenesis of rats (author's transl)].
Topics: Age Factors; Animals; Male; Pentylenetetrazole; Phenobarbital; Rats; Seizures | 1980 |
Flash-evoked afterdischarge in rat as a model of the absence seizure: dose-response studies with therapeutic drugs.
Topics: Acetazolamide; Animals; Dose-Response Relationship, Drug; Ethosuximide; Evoked Potentials; Male; Mep | 1980 |
[Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)].
Topics: Acute Kidney Injury; Adolescent; Adult; Brain Edema; Critical Care; Diazepam; Dihydralazine; Eclamps | 1980 |
Febrile seizures: long-term management of children with fever-associated seizures. Summary of an NIH consensus statement.
Topics: Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Phenobarbital; Risk; Seizures; Seizures | 1980 |
Acute and chronic antiepileptic drug effects in audiogenic seizure-susceptible rats.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administratio | 1980 |
Pharmacological modification of amygdaloid-kindled seizures.
Topics: Amygdala; Animals; Diazepam; Electric Stimulation; Electrodes, Implanted; Ketamine; Male; Phenobarbi | 1980 |
Phenobarbital in neurologically handicapped children.
Topics: Brain Damage, Chronic; Child; Humans; Intellectual Disability; Nervous System Diseases; Phenobarbita | 1981 |
[The convulsive disease state. Apropos of 79 cases].
Topics: Adult; Aged; Anticonvulsants; Brain Diseases; Cerebrovascular Disorders; Electroencephalography; Epi | 1980 |
Febrile seizures: a consensus of their significance, evaluation, and treatment.
Topics: Child; Fever; Humans; National Institutes of Health (U.S.); Phenobarbital; Seizures; United States | 1980 |
[Concentrations of phenobarbital in the cerebrospinal fluid and blood of newborn infants].
Topics: Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures | 1980 |
Primidone kinetics: effects of concurrent drugs and duration of therapy.
Topics: Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Humans; Kinetics; Male; Metabolic Cleara | 1981 |
Spatial and temporal characteristics of neonatal seizures.
Topics: Anticonvulsants; Cerebral Cortex; Electroencephalography; Humans; Infant, Newborn; Monitoring, Physi | 1995 |
Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Convulsants; Flurothyl; GABA Agents; GABA Agonists; | 1995 |
Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Injections, Su | 1995 |
Effect of antiepileptic drugs on absence-like seizures in the tremor rat.
Topics: Animals; Anticonvulsants; Data Interpretation, Statistical; Drug Therapy, Combination; Electroenceph | 1995 |
Aspirin and anticonvulsant interaction.
Topics: Animals; Aspirin; Carbamazepine; Disease Models, Animal; Drug Synergism; Electroshock; Female; Male; | 1995 |
Predictive value of early continuous amplitude integrated EEG recordings on outcome after severe birth asphyxia in full term infants.
Topics: Asphyxia Neonatorum; Brain Damage, Chronic; Electroencephalography; Follow-Up Studies; Humans; Infan | 1995 |
[Involvement of GABAergic and NMDA systems in drug-induced convulsions in mice].
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channels; Chloride Channels; Male; Mice; Mice, Inbred | 1995 |
Effects of the peptide BCH-325 upon the efficacy of common antiepileptic drugs.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Endorphin | 1994 |
Detection of propan-1,2-diol in neonatal brain by in vivo proton magnetic resonance spectroscopy.
Topics: Brain Chemistry; Humans; Infant, Newborn; Magnetic Resonance Spectroscopy; Pharmaceutical Vehicles; | 1994 |
GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice.
Topics: Animals; Bicuculline; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Levodopa; Mice | 1994 |
Competitive NMDA receptor antagonists enhance the antielectroshock activity of various antiepileptics.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbama | 1993 |
[The Stevens-Johnson syndrome induced by phenobarbital in a patient with Becker's disease].
Topics: Adolescent; Genetic Linkage; Humans; Male; Muscular Dystrophies; Phenobarbital; Psoriasis; Seizures; | 1994 |
Detailed description of a successful outpatient taper of phenobarbital therapy.
Topics: Aged; Cerebrovascular Disorders; Drug Administration Schedule; Female; Humans; Phenobarbital; Seizur | 1994 |
Nurses fail to keep physicians informed of multiple seizures. Case in point: Glassman v. St. Joseph Hospital 631 N.E. 2d 1186--IL (1994).
Topics: Brain Damage, Chronic; Coronary Artery Bypass; Humans; Illinois; Male; Malpractice; Nursing Staff, H | 1994 |
[Effect of sodium valproate, phenobarbital and diazepam during their combined use on convulsions induced by electroshock in mice].
Topics: Animals; Diazepam; Drug Synergism; Drug Therapy, Combination; Electroshock; Mice; Phenobarbital; Sei | 1993 |
Pharmacodynamics of phenobarbital anesthesia and pentylenetetrazol-induced maximal seizures in a rat model of neoplastic spinal cord compression.
Topics: Anesthesia; Animals; Histiocytoma, Benign Fibrous; Male; Paraplegia; Pentylenetetrazole; Phenobarbit | 1994 |
The effect of immunosuppression by total-body irradiation on the pharmacodynamics of centrally active drugs in rats.
Topics: Animals; Brain; Central Nervous System Agents; Central Nervous System Depressants; Ethanol; Female; | 1994 |
Phenobarbital modifies seizure-related brain injury in the developing brain.
Topics: Aging; Analysis of Variance; Animals; Brain Diseases; Kainic Acid; Male; Phenobarbital; Rats; Rats, | 1994 |
[Current composition of oral phenobarbital FNA mixture could lead to convulsions].
Topics: Administration, Oral; Ethanol; Humans; Infant; Infant, Newborn; Phenobarbital; Propylene Glycols; Se | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female | 1993 |
Cyclic antidepressant overdose: a review of current management strategies.
Topics: Animals; Antidepressive Agents, Tricyclic; Drug Overdose; Electrocardiography; Emergencies; Humans; | 1994 |
Characterization of the pharmacodynamics of several antiepileptic drugs in a direct cortical stimulation model of anticonvulsant effect in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Drug Evaluation, Preclinical; Female; Oxaz | 1994 |
[Current composition of phenobarbital solution FNA could lead to convulsions].
Topics: Drug Compounding; Humans; Pharmaceutical Vehicles; Phenobarbital; Seizures; Solutions | 1994 |
Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; | 1993 |
Dosage programming of phenobarbital in neonatal seizures.
Topics: Drug Administration Schedule; Humans; Infant; Infant, Newborn; Models, Biological; Phenobarbital; Se | 1993 |
Possible interaction between phenobarbital, carbamazepine and itraconazole.
Topics: Adult; Aspergillosis; Brain Diseases; Carbamazepine; Drug Interactions; Enzyme Induction; Humans; It | 1993 |
Alterations in both excitation and inhibition occur before the onset of seizure activity in the hippocampus.
Topics: Animals; Baclofen; Bicuculline; Diazepam; Electric Stimulation; Evoked Potentials; Hippocampus; Keta | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; M | 1993 |
Induction of tolerance to and physical dependence on pentobarbital continuous intracerebroventricular administration.
Topics: Animals; Body Temperature; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convu | 1993 |
[Lafora disease. Report of a new case diagnosed by biopsy from the axillary skin].
Topics: Axilla; Biopsy; Carbamazepine; Child; Eccrine Glands; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; | 1993 |
Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats.
Topics: Adrenalectomy; Animals; Blood Proteins; Corticosterone; Male; Pain; Pain Threshold; Phenobarbital; R | 1993 |
[Different effects of chronically administered phenobarbital on amygdaloid- and hippocampal-kindled seizures in the cat].
Topics: Administration, Oral; Amygdala; Animals; Cats; Hippocampus; Kindling, Neurologic; Models, Neurologic | 1993 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuxim | 1995 |
Short-term perioperative anticonvulsant prophylaxis for the surgical treatment of low-risk patients with intracranial aneurysms.
Topics: Adult; Aneurysm, Ruptured; Anticonvulsants; Craniotomy; Female; Humans; Intracranial Aneurysm; Male; | 1995 |
Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation.
Topics: Animals; Anticonvulsants; Caffeine; Electroshock; Male; Mice; Phenobarbital; Seizures; Valproic Acid | 1996 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbita | 1996 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, | 1996 |
[Treatment of convulsions in newborn infants].
Topics: Anticonvulsants; Clonazepam; Drug Administration Schedule; Drug Therapy, Combination; Humans; Infant | 1996 |
Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Fema | 1996 |
[Treatment of convulsions in newborn infants].
Topics: Anticonvulsants; Humans; Infant, Newborn; Phenobarbital; Seizures; Treatment Outcome | 1996 |
Clinical management and outcome of cats with seizure disorders: 30 cases (1991-1993).
Topics: Administration, Oral; Animals; Anticonvulsants; Cat Diseases; Cats; Dexamethasone; Diazepam; Follow- | 1997 |
Population pharmacokinetics of felbamate in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Felbamate; Hu | 1997 |
Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Carbamazepine; Cerebellum; gamma-Aminobutyric Acid; Glutamic Ac | 1997 |
Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dentate Gyrus; E | 1997 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Clinical, epidemiological and treatment results of idiopathic epilepsy in 54 labrador retrievers: a long-term study.
Topics: Administration, Oral; Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Follow-Up Stud | 1997 |
Phenobarbital-induced disinhibition in the developmentally disabled: case report.
Topics: Adult; Anticonvulsants; Child; Developmental Disabilities; Humans; Male; Personality Disorders; Phen | 1997 |
Therapeutic doses of theophylline exert proconvulsant effects in developing mice.
Topics: Aging; Animals; Anticonvulsants; Bronchodilator Agents; Dose-Response Relationship, Drug; Electrosho | 1997 |
Seizures in cerebral malaria.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Humans; Malaria, Cerebral; Middle Aged; Phenobarbital; Sei | 1997 |
Synthesis and anticonvulsant activity of new thiazolidinone and thioxoimidazolidinone derivatives derived from furochromones.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Convulsants; Imidazoles; Khellin; | 1997 |
Neutropenia and thrombocytopenia in three dogs treated with anticonvulsants.
Topics: Anemia; Animals; Anticonvulsants; Bacteremia; Blood Cell Count; Dog Diseases; Dogs; Female; Male; Ne | 1998 |
The influence of L-NG-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, upon the anticonvulsive activity of conventional antiepileptic drugs against maximal electroshock in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Drug Antagonism; Electroshock; Enzyme I | 1998 |
Comparison of anti-epileptic drug levels in different cases of sudden death.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cause of Death; Child; Child, Preschool | 1998 |
Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1998 |
Adverse effects of early phenobarbital administration in term newborns with perinatal asphyxia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Humans; Infant, Newborn; Perinatal Care; Phenobarbital; Retros | 1998 |
Measurement of cerebral oxygen consumption in the human neonate using near infrared spectroscopy: cerebral oxygen consumption increases with advancing gestational age.
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Female; Gestational Age; Humans; Infant; Male; Morp | 1998 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippo | 1998 |
Outcome of neonatal stroke in full-term infants without significant birth asphyxia.
Topics: Anticonvulsants; Apgar Score; Asphyxia Neonatorum; Cerebrovascular Disorders; Female; Gestational Ag | 1998 |
Fosphenytoin in infants.
Topics: Anticonvulsants; Drug Therapy, Combination; Female; Humans; Hydrogen-Ion Concentration; Infant; Infa | 1998 |
Clinical predictors of outcome in hypoxic ischaemic encephalopathy in term neonates.
Topics: Anticonvulsants; Apgar Score; Asphyxia Neonatorum; Cerebral Palsy; Cerebrovascular Disorders; Female | 1998 |
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Eth | 1999 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroe | 1999 |
Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine.
Topics: Adenosine; Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Combinations; Male; Pentylenet | 1999 |
Phenobarbital dosing and pharmacokinetics in a neonate receiving extracorporeal membrane oxygenation.
Topics: Anticonvulsants; Extracorporeal Membrane Oxygenation; Hernia, Diaphragmatic; Hernias, Diaphragmatic, | 1999 |
Similar name, different diagnosis. When two patients shouldn't be in the same room.
Topics: Anticonvulsants; Drug Interactions; Humans; Medication Errors; Nursing Records; Phenobarbital; Pheny | 1999 |
The use of phenobarbitone in the management of agitation and seizures at the end of life.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Phenobar | 1999 |
Demographics and diagnosis of pyridoxine-dependent seizures.
Topics: Anticonvulsants; Humans; Incidence; Infant, Newborn; Phenobarbital; Pyridoxine; Seizures; United Kin | 1999 |
Effects of experimental cortical seizures on respiratory motor nerve activities in piglets.
Topics: Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; Female; Heart Rate; Male; Motor Neurons; | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine | 1999 |
Effects of phenobarbital treatment on serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Aspartate Aminotransferases; B | 1999 |
Ketamine and phenobarbital do not reduce the evoked-potential enhancement induced by electroconvulsive shock seizures in the rat.
Topics: Animals; Electroshock; Evoked Potentials; Ketamine; Male; Neuroprotective Agents; Phenobarbital; Rat | 1999 |
Clinical findings, treatment, and outcome of dogs with status epilepticus or cluster seizures: 156 cases (1990-1995).
Topics: Animals; Anticonvulsants; Bromides; Cerebrospinal Fluid; Diazepam; Dog Diseases; Dogs; Female; Male; | 1999 |
Treatment of neonatal seizures.
Topics: Anticonvulsants; Humans; Infant, Newborn; Intensive Care Units; Phenobarbital; Phenytoin; Randomized | 1999 |
Phenobarbital still has a role in epilepsy treatment.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Retr | 1999 |
The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Evaluation, Preclini | 2000 |
Impact of malaria on the brain and its prevention.
Topics: Africa; Animals; Anticonvulsants; Child, Preschool; Cognition Disorders; Humans; Malaria, Cerebral; | 2000 |
Phenobarbital administration directed against kindled seizures delays functional recovery following brain insult.
Topics: Amygdala; Animals; Anticonvulsants; Astrocytes; Brain Damage, Chronic; Cerebral Cortex; Drug Adminis | 2000 |
Re: The use of phenobarbitone in the management of agitation and seizures at the end of life.
Topics: Humans; Phenobarbital; Psychomotor Agitation; Seizures; Terminal Care | 2000 |
Sedation in cerebral malaria.
Topics: Anticonvulsants; Child; Humans; Malaria, Cerebral; Phenobarbital; Seizures | 2000 |
Double-chambered right ventricle in a dog.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Chloramphenicol; Dog Disea | 2000 |
Phenobarbital for children with cerebral malaria.
Topics: Anticonvulsants; Chemoprevention; Child; Diazepam; Drug Interactions; Humans; Logistic Models; Malar | 2000 |
Effects of diet on pharmacokinetics of phenobarbital in healthy dogs.
Topics: Alkaline Phosphatase; Animal Feed; Animals; Anticonvulsants; Area Under Curve; Calorimetry, Indirect | 2000 |
Shoulder-hand syndrome in neurosurgical patients treated with barbiturates. A long term evaluation.
Topics: Adult; Barbiturates; Craniocerebral Trauma; Female; Follow-Up Studies; Humans; Intracranial Aneurysm | 2000 |
Comparison of effect of ethanol and anticonvulsants on cardiovascular drug-modified cocaine toxicity.
Topics: Animals; Anticonvulsants; Cardiovascular Agents; Cocaine; Diazepam; Enalapril; Ethanol; Male; Mice; | 2000 |
Neurological dysfunction in dogs following attenuation of congenital extrahepatic portosystemic shunts.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Ligation; Male; Nervous System Diseases; Pheno | 2000 |
Antiepileptogenic properties of phenobarbital: behavior and neurochemical analysis.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Dizocilpine Maleate; Excitatory Amino Acid A | 2000 |
Necrotizing meningoencephalitis associated with cortical hippocampal hamartia in a Pekingese dog.
Topics: Amoxicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dexamethasone; Dogs; | 2001 |
Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase.
Topics: Aldehyde Oxidoreductases; Animals; Anticonvulsants; Base Sequence; Brain; DNA Primers; Genotype; Gli | 2001 |
Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues.
Topics: Amino Acids; Animals; Anticonvulsants; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; | 2001 |
Synergistic protection of allopregnanolone and phenobarbital against maximal electroshock seizures in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Drug Synergism; Electroshock; Flunitrazepam; GABA Modulat | 2001 |
Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde.
Topics: Anticonvulsants; Cohort Studies; Diazepam; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infusio | 2001 |
Suspected hypersensitivity to phenobarbital in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Diagnosis, Differential; Drug Eruptions; Male; Phenoba | 1999 |
[Treatment of epileptic seizures resistant to phenobarbital in children during the first year of life].
Topics: Anticonvulsants; Drug Resistance; Epilepsy; Humans; Infant; Phenobarbital; Prospective Studies; Seiz | 2002 |
Phenobarbitone, neonatal seizures, and video-EEG.
Topics: Anticonvulsants; Developmental Disabilities; Electroencephalography; Follow-Up Studies; Humans; Infa | 2002 |
Influence of phenytoin on the disposition of irinotecan: a case report.
Topics: Adolescent; Anticonvulsants; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy | 2002 |
Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2002 |
Prophylactic antiepileptic treatment in Sturge-Weber disease.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Male; Phenobarbital; Se | 2002 |
An unusual presentation of fifth-day fits in the newborn.
Topics: Anticonvulsants; Electroencephalography; Female; Humans; Infant, Newborn; Phenobarbital; Seizures | 2002 |
[Inhibitory processes in the cerebral cortex and the anticonvulsive action of benzodiazepine derivatives].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Cats; Cerebral Cortex; Clonazepam; Diazepam; E | 1977 |
[Re-evaluation of barbexaclone in 20 epileptic patients].
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Male; Phenoba | 1978 |
[Barbexaclone in the treatment of cerebral dysrhythmia].
Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsy, Absence; Epilepsy, Ton | 1978 |
Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse.
Topics: Animals; Barbital; Barbiturates; Dose-Response Relationship, Drug; Male; Mice; Neuromuscular Disease | 1979 |
Distribution of lindane in brains of control and phenobarbital pretreated dogs at the onset of lindane-induced convulsions.
Topics: Animals; Brain Chemistry; Dogs; Hexachlorocyclohexane; Male; Phenobarbital; Seizures; Time Factors | 1975 |
Motor and electrical signs of epileptiform activity induced by penicillin in the spinal cords of decapitate cats.
Topics: Animals; Blood Pressure; Cats; Chloralose; Decerebrate State; Dose-Response Relationship, Drug; Peni | 1976 |
Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Cerebellum; Diazepam; gamma-Aminobutyric | 1978 |
Alterations in learning performance in the seizure-prone baboon: effects of elicited seizures and chronic treatment with diazepam and phenobarbital.
Topics: Animals; Diazepam; Female; Haplorhini; Learning; Male; Motor Activity; Papio; Phenobarbital; Seizure | 1978 |
Gamma hydroxybutyrate in the monkey. III. Effect of intravenous anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Diazepam; Electroencephalography; Ethosuximi | 1978 |
Cerebellar stimulation in alumina-gel monkey model: inverse relationship between clinical seizures and EEG interictal bursts.
Topics: Animals; Cerebellum; Electric Stimulation; Electroencephalography; Haplorhini; Macaca mulatta; Motor | 1979 |
Relationships between plasma concentrations of diphenylhydantoin, phenobarbital, carbamazepine, and 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810), a new anticonvulsant agent, and their anticonvulsant or neurotoxic effects in experimental animals.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Dogs; Dose-Response Relationship, Drug; Haplorhini; | 1979 |
Effect of p-chlorophenylalanine on the central nervous excitability threshold and on the activity of some central depressants.
Topics: Animals; Central Nervous System; Depression, Chemical; Fenclonine; Hypnotics and Sedatives; Injectio | 1975 |
Cyclic 3',5'-adenosine monophosphate in mouse cerebral cortex during homocysteine convulsions and their prevention by sodium phenobarbital.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Homocysteine; Male; Mice; Phenobarbital; Seizures | 1975 |
Effect of convulsions and anticonvulsive drugs on cerebrospinal fluid cyclic AMP in rabbits.
Topics: Animals; Aspartate Aminotransferases; Carbamazepine; Cyclic AMP; Depression, Chemical; Female; Male; | 1976 |
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimula | 1976 |
Effects of gaba, gabob and some anticonvulsant drugs on dibutyryl cyclic AMP evoked seizures.
Topics: Aminobutyrates; Animals; Anticonvulsants; Bucladesine; Chickens; Diazepam; Electroencephalography; F | 1977 |
Differential interactions of phenobarbital and pentobarbital with beta-adrenergic mechanisms in vitro and in vivo.
Topics: Action Potentials; Animals; Anura; Bucladesine; Calcium; Cyclic AMP; Dose-Response Relationship, Dru | 1977 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
Changes of cyclic AMP and phosphorylase a in mouse cerebral cortex during seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Cerebral Cortex; Cyclic AMP; Male; Mice; Phenobarbital; Phosphory | 1977 |
Cyclic nucleotides in epileptic brain: effects of pentylenetetrazol on regional cyclic AMP and cyclic GMP levels in vivo.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Cyclic AMP; Cyclic GMP; Ethosuximide; | 1977 |
Temperature-induced seizure and frequency-dependent neuromuscular block in a ts mutant of Drosophila.
Topics: Action Potentials; Animals; Drosophila melanogaster; Ganglia; Mutation; Neuromuscular Junction; Phen | 1978 |
Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebellum; Cerebral Cortex; Clonazepam; | 1979 |
Theophylline-induced seizures in adults. Correlation with serum concentrations.
Topics: Adult; Aged; Creatinine; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Co | 1975 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
Interaction of delta9-tetrahydrocannabinol and cannabidiol with phenobarbitone in protecting mice from electrically induced convulsions.
Topics: Animals; Cannabis; Drug Synergism; Electroshock; Male; Mice; Phenobarbital; Seizures | 1975 |
Metabolism prediction and simultaneous measurement of PO2 and flow at the same locus during seizures and barbiturate suppression of EEG.
Topics: Animals; Brain; Cerebrovascular Circulation; Electroencephalography; Gerbillinae; Partial Pressure; | 1977 |
Changes in seizure susceptibility after intracerebral treatment with 5,7-dihydroxytryptamine: role of serotonergic neurons.
Topics: 5,7-Dihydroxytryptamine; Acetazolamide; Animals; Anticonvulsants; Dihydroxytryptamines; Electroshock | 1978 |
The initial management of simple febrile seizures.
Topics: Child; Humans; Phenobarbital; Seizures; Seizures, Febrile | 1978 |
Brain tumors in children exposed to barbiturates.
Topics: Adolescent; Barbiturates; Brain Neoplasms; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; | 1979 |
Brain tumors in children exposed to barbiturates.
Topics: Adolescent; Barbiturates; Brain Neoplasms; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; | 1979 |
Trials of the elimination of the central effects of Ronpacon Cerebral 280 after its administration into the cerebral lateral ventricle in rats.
Topics: Animals; Cerebral Ventriculography; Contrast Media; Diazepam; Drug Antagonism; Female; Glutethimide; | 1978 |
A study of the action of valproic acid on the kindling effect.
Topics: Amygdala; Animals; Cats; Electric Stimulation; Male; Phenobarbital; Seizures; Valerates; Valproic Ac | 1977 |
[Study of the immunosuppressive effect of some anticonvulsants in children].
Topics: Adolescent; Anticonvulsants; B-Lymphocytes; Child; Child, Preschool; Epilepsy; Female; Humans; Immun | 1977 |
A comparative study of the efficacy of newer antiepiletpic drugs on experimentally-induced febrile convulsions.
Topics: Animals; Anticonvulsants; Body Temperature; Carbamazepine; Clonazepam; Male; Mice; Phenobarbital; Se | 1977 |
[Simultaneous estimation of phenobarbitone and valproic acid in the plasma by high performance liquid chromatography (author's transl)].
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Colorimetry; Humans; Phenobarbital; Seizu | 1978 |
[The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)].
Topics: Antacids; Anticonvulsants; Biological Availability; Carbamazepine; Chromatography, Gas; Clonazepam; | 1979 |
Effect of anticonvulsants on cortical focal seizure in cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epileps | 1977 |
A proposed treatment for trimethylolpropane phosphite poisoning.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Haplorhini; Humans; Injections, Intramuscular; Let | 1977 |
A comparison of the effects of chronically administered diazepam and phenobarbital and learning in the Papio papio model of epilepsy.
Topics: Animals; Diazepam; Disease Models, Animal; Haplorhini; Learning; Papio; Phenobarbital; Seizures; Sti | 1977 |
Further studies on the site of action of diazepam: anticonvulsant effect in the rabbit.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Diazepam; Electric Stimulation; Electroenceph | 1979 |
Anticonvulsant therapy. Approaches to some common clinical problems.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Eth | 1979 |
Continuous phenobarbital treatment after a 'simple febrile convulsion'.
Topics: Animals; Child; Epilepsy; Humans; Phenobarbital; Recurrence; Seizures; Seizures, Febrile | 1979 |
Management of the convulsing child.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Infant, Newborn; Infant, Newborn, Disea | 1979 |
[Continuous administration of phenobarbital as prevention of febrile convulsions in children. Critical review].
Topics: Child, Preschool; Female; Humans; Infant; Male; Methods; Phenobarbital; Seizures; Seizures, Febrile | 1979 |
Correlation between age and plasma level/dosage ratio for phenobarbital in infants and children.
Topics: Age Factors; Body Weight; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Seizures | 1979 |
Stages in development of high-pressure neurological syndrome in the mouse.
Topics: Animals; Atropine; Brain; Dose-Response Relationship, Drug; Electroencephalography; Female; Heart; H | 1979 |
Single-dose pharmacokinetics and anticonvulsant efficacy of primidone in mice.
Topics: Animals; Biotransformation; Brain Chemistry; Dose-Response Relationship, Drug; Female; Mice; Phenoba | 1979 |
Behavioral analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Clonazepam; Diazepam; Dogs; Electric St | 1979 |
Epileptic-type convulsions and magnesium deficiency.
Topics: Acclimatization; Adult; Chlorides; Epilepsy; Hot Temperature; Humans; Magnesium; Magnesium Deficienc | 1979 |
Febrile convulsions--current controversies.
Topics: Child, Preschool; Humans; Infant; Infant, Newborn; Phenobarbital; Prognosis; Risk; Seizures; Seizure | 1979 |
The estimation of the survival rate of tetanus-intoxicated mice. A model for screening anti-tetanus drugs.
Topics: Animals; Chlorpromazine; Diazepam; Drug Evaluation, Preclinical; Halothane; Male; Mice; Phenobarbita | 1979 |
[Lesions of the nervous system in premature children with "conjugated" jaundices].
Topics: Apnea; Eye Manifestations; Face; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neo | 1979 |
Post-trial barbiturates do not affect amygdaloid kindling.
Topics: Amygdala; Animals; Electric Stimulation; Evoked Potentials; Male; Methohexital; Phenobarbital; Rats; | 1979 |
Decreased serum 24,25-dihydroxy vitamin D concentrations in children receiving chronic anticonvulsant therapy.
Topics: Adolescent; Calcium; Child; Child, Preschool; Chronic Disease; Dihydroxycholecalciferols; Humans; Hy | 1979 |
Changes in heart rate associated with high-pressure convulsions in rodents.
Topics: Age Factors; Animals; Atmospheric Pressure; Atropine; Bradycardia; Female; Heart Rate; Mice; Phenoba | 1979 |
Evaluation of anticonvulsants in barbiturate withdrawal.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dimethadione; Female; Humans; Male; Pentobarbital; | 1977 |
Effect of benzhydryl piperazines, phenobarbital and phenytoin on maximal electroshock seizures in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Electroshock; Hindlimb; Humans; Male; Phenobarbital; Phen | 1977 |
Controversies in the treatment of febrile convulsions.
Topics: Child; Epilepsy; Humans; Intelligence; Phenobarbital; Phenytoin; Prognosis; Seizures; Seizures, Febr | 1979 |
Phenobarbital dosage for control of neonatal seizures.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures | 1979 |
The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroenc | 1977 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; | 1977 |
Phenobarbitone dosage in the neonate--preliminary communication.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intramuscular; Injections, Intraveno | 1977 |
Pharmacological prophylaxis against the development of kindled amygdaloid seizures.
Topics: Acetazolamide; Amygdala; Animals; Cats; Dexamethasone; Electric Stimulation; Ethosuximide; Phenobarb | 1977 |
Phenobarbital and diphenylhydantoin levels in neonates with seizures.
Topics: Administration, Oral; Female; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infusio | 1978 |
Continuous phenobarbital treatment after a 'simple febril convulsion'.
Topics: Child; Epilepsy; Humans; Phenobarbital; Seizures; Seizures, Febrile; Time Factors | 1978 |
Phenobarbital pharmacokinetics in neonates.
Topics: Aging; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Kinetics; Models, Biol | 1978 |
Phenobarbital for febrile convulsions.
Topics: Administration, Oral; Child; Humans; Phenobarbital; Seizures; Seizures, Febrile | 1978 |
Management of narcotic withdrawal in neonates.
Topics: Diazepam; Drug Therapy, Combination; Humans; Infant, Newborn; Infant, Newborn, Diseases; Narcotics; | 1978 |
Behavior disturbance, phenobarbital, and febrile seizures.
Topics: Barbiturates; Child Behavior Disorders; Humans; Hyperkinesis; Mephobarbital; Phenobarbital; Recurren | 1978 |
Febrile seizures: an end to confusion.
Topics: Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Hyperkinesis; Infant; Infant, | 1978 |
Simple febrile seizures.
Topics: Child; Community Participation; Decision Making; Humans; Parents; Phenobarbital; Recurrence; Seizure | 1978 |
'Simple febrile convulsion'.
Topics: Humans; Phenobarbital; Recurrence; Seizures; Seizures, Febrile | 1978 |
Phenobarbital and febrile seizures.
Topics: Drug Administration Schedule; Humans; Phenobarbital; Recurrence; Seizures; Seizures, Febrile | 1978 |
Effects of sodium phenobarbital on brain stimulation behavior, behavioral seizures, and EEG seizure activity.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Operant; Electroencephalography; Male; Phenobarbital | 1978 |
Seizure susceptibility and anticonvulsant activity of carbamazepine, diphenylhydantoin and phenobarbital in rats with selective depletions of brain monoamines.
Topics: Animals; Anticonvulsants; Biogenic Amines; Brain; Carbamazepine; Electroshock; Female; Hydroxydopami | 1978 |
Effects of phenobarbital and SC-13504 on partially kindled hippocampal seizures in rats.
Topics: Animals; Anticonvulsants; Hippocampus; Male; Phenobarbital; Piperazines; Pyridines; Rats; Seizures | 1978 |
Effects of phenobarbital on seizure activity in the gerbil.
Topics: Animals; Behavior, Animal; Brain; Female; Gerbillinae; Male; Neural Inhibition; Phenobarbital; Seizu | 1978 |
Elevation of seizure thresholds: a comparison of cerebellar stimulation, phenobarbital, and diphenylhydantoin.
Topics: Animals; Cerebellar Cortex; Cerebral Cortex; Electric Stimulation; Electroencephalography; Male; Pen | 1978 |
Preventing febrile convulsions.
Topics: Child, Preschool; Diazepam; Humans; Infant; Phenobarbital; Seizures; Seizures, Febrile | 1978 |
Changes in the convulsion threshold and in the level of brain biogenic amines in rats chronically treated with phenobarbital or diazepam.
Topics: Animals; Biogenic Amines; Brain Chemistry; Diazepam; Dopamine; Drug Synergism; Male; Norepinephrine; | 1978 |
Febrile seizures.
Topics: Anticonvulsants; Child; Humans; Phenobarbital; Seizures; Seizures, Febrile | 1979 |
The anticonvulsant activity of ropizine in the rat.
Topics: Action Potentials; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Electroshock; Hippocampus; M | 1979 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; | 1976 |
Problems of childhood. Febrile fits.
Topics: Age Factors; Child, Preschool; Diazepam; Epilepsy, Tonic-Clonic; Female; Fever; Humans; Infant; Male | 1976 |
Thyrotropin-releasing hormone (TRH) and its beta-alanine analogue: potentiation of the anticonvulsant potency of phenobarbital in mice.
Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Male; Mice; Peptides; Phenobarbital; Seizure | 1975 |
Prophylaxis with diphenylhydantoin and phenobarbital and alumina-gel monkey model. I. Twelve months of treatment: seizure, EEG, blood, and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; | 1976 |
Prophylaxis with diphenylhydantoin and phenobarbital in alumina-gel monkey model. II. Fourth-month follow-up period: seizure, EEG, blood and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; | 1976 |
Acute anticonvulsant effects of diphenylhydantoin, phenobarbital, and carbamazepine: a combined electroclinical and serum level study in amygdaloid kindled cats and baboons.
Topics: Amygdala; Animals; Carbamazepine; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 1976 |
[Results of Fali-lepsin therapy of cerebral convulsions in childhood].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Epilepsy; Epilepsy, Tonic-Clonic; Female; Fever; H | 1976 |
Anticonvulsant drug antagonism of delta9tetrahydrocannabinol-induced seizures in rabbits.
Topics: Animals; Anticonvulsants; Cannabidiol; Cannabinol; Carbamazepine; Diazepam; Dose-Response Relationsh | 1977 |
[Phenemal prophylaxis and prognosis].
Topics: Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Prognosis; Recurrence; Seizures; S | 1977 |
Reye syndrome: diagnostic and therapeutic considerations.
Topics: Adolescent; Amino Acids; Brain; Child; Exchange Transfusion, Whole Blood; Fatty Liver; Glucose; Huma | 1977 |
Convulsant-anticonvulsant interactions on seizure activity and cortical acetylcholine release.
Topics: Acetylcholine; Animals; Anticonvulsants; Bicuculline; Blood Pressure; Cerebral Cortex; Convulsants; | 1977 |
Effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in "simple" febrile convulsions and "epilepsy triggered by fever".
Topics: Child; Diagnosis, Differential; Epilepsy; Humans; Phenobarbital; Seizures; Seizures, Febrile | 1977 |
Convulsions induced by hyperbaric oxygen: inhibition by phenobarbital, diazepam and baclofen.
Topics: Aminobutyrates; Animals; Baclofen; Diazepam; Female; gamma-Aminobutyric Acid; Glycine; Hyperbaric Ox | 1977 |
Prolonged seizures due to contact and inhalation exposure to camphor. A case report.
Topics: Camphor; Humans; Infant; Male; Phenobarbital; Seizures | 1977 |
Interaction of central nervous system effects of high pressures with barbiturates.
Topics: Animals; Atmosphere Exposure Chambers; Atmospheric Pressure; Barbital; Barbiturates; Female; Mice; P | 1977 |
Potentiation of Amipaque epileptogenic activity by neuroleptics.
Topics: Animals; Chlorpromazine; Contrast Media; Diazepam; Drug Synergism; Iodobenzoates; Metrizamide; Pheno | 1977 |
The behavioral and electrical interactions of electrically induced hippocampal seizures and four anticonvulsants.
Topics: Animals; Anticonvulsants; Conditioning, Operant; Diazepam; Electric Stimulation; Electroencephalogra | 1977 |
Effectiveness of N,N-dimethoxymethyl-phenobarbital (eterobarbital) on febrile seizures.
Topics: Administration, Oral; Animals; Injections, Intraperitoneal; Male; Mice; Phenobarbital; Seizures; Sei | 1977 |
The effectiveness of phenobarbital in the prevention of recurrent febrile convulsions in children with and without a history of pre-, peri- and postnatal abnormalities.
Topics: Child; Child, Preschool; Female; Follow-Up Studies; Humans; Obstetric Labor Complications; Phenobarb | 1977 |
Seizures in childhood encephalopathy or epilepsy?
Topics: Adolescent; Child; Epilepsy; Humans; Metabolic Diseases; Neurologic Examination; Phenobarbital; Prim | 1977 |
Cerebral energy reserves of mice during seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; An | 1977 |
Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine.
Topics: Animals; Digitoxin; Drug Interactions; Ethionine; Female; Hexobarbital; In Vitro Techniques; Liver; | 1977 |
Neonatal seizures associated with narcotic withdrawal.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenobarbital; Pregnanc | 1977 |
Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice.
Topics: Animals; Body Weight; Chlordiazepoxide; Dronabinol; Electroshock; Glucose; Male; Mice; Phenobarbital | 1977 |
Letter: Treatment of "febrile seizures".
Topics: Aspirin; Child; Drug Administration Schedule; Fever; Humans; Phenobarbital; Placebos; Seizures; Term | 1976 |
Increased CNS sensitivity to flurothyl as a measure of physical dependence in mice following morphine, phenobarbital, and ethanol treatment.
Topics: Animals; Ethanol; Flurothyl; Humans; Male; Mice; Mice, Inbred C57BL; Morphine Dependence; Phenobarbi | 1976 |
Determination of halothane-induced sleeping time in the rat: effect of prior administration of centrally active drugs.
Topics: Animals; Bemegride; Brain Chemistry; Circadian Rhythm; Drug Interactions; Female; Halothane; Injecti | 1976 |
The effects of phenobarbital and SC-13504 on the "kindled" seizures of rats.
Topics: Animals; Anticonvulsants; Electric Stimulation; Electroencephalography; Hippocampus; Male; Phenobarb | 1976 |
[Interval therapy of febrile convulsions for the management of their prognosis. I. Methods and therapeutic advice for interval therapy of febrile convulsions].
Topics: Child, Preschool; Epilepsy; Humans; Infant; Periodicity; Phenobarbital; Phenytoin; Recurrence; Seizu | 1976 |
[Interval therapy of febrile convulsions for management of the prognosis. II. Anticonvulsant longtime Fali-Lepsin therapy of complicated febrile convulsions].
Topics: Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Phenylpropanolamine; Progno | 1976 |
[Problems in the preventive treatment of repeated febrile convulsions].
Topics: Child; Child, Preschool; Chronic Disease; Female; Humans; Infant; Male; Phenobarbital; Prognosis; Re | 1976 |
[Heroin withdrawal syndrome in newborns (author's transl].
Topics: Chloral Hydrate; Diazepam; Female; Heroin; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant | 1976 |
[Ultrastructural changes of the rat cerebellum due to pentetrazol and phenobarbital administration--in special references to the changes of synaptic vesicles associated with convulsive seizures (author's transl)].
Topics: Animals; Cerebellum; Male; Pentylenetetrazole; Phenobarbital; Rats; Seizures; Synaptic Vesicles | 1976 |
Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Anticonvulsants; Child; Child, Preschool; Ethosuximide; | 1976 |
Febrile seizures in children.
Topics: Analgesics; Child, Preschool; Diagnosis, Differential; Dysentery, Bacillary; Electroencephalography; | 1975 |
Changes in glycogen phosphorylase activity and glycogen levels of mouse cerebral cortex during convulsions induced by homocysteine.
Topics: Animals; Cerebral Cortex; Female; Glycine; Glycogen; Homocysteine; Mice; Mice, Inbred Strains; Pheno | 1975 |
Unconjugated hyperbilirubinemia. Physiologic evaluation and experimental approaches to therapy.
Topics: Adult; Albumins; Animals; Bilirubin; Crigler-Najjar Syndrome; Ethosuximide; Female; Gilbert Disease; | 1975 |
Anticonvulsant activities of delta-8 and delta-9 tetrahydrocannabinol and uridine.
Topics: Animals; Anticonvulsants; Cannabis; Dronabinol; Electroshock; Male; Mice; Pentylenetetrazole; Phenob | 1975 |
Treatment of hypernatraemic dehydration in infancy.
Topics: Bicarbonates; Body Weight; Dehydration; Gastroenteritis; Humans; Hyperglycemia; Hypernatremia; Hypoc | 1975 |
Plasma concentrations of phenobarbital in the treatment of seizures in newborns.
Topics: Administration, Oral; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; I | 1975 |
Anticonvulsant osteomalacia.
Topics: Adolescent; Anticonvulsants; Bone and Bones; Humans; Male; Mephenytoin; Minerals; Osteomalacia; Phen | 1975 |
[Toxic epidermic necrolysis].
Topics: Child; Female; Humans; Phenobarbital; Seizures; Stevens-Johnson Syndrome | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
Phenobarbital disposition in the neonate.
Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature, Diseases; Phenobarbital; Seizures; S | 1975 |
Drug interaction: diazoxide and diphenylhydantoin.
Topics: Administration, Oral; Adolescent; Child, Preschool; Chromatography, Gas; Diazoxide; Drug Therapy, Co | 1975 |
Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures.
Topics: Aluminum; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Feeding Behavior | 1975 |
The role of 5-hydroxytryptamine in the mechanism of action of anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Female; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Serotonin | 1975 |
Diazepam prophylaxis for lignocaine induced convulsions.
Topics: Animals; Diazepam; Gait; Injections, Intraperitoneal; Lidocaine; Phenobarbital; Rats; Seizures; Wake | 1975 |
The influence of anticonvulsant drugs on cerebral aspartate aminotransferase activity in mice with predisposition to audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Aspartate Aminotransferases; Brain; Mice; Phenobarbital; Phenytoin; S | 1975 |
Anticonvulsive properties of cinnarizine and flunarizine in rats and mice.
Topics: Animals; Anticonvulsants; Cinnarizine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica | 1975 |
Metabolism, distribution and anticonvulsant properties of N,N'- dimethoxymethyl-phenobarbital in the rat.
Topics: Animals; Anticonvulsants; Brain; Chromatography, Thin Layer; Electroshock; Liver; Male; Pentylenetet | 1976 |
Letter: Chronic versus intermittent phenobarbital therapy.
Topics: Child; Fever; Humans; Phenobarbital; Seizures | 1976 |
Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs.
Topics: Animals; Anticonvulsants; Cannabis; Chlordiazepoxide; Dronabinol; Electroshock; Male; Mice; Nicotine | 1976 |
Letter: Failure of phenobarbitone to prevent febrile convulsions.
Topics: Child; Child Behavior Disorders; Humans; Phenobarbital; Seizures | 1976 |
Letter: Phenobarbitone for convulsions in children.
Topics: Child; Humans; Phenobarbital; Seizures | 1976 |
Letter: Failure of phenobarbitone to prevent febrile convulsions.
Topics: Child; Fever; Humans; Phenobarbital; Seizures | 1976 |
Simple febrile convulsions.
Topics: Cerebrospinal Fluid; Child, Preschool; Diazepam; Emergency Service, Hospital; Fever; Humans; Infant; | 1976 |
Purulent meningitis in children: outcome using a standard management regimen with chloramphenicol.
Topics: Bacteria; Child; Child, Preschool; Chloramphenicol; Humans; Infant; Infant, Newborn; Meningitis, Bac | 1992 |
Removal of ethosuximide and phenobarbital by peritoneal dialysis in a child.
Topics: Child; Dialysis Solutions; Ethosuximide; Female; Humans; Peritoneal Dialysis; Phenobarbital; Renal I | 1992 |
Benign Familial Neonatal Seizures.
Topics: Adult; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 20; Diagnosis, Differe | 1992 |
Metal complexes of phenobarbituric acid. Chelating behavior of the phenobarbiturate ring. Anticonvulsant properties of the K2[Cu(N-methylphenobarbiturato)]4.8H2O.
Topics: Animals; Anticonvulsants; Chelating Agents; Copper; Electron Spin Resonance Spectroscopy; Electrosho | 1992 |
Effects of some GABAergic agents on quinine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; Male; Mice; Mice, Inb | 1992 |
Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models.
Topics: Animals; Anticonvulsants; Brain; Cells, Cultured; Electric Stimulation; Male; Mice; Models, Biologic | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Phenobarbital exacerbation of self-injurious behavior.
Topics: Acute Disease; Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hu | 1992 |
Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital.
Topics: Animals; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Nerve D | 1992 |
High-dose methotrexate does not affect the pharmacodynamics of phenobarbital hypnotic action but decreases the central nervous system (CNS) sensitivity to pentylenetetrazol-induced maximal seizures in rats.
Topics: Animals; Brain Chemistry; Central Nervous System; Chromatography, High Pressure Liquid; Glucose; Hyp | 1992 |
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy | 1992 |
Massive theophylline dosing in a heavy smoker receiving both phenytoin and phenobarbital.
Topics: Adult; Asthma; Drug Administration Schedule; Female; Humans; Phenobarbital; Phenytoin; Seizures; Smo | 1992 |
Bromism.
Topics: Animals; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Phenobarbital; Potassium; Potassiu | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Rapid onset of seizures following aspiration of viscous lidocaine.
Topics: Drainage, Postural; Extracorporeal Membrane Oxygenation; Female; Humans; Inappropriate ADH Syndrome; | 1992 |
Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Drug Tolerance; Electrodes, Im | 1992 |
Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.
Topics: Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Infant; Ma | 1992 |
Convulsive behaviour during alcohol dependence: discrimination between the role of intoxication and withdrawal.
Topics: Alcoholism; Analysis of Variance; Animals; Behavior, Animal; Male; Phenobarbital; Rats; Rats, Inbred | 1992 |
Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Chloroquine; Diazepam; gamma-Aminobutyric Ac | 1992 |
Anticonvulsant drug potentiation by glycine in maximal electroshock seizures is mimicked by D-serine and antagonized by 7-chlorokynurenic acid.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Glycine; Kynurenic Acid; Male | 1991 |
Hepatotoxicity of phenobarbital in dogs: 18 cases (1985-1989).
Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Female; Liver; Liver Diseases; | 1991 |
[Epidural hematoma in a newborn infant: spontaneous resolution].
Topics: Hematoma, Epidural, Cranial; Humans; Infant, Newborn; Male; Phenobarbital; Remission, Spontaneous; S | 1991 |
Influence of MK-801 on the anticonvulsant activity of antiepileptics.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dizocilpine Maleate; Drug Synergism; Electroshock; Learn | 1991 |
Effect of phenobarbital on motor seizures elicited by picrotoxin and bicuculline in rats.
Topics: Animals; Bicuculline; Male; Pentylenetetrazole; Phenobarbital; Picrotoxin; Rats; Rats, Inbred Strain | 1991 |
Reactive lymphohistiocytosis with recurrence in the optic chiasm.
Topics: Adrenal Cortex Hormones; Adult; Cranial Nerve Diseases; Histiocytosis, Non-Langerhans-Cell; Humans; | 1991 |
[Pharmacologic modulation of central noradrenergic mechanisms and the effect of selected substances on the anticonvulsant effect of phenobarbital in the maximal pentylenetetrazole-seizure test (mice)].
Topics: Animals; Anticonvulsants; Drug Synergism; Male; Mice; Norepinephrine; Pentylenetetrazole; Phenobarbi | 1991 |
Diazepam and intubation in emergency treatment of seizures in children.
Topics: Adolescent; Body Weight; Case-Control Studies; Child; Child, Preschool; Diazepam; Drug Therapy, Comb | 1991 |
Seizures induced by aminooxyacetic acid in mice: pharmacological characteristics.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Cerebral Cortex; Cerebral Ventricles; Diazepam | 1991 |
Croton zehntneri: possible central nervous system effects in rodents.
Topics: Animals; Anticonvulsants; Brazil; Male; Medicine, Traditional; Mice; Phenobarbital; Picrotoxin; Plan | 1991 |
Impaired water homeostasis following mixed carbamazepine and phenobarbital overdose.
Topics: Adult; Body Water; Carbamazepine; Female; Homeostasis; Humans; Osmolar Concentration; Phenobarbital; | 1991 |
Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children.
Topics: Analysis of Variance; Carbamazepine; Carnitine; Child; Drug Combinations; Fatty Acids; Fatty Acids, | 1991 |
Use of activated charcoal to reduce elevated serum phenobarbital concentration in a neonate.
Topics: Administration, Oral; Asphyxia Neonatorum; Charcoal; Half-Life; Humans; Infant, Newborn; Male; Pheno | 1991 |
Phenobarbital.
Topics: Humans; Infant, Newborn; Phenobarbital; Seizures | 1991 |
Management of hyponatremic seizures in children with hypertonic saline: a safe and effective strategy.
Topics: Adolescent; Anticonvulsants; Apnea; Benzodiazepines; Brain Chemistry; Brain Diseases; Child; Child, | 1991 |
Substantia nigra regulates action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Ethosuximide; Ma | 1990 |
Thiopental efficacy in phenobarbital-resistant neonatal seizures.
Topics: Drug Evaluation; Drug Resistance; Female; Gestational Age; Half-Life; Humans; Infant, Newborn; Inten | 1990 |
Failure of nine-month phenobarbital administration to reverse amygdaloid-kindled seizure susceptibility in cats.
Topics: Amygdala; Animals; Cats; Electric Stimulation; Electroencephalography; Kindling, Neurologic; Male; P | 1990 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximi | 1990 |
The effect of interstimulation interval on the assessment of anticonvulsant drug potency in fully kindled rats.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Kindling, Neurologic; Male; Phenobarbital; Rats; Ra | 1990 |
Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal.
Topics: Aggression; Animals; Anticonvulsants; Lorazepam; Male; Mice; Pentylenetetrazole; Phenobarbital; Phen | 1990 |
Effects of anticonvulsants on hippocampus-generating seizures.
Topics: Animals; Anticonvulsants; Carbamazepine; Cats; Dose-Response Relationship, Drug; Electric Stimulatio | 1990 |
Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Chromatography, High Pressure Liquid; Diaz | 1990 |
Diagnostic pitfalls associated with amoxapine overdose: a case report.
Topics: Amoxapine; Child; Dibenzoxazepines; Electroencephalography; Emergencies; Female; Humans; Phenobarbit | 1990 |
Anticonvulsant drug mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clonazepa | 1985 |
The effects of lindane, DDT, and chlordecone on avoidance responding and seizure activity.
Topics: Animals; Avoidance Learning; Chlordecone; Chlordiazepoxide; DDT; Dose-Response Relationship, Drug; H | 1987 |
The effect of repeated seizures on anticonvulsant drug response in the kindling model.
Topics: Animals; Brain; Carbamazepine; Kindling, Neurologic; Male; Membrane Potentials; Phenobarbital; Pheny | 1987 |
Carnitine deficiency associated with anticonvulsant therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Carnitine; Cerebral Palsy; Drug Therapy, Co | 1989 |
Patterns of convulsive susceptibility in the long-sleep and short-sleep selected mouse lines.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Female; Flumazenil; Male; Mice; Pentylenetetrazo | 1989 |
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primi | 1989 |
Interaction between GABAergic anticonvulsants and the NMDA receptor antagonist MK 801 against MES- and picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Diazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Electroshock; Ethanol | 1989 |
Systemic effect of ipecac on acute toxicity of phenobarbital and theophylline in rats.
Topics: Animals; Cardiovascular Diseases; Ipecac; Male; Nervous System Diseases; Phenobarbital; Rats; Rats, | 1989 |
Kinetics of drug action in disease states. XXXVII. Effects of acute fluid overload and water deprivation on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline in rats.
Topics: Animals; Dehydration; Glucose; Male; Phenobarbital; Rats; Rats, Inbred Lew; Seizures; Theophylline; | 1989 |
Autoregulation of cerebral blood flow. Effect of phenobarbital and pancuronium in the newborn piglet.
Topics: Animals; Animals, Newborn; Bicuculline; Blood Gas Analysis; Cardiac Output; Cerebrovascular Circulat | 1989 |
Some correlations between procaine-induced convulsions and monoamines in the spinal cord of rats.
Topics: Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Male; Phenobarbital; Procaine; Rats; | 1989 |
[Effects of phenobarbital and phenytoin on hippocampus generating seizures].
Topics: Amygdala; Animals; Cats; Hippocampus; Kindling, Neurologic; Phenobarbital; Phenytoin; Seizures | 1989 |
Phenobarbital for treatment of seizures in preterm infant: a new administration scheme.
Topics: Drug Administration Schedule; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Phenobarb | 1989 |
Effects of carbamazepine and phenobarbital on kainic acid-induced model of psychomotor seizures during ontogenesis in the rat.
Topics: Aging; Animals; Carbamazepine; Dose-Response Relationship, Drug; Kainic Acid; Male; Phenobarbital; R | 1989 |
Effects of phenytoin and phenobarbital on schedule-controlled responding and seizure activity in the amygdala-kindled rat.
Topics: Amygdala; Animals; Conditioning, Operant; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Rats | 1989 |
Rapid sequential phenobarbital treatment of neonatal seizures.
Topics: Dose-Response Relationship, Drug; Gestational Age; Humans; Infant, Newborn; Lorazepam; Phenobarbital | 1989 |
Comparison of the anticonvulsant efficacy of primidone and phenobarbital during chronic treatment of amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Electrodes, Implanted; Female; Kindling, Neuro | 1989 |
Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Models, Biological; Pentylenetetrazole; Phenobarb | 1989 |
Unexpected cocaine intoxication presenting as seizures in children.
Topics: Child, Preschool; Cocaine; Diazepam; Emergencies; Female; Gastric Lavage; Humans; Infant; Male; Phen | 1989 |
Effect of aminophylline upon the protective activity of common antiepileptic drugs and their plasma levels in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Male; Mice | 1989 |
Effects of intranigral application of clinically-effective anticonvulsants on electroshock-induced seizures.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Electroshock; Hindlimb; I | 1989 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Di | 1987 |
Effect of anticonvulsants on pentylenetetrazol-induced power spectrum changes in electroencephalograms in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cyclic AMP; Electroencephalography; Ethosuximide; Male; P | 1987 |
Interactions of pentobarbital and phenobarbital with GABAergic drugs against chemoconvulsants in rats.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Diazepam; Drug Interactions; Isoxazole | 1988 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picroto | 1986 |
Prolonged CNS hyperexcitability in mice after a single exposure to delta-9-tetrahydrocannabinol.
Topics: Animals; Central Nervous System; Dronabinol; Drug Tolerance; Electroshock; Male; Mice; Phenobarbital | 1986 |
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscim | 1986 |
Neonatal hypoxic-ischemic encephalopathy: current management practices.
Topics: Academic Medical Centers; Asphyxia Neonatorum; Brain Ischemia; Electroencephalography; Humans; Infan | 1988 |
[The correlation between concentrations of anticonvulsive drugs in the brain and various parameters of maximal electroshock seizures in mice].
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Drug Evaluation, Preclinical; Electroshock | 1986 |
Anticonvulsant properties of phencyclidine and ketamine.
Topics: Animals; Anticonvulsants; Hippocampus; Ketamine; Kindling, Neurologic; Mice; Mice, Inbred ICR; Penty | 1986 |
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital; | 1986 |
Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Carbamazepine; Diazepam; Female; Glutamates; Mice; Ox | 1986 |
A possible role for spinal noradrenaline in the mechanisms of 6-hydroxydopamine against pentylenetetrazol induced convulsions in rats.
Topics: Animals; Female; Hydroxydopamines; Male; Norepinephrine; Oxidopamine; Pentylenetetrazole; Phenobarbi | 1988 |
Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital.
Topics: Animals; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Electroshock; Female; M | 1988 |
Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice.
Topics: Animals; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Mice; Phenobarbital; Phenytoin; Sei | 1988 |
Chronic primidone treatment in the rat: an animal model of primidone therapy.
Topics: Administration, Oral; Animals; Male; Models, Biological; Phenobarbital; Primidone; Rats; Rats, Inbre | 1988 |
The neurotoxicity of phenobarbital and its effect in preventing pentylenetetrazole-induced maximal seizure in aging mice.
Topics: Administration, Oral; Aging; Animals; Drug Tolerance; Female; Injections, Intraperitoneal; Mice; Pen | 1988 |
Developmental aspects of phenobarbital dosage requirements in newborn infants with seizures.
Topics: Drug Administration Schedule; Gestational Age; Half-Life; Humans; Infant, Newborn; Phenobarbital; Se | 1988 |
Phenobarbital increases aminophylline requirement in premature infants.
Topics: Aminophylline; Apnea; Humans; Infant, Newborn; Infant, Premature, Diseases; Phenobarbital; Seizures | 1988 |
Seizures in the neonatal intensive care unit of the 1980s. Types, Etiologies, Timing.
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Epilepsy; Female; Gestational Age; Humans; Infant, L | 1988 |
Development of phenobarbital glucosidation in the human neonate.
Topics: Female; Glucose; Half-Life; Humans; Infant, Newborn; Injections, Intravenous; Male; Phenobarbital; S | 1988 |
Seizures during barbiturate withdrawal: relation to blood level.
Topics: Humans; Phenobarbital; Primidone; Seizures; Substance Withdrawal Syndrome; Time Factors | 1987 |
[Nonconvulsive status epilepticus in relation to phenobarbital poisoning].
Topics: Child; Electroencephalography; Humans; Male; Phenobarbital; Seizures; Status Epilepticus | 1987 |
Effects of aminophylline and enprofylline on the protective activity of phenobarbital against amygdala-kindled seizures in rats.
Topics: Aminophylline; Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactio | 1987 |
Phenytoin and phenobarbital protein binding alterations in a uremic burn patient.
Topics: Burns; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Protein Binding; Seizures; Serum Albumin | 1987 |
Intravenous phenobarbital for alcohol withdrawal and convulsions.
Topics: Acute Disease; Adult; Alcohol Withdrawal Delirium; Drug Evaluation; Ethanol; Female; Follow-Up Studi | 1987 |
Circadian patterns of vigilance and seizure susceptibility in genetically epileptic mice: heuristic aspects in neurology.
Topics: Animals; Arousal; Brain; Circadian Rhythm; Dextroamphetamine; Epilepsy; Light; Mice; Phenobarbital; | 1987 |
[Effects of phenobarbitol in the convulsive syndrome in newborn infants].
Topics: Female; Humans; Infant, Newborn; Male; Phenobarbital; Seizures; Time Factors | 1987 |
Characterization and classification of neonatal seizures.
Topics: Brain; Electroencephalography; Humans; Infant, Newborn; Monitoring, Physiologic; Phenobarbital; Seiz | 1987 |
Effects of glutathione and phenobarbital on the toxicity of codeinone.
Topics: Animals; Codeine; Glutathione; Male; Mice; Mice, Inbred Strains; Naloxone; Phenobarbital; Seizures; | 1986 |
Phenobarbital improves survival in theophylline-intoxicated rabbits.
Topics: Animals; Injections, Intravenous; Phenobarbital; Phenytoin; Rabbits; Seizures; Theophylline | 1986 |
Astroblastoma revisited: a report of three cases.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Electroencephalography; Female | 1986 |
Graft versus host-like illness in a child with phenobarbital hypersensitivity.
Topics: Antigen-Antibody Complex; Autoimmune Diseases; Biopsy; Child; Drug Hypersensitivity; Female; Graft v | 1986 |
Efficacy of baclofen and phenobarbital against the kainic acid limbic seizure-brain damage syndrome.
Topics: Animals; Baclofen; Behavior, Animal; Brain; Electroencephalography; Injections, Intraventricular; Ka | 1986 |
[Effect of diazepam and phenobarbital on the acute toxicity of bicyclic organophosphorus esters].
Topics: Acute Disease; Animals; Diazepam; Esters; Male; Organophosphorus Compounds; Phenobarbital; Rats; Rat | 1986 |
Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Hippocampus; Kainic Acid; Limbic Syste | 1986 |
Phenobarbital increases the theophylline requirement of premature infants being treated for apnea.
Topics: Apnea; Cerebral Hemorrhage; Drug Interactions; Humans; Infant, Newborn; Infant, Premature; Phenobarb | 1987 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |
[Serum levels of phenobarbital in the newborn infant using different doses calculated for obtaining a predetermined level].
Topics: Apgar Score; Female; Fetal Hypoxia; Gestational Age; Humans; Infant, Newborn; Male; Phenobarbital; P | 1985 |
Neonatal seizures: Part II. Recognition, treatment, and prognosis.
Topics: Education, Nursing, Continuing; Humans; Infant, Newborn; Phenobarbital; Prognosis; Seizures | 1985 |
Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroshock; Female; Kinetics; Mice; Phenobarbital; Phenyt | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Convulsive thresholds and severity and the anticonvulsant effect of phenobarbital and phenytoin in adult rats administered 6-hydroxydopamine or 5,7-dihydroxytryptamine during postnatal development.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Anticonvulsants; Biogenic Amines; Dihydroxytrypt | 1985 |
Seizure control following administration of anticonvulsant drugs in the quaking mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Mice; Mice, Inbred C57BL; Mice, Qua | 1985 |
Intravenous paraldehyde for seizure control in newborn infants.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intravenous; Male; Metabolic | 1986 |
Cassette electroencephalography in the evaluation of neonatal seizures.
Topics: Apnea; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Se | 1986 |
Infantile seizures caused by voluntary water intoxication.
Topics: Diagnosis, Differential; Hot Temperature; Humans; Infant; Male; Phenobarbital; Seizures; Water Intox | 1986 |
Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats.
Topics: Administration, Oral; Aging; Animals; Animals, Suckling; Blood Glucose; Deoxyglucose; Dieldrin; Drug | 1986 |
Modification of the antiepileptic actions of phenobarbital and phenytoin by the taurine transport inhibitor, guanidinoethane sulfonate.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Electroshock; Male; Mice; Phenobarbital; Phenytoin; Se | 1985 |
The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat.
Topics: Animals; Body Weight; Drug Tolerance; Lethal Dose 50; Male; Manganese; Manganese Poisoning; Organ Si | 1985 |
Safety of a higher loading dose of phenobarbital in the term newborn.
Topics: Asphyxia Neonatorum; Humans; Infant, Newborn; Phenobarbital; Seizures | 1985 |
Epilepsy in a community--management and social impact.
Topics: Adolescent; Adult; Aged; Ambulatory Care Facilities; Carbamazepine; Craniocerebral Trauma; Epilepsy; | 1985 |
Regional cerebral blood flow during bicuculline-induced seizures in the newborn piglet: effect of phenobarbital.
Topics: Acid-Base Equilibrium; Animals; Animals, Newborn; Bicuculline; Blood Gas Analysis; Blood Pressure; C | 1985 |
Practical problems of therapeutic drug monitoring of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Specimen Collection; Child; Humans; Kinetics; Monitoring, | 1985 |
Once-daily administration of phenobarbital in adults. Clinical efficacy and benefit.
Topics: Adult; Brain Injuries; Coma; Female; Humans; Male; Middle Aged; Phenobarbital; Seizures | 1985 |
Efficacy of phenobarbital in neonatal seizures.
Topics: Humans; Infant, Newborn; Phenobarbital; Phenytoin; Retrospective Studies; Seizures | 1985 |
Reduced taurine contents and modification of anticonvulsive effects of phenobarbital and phenytoin by guanidinoethane sulfonate in mice.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Male; Phenobarbital; Phenytoin; Rats; Seizures; Taurin | 1985 |
Intracranial hemorrhage in children with sickle cell disease.
Topics: Anemia, Sickle Cell; Arteries; Brain; Cerebral Infarction; Child; Child, Preschool; Exchange Transfu | 1985 |
Seizures during infancy and childhood.
Topics: Child, Preschool; Humans; Male; Phenobarbital; Seizures | 1985 |
[Convulsive crises in childhood].
Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi | 1985 |
[Control of long-term therapy with diphenylhydantoin. Gas-chromatographic determination of diphenylhydantoin and hydroxy-diphenylhydantoin].
Topics: Chromatography, Gas; Humans; Methods; Phenobarbital; Phenytoin; Seizures; Time Factors | 1973 |
Cutis aplasia and cerebral malformation.
Topics: Cephalometry; Cerebrospinal Fluid Proteins; Developmental Disabilities; Female; Humans; Hydranenceph | 1973 |
Letter: Prevention of convulsions.
Topics: Humans; Infant; Pertussis Vaccine; Phenobarbital; Seizures | 1974 |
Mesial temporal (Ammon's horn) sclerosis as a common cause of epilepsy. Aetiology, treatment, and prevention.
Topics: Administration, Oral; Adolescent; Animals; Brain Diseases; Child; Child, Preschool; Diazepam; Epilep | 1974 |
The protection against the cerebral and pulmonary effects of hyperbaric oxygen by pharmacological agents and lithium salts in mice.
Topics: Acetates; Aminobutyrates; Animals; Anticonvulsants; Antipsychotic Agents; Brain; Chlorpromazine; Fem | 1973 |
Possible role of gamma-aminobutyric acid in paraoxon-induced convulsions.
Topics: Aminobutyrates; Animals; Brain Chemistry; Insecticides; Isoniazid; Male; Paraoxon; Phenobarbital; Ra | 1972 |
Comparative convulsant activity of various penicillins after intracerebral injection in mice.
Topics: Ampicillin; Animals; Cephaloridine; Drug Synergism; Hydrogen-Ion Concentration; Injections; Male; Me | 1973 |
Effects of convulsant and anticonvulsant drugs on the activity of some enzymes in the rat brain.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Stimulants; Electron Transport Complex IV; M | 1973 |
Vertigo in childhood. Comments on pathogenesis and management.
Topics: Adolescent; Anticonvulsants; Central Nervous System; Child; Dimenhydrinate; Female; Histamine H1 Ant | 1974 |
Effect of barbiturates and isoniazid on cerebral hemisphere gamma-aminobutyric acid content in pp' DDT treated mice.
Topics: Aminobutyrates; Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Brain Chemistry; DDT; Drug | 1974 |
Amitriptyline and imipramine poisoning.
Topics: Adult; Amitriptyline; Humans; Imipramine; Male; Neurologic Manifestations; Phenobarbital; Seizures | 1965 |
An animal model of light sensitive epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Diazepam; Elec | 1967 |
Longitudinal EEG and clinical study of children with febrile convulsions.
Topics: Acute Disease; Age Factors; Blood Chemical Analysis; Cerebral Cortex; Child, Preschool; Electroencep | 1968 |
Management of convulsions.
Topics: Child; Diazepam; Epilepsy; Humans; Phenobarbital; Seizures | 1970 |
Management of convulsions.
Topics: Child; Diazepam; Humans; Injections, Intravenous; Phenobarbital; Seizures | 1970 |
Toxicity of halogenated oxyquinolines in dogs. A clinical study. II. History, symptoms, laboratory findings, therapy, and follow-up.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dehydration; Dog Diseases; Dogs; Electrocardiograph | 1974 |
Therapy of seizures in children.
Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec | 1974 |
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence | 1974 |
Discharging cortical lesions produced by freezing. The effect of anticonvulsants on sodium-potassium-activated ATPase, sodium, and potassim in cortex.
Topics: Adenosine Triphosphatases; Animals; Anticonvulsants; Cerebral Cortex; Enzyme Repression; Female; Fre | 1969 |
Seizure susceptibility after manipulation of brain serotonin.
Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Blood-Brain Barrier; Bra | 1970 |
[Controlled action of phenobarbital on acoustic epilepsy in mice].
Topics: Animals; Mice; Phenobarbital; Seizures | 1969 |
The action of antiepileptic drugs--diphenylhydantoin and phenobarbital--on enzymatic systems involved in the active transport of cations. Study of ATP-ase activity in various brain regions and the erythrocyte of the cat.
Topics: Adenosine Triphosphatases; Animals; Brain; Cats; Erythrocytes; Phenobarbital; Phenytoin; Potassium; | 1973 |
[The treatment of epiletic seizures in childhood].
Topics: Adrenocorticotropic Hormone; Ambulatory Care; Anticonvulsants; Barbiturates; Child; Child, Preschool | 1968 |
A particular pharmacological effect on the propagation of experimental strychnine and penicillin epilepsy.
Topics: Acetates; Animals; Anticonvulsants; Cerebral Cortex; Chlorpromazine; Electroencephalography; Electro | 1969 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
Iatrogenic disorders in epilepsy.
Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug | 1970 |
The anticonvulsant activity of triethylcholine in cats.
Topics: Animals; Anticonvulsants; Cats; Choline; Female; Male; Pentylenetetrazole; Phenobarbital; Seizures | 1966 |
Effects of stimulants of the central nervous system on the pyridoxal phosphate content of the rat brain.
Topics: Amphetamine; Animals; Brain; Central Nervous System Stimulants; Injections, Intraperitoneal; Ipronia | 1965 |
On the neurotoxic effects induced by alkylating agents.
Topics: Alanine; Animals; Anti-Bacterial Agents; Antimetabolites; Azaserine; Behavior, Animal; Central Nervo | 1966 |
Motor convulsions and EEG during maximal electroshock in the rat.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cornea; Electric Stimulation; Electroencephalography; Ele | 1967 |
Pharmacological studies on antagonists against nicotine-induced convulsions and death.
Topics: Animals; Anticonvulsants; Chlorpromazine; Drug Antagonism; Female; Ganglionic Blockers; Hexamethoniu | 1966 |
The origin of epileptiform seizures caused by oil of Artemisia caerulescens L.
Topics: Aminobenzoates; Animals; Behavior, Animal; Cerebral Decortication; Magnoliopsida; Mephenesin; Mice; | 1968 |
Increased susceptibility of mice to seizures after some anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System Stimulants; Drug Synergism; Electroshock | 1967 |
[Convulsive and anticonvulsive effects of aliphatic and alicyclic sulfonamides].
Topics: Animals; Anticonvulsants; Blood Glucose; Carbonic Anhydrases; Central Nervous System; Central Nervou | 1968 |
Effects of ganglion blocking agents on nicotine extensor convulsions and lethality in mice.
Topics: Animals; Atropine; Cerebral Ventricles; Chlorisondamine; Chlorpromazine; Decamethonium Compounds; Ga | 1969 |
The effect of isoniazid and some anticonvulsant drugs on the gamma-aminobutyric acid content of mouse brain in insulin hypoglycaemia.
Topics: Aminobutyrates; Animals; Barbiturates; Brain; Brain Chemistry; Cerebral Cortex; Hypoglycemia; Insuli | 1970 |
[Comparative action of p-chlorbenzolsulfonamide with other anticonvulsants in audiogenic convulsions in rats].
Topics: Acetazolamide; Animals; Anticonvulsants; Hearing; Noise; Phenobarbital; Primidone; Rats; Seizures; S | 1969 |
Effects of drugs acting alone and in combination on the motor activity of intact mice.
Topics: Adjuvants, Anesthesia; Aminobutyrates; Animals; Bemegride; Caffeine; Central Nervous System; Central | 1970 |
3-mercaptopropionic acid: convulsant and lethal properties compared with other sulfur-convulsants; protection therefrom.
Topics: Animals; Central Nervous System Stimulants; Glucose; Homocysteine; Lethal Dose 50; Male; Methionine | 1970 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Letter: Primidone thrombocytopenia.
Topics: Adult; Female; Humans; Phenobarbital; Primidone; Seizures; Thrombocytopenia | 1974 |
Argininosuccinicaciduria: clinical, metabolic and dietary study.
Topics: Affective Symptoms; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginase; Arginine; Ataxia; Child | 1974 |
Epileptiform seizures in domestic fowl. IV. The effects of anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Chickens; Diazepam; Electroencephalography; Phenobarbital; Phenytoin; Phot | 1974 |
Plasma and cerebrospinal fluid concentrations of phenobarbital in infants given single doses.
Topics: Administration, Oral; Child, Preschool; Epilepsy; Female; Fever; Humans; Infant; Injections, Intramu | 1974 |
[Considerations and research on febrile convulsions].
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha | 1974 |
Alcohol, barbiturate, and bromide withdrawal syndromes in mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Barbiturates; Body Weight; Bromides; Diet; Disease Models, An | 1973 |
Acute dextropropoxyphene hydrochloride (Darvon) poisoning.
Topics: Adolescent; Brain Damage, Chronic; Dextropropoxyphene; Diazepam; Female; Humans; Nalorphine; Phenoba | 1973 |
Febrile convulsions in children.
Topics: Child; Fever; Humans; Phenobarbital; Salicylates; Seizures; Tranquilizing Agents | 1973 |
Seizures associated with the use of meglumine iothalamate 60 per cent in ventriculography.
Topics: Adult; Brain; Cerebral Ventriculography; Child; Curare; Diazepam; Electroencephalography; Female; Hu | 1972 |
Effects of diazepam and phenobarbital on electrically-induced amygdaloid seizures and seizure development.
Topics: Amygdala; Animals; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Imp | 1974 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |
[Fever convulsions].
Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care; | 1972 |
Folate metabolism and the anticonvulsant efficacy of phenobarbital.
Topics: Animals; Disease Models, Animal; Flurothyl; Folic Acid; Folic Acid Deficiency; Male; Phenobarbital; | 1973 |
Drugs for convulsions.
Topics: Adult; Child; Child, Preschool; Diazepam; Humans; Phenobarbital; Phenytoin; Seizures; Stevens-Johnso | 1973 |
Cyanate and thiocyanate: acute toxicity.
Topics: Amphetamine; Animals; Antidotes; Arginine; Cyanates; Female; Methemoglobin; Mice; Morphine; Oxyhemog | 1973 |
Carbohydrate metabolism in brain during convulsions and its modification by phenobarbitone.
Topics: Acetone; Animals; Brain; Carbohydrate Metabolism; Citrates; Electric Stimulation; Fumarates; Ketoglu | 1973 |
Chronic drug intoxication causing pseudoretardation in a young child.
Topics: Child; Child Development; Child, Preschool; Female; Humans; Iatrogenic Disease; Infant; Intellectual | 1973 |
Anticonvulsants. 3. Phenobarbital and mephobarbital derivatives.
Topics: Animals; Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Electroshock; Hypnotics and S | 1973 |
The properties of 3,4-methylenedioxyamphetamine (MDA). II. Studies of acute toxicity in the mouse and protection by various agents.
Topics: Amphetamine; Animals; Dioxoles; Lethal Dose 50; Mice; Mice, Inbred Strains; Phenobarbital; Phentolam | 1973 |
Metabolism and anticonvulsant properties of primidone in the rat.
Topics: Amides; Animals; Anticonvulsants; Brain Chemistry; Chromatography, Gas; Electroshock; Male; Malonate | 1973 |
A comparison of the anticonvulsant, neurotoxic and lethal effects of diphenylbarbituric acid, phenobarbital and diphenylhydantoin in the mouse.
Topics: Animals; Anticonvulsants; Barbiturates; Dose-Response Relationship, Drug; Electroshock; Lethal Dose | 1973 |
Chronic and severe phenobarbital intoxication in a child treated with primidone and diphenylhydantoin.
Topics: Anticonvulsants; Biotransformation; Chromatography, Gas; Drug Interactions; Female; Humans; Infant; | 1973 |
Vitamin D-dependent rickets in institutionalized, mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patients.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Child, Preschool; Female; Humans; | 1973 |
The effect of some anticonvulsant drugs on leptazol and bicuculline induced acetylcholine efflux from rat cerebral cortex.
Topics: Acetylcholine; Alkaloids; Animals; Anticonvulsants; Cerebral Cortex; Dioxoles; Dose-Response Relatio | 1973 |
Some studies on the convulsant action of folic acid.
Topics: Alkaloids; Animals; Auditory Threshold; Cerebral Ventricles; Dioxoles; Electroshock; Folic Acid; Fol | 1973 |
The management of febrile convulsions.
Topics: Administration, Oral; Aspirin; Child, Preschool; Diazepam; Fever; Humans; Infant; Injections, Intram | 1973 |
Transplacental passage of primidone.
Topics: Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, Obstetric; Maternal-Fetal | 1973 |
[Introduction of animal mass psychology in pharmacology. 9. Circadian rhythm of El-mouse convulsions and effect of anticonvulsants on simultaneity at 6 p.m].
Topics: Age Factors; Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Circadian Rhythm; Eosinophi | 1973 |
Dependence of anticonvulsant drug action on central monoamines.
Topics: Animals; Anticonvulsants; Dopamine; Drug Interactions; Electroshock; Ethosuximide; Lethal Dose 50; M | 1973 |
Letter: parenteral compliance in the continuous administration of phenobarbital for the prevention of febrile seizures.
Topics: Adult; Child; Fever; Humans; Parents; Phenobarbital; Prospective Studies; Seizures | 1973 |
Thresholds for electro- and chemoconvulsions in mice after termination of treatment with phenobarbital.
Topics: Animals; Anticonvulsants; Differential Threshold; Dose-Response Relationship, Drug; Electroshock; Fe | 1973 |
Anticonvulsants. 4. Metharbital and phenobarbital derivatives.
Topics: Animals; Anticonvulsants; Barbiturates; Electroshock; Lethal Dose 50; Male; Mice; Pentylenetetrazole | 1973 |
Febrile convulsions.
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Epilepsy, Temporal Lobe; Female; Fever of Unknown | 1973 |
Rickets associated with anticonvulsant medication.
Topics: Alkaline Phosphatase; Calcium; Child, Preschool; Female; Humans; Phenobarbital; Phenytoin; Phosphoru | 1974 |
Metabolic and genetic studies of a family with ornithine transcarbamylase deficiency.
Topics: Ammonia; Ammonium Chloride; Brain; Citrates; Dietary Proteins; Estradiol; Glucose; Heterozygote; Hum | 1974 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Brain amino acids during convulsions.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Brain; Electric Stimulation; Glutamate | 1974 |
Effect of seizures and anticonvulsant agents on hippocampal RNA concentration.
Topics: Anesthesia, General; Animals; Anticonvulsants; Cannabis; Cerebral Cortex; Depression, Chemical; Elec | 1974 |
Effect of anticonvulsant drugs on the number of afferent stimuli needed to cause a hippocampal seizure discharge.
Topics: Animals; Anticonvulsants; Cannabis; Dose-Response Relationship, Drug; Electric Stimulation; Electros | 1974 |
Treatment of febrile convulsions.
Topics: Anticonvulsants; Aspirin; Child; Child, Preschool; Diazepam; Epilepsy, Temporal Lobe; Fever; Humans; | 1974 |
Anticonvulsant effects of cannabinoids in mice: drug interactions within cannabinoids and cannabinoid interactions with phenytoin.
Topics: Animals; Cannabis; Depression, Chemical; Dose-Response Relationship, Drug; Drug Combinations; Drug I | 1974 |
An experimental investigation of dependence liability of methaqualone in rats.
Topics: Acoustic Stimulation; Animals; Body Temperature; Body Weight; Dose-Response Relationship, Drug; Drug | 1974 |
Effects of barbiturate withdrawal on audiogenic seizure susceptibility in BALB-c mice.
Topics: Acoustic Stimulation; Animals; Genetics, Behavioral; Humans; Mice; Mice, Inbred BALB C; Phenobarbita | 1974 |
Action of phenobarbitone on neocortical amino acid changes induced by a spiking focus.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Brain Chemistry; Cats; Cerebral Cortex; Depression, C | 1968 |
[New methods of seizure treatment in epilepsy].
Topics: Acetazolamide; Anticonvulsants; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tempo | 1965 |
[Paroxysmal crises of laughter and weeping of epileptic nature. Description of a case].
Topics: Child; Electroencephalography; Emotions; Epilepsy, Tonic-Clonic; Female; Humans; Laughter; Phenobarb | 1967 |
[A new animal model in study of the epilepsy: the baboon, Papio papio].
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Electromyography; Evoked Potentials; Eye | 1968 |
Extractum belladonnae as an adjuvant to luminal in the therapy of epilepsy with a possible explanation in neurophysiological and neurochemical terms.
Topics: Acetylcholine; Adolescent; Adult; Animals; Anticonvulsants; Anura; Atropine; Cats; Cerebral Cortex; | 1968 |
The hyperexcitable neuron as a model for the laboratory analysis of anticonvulsant drugs.
Topics: Acetazolamide; Action Potentials; Aluminum; Animals; Behavior, Animal; Cats; Cerebral Cortex; Electr | 1969 |
The anticonvulsant effects of phenobarbital, diphenylhydantoin and two benzodiazepines in the baboon, Papio papio.
Topics: Animals; Anticonvulsants; Benzazepines; Diazepam; Disease Models, Animal; Electrodes; Electroencepha | 1970 |
The pharmacology of prazepam. A new benzodiazepine derivative.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Chlordiazepoxide; Dia | 1970 |
Petit mal status. A variety of non-convulsive status epilepticus.
Topics: Adolescent; Adult; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalograph | 1971 |
[Cerebral seizures (conclusion). 4. Therapy].
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epileps | 1971 |
Further observations on the interactions between phenobarbital and diphenylhydantoin during chronic treatment in the rat.
Topics: Administration, Oral; Animals; Brain; Chemical Phenomena; Chemistry; Electroshock; Female; Injection | 1972 |
Long-term administration of antiepileptic drugs and the development of rickets.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Diazepam; Ethosuximide; Female; Gluconates; Humans; | 1972 |
Febrile convulsions in early childhood.
Topics: Diagnosis, Differential; Humans; Infant; Infant, Newborn; Meningitis; Phenobarbital; Seizures | 1972 |
Protection by catatoxic steroids and related compounds against proscillaridin intoxication.
Topics: Anabolic Agents; Androstanes; Animals; Bufanolides; Digitoxin; Ethylestrenol; Female; Glucocorticoid | 1972 |
Trichopoliodystrophy. I. Report of a case and biochemical studies.
Topics: Amino Acids; Brain Chemistry; Brain Diseases; Cerebellum; Cerebral Cortex; Cerebrosides; Cholesterol | 1972 |
Febrile convulsions in early childhood.
Topics: Child, Preschool; Epilepsy; Fever; Hospitalization; Humans; Phenobarbital; Phenytoin; Seizures | 1972 |
Whooping cough in Uganda.
Topics: Age Factors; Autopsy; Bronchopneumonia; Child; Child, Preschool; Chlorpromazine; Female; Humans; Inf | 1971 |
The effect of electroshock on regional CNS energy reserves in mice.
Topics: Adenosine Triphosphate; Animals; Brain Stem; Central Nervous System; Cerebellum; Cerebral Cortex; El | 1971 |
[Prophylaxis with fenemal in children with fever convulsions].
Topics: Child, Preschool; Fever; Humans; Phenobarbital; Seizures | 1971 |
Propylene glycol as a drug solvent in pharmacologic studies.
Topics: Animals; Anticonvulsants; Drug Interactions; Hexobarbital; Mice; Motor Activity; Phenobarbital; Prop | 1971 |
I.F. Anticonvulsants or antiepileptics. 4. Phenobarbital.
Topics: Epilepsy; Humans; Mephobarbital; Phenobarbital; Seizures | 1971 |
[Use of luminal in children with labile diabetes mellitus].
Topics: Adolescent; Child; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Humans; Male; Phenobarb | 1971 |
[Anticonvulsants. 5. Treatment of convulsions in the neonatal period].
Topics: Diazepam; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Phe | 1971 |
[Effect of anticonvulsants on the blood coagulation process in amidopyrine convulsions].
Topics: Aminopyrine; Animals; Anticonvulsants; Blood Coagulation; Dogs; Phenobarbital; Seizures | 1971 |
Pharmacological and biochemical studies on 2-amino-4-phenylsulphonylbenzenesulphonamide (NSD 3004): a new sulphonamide with anticonvulsant and carbonic anhydrase inhibitory properties.
Topics: Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Diuresis; Electroshock; Enzyme Activation; | 1971 |
Treatment of common uncomplicated seizure disorders in children.
Topics: Anticonvulsants; Child; Child, Preschool; Humans; Infant; Phenobarbital; Phenytoin; Seizures | 1971 |
Effects of convulsions and anticonvulsants on blood sugar in rabbits.
Topics: Animals; Blood Glucose; Electric Stimulation; Electroshock; Gallamine Triethiodide; Phenobarbital; P | 1965 |
An intensive one-year study of delirium tremens in Copenhagen from August 1, 1961, to July 31, 1962.
Topics: Adult; Aged; Barbiturates; Blood; Blood Glucose; Bromides; Chlorpromazine; Clinical Enzyme Tests; Co | 1965 |
Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms.
Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Male; Mental Disorders; Middle Age | 1966 |
Electro-myographic studies on sheep injected with the N,N-dimethylated tryptamine alkaloids of Phalaris tuberosa.
Topics: Alkaloids; Animals; Barbiturates; Cordotomy; Electric Stimulation; Electromyography; Injections, Int | 1967 |
Effects of antiepileptic drugs on electrically-induced responses of acutely and chronically isolated cerebral cortex of the cat.
Topics: Action Potentials; Animals; Anticonvulsants; Cats; Cerebral Cortex; Denervation; Depression, Chemica | 1968 |
Phenobarbital as prophylaxis for febrile convulsions. A preliminary report.
Topics: Age Factors; Ataxia; Child, Preschool; Dermatitis, Contact; Female; Fever; Humans; Infant; Male; Phe | 1971 |
[Acute death of mice during massive Gamma irradiation. 3].
Topics: Animals; Electrocardiography; Electromyography; Female; Heart Rate; Injections, Intraperitoneal; Mic | 1971 |
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxid | 1967 |
Effect of reserpine on brain levels of 14C-nicotine in relation to nicotine-induced convulsions.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Carbon Isotopes; Chlorpromazine; Dihydroxyphen | 1967 |
Generation of the seizure discharge in thin sections from the guinea pig brain in chloride-free medium in vitro.
Topics: Animals; Chlorides; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; Phenobarbital | 1968 |
A simple method to measure central antinocotinic activity.
Topics: Animals; Atropine; Brain; Female; Infusions, Parenteral; Injections; Male; Methods; Mice; Nicotine; | 1969 |
Dieldrin: studies in a poisoned child.
Topics: Accidents, Home; Adipose Tissue; Autopsy; Blood Proteins; Brain; Child, Preschool; Dieldrin; Electro | 1969 |
Intolerance to diphenylhydantoin in five cases of Vogt-Spielmeyer disease.
Topics: Ataxia; Brain; Humans; L-Lactate Dehydrogenase; Lipidoses; Phenobarbital; Phenytoin; Primidone; Seiz | 1969 |
[Antagonistic action of natural 5,6-hydrogenated Kava pyrones against strychnine poisoning and experimental local tetanus].
Topics: Anesthetics; Animals; Antidotes; Ataxia; Electromyography; Isonicotinic Acids; Male; Mephenesin; Mic | 1969 |
Diagnosis and management of febrile convulsions.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Fever; Humans; Infant; Phenobarbital; Seizures | 1969 |
[Detection and prognosis of the neonatal mal according to the electroclinical study of 150 cases].
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Congenital Abnormalities; Electroencephalography; Ep | 1969 |
High frequency electro-shock seizures and their antagonism during postnatal development in the mouse. II. Effects of phenobarbital sodium, mephobarbital, trimethadione, dimethadione, ethosuximide and acetazolamide.
Topics: Acetazolamide; Age Factors; Animals; Animals, Newborn; Anticonvulsants; Electroshock; Ethosuximide; | 1969 |
Febrile seizures: to treat or not to treat.
Topics: Acute Disease; Age Factors; Anticonvulsants; Child; Child, Preschool; Fever; Humans; Infant; Phenoba | 1970 |
Strychnine antagonistic potency of pyrone compounds of the kavaroot (Piper methysticum Forst.).
Topics: Animals; Mephenesin; Mice; Paralysis; Phenobarbital; Plants, Medicinal; Pyrans; Reflex; Seizures; St | 1970 |
Extreme elevations of cerebrospinal fluid protein. Association with hypernatremic dehydration.
Topics: Blood Proteins; Blood-Brain Barrier; Central Nervous System Diseases; Cerebrospinal Fluid Proteins; | 1970 |
Pharmacologic interactions of albutoin with other anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Drug Synergism; Electroshock; Hydantoins; Male; Mice; Pentylenetetrazole; | 1970 |
Clinical and biochemical-genetic aspects of intermittent branched-chain ketoaciduria. Report of two Scandinavian families.
Topics: Adolescent; Amino Acids; Biochemical Phenomena; Biochemistry; Carbon Isotopes; Child; Child, Prescho | 1970 |
Pharmacology of alkyl and hydroxyalkylpyrazines.
Topics: Animals; Anticonvulsants; Central Nervous System; Glucose; Hypnotics and Sedatives; Imidazoles; Male | 1970 |
Pyridoxine dependency and penicillamine.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kidney Function Tests; Penicillamine; Ph | 1970 |
[Case of tonic seizure].
Topics: Adult; Arm; Benzazepines; Diphenhydramine; Electroencephalography; Epilepsy; Humans; Injections, Int | 1970 |
Anticonvulsant drugs and self-stimulation rates in rats.
Topics: Acetazolamide; Animals; Chlordiazepoxide; Electrodes; Male; Meprobamate; Pentobarbital; Pentylenetet | 1970 |
A study of the excitatory effects of barbiturates.
Topics: Animals; Anticonvulsants; Barbiturates; Chemical Phenomena; Chemistry; Injections, Intravenous; Male | 1970 |
[Anticonvulsant action of imipramine and imitriptyline associated with phenobarbital, phenytoin and diazepam].
Topics: Amitriptyline; Animals; Anticonvulsants; Diazepam; Electroshock; Imipramine; Mice; Pentylenetetrazol | 1970 |
Seizures in infancy due to idiopathic hypoglycemia. Report of a case.
Topics: Fasting; Glucose; Humans; Hypoglycemia; Infant; Male; Phenobarbital; Seizures | 1970 |
[Introduction of mass psychology in animals to pharmacology. 7. Mutural relation in convulsion of El-mice and drugs acting on the central nervous system].
Topics: Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Hydantoins; Imidazoles; Mice; Phenobarbi | 1970 |
Synthesis and anticonvulsant activity of substituted 2-thioquinazolin-4-ones. I. Preliminary studies.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male; Mice; Pentylenetetrazol | 1971 |
Effect of drugs on interictal spikes and after-discharges in experimental epilepsy.
Topics: Animals; Anticonvulsants; Cats; Electroencephalography; Glutethimide; Hippocampus; Hydantoins; Mepro | 1971 |
A hitherto undescribed feature in the anticonvulsant effect of phenobarbital.
Topics: Acetylcholine; Aminobutyrates; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Dopamine; Electrosho | 1971 |
Seizures and fever.
Topics: Acetaminophen; Acidosis, Respiratory; Age Factors; Alkalosis, Respiratory; Aspirin; Brain Diseases; | 1971 |
A comparison of the anticonvulsant properties of 2-diethylaminopento-4-ynoyl-2',6'-xylidide (WY 21745) with lignocaine, phenytoin, phenobarbitone and trimethadione.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Drug Antagonism; Electroshock; Lethal Dose 50; Lidocai | 1971 |
Metabolism and anticonvulsant properties of mephobarbital and phenobarbital in rats.
Topics: Animals; Anticonvulsants; Barbiturates; Brain; Chromatography, Gas; Electroshock; Male; Mephobarbita | 1971 |
Encephalopathy following accidental isoniazid poisoning.
Topics: Brain Chemistry; Brain Diseases; Child, Preschool; Humans; Isoniazid; Male; Phenobarbital; Pyridoxin | 1971 |
[On acute isoniazid poisoning on the basis of 2 successfully treated cases].
Topics: Adult; Alcoholism; Blood Transfusion; Brain; Brain Edema; Gastric Lavage; Glucose; Glutamates; Human | 1967 |
Studies on electrically induced-seizures and their antagonism by anticonvulsants during neonatal development in the mouse.
Topics: Acetazolamide; Animals; Animals, Newborn; Anticonvulsants; Electric Stimulation; Ethosuximide; Mice; | 1967 |
Studies on the anticonvulsant properties of some benzodiazepines. (Chlordiazepoxide, diazepam, oxazepam).
Topics: Action Potentials; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Electroencephalography; Fem | 1967 |
Breath-holding spells in children. Studies of frequency, severity, management.
Topics: Child Behavior Disorders; Child, Preschool; Cyanosis; Female; Humans; Infant; Male; Parent-Child Rel | 1968 |
Pseudolymphoma syndrome. A sensitivity to anticonvulsant drugs.
Topics: Biopsy; Blood Cell Count; Blood Chemical Analysis; Chlordiazepoxide; Drug Hypersensitivity; Female; | 1968 |
Effect of diazepam (Valium) on experimental seizures in unanesthetized cat.
Topics: Animals; Cats; Cerebral Cortex; Coma; Diazepam; Electroencephalography; Light; Pentylenetetrazole; P | 1968 |
Management of prolonged motor seiqure activity in children.
Topics: Child; Child, Preschool; Diazepam; Humans; Infant; Infant, Newborn; Injections, Intravenous; Phenoba | 1968 |
Further studies on chemically induced siezures and their antagonism by anticonvulsants during postnatal development in the mouse.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Mice; Pentylenetetrazole; Phenobarbital; Picrotox | 1968 |
[On the inflence of fluid volume on the efficacy of bemegride, Pentetrazole and picrotoxin in phenobarbital poisoning].
Topics: Animals; Bemegride; Mice; Pentylenetetrazole; Pharmaceutical Vehicles; Phenobarbital; Picrotoxin; Se | 1968 |
Effects of antiepileptic drugs on brain energy reserves during convulsions.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain Chemistry; Cerebral Cortex; Electroshock; Gl | 1969 |
Fever in children in the tropics.
Topics: Anti-Bacterial Agents; Aspirin; Child; Child, Preschool; Chloroquine; Fever; Humans; Hypothermia; Ph | 1969 |
Acute chlordane poisoning. Clinical and chemical studies.
Topics: Adipose Tissue; Alkaline Phosphatase; Aspartate Aminotransferases; Body Temperature; Child, Preschoo | 1969 |
The hydrational effect of leptazol and its theoretical connection with glucose deficiency in the haemolysis of rabbit erythrocytes.
Topics: Animals; Barbiturates; Blood Glucose; Brain; Erythrocytes; Glucose; Hemolysis; Malonates; Pentylenet | 1969 |
The influence of lynestrenol on the rate of metabolism of phenobarbital, phenytoin and hexobarbital in mice.
Topics: Animals; Bemegride; Electroshock; Enzyme Induction; Female; Hexobarbital; Lynestrenol; Male; Mice; P | 1969 |
[Therapy of occasional convulsions in children and adolescents].
Topics: Adolescent; Age Factors; Anticonvulsants; Calcium; Child; Humans; Infant, Newborn; Infant, Newborn, | 1969 |
Convulsant action of Ro-4-1778 and its modification by barbiturates and tranquillisers.
Topics: Analgesics; Animals; Chlordiazepoxide; Phenobarbital; Quinolines; Rats; Reserpine; Seizures | 1964 |
[Acute isoniazid poisoning. Points of onset in the macro-organism, symptoms and measures of treatment].
Topics: Amino Acids; Ammonia; Animals; Barbiturates; Biochemical Phenomena; Biochemistry; Blood; Hexobarbita | 1965 |
Effect of diphenylhydantoin and phenobarbital on overt and latent tetany.
Topics: Adolescent; Adult; Aged; Blood; Calcium; Child; Drug Synergism; Female; Humans; Hypocalcemia; Hypopa | 1966 |
Effect of phenobarbital on cortical after-discharge and overt seizure patterns in the cat.
Topics: Animals; Cats; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Electrophysio | 1966 |