phenobarbital has been researched along with Renal Insufficiency in 4 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bromide toxicosis was diagnosed in an 8-year-old Labrador Retriever that had been treated for epilepsy with potassium bromide, at a dosage of 29 mg/kg of body weight/d." | 7.69 | Bromide toxicosis secondary to renal insufficiency in an epileptic dog. ( Linn, K; Nichols, ES; Trepanier, LA, 1996) |
| "Bromide toxicosis was diagnosed in an 8-year-old Labrador Retriever that had been treated for epilepsy with potassium bromide, at a dosage of 29 mg/kg of body weight/d." | 3.69 | Bromide toxicosis secondary to renal insufficiency in an epileptic dog. ( Linn, K; Nichols, ES; Trepanier, LA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wilson, TC | 2 |
| Levy, G | 2 |
| Nichols, ES | 1 |
| Trepanier, LA | 1 |
| Linn, K | 1 |
| Marquardt, ED | 1 |
| Ishisaka, DY | 1 |
| Batra, KK | 1 |
| Chin, B | 1 |
4 other studies available for phenobarbital and Renal Insufficiency
| Article | Year |
|---|---|
Kinetics of drug action in disease states. XLIII: Potentiating effect of L-tryptophan on the hypnotic action of phenobarbital and ethanol in rats.
Topics: Animals; Blood Proteins; Brain; Drug Synergism; Ethanol; Female; Hypnotics and Sedatives; Infusions, | 1994 |
Bromide toxicosis secondary to renal insufficiency in an epileptic dog.
Topics: Animals; Anticonvulsants; Bromides; Creatinine; Diuresis; Dog Diseases; Dogs; Drug Therapy, Combinat | 1996 |
Kinetics of drug action in disease states. 45. Effect of elevated plasma creatinine concentrations on the hypnotic action of phenobarbital in normal rats.
Topics: Animals; Creatinine; Female; Hypnotics and Sedatives; Phenobarbital; Rats; Rats, Inbred Lew; Renal I | 1994 |
Removal of ethosuximide and phenobarbital by peritoneal dialysis in a child.
Topics: Child; Dialysis Solutions; Ethosuximide; Female; Humans; Peritoneal Dialysis; Phenobarbital; Renal I | 1992 |