phenobarbital has been researched along with Psychomotor Agitation in 11 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Psychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Terminal restlessness is a variant of delirium observed in some patients in their last days of life." | 2.40 | Palliative care: an update on "terminal restlessness". ( Burke, AL, 1997) |
| "No further seizures occurred." | 1.30 | The use of phenobarbitone in the management of agitation and seizures at the end of life. ( Kurowska, A; Stirling, LC; Tookman, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, C | 1 |
| Kleinig, P | 1 |
| Bakker, M | 1 |
| Tait, P | 1 |
| Kailainathan, R | 1 |
| Wong, A | 1 |
| Greene, S | 1 |
| Koutsogiannis, Z | 1 |
| DE RAMIREZ DE ARELLANO, MI | 1 |
| ACHALLE, JY | 1 |
| ACHALLE, P | 1 |
| FADEUILHE, A | 1 |
| Gold, JA | 1 |
| Rimal, B | 1 |
| Nolan, A | 1 |
| Nelson, LS | 1 |
| Walther, H | 1 |
| Meyer, FP | 1 |
| Burke, AL | 1 |
| Stirling, LC | 1 |
| Kurowska, A | 1 |
| Tookman, A | 1 |
| Keen, JC | 1 |
| Poindexter, AR | 1 |
| Garza-Treviño, ES | 1 |
| Hollister, LE | 1 |
| Overall, JE | 1 |
| Alexander, WF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phenobarbital and Psychomotor Agitation
| Article | Year |
|---|---|
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed | 2019 |
Palliative care: an update on "terminal restlessness".
Topics: Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Clonazepam; Delirium; Diazepam; Humans; | 1997 |
1 trial available for phenobarbital and Psychomotor Agitation
| Article | Year |
|---|---|
Efficacy of combinations of intramuscular antipsychotics and sedative-hypnotics for control of psychotic agitation.
Topics: Adolescent; Adult; Drug Combinations; Drug Therapy, Combination; Female; Haloperidol; Humans; Inject | 1989 |
8 other studies available for phenobarbital and Psychomotor Agitation
| Article | Year |
|---|---|
Recognition of gamma-hydroxybutyric acid withdrawal: Rapid progression and prolonged symptomatology.
Topics: Adult; Anti-Bacterial Agents; Australia; Baclofen; Benzodiazepines; Diazepam; Humans; Hydroxybutyrat | 2017 |
Effect of metrazol on the electrical excitability of the respiratory center when depressed by phenobarbital.
Topics: Barbital; Barbiturates; Mental Disorders; Pentylenetetrazole; Phenobarbital; Psychomotor Agitation; | 1947 |
[Therapeutic action of a combination of a bromo derivative of hydantoin & phenobarbital in agitation states in the aged & in children].
Topics: Anticonvulsants; Child; Humans; Hydantoins; Mental Disorders; Phenobarbital; Psychomotor Agitation; | 1957 |
A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens.
Topics: Adult; Alcohol Withdrawal Delirium; Cohort Studies; Cross Infection; Diazepam; Dose-Response Relatio | 2007 |
[Effect of phenobarbital on self-ratings of healthy subjects in comparison to the objective impairment of their performance].
Topics: Adult; Cognition; Female; Humans; Male; Personality Inventory; Phenobarbital; Psychomotor Agitation | 1980 |
The use of phenobarbitone in the management of agitation and seizures at the end of life.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Phenobar | 1999 |
Re: The use of phenobarbitone in the management of agitation and seizures at the end of life.
Topics: Humans; Phenobarbital; Psychomotor Agitation; Seizures; Terminal Care | 2000 |
Phenobarbital, propranolol, and aggression.
Topics: Aggression; Anti-Anxiety Agents; Anticonvulsants; Humans; Phenobarbital; Propranolol; Psychomotor Ag | 2000 |