phenobarbital has been researched along with Pruritus in 26 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum bile acid concentrations were followed in 29 patients with cholestasis of pregnancy treated for pruritus with either phenobarbital or cholestyramine." | 7.66 | Effect of cholestyramine and phenobarbital on pruritus and serum bile acid levels in cholestasis of pregnancy. ( Laatikainen, T, 1978) |
| "The itching was relieved in five of the seven cases during the first week of treatment, but after that the symptom tended to reappear." | 5.26 | Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. ( Heikkinen, J; Jänne, O; Mäentausta, O; Ylöstalo, P, 1982) |
| "Phenobarbital was administered to a patient with extrahepatic biliary obstruction who was initially thought to have cholestatic hepatitis." | 5.25 | Effect of phenobarbital in a case of extrahepatic cholestasis. ( Bismuth, H; Dhumeaux, D; Franco, D; Metreau, JM, 1975) |
| "Depending on the underlying disease state resulting in cholestasis, phenobarbital, ursodiol, bile sequestering agents, and opioid antagonists appear to be most effective for treating pruritus related to intrahepatic cholestasis." | 4.84 | Treatment of cholestatic pruritus in children. ( Cies, JJ; Giamalis, JN, 2007) |
| "A comprehensive literature search was conducted in MEDLINE (1966-July 2002) using the following MeSH terms: pregnancy, itching, intrahepatic cholestasis, cholestyramine, ursodeoxycholic acid, and phenobarbital." | 4.81 | Treatment of itching associated with intrahepatic cholestasis of pregnancy. ( Boothby, LA; Jenkins, JK, 2002) |
| "Serum bile acid concentrations were followed in 29 patients with cholestasis of pregnancy treated for pruritus with either phenobarbital or cholestyramine." | 3.66 | Effect of cholestyramine and phenobarbital on pruritus and serum bile acid levels in cholestasis of pregnancy. ( Laatikainen, T, 1978) |
| " Sequential addition of cholestyramine and phenobarbital to his medical regimen, following an initial response to bile drainage, resulted in the disappearance of xanthomas and pruritus, and the restoration of normal serum concentrations of lipids and bile acids." | 3.65 | Immunodeficiency, xanthomas and obstructive liver disease. ( Hanson, RF; Isenberg, JN; Page, AR; Sharp, HL; Williams, GC; Zavoral, J, 1976) |
| " Except for the patients with cholestatic hepatitis, in whom marked cholestasis was virtually the only abnormality in liver biopsy specimens, serum bilirubin and bile acid concentrations were diminished during therapy, the hepatic clearance of sulfobromophthalein and 131-I-rose bengal was variably enhanced, and there was relief from pruritus." | 3.65 | Phenobarbital effects in cholestatic liver diseases. ( Bloomer, JR; Boyer, JL, 1975) |
| "The treatment with ondansetron may also have effects on the pruritus of patients with cholestasis." | 1.32 | [Pathogenesis and treatment of pruritus in patients with cholestasis]. ( Blumenstein, I; Schirrmacher, S; Stein, J, 2003) |
| "Pruritus was a prominent symptom in five." | 1.30 | Nonsyndromic paucity of interlobular bile ducts: clinical and laboratory findings of 10 cases. ( Cağlar, M; Göğüş, S; Gürakan, F; Kale, G; Koçak, N; Yüce, A, 1997) |
| "The itching was relieved in five of the seven cases during the first week of treatment, but after that the symptom tended to reappear." | 1.26 | Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. ( Heikkinen, J; Jänne, O; Mäentausta, O; Ylöstalo, P, 1982) |
| "Phenobarbital was administered to a patient with extrahepatic biliary obstruction who was initially thought to have cholestatic hepatitis." | 1.25 | Effect of phenobarbital in a case of extrahepatic cholestasis. ( Bismuth, H; Dhumeaux, D; Franco, D; Metreau, JM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (69.23) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takeuchi, S | 1 |
| Yasukawa, F | 1 |
| Furue, M | 1 |
| Katz, SI | 1 |
| Jenkins, JK | 1 |
| Boothby, LA | 1 |
| Schirrmacher, S | 1 |
| Blumenstein, I | 1 |
| Stein, J | 1 |
| CATZ, B | 1 |
| Cies, JJ | 1 |
| Giamalis, JN | 1 |
| Gupta, R | 1 |
| Gupta, S | 1 |
| Heikkinen, J | 1 |
| Mäentausta, O | 1 |
| Ylöstalo, P | 1 |
| Jänne, O | 1 |
| Sigl, B | 1 |
| Koçak, N | 1 |
| Gürakan, F | 1 |
| Yüce, A | 1 |
| Cağlar, M | 1 |
| Kale, G | 1 |
| Göğüş, S | 1 |
| Laatikainen, T | 1 |
| Brunner, G | 1 |
| Isenberg, JN | 1 |
| Hanson, RF | 1 |
| Williams, GC | 1 |
| Zavoral, J | 1 |
| Page, AR | 1 |
| Sharp, HL | 1 |
| Metreau, JM | 1 |
| Bismuth, H | 1 |
| Franco, D | 1 |
| Dhumeaux, D | 1 |
| Bloomer, JR | 1 |
| Boyer, JL | 1 |
| Moreno, JA | 1 |
| Kleier, RS | 1 |
| Breneman, DL | 1 |
| Boiko, S | 1 |
| Bachs, L | 1 |
| Parés, A | 1 |
| Elena, M | 1 |
| Piera, C | 1 |
| Rodés, J | 1 |
| Javitt, NB | 1 |
| Shojania, AM | 1 |
| Grewar, D | 1 |
| Gips, CH | 1 |
| Lucey, JF | 1 |
| Stiehl, A | 1 |
| Thaler, MM | 1 |
| Admirand, WH | 1 |
| Ballow, M | 1 |
| Margolis, CZ | 1 |
| Schachtel, B | 1 |
| Hsia, YE | 1 |
| Caroli, J | 1 |
| Nusinovici, V | 1 |
| Amar, AB | 1 |
| Lévy, VG | 1 |
| Espinoza, J | 1 |
| Barnafi, L | 1 |
| Schnaidt, E | 1 |
| Wong, D | 1 |
| Lopapa, AF | 1 |
| Haddad, ZH | 1 |
3 reviews available for phenobarbital and Pruritus
| Article | Year |
|---|---|
Treatment of itching associated with intrahepatic cholestasis of pregnancy.
Topics: Adult; Antipruritics; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Female; Humans; Phenob | 2002 |
Treatment of cholestatic pruritus in children.
Topics: Antipruritics; Child; Cholagogues and Choleretics; Cholestasis, Extrahepatic; Cholestasis, Intrahepa | 2007 |
Cholestatic liver disease and its management.
Topics: Cholestasis, Intrahepatic; Colchicine; Humans; Phenobarbital; Pruritus; Ursodeoxycholic Acid | 1989 |
1 trial available for phenobarbital and Pruritus
| Article | Year |
|---|---|
Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.
Topics: Adult; Cholestasis; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Liver Ci | 1989 |
22 other studies available for phenobarbital and Pruritus
| Article | Year |
|---|---|
Collared mice: a model to assess the effects of scratching.
Topics: Adrenal Cortex Hormones; Animals; Antibodies, Monoclonal; Dermatitis, Contact; Ear; Epidermis; Flow | 2010 |
[Pathogenesis and treatment of pruritus in patients with cholestasis].
Topics: Brain; Cholestasis; Cholestyramine Resin; Dronabinol; Enzyme Induction; Humans; Liver; Narcotic Anta | 2003 |
Additive toxic effects of phenobarbital and itrumil.
Topics: Barbiturates; Humans; Phenobarbital; Pruritus; Thiouracil | 1953 |
Exanthematous allergic drug reactions due to four chemically unrelated drugs.
Topics: Adult; Antibiotics, Antitubercular; Anticonvulsants; Antitubercular Agents; Erythema; Ethambutol; Ex | 2008 |
Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholestasis, Intrahepatic; Cholestyramine Resin; Cholic | 1982 |
[Pathogenesis and therapy of pruritus in pregnancy].
Topics: Animals; Cholestasis, Intrahepatic; Cholestyramine Resin; Female; Histamine H1 Antagonists; Humans; | 1994 |
Nonsyndromic paucity of interlobular bile ducts: clinical and laboratory findings of 10 cases.
Topics: Bile Ducts; Biopsy; Child, Preschool; Cholestasis; Cholestyramine Resin; Consanguinity; Female; Huma | 1997 |
Effect of cholestyramine and phenobarbital on pruritus and serum bile acid levels in cholestasis of pregnancy.
Topics: Adult; Bile Acids and Salts; Chenodeoxycholic Acid; Cholestasis; Cholestyramine Resin; Cholic Acids; | 1978 |
[Therapy of the chronic destructive, non-purulent cholangitis (primary biliary cirrhosis)].
Topics: Azathioprine; Calcium; Cholangitis; Cholestyramine Resin; Clofibrate; Humans; Hypercholesterolemia; | 1976 |
Immunodeficiency, xanthomas and obstructive liver disease.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Child; Cholestyramine Resin; Cholic Acids; Humans; Hype | 1976 |
Effect of phenobarbital in a case of extrahepatic cholestasis.
Topics: Adult; Bile Acids and Salts; Bilirubin; Cholestasis; Diagnosis, Differential; Female; Humans; Phenob | 1975 |
Phenobarbital effects in cholestatic liver diseases.
Topics: Adult; Bile Ducts, Intrahepatic; Bilirubin; Chenodeoxycholic Acid; Child; Child, Preschool; Cholangi | 1975 |
[Use of phenobarbital in the management of pruritus associated with cholestatic jaundice of pregnancy].
Topics: Administration, Oral; Biliary Tract Diseases; Drug Evaluation; Female; Humans; Jaundice; Phenobarbit | 1975 |
Generalized pustulation as a manifestation of the anticonvulsant hypersensitivity syndrome.
Topics: Adult; Carbamazepine; Cross Reactions; Drug Eruptions; Facial Dermatoses; Humans; Male; Middle Aged; | 1991 |
Hypoprothrombinemic hemorrhage due to cholestyramine therapy.
Topics: Bile Duct Diseases; Child, Preschool; Cholestyramine Resin; Female; Hemorrhage; Humans; Hypoprothrom | 1986 |
Reflections on the treatment of itch in primary biliary cirrhosis.
Topics: Adult; Azathioprine; Child, Preschool; Cholangitis; Cholestyramine Resin; Female; Humans; Phenobarbi | 1973 |
Rare diseases, old drug, new knowledge.
Topics: Animals; Bilirubin; Epilepsy; Female; Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1973 |
Effects of phenobarbital on bile salt metabolism in cholestasis due to intrahepatic bile duct hypoplasia.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Bile Ducts, Intrahepatic; B | 1973 |
Progressive familial intrahepatic cholestasis.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Bile Ducts, Intrahepatic; C | 1973 |
[Acholangic cholestatic hepatitis evolving towards xanthomatosis and cirrhosis].
Topics: Bile Ducts; Bilirubin; Biopsy; Blood Proteins; Cholestasis; Female; Glutethimide; Hepatitis; Humans; | 1973 |
The effect of phenobarbital on intrahepatic cholestasis of pregnancy.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Pro | 1974 |
Immediate hypersensitivity reaction to aminophylline. Report of a case with immunologic confirmation by an in vitro procedure.
Topics: Aminophylline; Animals; Antibodies; Antigens; Asthma; Child; Cytoplasmic Granules; Ephedrine; Humans | 1971 |