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phenobarbital and Precancerous Conditions

phenobarbital has been researched along with Precancerous Conditions in 146 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Precancerous Conditions: Pathological conditions that tend eventually to become malignant.

Research Excerpts

ExcerptRelevanceReference
"Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine; subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg body weight for up to 49 weeks."3.68DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. ( Barthel, G; Bursch, W; Schulte-Hermann, R; Timmermann-Trosiener, I, 1990)
"05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas."3.65The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977)
"Cyproterone acetate (CPA) is a synthetic antiandrogenic compound which is widely used in clinic but suspected to be hepatocarcinogenic."1.33Long term phenobarbital administration does not promote the multiplication of hepatocytes replicating after single cyproterone acetate administration. ( Ferry, N; Pichard, V, 2005)
"Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining."1.33Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005)
"Phenobarbital treatment increased the number of CYP2A5-positive centrilobular hepatocytes and the CYP2A5-positive areas were extended into the middle zone in all strains, but periportal hepatocytes remained negative."1.30Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions. ( Bursch, W; Camus-Randon, AM; Grasl-Kraupp, B; Lang, MA; Rossmanith, W; Schulte-Hermann, R; Wastl, UM, 1998)
"Phenobarbital sodium (PB) was administered at dietary levels of 0 (control), 8, 30, 125 and 500 ppm to groups of 20 male F344/DuCrj rats for 104 weeks."1.30Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. ( Fukushima, S; Funae, Y; Hagiwara, A; Ito, N; Masuda, C; Miyata, E; Sano, M; Shirai, T; Tamano, S, 1999)
"The dose-response characteristics of initiation of hepatocarcinogenesis by diethylnitrosamine (DEN) was investigated in the neonatal female rat by means of the quantitative stereologic estimation of altered hepatic foci (AHF) expressing multiple markers."1.29The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats. ( Dragan, YP; Pitot, HC; Xu, YH, 1993)
"Chlordecone (Kepone) has been extensively studied for its toxicity in male production workers who were exposed to large quantities of this organochlorine pesticide."1.28Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence. ( Blanke, RV; Fitzgerald, R; Guzelian, PS; Sirica, AE; Wilkerson, CS; Wu, LL, 1989)
"Phenobarbital (PB) promotes hepatic tumorigenesis when chronically administered to male B6C3F1 mice after initiation with diethylnitrosamine (DENA) at 30 days of age."1.28Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender. ( Klaunig, JE; Weghorst, CM, 1989)
" The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0."1.27Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983)
" A single administration of N-nitrosomorpholine (75 mg/kg, 24 h after partial hepatectomy) was used for initiation and chronic administration of phenobarbital (0."1.27Effects of N-nitrosomorpholine and phenobarbital on UDP-glucuronyltransferase in putative preneoplastic foci of rat liver. ( Bock, KW; Fischer, G; Ulrich, D, 1985)
"Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)."1.27Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986)
"Acetoxime was highly volatile and was not mutagenic in the Ames test under a variety of conditions."1.27Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone. ( Lawson, TA; Markin, RS; Mirvish, SS; Nickols, JG, 1988)
"A phenobarbital-mediated increase in enzyme protein and a concomitant enhancement of the corresponding mRNA was seen in hepatocytes of the centrilobular areas of the liver acinus."1.27Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization. ( Buchmann, A; Friedberg, T; Kunz, W; Peres, G; Schwarz, M; Waxman, DJ, 1987)

Research

Studies (146)

TimeframeStudies, this research(%)All Research%
pre-199065 (44.52)18.7374
1990's56 (38.36)18.2507
2000's19 (13.01)29.6817
2010's6 (4.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shen, T1
Khor, SC1
Zhou, F1
Duan, T1
Xu, YY1
Zheng, YF1
Hsu, S1
DE Stefano, J1
Yang, J1
Xu, LH1
Zhu, XQ1
Taya, S1
Punvittayagul, C1
Inboot, W1
Fukushima, S8
Wongpoomchai, R1
Klaunig, JE6
Gehen, SC1
Wang, Z1
Klein, PJ1
Billington, R1
Solano, ML1
Rocha, NS2
Barbisan, LF2
Franchi, CA1
Spinardi-Barbisan, AL1
de Oliveira, ML1
Salvadori, DM2
Ribeiro, LR2
de Camargo, JL2
Phillips, JM2
Burgoon, LD1
Goodman, JI2
Bishayee, A1
Barnes, KF1
Bhatia, D1
Darvesh, AS1
Carroll, RT1
Kakehashi, A1
Ishii, N1
Shibata, T1
Wei, M2
Okazaki, E1
Tachibana, T1
Wanibuchi, H3
Morimura, K2
Nakae, D3
Konishi, Y6
Tsuda, H6
Takasuka, N1
Imaida, K3
Shirai, T7
Tatematsu, M4
Tsukamoto, T1
Hirose, M4
Furukawa, F2
Bursch, W4
Chabicovsky, M1
Wastl, U1
Grasl-Kraupp, B4
Bukowska, K2
Taper, H3
Schulte-Hermann, R10
Pichard, V1
Ferry, N1
Cardani, R1
Zavanella, T1
Numazawa, S1
Shindo, S1
Maruyama, K1
Chibana, F1
Kawahara, Y1
Ashino, T1
Tanaka, S1
Yoshida, T2
Shahjahan, M1
Vani, G1
Shyamaladevi, CS1
Hokaiwado, N1
Asamoto, M2
Ogawa, K2
Kitano, M1
Wada, J1
Ariki, Y1
Kato, M1
Hidaka, T1
Hosoe, K1
Yamamoto, Y1
Negishi, M1
Maronpot, RR2
Chakraborty, T1
Swamy, AH1
Chatterjee, A1
Rana, B1
Shyamsundar, A1
Chatterjee, M2
Kitagawa, T3
Imai, F1
Sato, K3
Moore, MA2
Hacker, HJ1
Kunz, HW2
Bannasch, P1
Pereira, MA2
Herren-Freund, SL2
Britt, AL1
Khoury, MM1
DeAngelo, AB2
Garrett, CT2
Queral, AE2
Ohde, G1
Schuppler, J3
Timmermann-Trosiener, I5
Tennekes, HA1
Port, RE1
Schwartz, M1
Lorke, D1
Schaude, G2
Kaneko, A2
Dempo, K2
Kaku, T2
Yokoyama, S1
Satoh, M1
Mori, M2
Onoé, T2
Skach, M1
Liska, K1
Roome, N1
Williams, GM2
Furuya, K1
Taper, HS1
Lans, M3
de Gerlache, J3
Fort, L1
Roberfroid, M2
Kurata, Y2
Ito, N15
Nakanishi, K3
Kunz, W3
Schwarz, M5
Tennekes, H1
Lindahl, R1
Jenke, HS1
Deml, E1
Oesterle, D1
Deguchi, T1
Pitot, HC16
Sherman, CD1
Portier, CJ1
Simile, MM2
Pascale, R4
De Miglio, MR1
Nufris, A1
Daino, L4
Seddaiu, MA2
Gaspa, L2
Feo, F5
Hammerl, R1
Kirchner, T1
Neumann, HG1
Tamano, S2
Merlino, GT1
Ward, JM2
Chen, ZY2
Eaton, DL2
Shimo, T1
Mitsumori, K1
Onodera, H1
Yasuhara, K1
Kitaura, K1
Takahashi, M2
Kanno, J1
Hayashi, Y2
Jirtle, RL1
Hankins, GR1
Reisenbichler, H1
Boyer, IJ1
Hasegawa, R6
Mizoguchi, Y1
Futakuchi, M1
Kim, DJ3
Cui, L1
Dragan, YP3
Xu, YH4
Leibold, E1
Schwarz, LR1
Nomura, M1
Nakachiyama, M1
Hida, T1
Ohtaki, Y1
Sudo, K1
Aizawa, T1
Aburada, M1
Miyamoto, KI1
Neveu, MJ2
Hully, JR2
Babcock, KL1
Hertzberg, EL1
Nicholson, BJ1
Paul, DL2
Zalatnai, A1
Lapis, K1
Peterson, J1
Tang, Q1
Denda, A5
Tsujiuchi, T4
Tsutsumi, M4
Amanuma, T3
Murata, Y1
Maruyama, H4
Kolaja, KL3
Stevenson, DE3
Walborg, EF3
Wada, S3
Kato, T2
Mutai, M2
Ozaki, K2
Yamaguchi, S4
Baba-Toriyama, H1
Chaumontet, C1
Suschetet, M1
Honikman-Leban, E1
Krutovskikh, VA1
Berges, R1
Le Bon, AM1
Heberden, C1
Shahin, MM1
Yamasaki, H1
Martel, P1
Matsumoto, N1
Kohri, T1
Okushio, K1
Hara, Y1
Sugie, S1
Okamoto, K1
Makita, H1
Ohnishi, M1
Kawamori, T1
Watanabe, T1
Tanaka, T1
Mori, H1
Wastl, UM1
Rossmanith, W1
Lang, MA1
Camus-Randon, AM1
Lee, KK1
Hong, JT1
Spinardi, AL1
Kaneno, R1
Rodrigues, MA1
Ha, TG1
Jang, JJ2
Kim, SG1
Kim, ND1
Hagiwara, A1
Miyata, E1
Sano, M1
Masuda, C1
Funae, Y1
Löw-Baselli, A2
Hufnagl, K1
Parzefall, W1
Finnberg, N1
Stenius, U1
Högberg, J1
Sanders, S1
Thorgeirsson, SS1
Moennikes, O1
Buchmann, A4
Romualdi, A1
Ott, T1
Werringloer, J1
Willecke, K1
Shepherd, AG1
Manson, MM1
Ball, HW1
McLellan, LI1
Huber, WW1
Käfer, M1
Basak, R1
Carrillo, MC1
Favre, C1
Carnovale, CE1
Monti, JA1
Alvarez, ML1
Scapini, C1
Pisani, GB1
Lugano, MC1
Pugh, TD1
Goldfarb, S1
Hirakawa, T1
Ishikawa, T1
Nemoto, N1
Takayama, S1
Murasaki, G2
Miyata, Y1
Sugano, H1
Watanabe, K1
Chisaka, N1
Enomoto, K1
Canuto, RA1
Garcea, R4
Brossa, O1
Caselli, GC1
Uwagawa, S1
Hakoi, K1
Aoki, T2
Farin, F1
Omiecinski, CJ1
Takashima, Y1
Yoshiji, H2
Armato, U1
Testolin, L1
Menegazzi, M1
Menapace, L1
Ribecco, M1
Carcereri dePrati, A1
Miwa, M1
Suzuki, H1
Kinugasa, T1
Matsuzaki, M1
Tsujii, T1
Gerbracht, U1
Kraus, P1
Putz, B1
Reinacher, M1
Dong, JM1
Kilianska, Z1
Fukuda, K1
Chiu, JF1
Lechner, MC2
Barroso, M2
Decloitre, F2
Lafarge-Frayssinet, C2
Ouldelhkim, M2
Frayssinet, C2
Takahashi, S2
Saeter, G1
Seglen, PO1
Campbell, HA1
Sattler, GL1
Hendrich, S4
Maronpot, R2
Kitazawa, S1
Hasegawa, K1
Tamura, K1
Jack, EM1
Stäubli, W1
Waechter, F1
Bentley, P1
Suter, J1
Bieri, F1
Muakkassah-Kelly, SF1
Cruz-Orive, LM1
Kraupp-Grasl, B1
Huber, W1
Xu, YD1
Young, T1
Ding, LA1
Shibata, MA1
Barthel, G1
Yang, YP1
Saito, R1
Chandar, N1
Janosky, JE1
Lombardi, B1
Masuda, A1
Huber, BE1
Wirth, PJ1
Miller, MJ1
Glowinski, IB1
Sirica, AE1
Wilkerson, CS1
Wu, LL1
Fitzgerald, R1
Blanke, RV1
Guzelian, PS1
Goodspeed, D1
Dunn, T1
Moran, S1
Puddu, M1
Frassetto, S2
Cozzolino, P2
Cattley, RC1
Popp, JA2
Mahr, J1
Bauer-Hofmann, R1
Estadella, MD2
Pujol, MJ2
Domingo, J2
Irwin, D1
Hei, TK1
Sudilovsky, O1
Fischer, G1
Ulrich, D1
Bock, KW1
Hosoda, K1
Hirose, K1
Glauert, HP3
Hanigan, M1
Hanigan, MH2
Greaves, P1
Irisarri, E1
Monro, AM1
Préat, V1
Gregg, RG1
Davidson, M1
Wilce, PA1
Leonard, TB1
Adams, T1
Pirisi, L1
Donaera, A1
Peraino, C1
Haugen, DA1
Carnes, BA1
Reilly, CA1
Springer, DL1
Mahlum, DD1
Weghorst, CM1
Thamavit, W1
Ruggiu, ME1
Rizvi, TA1
Kennan, W1
Lynch, P1
Riggs, C1
Toyoda, K1
Yamashita, K1
Sato, S1
Mirvish, SS1
Markin, RS1
Lawson, TA1
Nickols, JG1
Schmitt, R1
Wolf, CR1
Oesch, F1
Peres, G1
Friedberg, T1
Waxman, DJ1
Pickett, CB1
Telakowski-Hopkins, CA1
Ding, GJ1
Ding, VD1
King, RG1
Barbason, H1
Mormont, C1
Massart, S1
Bouzahzah, B1
Deleener, A1
Kirsch-Volders, M1
Timchalk, C1
Charles, AK1
Abraham, R1
Aquino, TM1
Porta, EA1
Sablan, HM1
Dorado, RD1
McLean, AE1
Marshall, A1

Reviews

3 reviews available for phenobarbital and Precancerous Conditions

ArticleYear
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
    Carcinogenesis; a comprehensive survey, 1982, Volume: 7

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do

1982
Cell biology of hepatocarcinogenesis.
    Critical reviews in oncogenesis, 1990, Volume: 1, Issue:4

    Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N

1990
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
    Cancer letters, 1985, Volume: 29, Issue:1

    Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros

1985

Other Studies

143 other studies available for phenobarbital and Precancerous Conditions

ArticleYear
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
    Anticancer research, 2014, Volume: 34, Issue:2

    Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver;

2014
Cleistocalyx nervosum extract ameliorates chemical-induced oxidative stress in early stages of rat hepatocarcinogenesis.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:6

    Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Diethylnitrosamine; Immunoenzyme Techniqu

2014
Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: Adenoma, Liver Cell; Allyl Compounds; Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transform

2015
Alternative Multiorgan Initiation-Promotion Assay for Chemical Carcinogenesis in the Wistar Rat.
    Toxicologic pathology, 2016, Volume: 44, Issue:8

    Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Carcinogenicity Tes

2016
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
    Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 110, Issue:2

    Topics: Animals; Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; D

2009
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:6

    Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose

2010
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 119, Issue:1

    Topics: Animals; Cell Proliferation; Diethylnitrosamine; Glutathione S-Transferase pi; Immunohistochemistry;

2011
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
    Cancer letters, 2003, Feb-28, Volume: 191, Issue:1

    Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism

2003
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
    Toxicological sciences : an official journal of the Society of Toxicology, 2005, Volume: 85, Issue:1

    Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethyl

2005
Long term phenobarbital administration does not promote the multiplication of hepatocytes replicating after single cyproterone acetate administration.
    Life sciences, 2005, May-13, Volume: 76, Issue:26

    Topics: Androgen Antagonists; Animals; Animals, Genetically Modified; beta-Galactosidase; Carcinogens; Cell

2005
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
    Histology and histopathology, 2005, Volume: 20, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm

2005
Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital.
    FEBS letters, 2005, Jul-04, Volume: 579, Issue:17

    Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Constitutive Androstane Receptor; Cytochrome

2005
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
    Chemico-biological interactions, 2005, Oct-20, Volume: 156, Issue:2-3

    Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Di

2005
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
    Toxicologic pathology, 2005, Volume: 33, Issue:6

    Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Con

2005
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis.
    Cancer science, 2006, Volume: 97, Issue:6

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Glutathione S-Transferase pi; Hepat

2006
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 96, Issue:1

    Topics: Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplastic; Constitutive Androstane

2007
Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats.
    Journal of cellular biochemistry, 2007, May-01, Volume: 101, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic;

2007
Re-elevation of gamma-glutamyl transpeptidase activity in periportal hepatocytes of rats with age.
    Gan, 1980, Volume: 71, Issue:3

    Topics: Aging; Animals; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous

1980
Enhancement of NNM-induced carcinogenesis in the rat liver by phenobarbital: a combined morphological and enzyme histochemical approach.
    Carcinogenesis, 1983, Volume: 4, Issue:4

    Topics: Acyltransferases; Animals; Carcinogens; Cell Transformation, Neoplastic; Drug Synergism; Liver; Live

1983
Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats.
    Journal of the National Cancer Institute, 1984, Volume: 72, Issue:3

    Topics: Animals; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms, E

1984
Inhibition of phenobarbital and dietary choline deficiency promoted preneoplastic lesions in rat liver by environmental contaminant di(2-ethylhexyl)phthalate.
    Cancer letters, 1984, Volume: 23, Issue:3

    Topics: Animals; Choline Deficiency; Diet; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver Neoplasm

1984
Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.
    Cancer research, 1981, Volume: 41, Issue:6

    Topics: Animals; Autoradiography; Cell Division; Cocarcinogenesis; DNA; Female; gamma-Glutamyltransferase; H

1981
Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.
    Environmental health perspectives, 1983, Volume: 50

    Topics: Adenosine Triphosphatases; Animals; Biotransformation; Carcinogens; Cocarcinogenesis; Dieldrin; Dose

1983
Effect of phenobarbital administration on hepatocytes constituting the hyperplastic nodules induced in rat liver by 3'-methyl-4-dimethylaminoazobenzene.
    Cancer research, 1980, Volume: 40, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cytochrome P-450 Enzyme System; Ester

1980
[Toxic-allergic reactions to hydantoinate and its transformation into carcinoma after 30 years].
    Ceskoslovenska stomatologie, 1983, Volume: 83, Issue:6

    Topics: Anticonvulsants; Carcinoma, Squamous Cell; Drug Hypersensitivity; Humans; Hydantoins; Leukoplakia, O

1983
Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver.
    Carcinogenesis, 1984, Volume: 5, Issue:2

    Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Histocytochemistry;

1984
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
    Carcinogenesis, 1984, Volume: 5, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopla

1984
Morphological alterations and DNase deficiency in phenobarbital promotion of N-nitrosomorpholine initiated rat hepatocarcinogenesis.
    Carcinogenesis, 1983, Volume: 4, Issue:2

    Topics: Animals; Carcinogens; Deoxyribonucleases; Drug Synergism; Liver; Liver Neoplasms; Male; Neoplasms, E

1983
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
    Cancer research, 1983, Volume: 43, Issue:7

    Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr

1983
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
    Environmental health perspectives, 1983, Volume: 50

    Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi

1983
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
    Progress in clinical and biological research, 1982, Volume: 114

    Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine

1982
C-raf expression in early rat liver tumorigenesis after promotion with polychlorinated biphenyls or phenobarbital.
    Xenobiotica; the fate of foreign compounds in biological systems, 1994, Volume: 24, Issue:6

    Topics: Animals; Blotting, Northern; Carcinogens; DNA; Female; Gene Expression; Histocytochemistry; Hydrogen

1994
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
    Molecular carcinogenesis, 1995, Volume: 14, Issue:3

    Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltrans

1995
Quantitative analysis of multiple phenotype enzyme-altered foci in rat hepatocarcinogenesis experiments: the multipath/multistage model.
    Carcinogenesis, 1995, Volume: 16, Issue:10

    Topics: Adenosine Triphosphatases; Animals; Carcinogens; Cell Transformation, Neoplastic; Diet; Female; Live

1995
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
    Cancer letters, 1994, Apr-29, Volume: 79, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regul

1994
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation.
    Chemico-biological interactions, 1994, Volume: 93, Issue:1

    Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma

1994
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
    Carcinogenesis, 1994, Volume: 15, Issue:9

    Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi

1994
Association between responsiveness to phenobarbital induction of CYP2B1/2 and 3A1 in rat hepatic hyperplastic nodules and their zonal origin.
    Environmental health perspectives, 1993, Volume: 101 Suppl 5

    Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3

1993
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
    Environmental health perspectives, 1993, Volume: 101 Suppl 5

    Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop

1993
Synergistic effects of phenobarbital and thiourea on proliferative lesions in the rat liver.
    Cancer letters, 1994, Jun-15, Volume: 81, Issue:1

    Topics: Animals; Cell Division; Drug Synergism; Liver; Liver Neoplasms, Experimental; Lung; Male; Nitrosamin

1994
Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital.
    Carcinogenesis, 1994, Volume: 15, Issue:8

    Topics: Animals; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; R

1994
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
    Cancer letters, 1994, Aug-15, Volume: 83, Issue:1-2

    Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male;

1994
The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.
    Carcinogenesis, 1993, Volume: 14, Issue:3

    Topics: Animals; Animals, Newborn; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta

1993
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
    Carcinogenesis, 1993, Volume: 14, Issue:10

    Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Gluta

1993
Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene.
    Cancer letters, 1994, Jan-15, Volume: 76, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Nucleus; Cyclooctanes; Dioxoles; Drugs, Chinese

1994
Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
    Journal of cell science, 1994, Volume: 107 ( Pt 1)

    Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Connexin 26; Connexin 43; Connexins; D

1994
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
    Cancer letters, 1994, Apr-29, Volume: 79, Issue:1

    Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr

1994
Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion.
    Carcinogenesis, 1993, Volume: 14, Issue:7

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Albumins; Animals; Female; Glutathione Transferase; Liver; Liver N

1993
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
    Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:2

    Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Li

1993
The effect of dieldrin and phenobarbital on preneoplastic hepatic lesion growth in male F344 rat and B6C3F1 mouse.
    Progress in clinical and biological research, 1995, Volume: 391

    Topics: Animals; Carcinogens; Dieldrin; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Phenobarbital; Pr

1995
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:3

    Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo

1996
Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis.
    Carcinogenesis, 1996, Volume: 17, Issue:5

    Topics: Animals; Apoptosis; Carcinogens; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Liver Ne

1996
Reversibility of promoter induced hepatic focal lesion growth in mice.
    Carcinogenesis, 1996, Volume: 17, Issue:7

    Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eos

1996
Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication.
    Nutrition and cancer, 1996, Volume: 26, Issue:3

    Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinogens; Cell Line; Cricetinae; Flavanones; Flavon

1996
Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diethylnitrosamine; Drug Screening Assays,

1996
Inhibitory effect of chlorophyllin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
    Japanese journal of cancer research : Gann, 1996, Volume: 87, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Chlorophyllides; Diethylnitrosa

1996
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
    Molecular carcinogenesis, 1998, Volume: 22, Issue:4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP2A6; Cyt

1998
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
    Archives of pharmacal research, 1998, Volume: 21, Issue:4

    Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine;

1998
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
    Japanese journal of cancer research : Gann, 1999, Volume: 90, Issue:1

    Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc

1999
2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
    Chemico-biological interactions, 1999, Jul-01, Volume: 121, Issue:2

    Topics: Aflatoxin B1; Animals; Carcinogenicity Tests; DNA Adducts; DNA, Neoplasm; Enzyme Inhibitors; Glutath

1999
Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1999, Volume: 37, Issue:8

    Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diet; Dose-Respo

1999
Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis.
    Carcinogenesis, 2000, Volume: 21, Issue:1

    Topics: Animals; Cell Division; Cells, Cultured; Cyproterone Acetate; DNA; Glutathione Transferase; Liver; L

2000
Xenobiotics modulate the p53 response to DNA damage in preneoplastic enzyme-altered foci in rat liver; effects of diethylnitrosamine and phenobarbital.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 54, Issue:1

    Topics: Animals; Blotting, Western; Body Weight; Carcinogens; Cell Count; Diethylnitrosamine; DNA Damage; Fe

2000
Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.
    Molecular carcinogenesis, 2000, Volume: 28, Issue:3

    Topics: Animals; Apoptosis; bcl-X Protein; Carcinogens; Cell Transformation, Neoplastic; Crosses, Genetic; G

2000
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synerg

2000
Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.
    Carcinogenesis, 2000, Volume: 21, Issue:10

    Topics: 4-Butyrolactone; Aflatoxin B1; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalyti

2000
Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note.
    Carcinogenesis, 2000, Volume: 21, Issue:10

    Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell Division; DNA; Eating; G

2000
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
    Life sciences, 2000, Dec-01, Volume: 68, Issue:2

    Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera

2000
Involvement of mu class glutathione S-transferase subunit M2 (rGST M2) levels in the initiation and promotion of hepatocellular carcinogenesis in old rats.
    Experimental gerontology, 2001, Volume: 36, Issue:2

    Topics: Aflatoxin B1; Aging; Animals; Carcinogens; Glutathione Transferase; Immunohistochemistry; Liver Neop

2001
The natural history of neoplasia. Newer insights into an old problem.
    The American journal of pathology, 1977, Volume: 89, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet

1977
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
    Cancer research, 1978, Volume: 38, Issue:12

    Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glu

1978
Induction of enzyme-altered islands in rat liver by a single treatment with benzo[a]pyrene after partial hepatectomy.
    Gan, 1979, Volume: 70, Issue:3

    Topics: Adenosine Triphosphatases; Animals; Benzopyrenes; gamma-Glutamyltransferase; Hepatectomy; Liver; Liv

1979
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
    Journal of the National Cancer Institute, 1979, Volume: 63, Issue:6

    Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla

1979
Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.
    Gan, 1978, Volume: 69, Issue:5

    Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms, Expe

1978
Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions.
    Journal of the National Cancer Institute, 1978, Volume: 61, Issue:5

    Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Con

1978
A microsomal butyrylesterase appearing in rat livers during development, regeneration, and carcinogenesis, and after phenobarbital treatment.
    Journal of the National Cancer Institute, 1979, Volume: 62, Issue:6

    Topics: Animals; Butyrates; Carboxylic Ester Hydrolases; Fetus; Isoenzymes; Liver Neoplasms, Experimental; L

1979
Enhancing effect of chemicals on production of hyperplastic liver nodules induced by n-2-fluorenylacetamide in hepatectomized rats.
    Gan, 1978, Volume: 69, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Flavonoids; Fluorenes; Hepatectomy; Liver; Liver Neo

1978
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
    Cancer letters, 1978, Volume: 5, Issue:1

    Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Ethionine; Hyperplasia; Liver Ne

1978
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:11

    Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phtha

1992
Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats.
    Carcinogenesis, 1992, Volume: 13, Issue:4

    Topics: Animals; Cell Division; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; gamma-Glutamyltrans

1992
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
    Carcinogenesis, 1992, Volume: 13, Issue:8

    Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Fu

1992
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
    Biochemical and biophysical research communications, 1992, Feb-14, Volume: 182, Issue:3

    Topics: Animals; Animals, Newborn; Benzamides; Calcium; Cell Cycle; Cell Nucleus; Cells, Cultured; Dimethyln

1992
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
    Cancer letters, 1992, Jun-15, Volume: 64, Issue:2

    Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Merc

1992
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
    British journal of cancer, 1991, Volume: 64, Issue:5

    Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltrans

1991
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
    Teratogenesis, carcinogenesis, and mutagenesis, 1991, Volume: 11, Issue:5

    Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi

1991
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
    Carcinogenesis, 1990, Volume: 11, Issue:4

    Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Fema

1990
The appearance of hepatoma-associated chromosomal non-histone proteins in rat liver after a single dose of 3'-MDAB followed by treatment of phenobarbital.
    Cancer letters, 1990, Jun-15, Volume: 51, Issue:3

    Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cell Nucleus; Chromatin; Chromosomal Proteins, Non-H

1990
Modulation of P-450 IIC7 and IIIA1,2 mRNA in pre-neoplastic liver. Effect of promotion by phenobarbital.
    Biochimica et biophysica acta, 1990, Oct-23, Volume: 1087, Issue:2

    Topics: alpha-Fetoproteins; Alpha-Globulins; Animals; Blotting, Northern; Carcinogens; Cytochrome P-450 Enzy

1990
Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1990, Volume: 11, Issue:6

    Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cytochrome P-450 Enzyme System; DNA; gamma-Glutamylt

1990
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:3

    Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D

1991
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
    Cancer research, 1990, Feb-01, Volume: 50, Issue:3

    Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransfera

1990
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
    Carcinogenesis, 1990, Volume: 11, Issue:2

    Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta

1990
Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.
    Cancer communications, 1990, Volume: 2, Issue:1

    Topics: Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Connexins; Diethylnitrosamine; Ethylnitrosou

1990
Enhanced preneoplastic liver lesion development under 'selection pressure' conditions after administration of deoxycholic or lithocholic acid in the initiation phase in rats.
    Carcinogenesis, 1990, Volume: 11, Issue:8

    Topics: Animals; Body Weight; Deoxycholic Acid; gamma-Glutamyltransferase; Glutathione Transferase; Lithocho

1990
Ultrastructural changes in chemically induced preneoplastic focal lesions in the rat liver: a stereological study.
    Carcinogenesis, 1990, Volume: 11, Issue:9

    Topics: Animals; Animals, Newborn; Biomarkers, Tumor; Diethylnitrosamine; Female; gamma-Glutamyltransferase;

1990
Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously.
    Cancer research, 1991, Jan-15, Volume: 51, Issue:2

    Topics: Aging; Animals; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Phenobarbital; P

1991
The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.
    Carcinogenesis, 1991, Volume: 12, Issue:6

    Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Exper

1991
[Inhibition effect of epicatechin on phenobarbitol-induced proliferation precancerous liver cells].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 1990, Volume: 19, Issue:4

    Topics: Animals; Catechin; Diethylnitrosamine; Flavonoids; Liver Neoplasms; Male; Phenobarbital; Precancerou

1990
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
    Cancer letters, 1990, Volume: 49, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase;

1990
Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model.
    Carcinogenesis, 1990, Volume: 11, Issue:6

    Topics: Animals; Carcinogens; Hyperplasia; Male; Neoplasms, Experimental; Nitrosamines; Organ Specificity; P

1990
DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.
    Cancer research, 1990, Aug-15, Volume: 50, Issue:16

    Topics: Animals; Body Weight; Carcinogens; Cell Division; DNA Replication; Female; Liver; Liver Neoplasms; N

1990
[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 1990, Volume: 19, Issue:1

    Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diethylnitrosamine; Female; Gene Expression; Immuno

1990
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:2

    Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diet; Liver; Liver Neoplasms, Experiment

1990
Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens.
    Cancer letters, 1986, Volume: 32, Issue:1

    Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Hepatectomy; Hexachlorocyclohexane; Liver

1986
Comparison of gene expression in preneoplastic and neoplastic rat liver to adult, fetal, regenerating, and tumor-promoted liver.
    Cancer research, 1988, May-01, Volume: 48, Issue:9

    Topics: Animals; Fetus; In Vitro Techniques; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male;

1988
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence.
    Carcinogenesis, 1989, Volume: 10, Issue:6

    Topics: Animals; Chlordecone; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Hepatectomy; Insecticid

1989
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
    Toxicology and applied pharmacology, 1989, Volume: 97, Issue:1

    Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltrans

1989
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.
    Cancer research, 1989, Apr-01, Volume: 49, Issue:7

    Topics: Adenosine; Animals; Deoxyadenosines; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental;

1989
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.
    Cancer research, 1989, Jun-15, Volume: 49, Issue:12

    Topics: Adenosine Triphosphatases; Animals; Anticholesteremic Agents; Carcinogens; Diethylnitrosamine; gamma

1989
Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse.
    Molecular carcinogenesis, 1989, Volume: 2, Issue:3

    Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Genes, ras; Liver; Liver Neoplasms; Male; Mice; M

1989
Cell phenotype instability in preneoplastic foci of rat liver.
    Carcinogenesis, 1988, Volume: 9, Issue:4

    Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Live

1988
Phosphorylation of specific rat plasma membrane proteins during promotion of gamma-glutamyl transpeptidase-positive hepatic foci and inhibition by di(2-ethylhexyl)phthalate.
    Cancer research, 1985, Volume: 45, Issue:6

    Topics: Animals; Chlorine; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experi

1985
Effects of a high-sucrose diet on the development of enzyme-altered foci in chemical hepatocarcinogenesis in rats.
    Cancer research, 1985, Volume: 45, Issue:6

    Topics: Animals; Body Weight; Cocarcinogenesis; Dietary Carbohydrates; DNA; Female; gamma-Glutamyltransferas

1985
Effects of N-nitrosomorpholine and phenobarbital on UDP-glucuronyltransferase in putative preneoplastic foci of rat liver.
    Carcinogenesis, 1985, Volume: 6, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Aryl Hydrocarbon Hydroxylases; gamma-Glutamyltransferase; Glucur

1985
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
    Cancer letters, 1985, Volume: 27, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima

1985
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
    Cancer letters, 1985, Sep-15, Volume: 28, Issue:2

    Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex

1985
Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver.
    Journal of the National Cancer Institute, 1985, Volume: 75, Issue:6

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Separation; Cytochrome P-450 Enzyme System; Diethylnitr

1985
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
    Journal of the National Cancer Institute, 1986, Volume: 76, Issue:3

    Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De

1986
Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis.
    Carcinogenesis, 1986, Volume: 7, Issue:6

    Topics: Animals; Butylated Hydroxytoluene; Cocarcinogenesis; DDT; gamma-Glutamyltransferase; Liver Neoplasms

1986
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
    The International journal of biochemistry, 1986, Volume: 18, Issue:4

    Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxym

1986
Facilitated expression of adaptive responses to phenobarbital in putative pre-stages of liver cancer.
    Carcinogenesis, 1986, Volume: 7, Issue:10

    Topics: Adaptation, Physiological; Animals; Cytochrome P-450 Enzyme System; DNA; Female; gamma-Glutamyltrans

1986
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
    Carcinogenesis, 1986, Volume: 7, Issue:11

    Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; ga

1986
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
    Toxicologic pathology, 1987, Volume: 15, Issue:1

    Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma

1987
Phenotypically selective promotion of diethylnitrosamine-initiated altered hepatocyte foci by dietary phenobarbital or a topically applied coal-derived organic mixture in male and female rats.
    Cancer letters, 1987, Oct-30, Volume: 37, Issue:2

    Topics: Administration, Topical; Animals; Coal; Cocarcinogenesis; Female; gamma-Glutamyltransferase; Iron; L

1987
Dietary effects on initiation and promotion of hepatocarcinogenesis in rat.
    Journal of cancer research and clinical oncology, 1988, Volume: 114, Issue:2

    Topics: Animals; Body Weight; Diet; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental;

1988
Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender.
    Carcinogenesis, 1989, Volume: 10, Issue:3

    Topics: Animals; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital;

1989
The influence of subsequent dehydroepiandrosterone, diaminopropane, phenobarbital, butylated hydroxyanisole and butylated hydroxytoluene treatment on the development of preneoplastic and neoplastic lesions in the rat initiated with di-hydroxy-di-n-propyl
    Cancer letters, 1986, Volume: 30, Issue:2

    Topics: Animals; Anisoles; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogens; Dehydroepiandros

1986
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
    Toxicologic pathology, 1987, Volume: 15, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo

1987
The effects of dose and duration of administration on the promotion index of phenobarbital in multistage hepatocarcinogenesis in the rat.
    APMIS. Supplementum, 1988, Volume: 2

    Topics: Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; L

1988
Rapid development of hepatocellular neoplasms in aging male C3H/HeNCr mice given phenobarbital.
    Cancer letters, 1988, Volume: 39, Issue:1

    Topics: Age Factors; Animals; Carcinogens; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Phen

1988
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats.
    Carcinogenesis, 1988, Volume: 9, Issue:5

    Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Ne

1988
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
    Cell biology international reports, 1988, Volume: 12, Issue:3

    Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neopl

1988
Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone.
    Cancer letters, 1988, Aug-15, Volume: 41, Issue:2

    Topics: Animals; Carcinogens; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nitrosamines; Oxazolidin

1988
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
    Cancer research, 1987, Jun-01, Volume: 47, Issue:11

    Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver

1987
Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization.
    Carcinogenesis, 1987, Volume: 8, Issue:9

    Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Histocytochemistry; Liver Neoplas

1987
Expression of genes encoding glutathione S-transferases in normal and preneoplastic liver.
    Biochemical Society transactions, 1987, Volume: 15, Issue:4

    Topics: Animals; Gene Expression Regulation; Glutathione Transferase; Liver; Liver Neoplasms; Methylcholanth

1987
The phenotypic stability of altered hepatic foci: effects of withdrawal and subsequent readministration of phenobarbital.
    Carcinogenesis, 1986, Volume: 7, Issue:12

    Topics: Animals; Diet; Edible Grain; Female; Liver Neoplasms, Experimental; Phenobarbital; Phenotype; Precan

1986
Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.
    European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:9

    Topics: Animals; Diethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mitotic Index;

1986
Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Female; Liver; Liver Transplantation; Male; Phenobarbit

1985
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
    Cancer genetics and cytogenetics, 1985, Volume: 17, Issue:2

    Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti

1985
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 180, Issue:2

    Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; In

1985
Effects of selenium supplementation on hepatocarcinogenesis in rats.
    Nutrition and cancer, 1985, Volume: 7, Issue:1-2

    Topics: Animals; Body Weight; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Org

1985
Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone.
    British journal of experimental pathology, 1971, Volume: 52, Issue:3

    Topics: Aflatoxins; Animals; Biotransformation; Body Weight; Carcinogens; Enzyme Induction; Liver; Liver Neo

1971