phenobarbital has been researched along with Precancerous Conditions in 146 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Precancerous Conditions: Pathological conditions that tend eventually to become malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine; subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg body weight for up to 49 weeks." | 3.68 | DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. ( Barthel, G; Bursch, W; Schulte-Hermann, R; Timmermann-Trosiener, I, 1990) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Cyproterone acetate (CPA) is a synthetic antiandrogenic compound which is widely used in clinic but suspected to be hepatocarcinogenic." | 1.33 | Long term phenobarbital administration does not promote the multiplication of hepatocytes replicating after single cyproterone acetate administration. ( Ferry, N; Pichard, V, 2005) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "Phenobarbital treatment increased the number of CYP2A5-positive centrilobular hepatocytes and the CYP2A5-positive areas were extended into the middle zone in all strains, but periportal hepatocytes remained negative." | 1.30 | Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions. ( Bursch, W; Camus-Randon, AM; Grasl-Kraupp, B; Lang, MA; Rossmanith, W; Schulte-Hermann, R; Wastl, UM, 1998) |
| "Phenobarbital sodium (PB) was administered at dietary levels of 0 (control), 8, 30, 125 and 500 ppm to groups of 20 male F344/DuCrj rats for 104 weeks." | 1.30 | Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. ( Fukushima, S; Funae, Y; Hagiwara, A; Ito, N; Masuda, C; Miyata, E; Sano, M; Shirai, T; Tamano, S, 1999) |
| "The dose-response characteristics of initiation of hepatocarcinogenesis by diethylnitrosamine (DEN) was investigated in the neonatal female rat by means of the quantitative stereologic estimation of altered hepatic foci (AHF) expressing multiple markers." | 1.29 | The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats. ( Dragan, YP; Pitot, HC; Xu, YH, 1993) |
| "Chlordecone (Kepone) has been extensively studied for its toxicity in male production workers who were exposed to large quantities of this organochlorine pesticide." | 1.28 | Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence. ( Blanke, RV; Fitzgerald, R; Guzelian, PS; Sirica, AE; Wilkerson, CS; Wu, LL, 1989) |
| "Phenobarbital (PB) promotes hepatic tumorigenesis when chronically administered to male B6C3F1 mice after initiation with diethylnitrosamine (DENA) at 30 days of age." | 1.28 | Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender. ( Klaunig, JE; Weghorst, CM, 1989) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " A single administration of N-nitrosomorpholine (75 mg/kg, 24 h after partial hepatectomy) was used for initiation and chronic administration of phenobarbital (0." | 1.27 | Effects of N-nitrosomorpholine and phenobarbital on UDP-glucuronyltransferase in putative preneoplastic foci of rat liver. ( Bock, KW; Fischer, G; Ulrich, D, 1985) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| "Acetoxime was highly volatile and was not mutagenic in the Ames test under a variety of conditions." | 1.27 | Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone. ( Lawson, TA; Markin, RS; Mirvish, SS; Nickols, JG, 1988) |
| "A phenobarbital-mediated increase in enzyme protein and a concomitant enhancement of the corresponding mRNA was seen in hepatocytes of the centrilobular areas of the liver acinus." | 1.27 | Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization. ( Buchmann, A; Friedberg, T; Kunz, W; Peres, G; Schwarz, M; Waxman, DJ, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 65 (44.52) | 18.7374 |
| 1990's | 56 (38.36) | 18.2507 |
| 2000's | 19 (13.01) | 29.6817 |
| 2010's | 6 (4.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, T | 1 |
| Khor, SC | 1 |
| Zhou, F | 1 |
| Duan, T | 1 |
| Xu, YY | 1 |
| Zheng, YF | 1 |
| Hsu, S | 1 |
| DE Stefano, J | 1 |
| Yang, J | 1 |
| Xu, LH | 1 |
| Zhu, XQ | 1 |
| Taya, S | 1 |
| Punvittayagul, C | 1 |
| Inboot, W | 1 |
| Fukushima, S | 8 |
| Wongpoomchai, R | 1 |
| Klaunig, JE | 6 |
| Gehen, SC | 1 |
| Wang, Z | 1 |
| Klein, PJ | 1 |
| Billington, R | 1 |
| Solano, ML | 1 |
| Rocha, NS | 2 |
| Barbisan, LF | 2 |
| Franchi, CA | 1 |
| Spinardi-Barbisan, AL | 1 |
| de Oliveira, ML | 1 |
| Salvadori, DM | 2 |
| Ribeiro, LR | 2 |
| de Camargo, JL | 2 |
| Phillips, JM | 2 |
| Burgoon, LD | 1 |
| Goodman, JI | 2 |
| Bishayee, A | 1 |
| Barnes, KF | 1 |
| Bhatia, D | 1 |
| Darvesh, AS | 1 |
| Carroll, RT | 1 |
| Kakehashi, A | 1 |
| Ishii, N | 1 |
| Shibata, T | 1 |
| Wei, M | 2 |
| Okazaki, E | 1 |
| Tachibana, T | 1 |
| Wanibuchi, H | 3 |
| Morimura, K | 2 |
| Nakae, D | 3 |
| Konishi, Y | 6 |
| Tsuda, H | 6 |
| Takasuka, N | 1 |
| Imaida, K | 3 |
| Shirai, T | 7 |
| Tatematsu, M | 4 |
| Tsukamoto, T | 1 |
| Hirose, M | 4 |
| Furukawa, F | 2 |
| Bursch, W | 4 |
| Chabicovsky, M | 1 |
| Wastl, U | 1 |
| Grasl-Kraupp, B | 4 |
| Bukowska, K | 2 |
| Taper, H | 3 |
| Schulte-Hermann, R | 10 |
| Pichard, V | 1 |
| Ferry, N | 1 |
| Cardani, R | 1 |
| Zavanella, T | 1 |
| Numazawa, S | 1 |
| Shindo, S | 1 |
| Maruyama, K | 1 |
| Chibana, F | 1 |
| Kawahara, Y | 1 |
| Ashino, T | 1 |
| Tanaka, S | 1 |
| Yoshida, T | 2 |
| Shahjahan, M | 1 |
| Vani, G | 1 |
| Shyamaladevi, CS | 1 |
| Hokaiwado, N | 1 |
| Asamoto, M | 2 |
| Ogawa, K | 2 |
| Kitano, M | 1 |
| Wada, J | 1 |
| Ariki, Y | 1 |
| Kato, M | 1 |
| Hidaka, T | 1 |
| Hosoe, K | 1 |
| Yamamoto, Y | 1 |
| Negishi, M | 1 |
| Maronpot, RR | 2 |
| Chakraborty, T | 1 |
| Swamy, AH | 1 |
| Chatterjee, A | 1 |
| Rana, B | 1 |
| Shyamsundar, A | 1 |
| Chatterjee, M | 2 |
| Kitagawa, T | 3 |
| Imai, F | 1 |
| Sato, K | 3 |
| Moore, MA | 2 |
| Hacker, HJ | 1 |
| Kunz, HW | 2 |
| Bannasch, P | 1 |
| Pereira, MA | 2 |
| Herren-Freund, SL | 2 |
| Britt, AL | 1 |
| Khoury, MM | 1 |
| DeAngelo, AB | 2 |
| Garrett, CT | 2 |
| Queral, AE | 2 |
| Ohde, G | 1 |
| Schuppler, J | 3 |
| Timmermann-Trosiener, I | 5 |
| Tennekes, HA | 1 |
| Port, RE | 1 |
| Schwartz, M | 1 |
| Lorke, D | 1 |
| Schaude, G | 2 |
| Kaneko, A | 2 |
| Dempo, K | 2 |
| Kaku, T | 2 |
| Yokoyama, S | 1 |
| Satoh, M | 1 |
| Mori, M | 2 |
| Onoé, T | 2 |
| Skach, M | 1 |
| Liska, K | 1 |
| Roome, N | 1 |
| Williams, GM | 2 |
| Furuya, K | 1 |
| Taper, HS | 1 |
| Lans, M | 3 |
| de Gerlache, J | 3 |
| Fort, L | 1 |
| Roberfroid, M | 2 |
| Kurata, Y | 2 |
| Ito, N | 15 |
| Nakanishi, K | 3 |
| Kunz, W | 3 |
| Schwarz, M | 5 |
| Tennekes, H | 1 |
| Lindahl, R | 1 |
| Jenke, HS | 1 |
| Deml, E | 1 |
| Oesterle, D | 1 |
| Deguchi, T | 1 |
| Pitot, HC | 16 |
| Sherman, CD | 1 |
| Portier, CJ | 1 |
| Simile, MM | 2 |
| Pascale, R | 4 |
| De Miglio, MR | 1 |
| Nufris, A | 1 |
| Daino, L | 4 |
| Seddaiu, MA | 2 |
| Gaspa, L | 2 |
| Feo, F | 5 |
| Hammerl, R | 1 |
| Kirchner, T | 1 |
| Neumann, HG | 1 |
| Tamano, S | 2 |
| Merlino, GT | 1 |
| Ward, JM | 2 |
| Chen, ZY | 2 |
| Eaton, DL | 2 |
| Shimo, T | 1 |
| Mitsumori, K | 1 |
| Onodera, H | 1 |
| Yasuhara, K | 1 |
| Kitaura, K | 1 |
| Takahashi, M | 2 |
| Kanno, J | 1 |
| Hayashi, Y | 2 |
| Jirtle, RL | 1 |
| Hankins, GR | 1 |
| Reisenbichler, H | 1 |
| Boyer, IJ | 1 |
| Hasegawa, R | 6 |
| Mizoguchi, Y | 1 |
| Futakuchi, M | 1 |
| Kim, DJ | 3 |
| Cui, L | 1 |
| Dragan, YP | 3 |
| Xu, YH | 4 |
| Leibold, E | 1 |
| Schwarz, LR | 1 |
| Nomura, M | 1 |
| Nakachiyama, M | 1 |
| Hida, T | 1 |
| Ohtaki, Y | 1 |
| Sudo, K | 1 |
| Aizawa, T | 1 |
| Aburada, M | 1 |
| Miyamoto, KI | 1 |
| Neveu, MJ | 2 |
| Hully, JR | 2 |
| Babcock, KL | 1 |
| Hertzberg, EL | 1 |
| Nicholson, BJ | 1 |
| Paul, DL | 2 |
| Zalatnai, A | 1 |
| Lapis, K | 1 |
| Peterson, J | 1 |
| Tang, Q | 1 |
| Denda, A | 5 |
| Tsujiuchi, T | 4 |
| Tsutsumi, M | 4 |
| Amanuma, T | 3 |
| Murata, Y | 1 |
| Maruyama, H | 4 |
| Kolaja, KL | 3 |
| Stevenson, DE | 3 |
| Walborg, EF | 3 |
| Wada, S | 3 |
| Kato, T | 2 |
| Mutai, M | 2 |
| Ozaki, K | 2 |
| Yamaguchi, S | 4 |
| Baba-Toriyama, H | 1 |
| Chaumontet, C | 1 |
| Suschetet, M | 1 |
| Honikman-Leban, E | 1 |
| Krutovskikh, VA | 1 |
| Berges, R | 1 |
| Le Bon, AM | 1 |
| Heberden, C | 1 |
| Shahin, MM | 1 |
| Yamasaki, H | 1 |
| Martel, P | 1 |
| Matsumoto, N | 1 |
| Kohri, T | 1 |
| Okushio, K | 1 |
| Hara, Y | 1 |
| Sugie, S | 1 |
| Okamoto, K | 1 |
| Makita, H | 1 |
| Ohnishi, M | 1 |
| Kawamori, T | 1 |
| Watanabe, T | 1 |
| Tanaka, T | 1 |
| Mori, H | 1 |
| Wastl, UM | 1 |
| Rossmanith, W | 1 |
| Lang, MA | 1 |
| Camus-Randon, AM | 1 |
| Lee, KK | 1 |
| Hong, JT | 1 |
| Spinardi, AL | 1 |
| Kaneno, R | 1 |
| Rodrigues, MA | 1 |
| Ha, TG | 1 |
| Jang, JJ | 2 |
| Kim, SG | 1 |
| Kim, ND | 1 |
| Hagiwara, A | 1 |
| Miyata, E | 1 |
| Sano, M | 1 |
| Masuda, C | 1 |
| Funae, Y | 1 |
| Löw-Baselli, A | 2 |
| Hufnagl, K | 1 |
| Parzefall, W | 1 |
| Finnberg, N | 1 |
| Stenius, U | 1 |
| Högberg, J | 1 |
| Sanders, S | 1 |
| Thorgeirsson, SS | 1 |
| Moennikes, O | 1 |
| Buchmann, A | 4 |
| Romualdi, A | 1 |
| Ott, T | 1 |
| Werringloer, J | 1 |
| Willecke, K | 1 |
| Shepherd, AG | 1 |
| Manson, MM | 1 |
| Ball, HW | 1 |
| McLellan, LI | 1 |
| Huber, WW | 1 |
| Käfer, M | 1 |
| Basak, R | 1 |
| Carrillo, MC | 1 |
| Favre, C | 1 |
| Carnovale, CE | 1 |
| Monti, JA | 1 |
| Alvarez, ML | 1 |
| Scapini, C | 1 |
| Pisani, GB | 1 |
| Lugano, MC | 1 |
| Pugh, TD | 1 |
| Goldfarb, S | 1 |
| Hirakawa, T | 1 |
| Ishikawa, T | 1 |
| Nemoto, N | 1 |
| Takayama, S | 1 |
| Murasaki, G | 2 |
| Miyata, Y | 1 |
| Sugano, H | 1 |
| Watanabe, K | 1 |
| Chisaka, N | 1 |
| Enomoto, K | 1 |
| Canuto, RA | 1 |
| Garcea, R | 4 |
| Brossa, O | 1 |
| Caselli, GC | 1 |
| Uwagawa, S | 1 |
| Hakoi, K | 1 |
| Aoki, T | 2 |
| Farin, F | 1 |
| Omiecinski, CJ | 1 |
| Takashima, Y | 1 |
| Yoshiji, H | 2 |
| Armato, U | 1 |
| Testolin, L | 1 |
| Menegazzi, M | 1 |
| Menapace, L | 1 |
| Ribecco, M | 1 |
| Carcereri dePrati, A | 1 |
| Miwa, M | 1 |
| Suzuki, H | 1 |
| Kinugasa, T | 1 |
| Matsuzaki, M | 1 |
| Tsujii, T | 1 |
| Gerbracht, U | 1 |
| Kraus, P | 1 |
| Putz, B | 1 |
| Reinacher, M | 1 |
| Dong, JM | 1 |
| Kilianska, Z | 1 |
| Fukuda, K | 1 |
| Chiu, JF | 1 |
| Lechner, MC | 2 |
| Barroso, M | 2 |
| Decloitre, F | 2 |
| Lafarge-Frayssinet, C | 2 |
| Ouldelhkim, M | 2 |
| Frayssinet, C | 2 |
| Takahashi, S | 2 |
| Saeter, G | 1 |
| Seglen, PO | 1 |
| Campbell, HA | 1 |
| Sattler, GL | 1 |
| Hendrich, S | 4 |
| Maronpot, R | 2 |
| Kitazawa, S | 1 |
| Hasegawa, K | 1 |
| Tamura, K | 1 |
| Jack, EM | 1 |
| Stäubli, W | 1 |
| Waechter, F | 1 |
| Bentley, P | 1 |
| Suter, J | 1 |
| Bieri, F | 1 |
| Muakkassah-Kelly, SF | 1 |
| Cruz-Orive, LM | 1 |
| Kraupp-Grasl, B | 1 |
| Huber, W | 1 |
| Xu, YD | 1 |
| Young, T | 1 |
| Ding, LA | 1 |
| Shibata, MA | 1 |
| Barthel, G | 1 |
| Yang, YP | 1 |
| Saito, R | 1 |
| Chandar, N | 1 |
| Janosky, JE | 1 |
| Lombardi, B | 1 |
| Masuda, A | 1 |
| Huber, BE | 1 |
| Wirth, PJ | 1 |
| Miller, MJ | 1 |
| Glowinski, IB | 1 |
| Sirica, AE | 1 |
| Wilkerson, CS | 1 |
| Wu, LL | 1 |
| Fitzgerald, R | 1 |
| Blanke, RV | 1 |
| Guzelian, PS | 1 |
| Goodspeed, D | 1 |
| Dunn, T | 1 |
| Moran, S | 1 |
| Puddu, M | 1 |
| Frassetto, S | 2 |
| Cozzolino, P | 2 |
| Cattley, RC | 1 |
| Popp, JA | 2 |
| Mahr, J | 1 |
| Bauer-Hofmann, R | 1 |
| Estadella, MD | 2 |
| Pujol, MJ | 2 |
| Domingo, J | 2 |
| Irwin, D | 1 |
| Hei, TK | 1 |
| Sudilovsky, O | 1 |
| Fischer, G | 1 |
| Ulrich, D | 1 |
| Bock, KW | 1 |
| Hosoda, K | 1 |
| Hirose, K | 1 |
| Glauert, HP | 3 |
| Hanigan, M | 1 |
| Hanigan, MH | 2 |
| Greaves, P | 1 |
| Irisarri, E | 1 |
| Monro, AM | 1 |
| Préat, V | 1 |
| Gregg, RG | 1 |
| Davidson, M | 1 |
| Wilce, PA | 1 |
| Leonard, TB | 1 |
| Adams, T | 1 |
| Pirisi, L | 1 |
| Donaera, A | 1 |
| Peraino, C | 1 |
| Haugen, DA | 1 |
| Carnes, BA | 1 |
| Reilly, CA | 1 |
| Springer, DL | 1 |
| Mahlum, DD | 1 |
| Weghorst, CM | 1 |
| Thamavit, W | 1 |
| Ruggiu, ME | 1 |
| Rizvi, TA | 1 |
| Kennan, W | 1 |
| Lynch, P | 1 |
| Riggs, C | 1 |
| Toyoda, K | 1 |
| Yamashita, K | 1 |
| Sato, S | 1 |
| Mirvish, SS | 1 |
| Markin, RS | 1 |
| Lawson, TA | 1 |
| Nickols, JG | 1 |
| Schmitt, R | 1 |
| Wolf, CR | 1 |
| Oesch, F | 1 |
| Peres, G | 1 |
| Friedberg, T | 1 |
| Waxman, DJ | 1 |
| Pickett, CB | 1 |
| Telakowski-Hopkins, CA | 1 |
| Ding, GJ | 1 |
| Ding, VD | 1 |
| King, RG | 1 |
| Barbason, H | 1 |
| Mormont, C | 1 |
| Massart, S | 1 |
| Bouzahzah, B | 1 |
| Deleener, A | 1 |
| Kirsch-Volders, M | 1 |
| Timchalk, C | 1 |
| Charles, AK | 1 |
| Abraham, R | 1 |
| Aquino, TM | 1 |
| Porta, EA | 1 |
| Sablan, HM | 1 |
| Dorado, RD | 1 |
| McLean, AE | 1 |
| Marshall, A | 1 |
3 reviews available for phenobarbital and Precancerous Conditions
| Article | Year |
|---|---|
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
143 other studies available for phenobarbital and Precancerous Conditions
| Article | Year |
|---|---|
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver; | 2014 |
Cleistocalyx nervosum extract ameliorates chemical-induced oxidative stress in early stages of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Diethylnitrosamine; Immunoenzyme Techniqu | 2014 |
Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.
Topics: Adenoma, Liver Cell; Allyl Compounds; Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transform | 2015 |
Alternative Multiorgan Initiation-Promotion Assay for Chemical Carcinogenesis in the Wistar Rat.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biological Assay; Carcinogenicity Tes | 2016 |
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Topics: Animals; Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; D | 2009 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Glutathione S-Transferase pi; Immunohistochemistry; | 2011 |
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism | 2003 |
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethyl | 2005 |
Long term phenobarbital administration does not promote the multiplication of hepatocytes replicating after single cyproterone acetate administration.
Topics: Androgen Antagonists; Animals; Animals, Genetically Modified; beta-Galactosidase; Carcinogens; Cell | 2005 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital.
Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Constitutive Androstane Receptor; Cytochrome | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Di | 2005 |
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Con | 2005 |
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Glutathione S-Transferase pi; Hepat | 2006 |
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
Topics: Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplastic; Constitutive Androstane | 2007 |
Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; | 2007 |
Re-elevation of gamma-glutamyl transpeptidase activity in periportal hepatocytes of rats with age.
Topics: Aging; Animals; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous | 1980 |
Enhancement of NNM-induced carcinogenesis in the rat liver by phenobarbital: a combined morphological and enzyme histochemical approach.
Topics: Acyltransferases; Animals; Carcinogens; Cell Transformation, Neoplastic; Drug Synergism; Liver; Live | 1983 |
Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats.
Topics: Animals; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms, E | 1984 |
Inhibition of phenobarbital and dietary choline deficiency promoted preneoplastic lesions in rat liver by environmental contaminant di(2-ethylhexyl)phthalate.
Topics: Animals; Choline Deficiency; Diet; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver Neoplasm | 1984 |
Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.
Topics: Animals; Autoradiography; Cell Division; Cocarcinogenesis; DNA; Female; gamma-Glutamyltransferase; H | 1981 |
Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.
Topics: Adenosine Triphosphatases; Animals; Biotransformation; Carcinogens; Cocarcinogenesis; Dieldrin; Dose | 1983 |
Effect of phenobarbital administration on hepatocytes constituting the hyperplastic nodules induced in rat liver by 3'-methyl-4-dimethylaminoazobenzene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cytochrome P-450 Enzyme System; Ester | 1980 |
[Toxic-allergic reactions to hydantoinate and its transformation into carcinoma after 30 years].
Topics: Anticonvulsants; Carcinoma, Squamous Cell; Drug Hypersensitivity; Humans; Hydantoins; Leukoplakia, O | 1983 |
Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Histocytochemistry; | 1984 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopla | 1984 |
Morphological alterations and DNase deficiency in phenobarbital promotion of N-nitrosomorpholine initiated rat hepatocarcinogenesis.
Topics: Animals; Carcinogens; Deoxyribonucleases; Drug Synergism; Liver; Liver Neoplasms; Male; Neoplasms, E | 1983 |
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1982 |
C-raf expression in early rat liver tumorigenesis after promotion with polychlorinated biphenyls or phenobarbital.
Topics: Animals; Blotting, Northern; Carcinogens; DNA; Female; Gene Expression; Histocytochemistry; Hydrogen | 1994 |
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltrans | 1995 |
Quantitative analysis of multiple phenotype enzyme-altered foci in rat hepatocarcinogenesis experiments: the multipath/multistage model.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Cell Transformation, Neoplastic; Diet; Female; Live | 1995 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regul | 1994 |
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation.
Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma | 1994 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
Association between responsiveness to phenobarbital induction of CYP2B1/2 and 3A1 in rat hepatic hyperplastic nodules and their zonal origin.
Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3 | 1993 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop | 1993 |
Synergistic effects of phenobarbital and thiourea on proliferative lesions in the rat liver.
Topics: Animals; Cell Division; Drug Synergism; Liver; Liver Neoplasms, Experimental; Lung; Male; Nitrosamin | 1994 |
Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital.
Topics: Animals; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; R | 1994 |
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; | 1994 |
The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1993 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Gluta | 1993 |
Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Nucleus; Cyclooctanes; Dioxoles; Drugs, Chinese | 1994 |
Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Connexin 26; Connexin 43; Connexins; D | 1994 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1994 |
Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Albumins; Animals; Female; Glutathione Transferase; Liver; Liver N | 1993 |
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Li | 1993 |
The effect of dieldrin and phenobarbital on preneoplastic hepatic lesion growth in male F344 rat and B6C3F1 mouse.
Topics: Animals; Carcinogens; Dieldrin; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Phenobarbital; Pr | 1995 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis.
Topics: Animals; Apoptosis; Carcinogens; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Liver Ne | 1996 |
Reversibility of promoter induced hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eos | 1996 |
Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinogens; Cell Line; Cricetinae; Flavanones; Flavon | 1996 |
Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diethylnitrosamine; Drug Screening Assays, | 1996 |
Inhibitory effect of chlorophyllin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Chlorophyllides; Diethylnitrosa | 1996 |
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP2A6; Cyt | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
Topics: Aflatoxin B1; Animals; Carcinogenicity Tests; DNA Adducts; DNA, Neoplasm; Enzyme Inhibitors; Glutath | 1999 |
Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diet; Dose-Respo | 1999 |
Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis.
Topics: Animals; Cell Division; Cells, Cultured; Cyproterone Acetate; DNA; Glutathione Transferase; Liver; L | 2000 |
Xenobiotics modulate the p53 response to DNA damage in preneoplastic enzyme-altered foci in rat liver; effects of diethylnitrosamine and phenobarbital.
Topics: Animals; Blotting, Western; Body Weight; Carcinogens; Cell Count; Diethylnitrosamine; DNA Damage; Fe | 2000 |
Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.
Topics: Animals; Apoptosis; bcl-X Protein; Carcinogens; Cell Transformation, Neoplastic; Crosses, Genetic; G | 2000 |
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synerg | 2000 |
Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.
Topics: 4-Butyrolactone; Aflatoxin B1; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalyti | 2000 |
Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell Division; DNA; Eating; G | 2000 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera | 2000 |
Involvement of mu class glutathione S-transferase subunit M2 (rGST M2) levels in the initiation and promotion of hepatocellular carcinogenesis in old rats.
Topics: Aflatoxin B1; Aging; Animals; Carcinogens; Glutathione Transferase; Immunohistochemistry; Liver Neop | 2001 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glu | 1978 |
Induction of enzyme-altered islands in rat liver by a single treatment with benzo[a]pyrene after partial hepatectomy.
Topics: Adenosine Triphosphatases; Animals; Benzopyrenes; gamma-Glutamyltransferase; Hepatectomy; Liver; Liv | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms, Expe | 1978 |
Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions.
Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Con | 1978 |
A microsomal butyrylesterase appearing in rat livers during development, regeneration, and carcinogenesis, and after phenobarbital treatment.
Topics: Animals; Butyrates; Carboxylic Ester Hydrolases; Fetus; Isoenzymes; Liver Neoplasms, Experimental; L | 1979 |
Enhancing effect of chemicals on production of hyperplastic liver nodules induced by n-2-fluorenylacetamide in hepatectomized rats.
Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Flavonoids; Fluorenes; Hepatectomy; Liver; Liver Neo | 1978 |
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Ethionine; Hyperplasia; Liver Ne | 1978 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phtha | 1992 |
Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats.
Topics: Animals; Cell Division; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; gamma-Glutamyltrans | 1992 |
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Fu | 1992 |
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
Topics: Animals; Animals, Newborn; Benzamides; Calcium; Cell Cycle; Cell Nucleus; Cells, Cultured; Dimethyln | 1992 |
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Merc | 1992 |
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltrans | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Fema | 1990 |
The appearance of hepatoma-associated chromosomal non-histone proteins in rat liver after a single dose of 3'-MDAB followed by treatment of phenobarbital.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cell Nucleus; Chromatin; Chromosomal Proteins, Non-H | 1990 |
Modulation of P-450 IIC7 and IIIA1,2 mRNA in pre-neoplastic liver. Effect of promotion by phenobarbital.
Topics: alpha-Fetoproteins; Alpha-Globulins; Animals; Blotting, Northern; Carcinogens; Cytochrome P-450 Enzy | 1990 |
Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cytochrome P-450 Enzyme System; DNA; gamma-Glutamylt | 1990 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransfera | 1990 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Connexins; Diethylnitrosamine; Ethylnitrosou | 1990 |
Enhanced preneoplastic liver lesion development under 'selection pressure' conditions after administration of deoxycholic or lithocholic acid in the initiation phase in rats.
Topics: Animals; Body Weight; Deoxycholic Acid; gamma-Glutamyltransferase; Glutathione Transferase; Lithocho | 1990 |
Ultrastructural changes in chemically induced preneoplastic focal lesions in the rat liver: a stereological study.
Topics: Animals; Animals, Newborn; Biomarkers, Tumor; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1990 |
Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously.
Topics: Aging; Animals; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Phenobarbital; P | 1991 |
The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Exper | 1991 |
[Inhibition effect of epicatechin on phenobarbitol-induced proliferation precancerous liver cells].
Topics: Animals; Catechin; Diethylnitrosamine; Flavonoids; Liver Neoplasms; Male; Phenobarbital; Precancerou | 1990 |
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; | 1990 |
Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model.
Topics: Animals; Carcinogens; Hyperplasia; Male; Neoplasms, Experimental; Nitrosamines; Organ Specificity; P | 1990 |
DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.
Topics: Animals; Body Weight; Carcinogens; Cell Division; DNA Replication; Female; Liver; Liver Neoplasms; N | 1990 |
[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diethylnitrosamine; Female; Gene Expression; Immuno | 1990 |
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diet; Liver; Liver Neoplasms, Experiment | 1990 |
Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Hepatectomy; Hexachlorocyclohexane; Liver | 1986 |
Comparison of gene expression in preneoplastic and neoplastic rat liver to adult, fetal, regenerating, and tumor-promoted liver.
Topics: Animals; Fetus; In Vitro Techniques; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; | 1988 |
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence.
Topics: Animals; Chlordecone; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Hepatectomy; Insecticid | 1989 |
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltrans | 1989 |
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.
Topics: Adenosine; Animals; Deoxyadenosines; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; | 1989 |
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.
Topics: Adenosine Triphosphatases; Animals; Anticholesteremic Agents; Carcinogens; Diethylnitrosamine; gamma | 1989 |
Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Genes, ras; Liver; Liver Neoplasms; Male; Mice; M | 1989 |
Cell phenotype instability in preneoplastic foci of rat liver.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Live | 1988 |
Phosphorylation of specific rat plasma membrane proteins during promotion of gamma-glutamyl transpeptidase-positive hepatic foci and inhibition by di(2-ethylhexyl)phthalate.
Topics: Animals; Chlorine; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experi | 1985 |
Effects of a high-sucrose diet on the development of enzyme-altered foci in chemical hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Dietary Carbohydrates; DNA; Female; gamma-Glutamyltransferas | 1985 |
Effects of N-nitrosomorpholine and phenobarbital on UDP-glucuronyltransferase in putative preneoplastic foci of rat liver.
Topics: Adenosine Triphosphatases; Animals; Aryl Hydrocarbon Hydroxylases; gamma-Glutamyltransferase; Glucur | 1985 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex | 1985 |
Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Separation; Cytochrome P-450 Enzyme System; Diethylnitr | 1985 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis.
Topics: Animals; Butylated Hydroxytoluene; Cocarcinogenesis; DDT; gamma-Glutamyltransferase; Liver Neoplasms | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxym | 1986 |
Facilitated expression of adaptive responses to phenobarbital in putative pre-stages of liver cancer.
Topics: Adaptation, Physiological; Animals; Cytochrome P-450 Enzyme System; DNA; Female; gamma-Glutamyltrans | 1986 |
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; ga | 1986 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma | 1987 |
Phenotypically selective promotion of diethylnitrosamine-initiated altered hepatocyte foci by dietary phenobarbital or a topically applied coal-derived organic mixture in male and female rats.
Topics: Administration, Topical; Animals; Coal; Cocarcinogenesis; Female; gamma-Glutamyltransferase; Iron; L | 1987 |
Dietary effects on initiation and promotion of hepatocarcinogenesis in rat.
Topics: Animals; Body Weight; Diet; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; | 1988 |
Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender.
Topics: Animals; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; | 1989 |
The influence of subsequent dehydroepiandrosterone, diaminopropane, phenobarbital, butylated hydroxyanisole and butylated hydroxytoluene treatment on the development of preneoplastic and neoplastic lesions in the rat initiated with di-hydroxy-di-n-propyl
Topics: Animals; Anisoles; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogens; Dehydroepiandros | 1986 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo | 1987 |
The effects of dose and duration of administration on the promotion index of phenobarbital in multistage hepatocarcinogenesis in the rat.
Topics: Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; L | 1988 |
Rapid development of hepatocellular neoplasms in aging male C3H/HeNCr mice given phenobarbital.
Topics: Age Factors; Animals; Carcinogens; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Phen | 1988 |
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats.
Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Ne | 1988 |
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neopl | 1988 |
Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone.
Topics: Animals; Carcinogens; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nitrosamines; Oxazolidin | 1988 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver | 1987 |
Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Histocytochemistry; Liver Neoplas | 1987 |
Expression of genes encoding glutathione S-transferases in normal and preneoplastic liver.
Topics: Animals; Gene Expression Regulation; Glutathione Transferase; Liver; Liver Neoplasms; Methylcholanth | 1987 |
The phenotypic stability of altered hepatic foci: effects of withdrawal and subsequent readministration of phenobarbital.
Topics: Animals; Diet; Edible Grain; Female; Liver Neoplasms, Experimental; Phenobarbital; Phenotype; Precan | 1986 |
Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.
Topics: Animals; Diethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mitotic Index; | 1986 |
Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Female; Liver; Liver Transplantation; Male; Phenobarbit | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; In | 1985 |
Effects of selenium supplementation on hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Org | 1985 |
Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone.
Topics: Aflatoxins; Animals; Biotransformation; Body Weight; Carcinogens; Enzyme Induction; Liver; Liver Neo | 1971 |