phenobarbital has been researched along with Porphyrias in 50 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute intermittent porphyria (AIP) is a rare metabolic disorder of heme biosynthesis characterized by enzymatic defect of porphobiligen desaminase with accumulation and increased excretion of porphyrins and their precursors." | 7.75 | [Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment]. ( Akopova-Larbi, R; Ben Youssef, TI; Gargouri, A; Gouider, R; Gouider-Khouja, N; Kraoua, I, 2009) |
| "In an effort to determine the role that metabolism by the cytochrome P-450 system plays in the development of hexachlorobenzene (HCB)-induced porphyria, Japanese quail were pretreated with either beta-naphthoflavone (BNF) or phenobarbital (PB) and then treated with HCB." | 7.67 | Hexachlorobenzene-induced porphyria in Japanese quail. Effect of pretreatment with phenobarbital or beta-naphthoflavone. ( Bender, RC; Buhler, DR; Carpenter, HM; Henderson, MC; Williams, DE, 1984) |
| "The excessive induction of hepatic delta-aminolevulinic acid synthetase in rats after the administration of porphyria-inducing compounds is prevented by prior treatment with phenobarbital." | 7.65 | Chemically induced porphyria: prevention by prior treatment with phenobarbital. ( Kaufman, L; Marver, HS; Swanson, AL, 1970) |
| "In untreated rats, tiagabine and topiramate caused a moderate increase of hepatic pentoxyresorufin-O-dealkylase activity (approximately 100 and 200 pmol/min." | 5.31 | Effect of tiagabine and topiramate on porphyrin metabolism in an in vivo model of porphyria. ( Krijt, J; Krijtová, H; Sanitrák, J, 2001) |
| "Acute intermittent porphyria (AIP) is a rare metabolic disorder of heme biosynthesis characterized by enzymatic defect of porphobiligen desaminase with accumulation and increased excretion of porphyrins and their precursors." | 3.75 | [Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment]. ( Akopova-Larbi, R; Ben Youssef, TI; Gargouri, A; Gouider, R; Gouider-Khouja, N; Kraoua, I, 2009) |
| "In an effort to determine the role that metabolism by the cytochrome P-450 system plays in the development of hexachlorobenzene (HCB)-induced porphyria, Japanese quail were pretreated with either beta-naphthoflavone (BNF) or phenobarbital (PB) and then treated with HCB." | 3.67 | Hexachlorobenzene-induced porphyria in Japanese quail. Effect of pretreatment with phenobarbital or beta-naphthoflavone. ( Bender, RC; Buhler, DR; Carpenter, HM; Henderson, MC; Williams, DE, 1984) |
| "The present study investigates the ability of several hexachlorobenzene (HCB) metabolites to induce porphyrin accumulation in chick embryo liver cells in ovo, in order to further clarify the role of metabolites in the mechanism of HCB-induced porphyria." | 3.67 | Ability of several hexachlorobenzene metabolites to induce porphyrin accumulation in chick embryo liver "in ovo". ( Billi, SC; San Martín de Viale, LC, 1985) |
| "Multiple doses of beta-naphthoflavone to iron-loaded C57BL/10ScSn mice for 6 weeks caused inhibition of hepatic uroporphyrinogen decarboxylase and a porphyria indistinguishable from that previously only reported for polyhalogenated aromatic chemicals." | 3.67 | Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations. ( Francis, JE; Smith, AG, 1987) |
| "It was investigated whether an increased demand for glycine, as postulated to occur in patients who have suffered from episodic psychoses accompanied by multiple perceptual distortions, could evoke psychotic reactions." | 3.66 | Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis? ( Bruinvels, J; Pepplinkhuizen, L; Schouten, MJ; Wilson, JH, 1983) |
| "The effect of DL-propranolol on 3',5'-diethoxycarbonyl-1,4-dihydrocollidine-induced experimental porphyria was studied." | 3.65 | The effect of beta-adrenergic blocking agents on experimental porphyria induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo and in vitro. ( Atsmon, A; Epstein, O; Schoenfeld, N, 1976) |
| " But enzyme induction can also lead to acute intermittent porphyrias and distrubances of the phosphorus-calcium metabolism." | 3.65 | [Liver metabolism of drugs (author's transl)]. ( Darnis, F, 1976) |
| " Phenobarbital, which exacerbates acute intermittent porphyria in man, induces drug-oxidizing enzymes in liver." | 3.65 | Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug. ( Alvares, AP; Bickers, DR; Bradlow, HL; Kappas, A, 1977) |
| "The effect of ethanol, phenobarbitone, griseofulvin or chloroquine on 3,4-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria in rats has been studied in experiments lasting up to 40 days." | 3.65 | Study of the effects of certain drugs on experimental porphyria in rats. ( Bhutani, LK; Bikhchandani, R; Deshpande, SG; Kandhari, KC; Narang, BS, 1977) |
| "The excessive induction of hepatic delta-aminolevulinic acid synthetase in rats after the administration of porphyria-inducing compounds is prevented by prior treatment with phenobarbital." | 3.65 | Chemically induced porphyria: prevention by prior treatment with phenobarbital. ( Kaufman, L; Marver, HS; Swanson, AL, 1970) |
| "In untreated rats, tiagabine and topiramate caused a moderate increase of hepatic pentoxyresorufin-O-dealkylase activity (approximately 100 and 200 pmol/min." | 1.31 | Effect of tiagabine and topiramate on porphyrin metabolism in an in vivo model of porphyria. ( Krijt, J; Krijtová, H; Sanitrák, J, 2001) |
| "The porphyria is not dependent on pretreatment with iron and persists for at least 21 days after withdrawal of ALA." | 1.27 | Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid. ( Bement, WJ; Elder, GH; Gorman, N; Lambrecht, RW; Roberts, AG; Sinclair, JA; Sinclair, PR; Urquhart, AJ, 1988) |
| " Aspirin, ibuprofen, indomethacin, ketoprofen, flurbiprofen, phenylbutazone, naproxen, prednisolone, and penicillamine did not increase ALA synthase activity and should be safe in porphyria." | 1.27 | Studies in laboratory animals to assess the safety of anti-inflammatory agents in acute porphyria. ( McColl, KE; Moore, MR; Thompson, GG, 1987) |
| " The activities of NADPH-cytochrome P-450 reductase, AHH, and ECOD following treatment with HCB were similar to those found after dosing with PB." | 1.27 | A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail. ( Buhler, DR; Carpenter, HM; Williams, DE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (86.00) | 18.7374 |
| 1990's | 3 (6.00) | 18.2507 |
| 2000's | 3 (6.00) | 29.6817 |
| 2010's | 1 (2.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, M | 1 |
| Desnick, RJ | 1 |
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
| Akopova-Larbi, R | 1 |
| Ben Youssef, TI | 1 |
| Gargouri, A | 1 |
| Kraoua, I | 1 |
| Gouider, R | 1 |
| Gouider-Khouja, N | 1 |
| TAKASAKI, H | 1 |
| SAKAKURA, T | 1 |
| ARAKI, T | 1 |
| TANAKA, A | 1 |
| IKEDA, N | 1 |
| SEKIUCHI, T | 1 |
| LEONARD, JM | 1 |
| De Verneuil, H | 1 |
| Sassa, S | 1 |
| Kappas, A | 3 |
| Schouten, MJ | 1 |
| Bruinvels, J | 1 |
| Pepplinkhuizen, L | 1 |
| Wilson, JH | 1 |
| Carpenter, HM | 2 |
| Williams, DE | 2 |
| Henderson, MC | 1 |
| Bender, RC | 1 |
| Buhler, DR | 2 |
| Wainstok de Calmanovici, R | 1 |
| Ríos de Molina, MC | 1 |
| Taira de Yamasato, MC | 1 |
| Tomio, JM | 1 |
| San Martin de Viale, LC | 2 |
| Lahav, M | 1 |
| Schoenfeld, N | 3 |
| Epstein, O | 2 |
| Greenblat, Y | 1 |
| Atsmon, A | 3 |
| Yeung, TC | 1 |
| Gidari, AS | 1 |
| Fuchs, T | 1 |
| Seubert, A | 1 |
| Seubert, S | 1 |
| Ippen, H | 1 |
| Lim, LK | 1 |
| Srivastava, G | 1 |
| Brooker, JD | 1 |
| May, BK | 1 |
| Elliott, WH | 1 |
| Varone, CL | 1 |
| Canepa, ET | 1 |
| Llambias, EB | 1 |
| Grinstein, M | 1 |
| Hahn, M | 1 |
| Gildemeister, OS | 1 |
| Krauss, GL | 1 |
| Pepe, JA | 1 |
| Lambrecht, RW | 2 |
| Donohue, S | 1 |
| Bonkovsky, HL | 1 |
| Krijt, J | 1 |
| Krijtová, H | 1 |
| Sanitrák, J | 1 |
| Darnis, F | 3 |
| Nusinovici, V | 1 |
| Levy, VG | 1 |
| Caroli, J | 1 |
| Bradlow, HL | 1 |
| Bickers, DR | 1 |
| Alvares, AP | 1 |
| Deshpande, SG | 1 |
| Kandhari, KC | 1 |
| Narang, BS | 1 |
| Bikhchandani, R | 1 |
| Bhutani, LK | 1 |
| Maxwell, JD | 1 |
| Meyer, UA | 2 |
| Mamet, R | 1 |
| Mevasser, R | 1 |
| Correia, MA | 1 |
| Lunetta, JM | 1 |
| Billi, SC | 1 |
| Urquhart, AJ | 1 |
| Elder, GH | 1 |
| Roberts, AG | 1 |
| Sinclair, PR | 1 |
| Bement, WJ | 1 |
| Gorman, N | 1 |
| Sinclair, JA | 1 |
| Francis, JE | 1 |
| Smith, AG | 1 |
| McColl, KE | 1 |
| Thompson, GG | 1 |
| Moore, MR | 1 |
| Strik, JJ | 1 |
| Haschen, RJ | 1 |
| Wada, O | 1 |
| Toyokawa, K | 1 |
| Urata, G | 1 |
| Yano, Y | 1 |
| Nakao, K | 1 |
| De Matteis, F | 6 |
| Kramer, S | 1 |
| Viljoen, D | 1 |
| Becker, D | 1 |
| Metz, J | 1 |
| Piper, WN | 1 |
| Tephly, TR | 1 |
| Windorfer, A | 1 |
| Badawy, AA | 1 |
| Evans, M | 1 |
| Blank, H | 1 |
| Song, CS | 1 |
| Moses, HL | 1 |
| Rosenthal, AS | 1 |
| Gelb, NA | 1 |
| Marver, HS | 2 |
| White, P | 1 |
| Durepaire-Fischer, R | 1 |
| Goudal, H | 1 |
| Bolgert, M | 1 |
| Kaufman, L | 1 |
| Swanson, AL | 1 |
| Creighton, JM | 1 |
| Marks, GS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evidence-based Assessment of Medication Sensitivity in Acute Hepatic Porphyria[NCT03906214] | 60 participants (Actual) | Observational | 2019-04-03 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for phenobarbital and Porphyrias
| Article | Year |
|---|---|
Murine models of the human porphyrias: Contributions toward understanding disease pathogenesis and the development of new therapies.
Topics: Anemia; Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Gen | 2019 |
[Hepatic-cell enzyme induction using phenobarbital: applications to the treatment of jaundice].
Topics: Bile Acids and Salts; Bilirubin; Cholestasis; Chronic Disease; Enzyme Induction; Gilbert Disease; Hu | 1976 |
[Progress in diagnostic enzymology].
Topics: Alcoholism; Aminopeptidases; Amylases; Aspartate Aminotransferases; Cholinesterases; Creatine Kinase | 1973 |
Toxic hepatic porphyrias.
Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyc | 1968 |
[Stimulation of the microsomal enzyme system as a therapeutic principle in the newborn infant].
Topics: Anticonvulsants; Blood Coagulation Disorders; Enzyme Induction; Female; Humans; Hyperbilirubinemia, | 1974 |
The actions and interactions of drugs: the therapeutic significance of enzyme induction.
Topics: Aging; Animals; Child; Chloral Hydrate; Dogs; Drug Antagonism; Drug Resistance, Microbial; Endoplasm | 1967 |
Disturbances of liver porphyrin metabolism caused by drugs.
Topics: Animals; Chlorpropamide; Drug-Related Side Effects and Adverse Reactions; Estrogens; Griseofulvin; H | 1967 |
43 other studies available for phenobarbital and Porphyrias
| Article | Year |
|---|---|
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |
[Neurological complications of acute intermittent porphyria precipitated by porphyrinogenic drugs and efficiency of heme-arginate treatment].
Topics: Acute Disease; Adolescent; Arginine; Electromyography; Famotidine; Female; Heme; Heme Oxygenase (Dec | 2009 |
[Two cases of acute porphyria].
Topics: Humans; Phenobarbital; Porphyria, Acute Intermittent; Porphyrias; Vitamin A; Vitamin K; Vitamins | 1963 |
[PORPHYRIA AND ANESTHESIA].
Topics: Anesthesia; Barbiturates; Humans; Phenobarbital; Porphyrias; Thiopental; Toxicology | 1963 |
Effects of polychlorinated biphenyl compounds, 2,3,7,8-tetrachlorodibenzo-p-dioxin, phenobarbital and iron on hepatic uroporphyrinogen decarboxylase. Implications for the pathogenesis of porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Cells, Cu | 1983 |
Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis?
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Catalepsy; Disease Models, Animal; Glycine; H | 1983 |
Hexachlorobenzene-induced porphyria in Japanese quail. Effect of pretreatment with phenobarbital or beta-naphthoflavone.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Chlorobenzenes; Coturnix | 1984 |
Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment.
Topics: 5-Aminolevulinate Synthetase; Animals; Carboxy-Lyases; Chlorobenzenes; Cytochrome P-450 Enzyme Syste | 1984 |
Effect of prolonged fasting on heme metabolism in the rat.
Topics: 5-Aminolevulinate Synthetase; Animals; Chromatography, Thin Layer; Fasting; Heme; Male; Phenobarbita | 1984 |
Effects of porphyrinogenic (porphyria-producing) agents on avian embryonic hepatic glutathione S-transferase activity.
Topics: Acetamides; Allylisopropylacetamide; Animals; Chick Embryo; Cyproterone; Cytochrome P-450 Enzyme Sys | 1981 |
Anticonvulsant-induced unclassified porphyria.
Topics: Adult; Aminolevulinic Acid; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenob | 1980 |
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzym | 1980 |
Glucose inhibits phenobarbital-induced delta-aminolevulinate synthase expression in normal but not in diabetic rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 5-Aminolevulinate Synthetase; Aden | 1996 |
Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells: potential implications for patients with acute porphyria.
Topics: Animals; Cells, Cultured; Chick Embryo; Deferoxamine; Dose-Response Relationship, Drug; Liver; Pheno | 1997 |
Effect of tiagabine and topiramate on porphyrin metabolism in an in vivo model of porphyria.
Topics: Animals; Anticonvulsants; Drug Interactions; Fructose; Herbicides; Kidney; Liver; Male; Mice; Mice, | 2001 |
The effect of beta-adrenergic blocking agents on experimental porphyria induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo and in vitro.
Topics: 5-Aminolevulinate Synthetase; Adrenergic beta-Antagonists; Aminolevulinic Acid; Animals; Chick Embry | 1976 |
[Liver metabolism of drugs (author's transl)].
Topics: Adult; Animals; Anticonvulsants; Biotransformation; Calcium; Child; Cushing Syndrome; Dicumarol; Dru | 1976 |
Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Androstenes; Antipyrine; Female; Humans; Ketosteroids; | 1977 |
Study of the effects of certain drugs on experimental porphyria in rats.
Topics: Animals; Chloroquine; Dicarbethoxydihydrocollidine; Ethanol; Griseofulvin; Liver; Phenobarbital; Por | 1977 |
Effect of lead on hepatic delta-aminolaevulinic acid synthetase activity in the rat: a model for drug sensitivity in intermittent acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Drug Hyp | 1976 |
[The liver and metabolism of drugs].
Topics: Biotransformation; Cushing Syndrome; Drug Antagonism; Enzyme Induction; Humans; Jaundice; Liver; Phe | 1976 |
Experimental latent and acute porphyria in the non-fasted rat; preventive effect of propranolol.
Topics: Acute Disease; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Coproporphyrins; Dicarbethoxyd | 1991 |
Acute hepatic heme depletion: impaired gluconeogenesis in rats.
Topics: Animals; Brain; Dicarbethoxydihydrocollidine; Gluconeogenesis; Glutathione; Glycerol; Heme; Hydroxyi | 1989 |
Ability of several hexachlorobenzene metabolites to induce porphyrin accumulation in chick embryo liver "in ovo".
Topics: Animals; Chick Embryo; Chlorobenzenes; Hexachlorobenzene; Liver; Phenobarbital; Phenols; Porphyrias; | 1985 |
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Hexachloroben | 1988 |
Polycyclic aromatic hydrocarbons cause hepatic porphyria in iron-loaded C57BL/10 mice: comparison of uroporphyrinogen decarboxylase inhibition with induction of alkoxyphenoxazone dealkylations.
Topics: Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; beta-Naphthoflavone; Carboxy-Lyases; Che | 1987 |
Studies in laboratory animals to assess the safety of anti-inflammatory agents in acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Animals; Anti-Inflammatory Agents; Liver; Male; Phenoba | 1987 |
A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Chemical and Drug Induced Liver Injury; Ch | 1985 |
Species differences in experimental porphyria caused by polyhalogenated aromatic compounds.
Topics: Animals; Biphenyl Compounds; Birds; Chick Embryo; Chickens; Cytochrome P-450 Enzyme System; Guinea P | 1973 |
Cholesterol biosynthesis in the liver of experimentally induced porphyric mice.
Topics: Acetates; Animals; Carbon Isotopes; Cholesterol; Griseofulvin; Hexachlorocyclohexane; Levulinic Acid | 1969 |
A possible explanation for the neurological disturbances in the porphyrias.
Topics: Adenosine Triphosphatases; Amino Acids; Animals; Brain; Cystine; Erythrocytes; Glycine; Humans; Levu | 1971 |
The reversal of experimental porphyria and the prevention of induction of hepatic mixed-function oxidase by acetate.
Topics: 5-Aminolevulinate Synthetase; Acetates; Aminolevulinic Acid; Animals; Cytochrome c Group; Cytochrome | 1974 |
The effects of drugs on the activities of 5-aminolaevulinate synthetase and other enzymes in the pathway of haem biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarboxylic Acids; Esters; Griseofu | 1972 |
Drug interactions in experimental hepatic porphyria. A model for the exacerbation by drugs of human variegate porphyria.
Topics: 5-Aminolevulinate Synthetase; Administration, Oral; Allylisopropylacetamide; Animals; Chickens; Coba | 1973 |
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dicarboxy | 1973 |
Drug interactions in experimental hepatic porphyria: a model for the exacerbation by drugs of human variegate porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug In | 1972 |
The influence of postnatal development on drug-induced hepatic porphyria and the synthesis of cytochrome P-450. A biochemical and morphological study.
Topics: Acyltransferases; Allyl Compounds; Amides; Amino Acids; Animals; Animals, Newborn; Carbon Isotopes; | 1971 |
Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide.
Topics: Acetamides; Allyl Compounds; Amides; Amino Acids; Animals; Carbon Isotopes; Cytochromes; Enzyme Indu | 1971 |
Porphyrin biosynthesis. Enhancement of the fractional catabolic rate of microsomal haem in chemically induced porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Carbon Isotopes; Cytochromes; Enzyme Induction; Heme; Iron Is | 1971 |
Carbon monoxide production and heme catabolism.
Topics: Acetamides; Allyl Compounds; Anemia, Sideroblastic; Animals; Bile Pigments; Bone Marrow; Carbon Isot | 1970 |
[Late cutaneous porphyria with sclerodermic syndrome revealed by taking estrogens, barbiturates and estro-progestational hormones].
Topics: Adult; Amenorrhea; Chemical and Drug Induced Liver Injury; Female; Humans; Lynestrenol; Mestranol; P | 1969 |
Chemically induced porphyria: prevention by prior treatment with phenobarbital.
Topics: Acyltransferases; Amides; Amino Acids; Animals; Biotransformation; Carbon Isotopes; Chromatography, | 1970 |
Drug-induced porphytin biosynthesis. I. The effect of porphyria-inducing drugs on N-demethylase activity of chick embryo liver.
Topics: Amides; Aminopyrine; Animals; Chemical Phenomena; Chemistry; Chick Embryo; Formaldehyde; In Vitro Te | 1969 |