phenobarbital has been researched along with Porphyrias, Hepatic in 4 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Porphyrias, Hepatic: A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, CD | 1 |
| Van Horn, CG | 1 |
| Wan, M | 1 |
| Bishop, C | 1 |
| Bonkovsky, HL | 1 |
| Yasuda, M | 1 |
| Desnick, RJ | 1 |
| Unzu, C | 1 |
| Sampedro, A | 1 |
| Mauleón, I | 1 |
| Alegre, M | 1 |
| Beattie, SG | 1 |
| de Salamanca, RE | 1 |
| Snapper, J | 1 |
| Twisk, J | 1 |
| Petry, H | 1 |
| González-Aseguinolaza, G | 1 |
| Artieda, J | 1 |
| Rodríguez-Pena, MS | 1 |
| Prieto, J | 1 |
| Fontanellas, A | 1 |
| Schuurmans, MM | 1 |
| Hoffmann, F | 1 |
| Lindberg, RL | 1 |
| Meyer, UA | 1 |
1 review available for phenobarbital and Porphyrias, Hepatic
| Article | Year |
|---|---|
Murine models of the human porphyrias: Contributions toward understanding disease pathogenesis and the development of new therapies.
Topics: Anemia; Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Gen | 2019 |
3 other studies available for phenobarbital and Porphyrias, Hepatic
| Article | Year |
|---|---|
Assessment of porphyrogenicity of drugs and chemicals in selected hepatic cell culture models through a fluorescence-based screening assay.
Topics: Cell Culture Techniques; Heme; Hepatocytes; Humans; Liver; Norgestrel; Phenobarbital; Phenytoin; Por | 2022 |
Sustained enzymatic correction by rAAV-mediated liver gene therapy protects against induced motor neuropathy in acute porphyria mice.
Topics: Animals; Dependovirus; Female; Genetic Therapy; Genetic Vectors; Humans; Hydroxymethylbilane Synthas | 2011 |
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Arginine; Cytosol; Drug C | 2001 |