phenobarbital has been researched along with Parkinson Disease in 8 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rotenone is a mitochondrial toxin which can produce Parkinson syndrome (PS) in rats." | 1.33 | Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism. ( Pasha, MK; Rajput, AH; Sharma, RK, 2005) |
| "Essential tremor is a common disorder whose aetiology is unknown." | 1.27 | Essential tremor. ( Findley, LJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ONUAGULUCHI, G | 1 |
| Pasha, MK | 1 |
| Sharma, RK | 1 |
| Rajput, AH | 1 |
| Marchand, L | 1 |
| Schobben, F | 1 |
| van der Kleijn, E | 1 |
| Gabreëls, FJ | 1 |
| Clarke, BM | 1 |
| Upton, A | 1 |
| Griffin, H | 1 |
| Hudoba, P | 1 |
| Findley, LJ | 1 |
| Knopp, W | 1 |
| Porot, M | 1 |
| Petit, G | 1 |
| Couadau, A | 1 |
| Bosson, P | 1 |
1 trial available for phenobarbital and Parkinson Disease
| Article | Year |
|---|---|
Psychiatric changes in patients treated with levodopa. I. The clinical experiment.
Topics: Activities of Daily Living; Adjustment Disorders; Aged; Amitriptyline; Clinical Trials as Topic; Dia | 1970 |
7 other studies available for phenobarbital and Parkinson Disease
| Article | Year |
|---|---|
Drug therapy in the crises of postencephalitic parkinsonism.
Topics: Amobarbital; Encephalitis; Encephalitis, Arbovirus; Humans; Parkinson Disease; Parkinson Disease, Po | 1961 |
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans | 2005 |
[Treatment of essential tremor].
Topics: Anti-Anxiety Agents; Anti-Dyskinesia Agents; Botulinum Toxins; Humans; Hypnotics and Sedatives; Meth | 1995 |
Pharmacokinetics of di-n-propylacetate in epileptic patients.
Topics: Administration, Oral; Aged; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; | 1975 |
Balance and cognitive impairment in two epileptic patients before and after vagal nerve stimulation.
Topics: Adult; Carbamazepine; Cognition; Electric Stimulation Therapy; Epilepsy, Temporal Lobe; Humans; Male | 1991 |
Essential tremor.
Topics: Diagnosis, Differential; Humans; Parkinson Disease; Phenobarbital; Phenylethylmalonamide; Primidone; | 1986 |
[Clinical tests of C.E. 10010 in tremor and abnormal movements].
Topics: Adult; Aged; Humans; Middle Aged; Movement Disorders; Parkinson Disease; Phenobarbital; Tremor | 1968 |