phenobarbital and Ototoxicity studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Ototoxicity: Damage to the EAR or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.

Research Excerpts

Excerpt	Relevance	Reference
"Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures."	9.41	Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023)
"Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures."	5.41	Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

phenobarbital and Ototoxicity

Research Excerpts

Research

Studies (1)

Authors

Reviews

Authors	Studies
Rao, S	1
Farhat, A	1
Rakshasbhuvankar, A	1
Athikarisamy, S	1
Ghosh, S	1
Nagarajan, L	1