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phenobarbital and Osteogenic Sarcoma

phenobarbital has been researched along with Osteogenic Sarcoma in 3 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Research Excerpts

ExcerptRelevanceReference
"Current treatment of high-grade osteosarcoma consists of preoperative chemotherapy, typically using some combination of doxorubicin, cisplatin, ifosfamide, and/or high-dose methotrexate followed by surgical resection."7.91Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation. ( Savani, M; Skubitz, KM, 2019)
"Ten patients (three males and seven females) were treated for sarcoma with high-dose ifosfamide (IFO) according to a 4 g/m2 1 h i."5.08Phenobarbital administration does not affect high-dose ifosfamide pharmacokinetics in humans. ( Lokiec, F; Santoni, J; Tubiana-Hulin, M; Weill, S, 1996)
"Current treatment of high-grade osteosarcoma consists of preoperative chemotherapy, typically using some combination of doxorubicin, cisplatin, ifosfamide, and/or high-dose methotrexate followed by surgical resection."3.91Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation. ( Savani, M; Skubitz, KM, 2019)
"When mitozolomide was administered i."1.27Plasma and tissue disposition of mitozolomide in mice. ( Antoniw, P; Brindley, CJ; Newlands, ES, 1986)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Savani, M1
Skubitz, KM1
Lokiec, F1
Santoni, J1
Weill, S1
Tubiana-Hulin, M1
Brindley, CJ1
Antoniw, P1
Newlands, ES1

Trials

1 trial available for phenobarbital and Osteogenic Sarcoma

ArticleYear
Phenobarbital administration does not affect high-dose ifosfamide pharmacokinetics in humans.
    Anti-cancer drugs, 1996, Volume: 7, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Area Under Curve; Chromatography, High Pressur

1996

Other Studies

2 other studies available for phenobarbital and Osteogenic Sarcoma

ArticleYear
Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation.
    Journal of pediatric hematology/oncology, 2019, Volume: 41, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cardiotoxicity; Dimethyl Sulf

2019
Plasma and tissue disposition of mitozolomide in mice.
    British journal of cancer, 1986, Volume: 53, Issue:1

    Topics: Animals; Antineoplastic Agents; Brain; Female; Half-Life; Kidney; Liver; Lung; Mice; Mice, Inbred AK

1986