phenobarbital has been researched along with Osteogenic Sarcoma in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Excerpt | Relevance | Reference |
---|---|---|
"Current treatment of high-grade osteosarcoma consists of preoperative chemotherapy, typically using some combination of doxorubicin, cisplatin, ifosfamide, and/or high-dose methotrexate followed by surgical resection." | 7.91 | Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation. ( Savani, M; Skubitz, KM, 2019) |
"Ten patients (three males and seven females) were treated for sarcoma with high-dose ifosfamide (IFO) according to a 4 g/m2 1 h i." | 5.08 | Phenobarbital administration does not affect high-dose ifosfamide pharmacokinetics in humans. ( Lokiec, F; Santoni, J; Tubiana-Hulin, M; Weill, S, 1996) |
"Current treatment of high-grade osteosarcoma consists of preoperative chemotherapy, typically using some combination of doxorubicin, cisplatin, ifosfamide, and/or high-dose methotrexate followed by surgical resection." | 3.91 | Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation. ( Savani, M; Skubitz, KM, 2019) |
"When mitozolomide was administered i." | 1.27 | Plasma and tissue disposition of mitozolomide in mice. ( Antoniw, P; Brindley, CJ; Newlands, ES, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (33.33) | 18.7374 |
1990's | 1 (33.33) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Savani, M | 1 |
Skubitz, KM | 1 |
Lokiec, F | 1 |
Santoni, J | 1 |
Weill, S | 1 |
Tubiana-Hulin, M | 1 |
Brindley, CJ | 1 |
Antoniw, P | 1 |
Newlands, ES | 1 |
1 trial available for phenobarbital and Osteogenic Sarcoma
Article | Year |
---|---|
Phenobarbital administration does not affect high-dose ifosfamide pharmacokinetics in humans.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Area Under Curve; Chromatography, High Pressur | 1996 |
2 other studies available for phenobarbital and Osteogenic Sarcoma
Article | Year |
---|---|
Long-term Outcome After Doxorubicin and Ifosfamide Overdose in a Patient With Osteosarcoma and BARD1 Mutation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cardiotoxicity; Dimethyl Sulf | 2019 |
Plasma and tissue disposition of mitozolomide in mice.
Topics: Animals; Antineoplastic Agents; Brain; Female; Half-Life; Kidney; Liver; Lung; Mice; Mice, Inbred AK | 1986 |