Page last updated: 2024-11-02

phenobarbital and Oligodendroglioma

phenobarbital has been researched along with Oligodendroglioma in 2 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Oligodendroglioma: A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)

Research Excerpts

ExcerptRelevanceReference
"Nervous system tumors were induced only in animals exposed to ENU."1.28Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea. ( Swenberg, JA; Walker, VE, 1989)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
JOHNSON, J1
Walker, VE1
Swenberg, JA1

Other Studies

2 other studies available for phenobarbital and Oligodendroglioma

ArticleYear
SEXUAL IMPOTENCE AND THE LIMBIC SYSTEM.
    The British journal of psychiatry : the journal of mental science, 1965, Volume: 111

    Topics: Astrocytoma; Brain Neoplasms; Diagnosis, Differential; Epilepsy; Epilepsy, Temporal Lobe; Erectile D

1965
Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea.
    Journal of neuropathology and experimental neurology, 1989, Volume: 48, Issue:3

    Topics: Animals; Astrocytes; Ethylnitrosourea; Female; Gestational Age; Glioma; Male; Maternal-Fetal Exchang

1989