phenobarbital has been researched along with Obesity in 31 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 7.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "The effect of genetic obesity and phenobarbital treatment on hepatic conjugation pathways was evaluated in the obese Zucker rat." | 7.68 | Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. ( Blouin, RA; Chaudhary, IP; McNamara, PJ; Robertson, LW; Tuntaterdtum, S, 1993) |
| "74 L/h) and elimination half-life of 61h were determined." | 5.28 | Phenobarbital pharmacokinetics in obesity. A case report. ( Danziger, LH; Rodvold, KA; Wilkes, L, 1992) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 3.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "The present study determined the effect of genetic obesity and phenobarbital (PB) treatment on the expression and regulation of the hepatic cytochrome P450 enzyme (CYP2C11) in Fa/? and fa/fa Zucker rats." | 3.68 | Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment. ( Bandyopadhyay, AM; Blouin, RA; Chaudhary, I; Gemzik, B; Parkinson, A; Robertson, LW, 1993) |
| "The effect of genetic obesity and phenobarbital treatment on hepatic conjugation pathways was evaluated in the obese Zucker rat." | 3.68 | Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways. ( Blouin, RA; Chaudhary, IP; McNamara, PJ; Robertson, LW; Tuntaterdtum, S, 1993) |
| "We evaluated the effects of phenobarbital, an inducer, on plasma glucose and serum immunoreactive insulin levels and on hepatic glucose and drug metabolism using an animal model of non-insulin dependent diabetes mellitus." | 3.67 | Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non-insulin dependent diabetes mellitus. ( Huupponen, R; Karvonen, I; Sotaniemi, EA; Stenbäck, FG; Stengård, JH, 1989) |
| " Phenobarbital induced the microsomal drugmetabolizing enzyme system in the fatty liver of genetically obese mice in the same way 2-3-fold as in the non-fatty liver of the lean littermates." | 3.66 | [Studies on drug metabolism in obese men and mice (author's transl)]. ( Grimmel, K; Richter, E; Zilly, W, 1979) |
| "In covariate (sub)models of population pharmacokinetic models, most covariates are normalized to the median value; however, for body weight, normalization to 70 kg or 1 kg is often applied." | 1.51 | The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models. ( Aarons, L; Calvier, EAM; Goulooze, SC; Knibbe, CAJ; Krekels, EHJ; Välitalo, PAJ; Völler, S, 2019) |
| "Phenobarbital treatment increased the concentrations of total cytochrome P450 in both lean and obese rats to the same extent." | 1.29 | Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment. ( Bandyopadhyay, AM; Blouin, RA; Robertson, LW; Zannikos, PN, 1994) |
| "Phenobarbital-treated (0." | 1.29 | Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: molecular characterization. ( Bandyopadhyay, AM; Blouin, RA; Chaudhary, I; Gemzik, B; Parkinson, A; Robertson, LW, 1993) |
| " Whether comparing the absolute or standardized pharmacokinetic data, lean and obese Zucker rats will exhibit 2- to 3-fold higher phenobarbital plasma concentrations after administration of a standard 75- to 100-mg/kg enzyme-inducing regimen relative to Sprague-Dawley rats." | 1.27 | Phenobarbital in the genetically obese Zucker rat. I. Pharmacokinetics after acute and chronic administration. ( Blouin, RA; Brouwer, KL; Kostenbauder, HB; McNamara, PJ, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (74.19) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goulooze, SC | 1 |
| Völler, S | 1 |
| Välitalo, PAJ | 1 |
| Calvier, EAM | 1 |
| Aarons, L | 1 |
| Krekels, EHJ | 1 |
| Knibbe, CAJ | 1 |
| NECHELES, H | 1 |
| SORTER, H | 1 |
| ZARAFONETIS, CJ | 1 |
| MOLTHAN, L | 1 |
| BARNES, RH | 1 |
| GURTLER, J | 1 |
| CORCORAN, AC | 1 |
| FINEBERG, SK | 1 |
| TURNER, RW | 1 |
| MILLIGAN, J | 1 |
| SIMKIN, B | 1 |
| WALLACE, L | 1 |
| Brouwer, KL | 2 |
| Kostenbauder, HB | 2 |
| McNamara, PJ | 4 |
| Blouin, RA | 8 |
| Roed, P | 1 |
| Hansen, PW | 1 |
| Bidstrup, B | 1 |
| Kaern, M | 1 |
| Helles, A | 1 |
| Petersen, KP | 1 |
| Koch, JA | 1 |
| Finkelstein, JA | 1 |
| Steggles, AW | 1 |
| Zannikos, PN | 1 |
| Bandyopadhyay, AM | 3 |
| Robertson, LW | 5 |
| Tuntaterdtum, S | 2 |
| Chaudhary, IP | 2 |
| Cibull, M | 2 |
| Chaudhary, I | 2 |
| Gemzik, B | 2 |
| Parkinson, A | 2 |
| Kuranari, M | 1 |
| Chiba, S | 1 |
| Ashikari, Y | 1 |
| Kodama, Y | 1 |
| Sakata, T | 1 |
| Takeyama, M | 1 |
| Grimmel, K | 2 |
| Richter, E | 1 |
| Zilly, W | 1 |
| Schriefers, H | 1 |
| Ockenfels, H | 1 |
| Paulini, K | 1 |
| Fevery, J | 1 |
| Wilkes, L | 1 |
| Danziger, LH | 1 |
| Rodvold, KA | 1 |
| Karvonen, I | 1 |
| Stengård, JH | 1 |
| Huupponen, R | 1 |
| Stenbäck, FG | 1 |
| Sotaniemi, EA | 1 |
| Patial, RK | 1 |
| Sarin, R | 1 |
| Patial, SB | 1 |
| Dickson, P | 1 |
| McClain, C | 1 |
| Ibsen, KK | 1 |
| Horiguchi, T | 1 |
| Tempero, KF | 1 |
| Sherwin, AL | 1 |
| Loynd, JS | 1 |
| Bock, GW | 1 |
| Sokolowski, CD | 1 |
| Beneke, G | 1 |
| Brauchle, I | 1 |
| Rakow, L | 1 |
1 review available for phenobarbital and Obesity
| Article | Year |
|---|---|
Angina pectoris: diagnosis, evaluation and therapy.
Topics: Angina Pectoris; Angiography; Digitalis Glycosides; Ethanol; Female; Heart Function Tests; Humans; M | 1973 |
1 trial available for phenobarbital and Obesity
| Article | Year |
|---|---|
[Elsinore banting tablets. A controlled clinical trial in general practice].
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Drug Combinations; Ephedrine; Female; Foll | 1980 |
29 other studies available for phenobarbital and Obesity
| Article | Year |
|---|---|
The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models.
Topics: Adult; Body Weight; Humans; Infant, Newborn; Models, Biological; Obesity; Pharmacokinetics; Phenobar | 2019 |
Balanced amphetamine and sedative combination in the treatment of obesity.
Topics: Amobarbital; Amphetamine; Amphetamines; Barbiturates; Hypnotics and Sedatives; Obesity; Phenobarbita | 1957 |
Apparent phenobarbital sensitivity syndrome from weight-reduction regimen; response to steroid hormone therapy.
Topics: Humans; Obesity; Phenobarbital; Steroids; Syndrome | 1957 |
Use of anorexigenic agent in a weight reduction clinic.
Topics: Ambulatory Care Facilities; Amphetamine; Amphetamines; Obesity; Phenobarbital; Weight Loss | 1958 |
[Medically indicated weight reduction with "Dexten" and "Barbidex" (Nicholas)].
Topics: Dextroamphetamine; Humans; Obesity; Phenobarbital; Weight Loss | 1963 |
TREATMENT OF THE PREHYPERTENSIVE PATIENT.
Topics: Diuretics; Humans; Hypertension; Meprobamate; Obesity; Phenobarbital | 1963 |
MASSIVE OBESITY AND WATER RETENTION.
Topics: Diet, Reducing; Diuretics; Edema; Heart Failure; Humans; Obesity; Phenmetrazine; Phenobarbital | 1964 |
HYPERTENSION AND ITS COMPLICATIONS. 2.
Topics: Amobarbital; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cold Temperature | 1964 |
Some quantitative observations on a methamphetamine-phenobarbital anorexic compound in obese outpatients.
Topics: Amphetamine; Amphetamines; Anorexia; Methamphetamine; Obesity; Outpatients; Phenobarbital | 1960 |
Phenobarbital in the genetically obese Zucker rat. I. Pharmacokinetics after acute and chronic administration.
Topics: Animals; Enzyme Induction; Kinetics; Male; Metabolic Clearance Rate; Obesity; Phenobarbital; Rats; R | 1984 |
Phenobarbital in the genetically obese Zucker rat. II. In vivo and in vitro assessments of microsomal enzyme induction.
Topics: Animals; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Male; Me | 1984 |
Cytochrome P-450 induction in genetically obese rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Male; Microsomes, Liver; Obesit | 1982 |
Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Di | 1994 |
Acetaminophen hepatotoxicity: influence of phenobarbital and beta-naphthoflavone treatment in obese and lean Zucker rats.
Topics: Acetaminophen; Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Enzyme A | 1993 |
Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Body Weight; Cytochrome P-450 Enzyme System; | 1993 |
Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Glutathione; Isoenz | 1993 |
Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: molecular characterization.
Topics: Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP2B1; Cytochrome | 1993 |
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate | 1996 |
[Studies on drug metabolism in obese men and mice (author's transl)].
Topics: Adolescent; Adult; Animals; Enzyme Induction; Fatty Liver; Female; Hexobarbital; Humans; Male; Mice; | 1979 |
[Hydroxylation of testosterone and induction of steroid hydroxylases by phenobarbital in genetically obese mice (author's transl)].
Topics: Animals; Enzyme Induction; Female; Hydroxylation; Mice; Mice, Inbred C57BL; Obesity; Organ Size; Phe | 1979 |
Conjugation of bilirubin--pathophysiological aspects.
Topics: Bilirubin; Fasting; Gilbert Disease; Glutethimide; Hyperbilirubinemia; Nicotinic Acids; Obesity; Phe | 1976 |
Phenobarbital pharmacokinetics in obesity. A case report.
Topics: Adult; Female; Humans; Infusions, Intravenous; Obesity; Phenobarbital | 1992 |
Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non-insulin dependent diabetes mellitus.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabete | 1989 |
Halothane associated hepatitis and phenobarbitone.
Topics: Adult; Anesthesia, Obstetrical; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halo | 1989 |
Phenobarbital induction and acetaminophen hepatotoxicity: resistance in the obese Zucker rodent.
Topics: Acetaminophen; Animals; Enzyme Induction; Glutathione; Liver; Obesity; Phenobarbital; Rats; Rats, Zu | 1987 |
[Obesity in the Prader-Willi syndrome treated with the Elsinore pill].
Topics: Child; Female; Humans; Obesity; Phenobarbital; Prader-Willi Syndrome; Tablets | 1985 |
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children].
Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit | 1971 |
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi | 1974 |
[Effect of phenobarbital on the fatty liver of genetically obese mice].
Topics: Animals; Fatty Liver; Lipids; Liver; Mice; Obesity; Organ Size; Phenobarbital; Proteins; RNA | 1971 |