phenobarbital has been researched along with Nutrition Disorders in 7 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Nutrition Disorders: Disorders caused by nutritional imbalance, either overnutrition or undernutrition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Based on the available data it seems that one may postulate the following conclusions: (1) that the distribution factors as well as changes in drug elimination capacities seem to play a role, perhaps with differing relative importance, during each of the maturational periods; (2) that the physicochemical properties of a drug and its dosage, as well as changes in the volume of distribution in children, in the course of certain disease states may have a significant effect on kinetics of drug disposition in the body; (3) that systemic clearance, a model independent parameter, rather than elimination half-life, a hybrid pharmacokinetic parameter, more accurately reflects elimination of some drugs from the body; (4) that each drug and every clinical situation may require the evaluation of the direct effect on pharmacokinetic processes, since general principles may not always apply; (5) that drug disposition studies should also be performed, if possible, on patients under actual clinical situations and receiving the usual therapeutic regime, and (6) that the half-life of colistin is independent of postnatal age which should serve as a warning not to generalize about drug excretion in the young infant." | 2.37 | Clinical pharmacokinetics of changes in drug elimination in children. ( Prandota, J, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, KP | 1 |
| Sanyal, AK | 1 |
| Jaiswal, AK | 1 |
| Bhattacharya, SK | 1 |
| Prandota, J | 1 |
| Anthony, LE | 1 |
| Reynolds, EH | 1 |
| Basu, TK | 1 |
| Dickerson, JW | 1 |
| Parke, DV | 1 |
| Smuckler, EA | 1 |
| Arcasoy, M | 1 |
2 reviews available for phenobarbital and Nutrition Disorders
| Article | Year |
|---|---|
Clinical pharmacokinetics of changes in drug elimination in children.
Topics: Adult; Anti-Bacterial Agents; Brain Injuries; Child; Child, Preschool; Colistin; Cystic Fibrosis; Di | 1985 |
Structural and functional changes of the endoplasmic reticulum of hepatic parenchymal cells.
Topics: Animals; Azo Compounds; Carbon Tetrachloride; Carcinogens; Cattle; Dogs; Endoplasmic Reticulum; Ethi | 1969 |
5 other studies available for phenobarbital and Nutrition Disorders
| Article | Year |
|---|---|
Effect of undernutrition on morphine analgesia, haloperidol catalepsy and pentobarbitone sodium hypnosis in developing new born rats.
Topics: Analgesia; Analgesics, Opioid; Animals; Animals, Newborn; Behavior, Animal; Catalepsy; Central Nervo | 2003 |
Effect of prenatal undernutrition and phenobarbitone administration on discrimination learning and passive avoidance behaviour in rats.
Topics: Animals; Avoidance Learning; Discrimination Learning; Female; Nutrition Disorders; Phenobarbital; Pr | 1996 |
Effects of protein-calorie malnutrition on drug metabolism in rat liver microsomes.
Topics: Animal Nutritional Physiological Phenomena; Animals; Cytochrome P-450 Enzyme System; Cytochrome Redu | 1973 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
Effect of underfeeding suckling rats on the activity of hepatic drug metabolizing enzymes.
Topics: Animals; Animals, Newborn; Benzoates; Biphenyl Compounds; Body Weight; Coumarins; Cytochrome P-450 E | 1973 |