phenobarbital has been researched along with Neuroleptic Malignant Syndrome in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "She underwent hemodialysis for treatment of acute renal failure and recovered from it after 16 sessions of hemodialysis." | 1.28 | [A case of neuroleptic malignant syndrome with acute renal failure]. ( Hayashi, M; Koya, J; Shiono, A; Yajima, H; Yamanaka, H, 1992) |
| "A case of neuroleptic malignant syndrome (NMS) is described in a congenitally brain-damaged deaf patient." | 1.28 | Neuroleptic malignant syndrome and preexisting brain damage. ( Lazarus, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsusue, A | 1 |
| Hara, K | 1 |
| Kageura, M | 1 |
| Kashiwagi, M | 1 |
| Lu, W | 1 |
| Ishigami, A | 1 |
| Gotohda, T | 1 |
| Tokunaga, I | 1 |
| Nisimura, A | 1 |
| Sugimura, T | 1 |
| Kubo, S | 1 |
| Shiono, A | 1 |
| Hayashi, M | 1 |
| Yamanaka, H | 1 |
| Yajima, H | 1 |
| Koya, J | 1 |
| Lazarus, A | 1 |
3 other studies available for phenobarbital and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene: an autopsy case of neuroleptic malignant syndrome related to vegetamin.
Topics: Adult; Amino Acid Substitution; Antipsychotic Agents; Brain; Brain Edema; Carnitine O-Palmitoyltrans | 2009 |
[A case of neuroleptic malignant syndrome with acute renal failure].
Topics: Acute Kidney Injury; Chlorpromazine; Drug Combinations; Female; Humans; Middle Aged; Neuroleptic Mal | 1992 |
Neuroleptic malignant syndrome and preexisting brain damage.
Topics: Adult; Brain Damage, Chronic; Drug Therapy, Combination; Haloperidol; Humans; Male; Neuroleptic Mali | 1992 |