phenobarbital has been researched along with Neurodevelopmental Disorders in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Neurodevelopmental Disorders: These are a group of conditions with onset in the developmental period. The disorders typically manifest early in development, often before the child enters grade school, and are characterized by developmental deficits that produce impairments of personal, social, academic, or occupational functioning. (From DSM-5).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital (PB) has been traditionally used as the first-line treatment for neonatal seizures." | 5.30 | Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience. ( Barbagallo, M; Corsello, G; Falsaperla, R; Mauceri, L; Pavone, P; Pisani, F; Ruggieri, M; Vitaliti, G, 2019) |
| "Seizures are common following perinatal asphyxia and may exacerbate secondary neuronal injury." | 2.53 | Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia. ( Berg, M; Soll, R; Young, L, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chin, EM | 1 |
| Cohen, JS | 1 |
| Harris, J | 1 |
| Falsaperla, R | 1 |
| Mauceri, L | 1 |
| Pavone, P | 1 |
| Barbagallo, M | 1 |
| Vitaliti, G | 1 |
| Ruggieri, M | 1 |
| Pisani, F | 1 |
| Corsello, G | 1 |
| Young, L | 1 |
| Berg, M | 1 |
| Soll, R | 1 |
1 review available for phenobarbital and Neurodevelopmental Disorders
| Article | Year |
|---|---|
Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Barbiturates; Humans; Infant; Infant, Newborn; Infant, Prematu | 2016 |
1 trial available for phenobarbital and Neurodevelopmental Disorders
| Article | Year |
|---|---|
Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience.
Topics: Anticonvulsants; Female; Humans; Infant, Newborn; Italy; Levetiracetam; Male; Neurodevelopmental Dis | 2019 |
1 other study available for phenobarbital and Neurodevelopmental Disorders
| Article | Year |
|---|---|
Vigabatrin as a Targeted Treatment of GABA
Topics: Animals; Anticonvulsants; Chromosomes, Human, Pair 9; Drug Substitution; Electroencephalography; Epi | 2019 |