Page last updated: 2024-11-02

phenobarbital and Neuralgia

phenobarbital has been researched along with Neuralgia in 8 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Research Excerpts

ExcerptRelevanceReference
"To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period."5.09Age-related alteration of carbamazepine-serum protein binding in man. ( Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A, 1999)
"CCI-ION induced facial mechanical hyperalgesia."1.91Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process. ( Callai, E; Caumo, W; da Silva, MD; de Souza, A; Finamor, F; Medeiros, LF; Scarabelot, VL; Stein, DJ; Torres, ILS, 2023)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's1 (12.50)18.2507
2000's1 (12.50)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
King, AM3
Salomé, C3
Dinsmore, J2
Salomé-Grosjean, E2
De Ryck, M3
Kaminski, R3
Valade, A2
Kohn, H3
Stables, JP1
Baruah, PK1
Provins, L1
Finamor, F3
Scarabelot, VL3
Medeiros, LF3
Stein, DJ3
da Silva, MD3
Callai, E3
Caumo, W3
de Souza, A3
Torres, ILS3
Koyama, H1
Sugioka, N1
Uno, A1
Mori, S1
Nakajima, K1
Rovetta, G1
Baratto, L1
Farinelli, G1
Monteforte, P1
Ferry, PC1
Klittscher, K1

Trials

1 trial available for phenobarbital and Neuralgia

ArticleYear
Age-related alteration of carbamazepine-serum protein binding in man.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Diethyl

1999

Other Studies

7 other studies available for phenobarbital and Neuralgia

ArticleYear
Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
    Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13

    Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Convulsants; Electroshock; Formaldehyde; Male; Mi

2011
Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain
    Journal of medicinal chemistry, 2011, Oct-13, Volume: 54, Issue:19

    Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Butyrates; Male; Mice; Neuralgia; Pain Measuremen

2011
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
    Bioorganic & medicinal chemistry, 2012, Jun-01, Volume: 20, Issue:11

    Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclini

2012
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Involvement of GABAergic, glutamatergic, opioidergic, and brain-derived neurotrophic factor systems in the trigeminal neuropathic pain process.
    Neuroscience letters, 2023, 01-10, Volume: 793

    Topics: Animals; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; GABAergic Neurons; Hyperalgesia; Mo

2023
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
    International journal of tissue reactions, 2001, Volume: 23, Issue:1

    Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid

2001
Diagnosis and office management of headaches in children.
    Clinical pediatrics, 1972, Volume: 11, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Female; Headache; Humans; Intracranial

1972
[Control of pain with target therapy with "Spasmo-Dolviran"].
    Hippokrates, 1967, Apr-15, Volume: 38, Issue:7

    Topics: Analgesics; Aspirin; Codeine; Female; Headache; Humans; Menopause; Neuralgia; Pain; Phenacetin; Phen

1967