phenobarbital has been researched along with Nervous System Disorders in 43 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 7.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| " Available data suggests that phenobarbital is as effective as other first-line drugs for treating tonic-clonic seizures, but side effect reports differ widely between high and low-income settings." | 5.40 | Medication side effects among people with epilepsy taking phenobarbital in Zambia. ( Birbeck, GL; Bui, E; Elafros, MA, 2014) |
| "To study the effect of phenobarbital given within six hours of life to term and near-term asphyxiated neonates, on mortality, neurological abnormality at discharge and seizures." | 5.11 | A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy. ( Kumar, P; Narang, A; Singh, D, 2005) |
| "This study evaluated the potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats." | 3.68 | Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats. ( Adams, HR; Frye, GD; Peterson, SL; Trzeciakowski, JP, 1990) |
| " Adverse effects of antiepileptic treatment may affect the patient's quality of life to an even greater extent than the occurrence of seizures." | 2.39 | Adverse effects of established and new antiepileptic drugs: an attempted comparison. ( Gram, L; Rogvi-Hansen, B, 1995) |
| " Available data suggests that phenobarbital is as effective as other first-line drugs for treating tonic-clonic seizures, but side effect reports differ widely between high and low-income settings." | 1.40 | Medication side effects among people with epilepsy taking phenobarbital in Zambia. ( Birbeck, GL; Bui, E; Elafros, MA, 2014) |
| ""Kernicterus" is a term currently used to describe bilirrubin induced brain injury in the neuro-pathological studies." | 1.38 | [Neurological dysfunction induced by bilirrubin]. ( Campistol, J; Cazorla, AG; Cusí, V; Galvez, H; Iriondo, M; Málaga, I, 2012) |
| "There were 73 children with seizures, 80% of whom had a greater than 50% reduction in seizure frequency following the start of simple anticonvulsant medication." | 1.32 | A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children. ( Allen, S; Burton, KJ, 2003) |
| " The diagnosis was established as the neuro-allergic Adverse Event Following DPT + Polio Immunisation." | 1.31 | [A severe adverse event after vaccine for diphtheria, tetanus, pertussis and poliomyelitis (DTP + polio) in a 4.5 month old infant]. ( Balcerska, A; Borzych, D; Irga, N; Wierzba, J, 2000) |
| "In phenobarbital treated animals striatal injection of 1 microg of MPP+ did not produce any effect on dopaminergic parameters but injection of 2 microg of MPP+ caused losses of dopamine levels and dopamine transporter although smaller than in control rats." | 1.30 | In vivo protection of striatal dopaminergic system against 1-methyl-4-phenylpyridinium neurotoxicity by phenobarbital. ( Cano, J; Machado, A; Merino, M; Vizuete, ML, 1997) |
| "Heroin exposure was accomplished by injecting dams during the same gestational period." | 1.29 | Neural grafting as a tool for the study and reversal of neurobehavioral birth defects. ( Abu-Roumi, M; Silverman, WF; Steingart, RA; Yanai, J, 1996) |
| "Amongst 149 cases of reflex sympathetic dystrophy syndrome (RSDS), 25 (16." | 1.27 | Reflex sympathetic dystrophy syndrome and barbiturates. A study of 25 cases treated with barbiturates compared with 124 cases treated without barbiturates. ( Gerster, JC; Horton, P, 1984) |
| "0 g of misonidazole, severe nausea and vomiting are prominent, so that this side effect is a determining factor in the treatment fractionation." | 1.27 | The role of microsomal enzyme inducers in the reduction of misonidazole neurotoxicity. ( Bleehen, NM; Jones, DH; Smith, NC; Workman, P, 1983) |
| "This syndrome consists of sustained seizures, resembling amygdaloid kindled seizures, and acute destruction of neural elements in limbic brain regions (amygdala, olfactory cortex, hippocampus, lateral septum and several thalamic nuclei)." | 1.26 | Only certain anticonvulsants protect against kainate neurotoxicity. ( Fuller, TA; Olney, JW, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (55.81) | 18.7374 |
| 1990's | 9 (20.93) | 18.2507 |
| 2000's | 5 (11.63) | 29.6817 |
| 2010's | 5 (11.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, M | 1 |
| Gan, L | 1 |
| Chen, B | 1 |
| Yu, C | 1 |
| Zhang, J | 1 |
| Gama-Sosa, MA | 1 |
| Pollak, DD | 1 |
| Berger, S | 1 |
| Phillips, JD | 1 |
| Edelmann, W | 1 |
| Desnick, RJ | 1 |
| Elafros, MA | 1 |
| Bui, E | 1 |
| Birbeck, GL | 1 |
| Saldarriaga, W | 1 |
| Lein, P | 1 |
| González Teshima, LY | 1 |
| Isaza, C | 1 |
| Rosa, L | 1 |
| Polyak, A | 1 |
| Hagerman, R | 1 |
| Girirajan, S | 1 |
| Silva, M | 1 |
| Tassone, F | 1 |
| Campistol, J | 1 |
| Galvez, H | 1 |
| Cazorla, AG | 1 |
| Málaga, I | 1 |
| Iriondo, M | 1 |
| Cusí, V | 1 |
| van Ommeren, M | 1 |
| Barbui, C | 1 |
| de Jong, K | 1 |
| Dua, T | 1 |
| Jones, L | 1 |
| Perez-Sales, P | 1 |
| Schilperoord, M | 1 |
| Ventevogel, P | 1 |
| Yasamy, MT | 1 |
| Saxena, S | 1 |
| Dayal, M | 1 |
| Parmar, D | 1 |
| Dhawan, A | 1 |
| Ali, M | 1 |
| Dwivedi, UN | 1 |
| Seth, PK | 1 |
| Burton, KJ | 1 |
| Allen, S | 1 |
| DENNEMARK, HG | 1 |
| Singh, D | 1 |
| Kumar, P | 1 |
| Narang, A | 1 |
| Matthieu, JM | 1 |
| Eggenberger, P | 1 |
| Almazan, G | 1 |
| Ginalski-Winkelmann, H | 1 |
| Escorihuela, R | 1 |
| Sandiumenge, J | 1 |
| Horton, P | 1 |
| Gerster, JC | 1 |
| Jones, DH | 1 |
| Bleehen, NM | 1 |
| Workman, P | 1 |
| Smith, NC | 1 |
| Fuller, TA | 1 |
| Olney, JW | 1 |
| Lasker, JM | 1 |
| Graham, DG | 1 |
| Abou-Donia, MB | 1 |
| Hashimoto, K | 1 |
| Sakamoto, J | 1 |
| Tanii, H | 1 |
| Schain, RJ | 2 |
| Lindberg, RL | 1 |
| Porcher, C | 1 |
| Grandchamp, B | 1 |
| Ledermann, B | 1 |
| Bürki, K | 1 |
| Brandner, S | 1 |
| Aguzzi, A | 1 |
| Meyer, UA | 1 |
| Rogvi-Hansen, B | 1 |
| Gram, L | 1 |
| Koch, S | 1 |
| Jäger-Roman, E | 1 |
| Lösche, G | 1 |
| Nau, H | 1 |
| Rating, D | 1 |
| Helge, H | 1 |
| Yanai, J | 1 |
| Abu-Roumi, M | 1 |
| Silverman, WF | 1 |
| Steingart, RA | 1 |
| Vizuete, ML | 1 |
| Merino, M | 1 |
| Cano, J | 1 |
| Machado, A | 1 |
| Wierzba, J | 1 |
| Irga, N | 1 |
| Balcerska, A | 1 |
| Borzych, D | 1 |
| Tisdall, PL | 1 |
| Hunt, GB | 1 |
| Youmans, KR | 1 |
| Malik, R | 1 |
| Boldyrev, AI | 1 |
| Fleĭs, EP | 1 |
| Vaĭntrub, MIa | 1 |
| Fishman, MA | 1 |
| Fein, A | 1 |
| Grossman, RF | 1 |
| Jones, JG | 1 |
| Overland, E | 1 |
| Pitts, L | 1 |
| Murray, JF | 1 |
| Staub, NC | 1 |
| Edel'shteĭn, EA | 1 |
| Bondarenko, ES | 1 |
| Mumladze, TA | 1 |
| Panikarskiĭ, VG | 1 |
| Yagi, K | 1 |
| Watanabe, M | 1 |
| Steele, TD | 1 |
| Brewster, WK | 1 |
| Johnson, MP | 1 |
| Nichols, DE | 1 |
| Yim, GK | 1 |
| Hoffman, A | 1 |
| Levy, G | 2 |
| Peterson, SL | 1 |
| Trzeciakowski, JP | 1 |
| Frye, GD | 1 |
| Adams, HR | 1 |
| Konno, N | 1 |
| Katoh, K | 1 |
| Yamaguchi, Y | 1 |
| Yamauchi, T | 1 |
| Fukushima, M | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Sato, S | 1 |
| Melamed, E | 1 |
| Martinovits, G | 1 |
| Pikarsky, E | 1 |
| Rosenthal, J | 1 |
| Uzzan, A | 1 |
| Lequesne, M | 1 |
| Ohlenschläger, G | 1 |
| Dobrescu, DI | 1 |
| Kaeser, HE | 1 |
| Chen, FC | 1 |
| Cavanagh, JB | 1 |
5 reviews available for phenobarbital and Nervous System Disorders
| Article | Year |
|---|---|
[Use of phenobarbital in febrile convulsive crisis].
Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr | 1983 |
Adverse effects of established and new antiepileptic drugs: an attempted comparison.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; gamma-Aminobutyric Acid; Gastrointestinal Disease | 1995 |
Febrile seizures: the treatment controversy.
Topics: Child; Epilepsy; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Recurrence; Seizures; Se | 1979 |
[Neurotoxicity of antiepileptic drugs].
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Ethosuximide; Humans; Male; Nervous S | 1992 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
3 trials available for phenobarbital and Nervous System Disorders
| Article | Year |
|---|---|
A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy.
Topics: Anticonvulsants; Female; Free Radicals; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Nerv | 2005 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Propranolol in the treatment of disturbances of the autonomic nervous system.
Topics: Adult; Amobarbital; Atropa belladonna; Autonomic Nervous System; Clinical Trials as Topic; Ergot Alk | 1971 |
35 other studies available for phenobarbital and Nervous System Disorders
| Article | Year |
|---|---|
Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria.
Topics: Aminolevulinic Acid; Animals; Central Nervous System; Gene Knock-In Techniques; Genes, Dominant; Hom | 2019 |
Medication side effects among people with epilepsy taking phenobarbital in Zambia.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Nervous System Diseases; Phenoba | 2014 |
Phenobarbital use and neurological problems in FMR1 premutation carriers.
Topics: Cognition Disorders; DNA Mutational Analysis; Excitatory Amino Acid Antagonists; Family Health; Fema | 2016 |
[Neurological dysfunction induced by bilirrubin].
Topics: Age of Onset; Autopsy; Electroencephalography; Evoked Potentials, Auditory; Exchange Transfusion, Wh | 2012 |
If you could only choose five psychotropic medicines: updating the interagency emergency health kit.
Topics: Amitriptyline; Anti-Anxiety Agents; Cholinergic Antagonists; Diazepam; Emergencies; Emergency Medica | 2011 |
Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin.
Topics: Animals; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inductio | 2003 |
A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Developmental Disabilities; Fem | 2003 |
[Medical treatment of nervous rhythm disorders, especially dies inversus].
Topics: Humans; Lobelia; Nervous System Diseases; Nitrites; Papaverine; Parasympathomimetics; Phenobarbital; | 1958 |
Anticonvulsive treatment of myelin-deficient (mld) mice improves survival and confirms the delayed increase of myelin basic protein.
Topics: Animals; Brain Chemistry; Mice; Mice, Neurologic Mutants; Myelin Basic Protein; Myelin Sheath; Nervo | 1984 |
Reflex sympathetic dystrophy syndrome and barbiturates. A study of 25 cases treated with barbiturates compared with 124 cases treated without barbiturates.
Topics: Adult; Aged; Barbiturates; Female; Humans; Male; Middle Aged; Nervous System Diseases; Phenobarbital | 1984 |
The role of microsomal enzyme inducers in the reduction of misonidazole neurotoxicity.
Topics: Adult; Aged; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Half-Life; Humans; K | 1983 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Pheny | 1981 |
Differential metabolism of O-ethyl O-4-nitrophenyl phenylphosphonothioate by rat and chicken hepatic microsomes.
Topics: Animals; Biotransformation; Chickens; Female; In Vitro Techniques; Insecticides; Male; Microsomes, L | 1982 |
Neurotoxicity of acrylamide and related compounds and their effects on male gonads in mice.
Topics: Acrylamides; Animals; Body Weight; Lethal Dose 50; Male; Mice; Nervous System Diseases; Organ Size; | 1981 |
Phenobarbital in neurologically handicapped children.
Topics: Brain Damage, Chronic; Child; Humans; Intellectual Disability; Nervous System Diseases; Phenobarbita | 1981 |
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Topics: Aminolevulinic Acid; Animals; Atrophy; Axons; Base Sequence; Chimera; Disease Models, Animal; Female | 1996 |
Neural grafting as a tool for the study and reversal of neurobehavioral birth defects.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Cell Transplantation; Congenital Abnormalit | 1996 |
In vivo protection of striatal dopaminergic system against 1-methyl-4-phenylpyridinium neurotoxicity by phenobarbital.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Catecholamines; Cytochrome P-450 Enzyme System; Dopamine; Dopa | 1997 |
[A severe adverse event after vaccine for diphtheria, tetanus, pertussis and poliomyelitis (DTP + polio) in a 4.5 month old infant].
Topics: Dexamethasone; Diphtheria Toxoid; Diphtheria-Tetanus-Pertussis Vaccine; Female; Humans; Hypersensiti | 2000 |
Neurological dysfunction in dogs following attenuation of congenital extrahepatic portosystemic shunts.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Ligation; Male; Nervous System Diseases; Pheno | 2000 |
[Neurologic complications following medical treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey | 1979 |
The value of edema fluid protein measurement in patients with pulmonary edema.
Topics: Adolescent; Adult; Aged; Blood Pressure; Blood Proteins; Body Fluids; Capillary Permeability; Female | 1979 |
[Lesions of the nervous system in premature children with "conjugated" jaundices].
Topics: Apnea; Eye Manifestations; Face; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neo | 1979 |
Problems with the use of conventional anticonvulsant drugs in mentally retarded individuals.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Cognition; Epilepsy; Humans; Intellec | 1979 |
[Problems in treatment of autonomic disorders accompanying hypertensive disease].
Topics: Adult; Autonomic Nervous System; Benzimidazoles; Caffeine; Calcium; Female; Gluconates; Humans; Hype | 1977 |
Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Biogenic Amines; Brain Chemistry; Chromatography, High Press | 1991 |
Kinetics of drug action in disease states. XXXIX. Effect of orally administered activated charcoal on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline administered intravenously to rats with renal failure.
Topics: Animals; Blood Proteins; Charcoal; Hypnotics and Sedatives; Injections, Intravenous; Kidney Failure, | 1990 |
Potentiation by glycine of anticonvulsant drugs in maximal electroshock seizures in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Chromatography, High Pressure Liquid; Diaz | 1990 |
Effect of phenobarbital on the delayed neurotoxicity of leptophos in hens.
Topics: Animals; Chickens; Female; Insecticides; Leptophos; Nervous System Diseases; Phenobarbital | 1986 |
Systemic effect of ipecac on acute toxicity of phenobarbital and theophylline in rats.
Topics: Animals; Cardiovascular Diseases; Ipecac; Male; Nervous System Diseases; Phenobarbital; Rats; Rats, | 1989 |
Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anticonvulsants; Male; Mice; Mice, Inbred C57 | 1986 |
[Etiology and pathogenesis of algodystrophies].
Topics: Antitubercular Agents; Cardiovascular Diseases; Extremities; Humans; Infections; Lung Diseases; Nerv | 1968 |
[Disorders of vegetative regulation. Symptoms and therapeutic possibilities].
Topics: Atropa belladonna; Autonomic Nervous System; Ergotamine; Humans; Nervous System Diseases; Phenobarbi | 1972 |
[Neurotoxicity of drugs].
Topics: Arsenic; Drug-Related Side Effects and Adverse Reactions; Humans; Nervous System Diseases; Nitrofura | 1972 |
Factors affecting neurotoxicity by p-bromophenylacetylurea in rats.
Topics: Acetylcholinesterase; Age Factors; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Chemi | 1971 |