phenobarbital has been researched along with Nerve Degeneration in 17 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bumetanide was suggested as an adjunct to phenobarbital for suppression of neonatal seizures." | 8.02 | A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia. ( Gailus, B; Gericke, B; Johne, M; Käufer, C; Löscher, W; Römermann, K, 2021) |
| "Bumetanide was suggested as an adjunct to phenobarbital for suppression of neonatal seizures." | 4.02 | A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia. ( Gailus, B; Gericke, B; Johne, M; Käufer, C; Löscher, W; Römermann, K, 2021) |
| " This may due in part to vascular damage, neuroinflammation and neuronal degeneration in the diencephalon, which is seen in animal models of pyrithiamine-enhanced thiamine deficiency." | 3.88 | Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency. ( Bowyer, JF; Hanig, JP; Sarkar, S; Tranter, KM, 2018) |
| "Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFα, IL-1β, and IL-18, but not IFNγ at 6 h." | 1.46 | Caffeine Protects Against Anticonvulsant-Induced Neurotoxicity in the Developing Rat Brain. ( Bendix, I; Bührer, C; Endesfelder, S; Schiller, C; Sifringer, M; Weichelt, U, 2017) |
| "Propylene glycol (PG) is a common solvent used in medical preparations." | 1.38 | Propylene glycol produces excessive apoptosis in the developing mouse brain, alone and in combination with phenobarbital. ( Farber, NB; Lau, K; Noguchi, KK; Reeves, N; Swiney, BS, 2012) |
| "The flupirtine-treated group showed less impairment in learning and memory and less obvious pathological changes in the brain following RFS compared with the phenobarbital-treated group." | 1.37 | Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures. ( He, X; Liu, W; Liu, Y; Peng, B; Wang, H; Wang, Y; Yin, J; Yu, F, 2011) |
| "As phenobarbital treatment did not protect against neuronal damage in CA3 or other regions of the hippocampus, the circuitry of the dentate gyrus was implicated as a locus of cellular alterations that influenced the development of kindling." | 1.28 | Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital. ( Cavazos, J; Golarai, G; Sutula, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Johne, M | 1 |
| Käufer, C | 1 |
| Römermann, K | 1 |
| Gailus, B | 1 |
| Gericke, B | 1 |
| Löscher, W | 4 |
| Endesfelder, S | 1 |
| Weichelt, U | 1 |
| Schiller, C | 1 |
| Sifringer, M | 2 |
| Bendix, I | 1 |
| Bührer, C | 1 |
| Bowyer, JF | 1 |
| Tranter, KM | 1 |
| Sarkar, S | 1 |
| Hanig, JP | 1 |
| Bethmann, K | 2 |
| Fritschy, JM | 2 |
| Brandt, C | 2 |
| Barks, JD | 1 |
| Liu, YQ | 1 |
| Shangguan, Y | 1 |
| Silverstein, FS | 1 |
| Yu, F | 1 |
| Liu, Y | 1 |
| Wang, Y | 1 |
| Yin, J | 1 |
| Wang, H | 1 |
| Liu, W | 1 |
| Peng, B | 1 |
| He, X | 1 |
| Bankstahl, M | 1 |
| Bankstahl, JP | 1 |
| Lau, K | 1 |
| Swiney, BS | 1 |
| Reeves, N | 1 |
| Noguchi, KK | 1 |
| Farber, NB | 1 |
| Bittigau, P | 1 |
| Genz, K | 1 |
| Reith, E | 1 |
| Pospischil, D | 1 |
| Govindarajalu, S | 1 |
| Dzietko, M | 1 |
| Pesditschek, S | 1 |
| Mai, I | 1 |
| Dikranian, K | 1 |
| Olney, JW | 1 |
| Ikonomidou, C | 1 |
| Volk, HA | 1 |
| Arabadzisz, D | 1 |
| de Oliveira, PA | 1 |
| Lino, FL | 1 |
| Cappelari, SE | 1 |
| da Silva Brum, LF | 1 |
| Picada, JN | 1 |
| Pereira, P | 1 |
| Fishman, RH | 1 |
| Ornoy, A | 1 |
| Yanai, J | 1 |
| Edwards, PM | 1 |
| Ibrahim, MZ | 1 |
| Sutula, T | 1 |
| Cavazos, J | 1 |
| Golarai, G | 1 |
| Nadler, JV | 1 |
| Okazaki, MM | 1 |
| Gruenthal, M | 1 |
| Ault, B | 1 |
| Armstrong, DR | 1 |
| French, JH | 1 |
| Sherard, ES | 1 |
| Lubell, H | 1 |
| Brotz, M | 1 |
| Moore, CL | 1 |
17 other studies available for phenobarbital and Nerve Degeneration
| Article | Year |
|---|---|
A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Benzylamines; Brain; Bumetanide; Do | 2021 |
Caffeine Protects Against Anticonvulsant-Induced Neurotoxicity in the Developing Rat Brain.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Caffeine; Cytokines; gamma-Aminobutyri | 2017 |
Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency.
Topics: Animals; Blood Vessels; Calcium-Binding Proteins; CD11b Antigen; Diet; Dizocilpine Maleate; Female; | 2018 |
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Resistance; Electric Stimulati | 2008 |
Phenobarbital augments hypothermic neuroprotection.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Hypothe | 2010 |
Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography | 2011 |
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2012 |
Propylene glycol produces excessive apoptosis in the developing mouse brain, alone and in combination with phenobarbital.
Topics: Animals; Anticonvulsants; Apoptosis; Brain; Caspase 3; Humans; Mice; Mice, Inbred C57BL; Nerve Degen | 2012 |
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain.
Topics: Animals; Anticonvulsants; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Diazepam; Disease Mod | 2002 |
Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Autoradiography; Disease Models, Animal; Drug Resistance; Electroencephalo | 2006 |
Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Dose- | 2008 |
Ultrastructural evidence of long-lasting cerebellar degeneration after early exposure to phenobarbital in mice.
Topics: Animals; Cerebellum; Double-Blind Method; Mice; Mice, Inbred Strains; Myelin Sheath; Nerve Degenerat | 1983 |
Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy.
Topics: Acrylamides; Animals; Ataxia; Brachial Plexus; Chickens; DDT; Female; Goldfish; Male; Nerve Degenera | 1975 |
Glycogen and its related enzymes of metabolism in the central nervous system.
Topics: 1,4-alpha-Glucan Branching Enzyme; Adenine Nucleotides; Adrenal Cortex Hormones; Animals; Blood Gluc | 1975 |
Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital.
Topics: Animals; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Nerve D | 1992 |
Kainic acid seizures and neuronal cell death: insights from studies of selective lesions and drugs.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Hippocampus; Kainic Acid; Limbic Syste | 1986 |
Trichopoliodystrophy. I. Report of a case and biochemical studies.
Topics: Amino Acids; Brain Chemistry; Brain Diseases; Cerebellum; Cerebral Cortex; Cerebrosides; Cholesterol | 1972 |