phenobarbital has been researched along with Neoplasms in 60 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Excerpt | Relevance | Reference |
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" In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
"Phenobarbital was then added, allowing dose escalation to 144 mg/m2." | 2.71 | A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital. ( Innocenti, F; Mani, S; Prado, M; Ramírez, J; Ratain, MJ; Schilsky, RL; Undevia, SD; Vogelzang, NJ, 2004) |
"Phenytoin has been causally implicated in three human cancers: lymphoma, myeloma and neuroblastoma, the latter specifically in the setting of foetal hydantoin syndrome." | 2.43 | Cancer risk in people with epilepsy: the role of antiepileptic drugs. ( Driever, PH; Sander, JW; Singh, G, 2005) |
"At exposures causing rodent liver tumors, PB has measurable effects on hepatocytes: PB inhibits cell-to-cell communication; PB induces enzymes, including P450 cytochromes; PB stimulates proliferation and inhibits apoptosis of hepatocytes in neoplastic foci." | 2.39 | Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. ( Ross, PM; Whysner, J; Williams, GM, 1996) |
"Each anticancer agent has its own pharmacologic activities." | 2.37 | [Drug interactions with anticancer agents]. ( Furue, H, 1985) |
"Within the cells of the liver and tumors, gallium is found in lysosomes, and rough endoplasmic reticulum." | 2.36 | Mechanisms of localization of gallium-67 in tumors. ( Larson, SM, 1978) |
"Drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments." | 2.36 | Some examples of interactions between drugs in cancer chemotherapy. ( Garattini, S; Spreafico, F, 1978) |
"Patients were divided into non-cancer and cancer groups." | 1.51 | Reduced Clearance of Phenobarbital in Advanced Cancer Patients near the End of Life. ( Echizen, H; Kato, T; Nakayama, H; Ogawa, R; Orii, T, 2019) |
"Ninety cancer patients with selective operation from March 2011 to May 2014 were randomly divided into group A (34 cases), group B (28 cases) and group C (28 cases)." | 1.40 | Influence of propofol, isoflurane and enflurance on levels of serum interleukin-8 and interleukin-10 in cancer patients. ( Liu, TC, 2014) |
" Here, we describe the use of a differential display technology to understand the molecular mechanisms related to 13 weeks of dosing with the prototype rodent nongenotoxic hepatocarcinogen, phenobarbital." | 1.33 | Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity. ( Alden, CL; Blomme, EA; Bunch, RT; Cabonce, MA; Curtiss, SW; Elrick, MM; Kier, LD; Kolaja, KL; Kramer, JA; Morris, DL; Rodi, CP, 2005) |
"The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
"Low melatonin levels seem to parallel cancer growth." | 1.29 | Hepatic hydroxylation of melatonin in the rat is induced by phenobarbital and 7,12-dimethylbenz[a]anthracene--implications for cancer etiology. ( Bartsch, C; Bartsch, H; Lippert, TH; Mecke, D; Praast, G, 1995) |
"The excess numbers of brain cancer were concentrated within 10 years of hospitalization (RR = 20." | 1.28 | Cancer among epileptic patients exposed to anticonvulsant drugs. ( Boice, JD; Fraumeni, JF; Jensen, JP; Olsen, JH, 1989) |
"National Cancer Institute and two Federal Agencies, seven drugs were listed." | 1.26 | Epidemiological studies of medically used drugs. ( Clemmesen, J; Hjalgrim-Jensen, S, 1980) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 42 (70.00) | 18.7374 |
1990's | 5 (8.33) | 18.2507 |
2000's | 10 (16.67) | 29.6817 |
2010's | 3 (5.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Tukey, RH | 1 |
Strassburg, CP | 1 |
Nakayama, H | 1 |
Echizen, H | 1 |
Ogawa, R | 1 |
Orii, T | 1 |
Kato, T | 1 |
Liu, TC | 1 |
Lakhoua, G | 1 |
Aouinti, I | 1 |
Sahnoun, R | 1 |
Kastalli, S | 1 |
Daghfous, R | 1 |
Zaïem, A | 1 |
Kaledin, VI | 1 |
Nikolin, VP | 1 |
Baimak, TY | 1 |
Galyamova, MR | 1 |
Popova, NA | 1 |
Andreeva, EM | 1 |
PARHON, CI | 1 |
BABES, A | 1 |
PETREA, I | 1 |
CERRA, R | 1 |
PERCESEPE, E | 1 |
NAKAMURA, H | 1 |
JENNINGS, RC | 1 |
SHAIKH, VA | 1 |
ALLEN, WM | 1 |
MARX, GF | 1 |
SCHEINBERG, L | 1 |
ROMNEY, SL | 1 |
CHURCHILL-DAVIDSON, I | 1 |
JOHNSON, J | 1 |
BRANCO, F | 1 |
GANDER, G | 1 |
HART, LG | 1 |
ADAMSON, RH | 1 |
MORRIS, HP | 1 |
FOUTS, JR | 1 |
Innocenti, F | 1 |
Undevia, SD | 1 |
Ramírez, J | 1 |
Mani, S | 1 |
Schilsky, RL | 1 |
Vogelzang, NJ | 1 |
Prado, M | 1 |
Ratain, MJ | 1 |
Singh, G | 1 |
Driever, PH | 1 |
Sander, JW | 1 |
Agrawal, AK | 1 |
Shapiro, BH | 1 |
Elrick, MM | 1 |
Kramer, JA | 1 |
Alden, CL | 1 |
Blomme, EA | 1 |
Bunch, RT | 1 |
Cabonce, MA | 1 |
Curtiss, SW | 1 |
Kier, LD | 1 |
Kolaja, KL | 1 |
Rodi, CP | 1 |
Morris, DL | 1 |
Carpenter, JS | 1 |
Yamada, H | 1 |
Ishii, Y | 1 |
Yamamoto, M | 1 |
Oguri, K | 1 |
Hozumi, M | 1 |
Yamasaki, H | 1 |
Greim, H | 1 |
Deml, E | 1 |
Oesterle, D | 1 |
Clemmesen, J | 5 |
Hjalgrim-Jensen, S | 3 |
Siegel, SE | 1 |
Moran, RG | 1 |
Wakui, A | 2 |
Maezawa, S | 1 |
Ohira, S | 1 |
Sakuma, M | 1 |
Matsuoka, S | 1 |
Saito, T | 1 |
Praast, G | 1 |
Bartsch, C | 1 |
Bartsch, H | 1 |
Mecke, D | 1 |
Lippert, TH | 1 |
Shaw, IC | 1 |
Jones, HB | 1 |
Whysner, J | 1 |
Ross, PM | 1 |
Williams, GM | 1 |
Watanabe, T | 1 |
Sugie, S | 1 |
Okamoto, K | 1 |
Rahman, KM | 1 |
Ushida, J | 1 |
Mori, H | 1 |
Cavalieri, EL | 1 |
Li, KM | 1 |
Balu, N | 1 |
Saeed, M | 1 |
Devanesan, P | 1 |
Higginbotham, S | 1 |
Zhao, J | 1 |
Gross, ML | 1 |
Rogan, EG | 1 |
White, SJ | 1 |
McLean, AE | 2 |
Howland, C | 1 |
Pitot, HC | 2 |
Larson, SM | 1 |
Marx, JL | 1 |
Garattini, S | 1 |
Spreafico, F | 1 |
Driver, HE | 1 |
Sutherland, IA | 1 |
Shimada, T | 1 |
Yamazaki, H | 1 |
Shimura, H | 1 |
Tanaka, R | 1 |
Guengerich, FP | 1 |
Lutz, W | 1 |
Sułkowski, W | 1 |
Olsen, JH | 1 |
Boice, JD | 1 |
Jensen, JP | 1 |
Fraumeni, JF | 1 |
Okey, AB | 1 |
Roberts, EA | 1 |
Harper, PA | 1 |
Denison, MS | 1 |
Grosso, LE | 1 |
Goldsworthy, T | 1 |
Furue, H | 1 |
Akintonwa, DA | 1 |
Schmähl, D | 1 |
Trosko, JE | 1 |
Chang, CC | 1 |
Macmahon, B | 1 |
Wattenberg, LW | 1 |
Fuglsang-Frederiksen, V | 1 |
Plum, CM | 1 |
Schneiderman, MA | 1 |
Gelboin, HV | 2 |
Papillon, P | 1 |
Grossetete, JL | 1 |
Nakamura, M | 1 |
19 reviews available for phenobarbital and Neoplasms
Article | Year |
---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats | 2005 |
State of the science: hot flashes and cancer. Part 2: management and future directions.
Topics: Antidepressive Agents; Antineoplastic Agents; Belladonna Alkaloids; Cimicifuga; Combined Modality Th | 2005 |
Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Enzyme Induction; Neoplasm | 2006 |
[Chemoprevention of carcinogenesis].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cyclic AMP; DNA, Neoplas | 1983 |
Report of ICPEMC Task Group 5 on the differentiation between genotoxic and non-genotoxic carcinogens.
Topics: Animals; Butylated Hydroxytoluene; Carcinogens; Cell Line; DDT; Dieldrin; Dioxins; Drug Evaluation, | 1984 |
Tumor promotion--mechanisms and implication to risk estimation.
Topics: Animals; Carcinogens; Cell Communication; Cell Differentiation; Cocarcinogenesis; Humans; Mutagens; | 1984 |
Problems in the chemotherapy of cancer in the neonate.
Topics: Age Factors; Antineoplastic Agents, Phytogenic; Blood Proteins; Glomerular Filtration Rate; Humans; | 1981 |
Mechanisms of non-genotoxic carcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Humans; Mutagens; Neoplasms; Phenobarbit | 1994 |
Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion.
Topics: Animals; Biotransformation; Carcinogenicity Tests; Carcinogens; Cell Division; Enzyme Induction; Hum | 1996 |
Mechanisms of localization of gallium-67 in tumors.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Gallium; Gallium Radioisotopes; G | 1978 |
Some examples of interactions between drugs in cancer chemotherapy.
Topics: Animals; Bacterial Vaccines; Cyclophosphamide; Daunorubicin; Doxorubicin; Drug Interactions; Drug Th | 1978 |
Liver tumour promotion by phenobarbital: comparison of rat and human studies.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Epilepsy; Humans; Liver Neoplasms; Liver Neoplasms, | 1992 |
[Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis].
Topics: Acetaminophen; Cytochrome P-450 CYP1A2; Cytochromes; Free Radicals; Humans; Hydroxylation; Mixed Fun | 1989 |
Induction of drug-metabolizing enzymes: mechanisms and consequences.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Chemical and Drug Induced Li | 1986 |
Genetics and epigenetics of neoplasia: facts and theories.
Topics: Age Factors; Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cul | 1985 |
[Drug interactions with anticancer agents].
Topics: Allopurinol; Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Interact | 1985 |
Studies on the mechanism of microsomal hydroxylase induction and its role in carcinogen action.
Topics: Animals; Anthracenes; Benz(a)Anthracenes; Carbon Isotopes; Carcinogens; Cells, Cultured; Cricetinae; | 1972 |
[6 Beta-hydroxycortisol].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Chemical Phenomena; Che | 1967 |
1 trial available for phenobarbital and Neoplasms
Article | Year |
---|---|
A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; C | 2004 |
40 other studies available for phenobarbital and Neoplasms
Article | Year |
---|---|
Reduced Clearance of Phenobarbital in Advanced Cancer Patients near the End of Life.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Female; Humans; Male; Metabolic Cl | 2019 |
Influence of propofol, isoflurane and enflurance on levels of serum interleukin-8 and interleukin-10 in cancer patients.
Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Enflurane; Female; Humans; Inflammat | 2014 |
A hemophagocytosis syndrome attributed to phenobarbital.
Topics: Anemia; Anticonvulsants; Autoimmune Diseases; Diagnosis, Differential; Drug Hypersensitivity Syndrom | 2016 |
Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it.
Topics: Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cimetidine | 2003 |
The action exercised by the thymus and several neurotropic substances in experimental cancer.
Topics: Animals; Benzoates; Caffeine; Humans; Neoplasms; Neoplasms, Experimental; Phenobarbital; Thymus Extr | 1957 |
[Clinical study of the use of a drug containing a combination of chlorpromazine, gardenal and theophylline-ethylenediamine in patients of malignant neoplasms].
Topics: Aminophylline; Biomedical Research; Chlorpromazine; Electroencephalography; Humans; Neoplasms; Pheno | 1958 |
[A STUDY ON THE SO-CALLED ATYPICAL LYMPHOCYTE WITH SPECIAL REFERENCE TO PHASE CONTRAST MICROSCOPY].
Topics: Anemia; Blood; Bone Marrow Diseases; Collagen Diseases; Coombs Test; Hodgkin Disease; Infectious Mon | 1963 |
RENAL ISCHAEMIA DUE TO THROMBOSIS OF RENAL ARTERY RESULTING FROM METASTASES FROM PRIMARY CARCINOMA OF THE BRONCHUS.
Topics: Adrenal Gland Neoplasms; Angiography; Bronchi; Bronchial Neoplasms; Chlorthalidone; Diagnosis, Diffe | 1964 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
HYPERBARIC OXYGENATIN. THE SMALL PATIENT CHAMBER, RADIOTHERAPY.
Topics: Anesthesia; Anesthesia, Intravenous; Equipment and Supplies; Humans; Hyperbaric Oxygenation; Meperid | 1965 |
SEXUAL IMPOTENCE AND THE LIMBIC SYSTEM.
Topics: Astrocytoma; Brain Neoplasms; Diagnosis, Differential; Epilepsy; Epilepsy, Temporal Lobe; Erectile D | 1965 |
[LYMPHADENOPATHIES AND BLOOD PROTEIN DISORDERS OR MEDICINAL ORIGIN, SIMULATING A MALIGNANT DISEASE].
Topics: Blood Protein Disorders; Blood Protein Electrophoresis; Diagnosis, Differential; Drug Hypersensitivi | 1964 |
THE STIMULATION OF DRUG METABOLISM IN VARIOUS RAT HEPATOMAS.
Topics: Aminopyrine; Aniline Compounds; Benzoates; Blood; Carcinoma, Hepatocellular; Chlordan; Hexobarbital; | 1965 |
Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span.
Topics: Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Female; Gene Ex | 2005 |
Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity.
Topics: Animals; Gene Expression; Liver; Male; Models, Biological; Neoplasms; Oxidative Stress; Phenobarbita | 2005 |
Drugs and environmental chemicals as promoters.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Humans; Li | 1984 |
Epidemiological studies of medically used drugs.
Topics: 2-Naphthylamine; Brain Neoplasms; Epidemiologic Methods; Female; Humans; Isoniazid; Liver Neoplasms; | 1980 |
[Approaches to the enhancement of anticancer activity in cancer chemotherapy].
Topics: Angiotensin II; Antineoplastic Agents; Drug Therapy, Combination; Humans; Hypertension; Neoplasms; P | 1982 |
Does phenobarbital cause intracranial tumors? A follow-up through 35 years.
Topics: Adult; Brain Neoplasms; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neoplasm | 1981 |
Effects of inducer of liver drug-metabolizing enzyme on blood level of active metabolites of cyclophosphamide in rats and in cancer patients.
Topics: Adult; Aged; Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Ther | 1981 |
Hepatic hydroxylation of melatonin in the rat is induced by phenobarbital and 7,12-dimethylbenz[a]anthracene--implications for cancer etiology.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hydroxylation; Liver; Melatonin; Neoplasms; Pheno | 1995 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |
Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases.
Topics: Apurinic Acid; Carcinogens; Catechols; DNA Adducts; Dopamine; Estrogens, Catechol; Horseradish Perox | 2002 |
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances.
Topics: Acriflavine; Animals; Anthralin; Aurothioglucose; Carcinogens; Chloroquine; Diazepam; Ethanolamines; | 1977 |
Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy.
Topics: Adolescent; Adult; Brain Neoplasms; Child; England; Epilepsy; Female; Follow-Up Studies; Humans; Mal | 1979 |
The stability of events in the natural history of neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Liver; Liver Neoplasms; Mammary Neoplasms, Experimental; | 1977 |
Statistical studies in the aetiology of malignant neoplasms. V. Trends and risks. Denmark 1943--72.
Topics: Adolescent; Adult; Aged; Air Pollution; Animals; Carcinogens; Child; Child, Preschool; Denmark; Fema | 1977 |
Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro | 1978 |
Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.
Topics: Anticonvulsants; Denmark; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neopla | 1978 |
Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes.
Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Furylfuramide; Humans; Inactivation, Metabol | 1990 |
Cancer among epileptic patients exposed to anticonvulsant drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Neoplasms; Child; Child, Preschool; Denmark; | 1989 |
High-pressure liquid chromatography separation of phenobarbitone, thiourea, and thioacetamide of toxicological interest.
Topics: Abnormalities, Drug-Induced; Acetamides; Animals; Chromatography, High Pressure Liquid; Mice; Mutage | 1985 |
Critical remarks on the validity of promoting effects in human carcinogenesis.
Topics: Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Humans; Neoplasms; Phenobarbital | 1985 |
Role of tumor promotion in affecting the multi-hit nature of carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Fema | 1985 |
Phenobarbital: epidemiological evidence.
Topics: Brain Neoplasms; Child; Female; Fetus; Follow-Up Studies; Humans; Lung Neoplasms; Male; Neoplasms; P | 1985 |
The role of the portal of entry in inhibition of tumorigenesis.
Topics: Animals; Azoles; Benzopyrenes; Biotransformation; Carcinogens; Diet; Dietary Fats; Environmental Pol | 1971 |
Are anticonvulsants oncogenic?
Topics: Anticonvulsants; Denmark; Epilepsy; Female; Humans; Male; Neoplasms; Phenobarbital; Phenytoin; Primi | 1974 |
Letter: Phenobarbitone and liver tumours.
Topics: Humans; Liver Neoplasms; Neoplasms; Phenobarbital | 1974 |
Carcinogenesis and gene action. Franz Bielschowsky Memorial Lecture.
Topics: Animals; Azo Compounds; Carcinogens; Dactinomycin; DNA; Enzyme Induction; Genes; Liver; Methylcholan | 1968 |
[Colchimax for control of the disturbing local reaction during antitumoral radiotherapy].
Topics: Adult; Aged; Colchicine; Female; Humans; Male; Middle Aged; Neoplasms; Opium; Phenobarbital; Radiati | 1970 |