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phenobarbital and Neoplasms

phenobarbital has been researched along with Neoplasms in 60 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
" In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome."4.80Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000)
"Phenobarbital was then added, allowing dose escalation to 144 mg/m2."2.71A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital. ( Innocenti, F; Mani, S; Prado, M; Ramírez, J; Ratain, MJ; Schilsky, RL; Undevia, SD; Vogelzang, NJ, 2004)
"Phenytoin has been causally implicated in three human cancers: lymphoma, myeloma and neuroblastoma, the latter specifically in the setting of foetal hydantoin syndrome."2.43Cancer risk in people with epilepsy: the role of antiepileptic drugs. ( Driever, PH; Sander, JW; Singh, G, 2005)
"At exposures causing rodent liver tumors, PB has measurable effects on hepatocytes: PB inhibits cell-to-cell communication; PB induces enzymes, including P450 cytochromes; PB stimulates proliferation and inhibits apoptosis of hepatocytes in neoplastic foci."2.39Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. ( Ross, PM; Whysner, J; Williams, GM, 1996)
"Each anticancer agent has its own pharmacologic activities."2.37[Drug interactions with anticancer agents]. ( Furue, H, 1985)
"Within the cells of the liver and tumors, gallium is found in lysosomes, and rough endoplasmic reticulum."2.36Mechanisms of localization of gallium-67 in tumors. ( Larson, SM, 1978)
"Drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments."2.36Some examples of interactions between drugs in cancer chemotherapy. ( Garattini, S; Spreafico, F, 1978)
"Patients were divided into non-cancer and cancer groups."1.51Reduced Clearance of Phenobarbital in Advanced Cancer Patients near the End of Life. ( Echizen, H; Kato, T; Nakayama, H; Ogawa, R; Orii, T, 2019)
"Ninety cancer patients with selective operation from March 2011 to May 2014 were randomly divided into group A (34 cases), group B (28 cases) and group C (28 cases)."1.40Influence of propofol, isoflurane and enflurance on levels of serum interleukin-8 and interleukin-10 in cancer patients. ( Liu, TC, 2014)
" Here, we describe the use of a differential display technology to understand the molecular mechanisms related to 13 weeks of dosing with the prototype rodent nongenotoxic hepatocarcinogen, phenobarbital."1.33Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity. ( Alden, CL; Blomme, EA; Bunch, RT; Cabonce, MA; Curtiss, SW; Elrick, MM; Kier, LD; Kolaja, KL; Kramer, JA; Morris, DL; Rodi, CP, 2005)
"The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0."1.31Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001)
"Low melatonin levels seem to parallel cancer growth."1.29Hepatic hydroxylation of melatonin in the rat is induced by phenobarbital and 7,12-dimethylbenz[a]anthracene--implications for cancer etiology. ( Bartsch, C; Bartsch, H; Lippert, TH; Mecke, D; Praast, G, 1995)
"The excess numbers of brain cancer were concentrated within 10 years of hospitalization (RR = 20."1.28Cancer among epileptic patients exposed to anticonvulsant drugs. ( Boice, JD; Fraumeni, JF; Jensen, JP; Olsen, JH, 1989)
"National Cancer Institute and two Federal Agencies, seven drugs were listed."1.26Epidemiological studies of medically used drugs. ( Clemmesen, J; Hjalgrim-Jensen, S, 1980)

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-199042 (70.00)18.7374
1990's5 (8.33)18.2507
2000's10 (16.67)29.6817
2010's3 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tukey, RH1
Strassburg, CP1
Nakayama, H1
Echizen, H1
Ogawa, R1
Orii, T1
Kato, T1
Liu, TC1
Lakhoua, G1
Aouinti, I1
Sahnoun, R1
Kastalli, S1
Daghfous, R1
Zaïem, A1
Kaledin, VI1
Nikolin, VP1
Baimak, TY1
Galyamova, MR1
Popova, NA1
Andreeva, EM1
PARHON, CI1
BABES, A1
PETREA, I1
CERRA, R1
PERCESEPE, E1
NAKAMURA, H1
JENNINGS, RC1
SHAIKH, VA1
ALLEN, WM1
MARX, GF1
SCHEINBERG, L1
ROMNEY, SL1
CHURCHILL-DAVIDSON, I1
JOHNSON, J1
BRANCO, F1
GANDER, G1
HART, LG1
ADAMSON, RH1
MORRIS, HP1
FOUTS, JR1
Innocenti, F1
Undevia, SD1
Ramírez, J1
Mani, S1
Schilsky, RL1
Vogelzang, NJ1
Prado, M1
Ratain, MJ1
Singh, G1
Driever, PH1
Sander, JW1
Agrawal, AK1
Shapiro, BH1
Elrick, MM1
Kramer, JA1
Alden, CL1
Blomme, EA1
Bunch, RT1
Cabonce, MA1
Curtiss, SW1
Kier, LD1
Kolaja, KL1
Rodi, CP1
Morris, DL1
Carpenter, JS1
Yamada, H1
Ishii, Y1
Yamamoto, M1
Oguri, K1
Hozumi, M1
Yamasaki, H1
Greim, H1
Deml, E1
Oesterle, D1
Clemmesen, J5
Hjalgrim-Jensen, S3
Siegel, SE1
Moran, RG1
Wakui, A2
Maezawa, S1
Ohira, S1
Sakuma, M1
Matsuoka, S1
Saito, T1
Praast, G1
Bartsch, C1
Bartsch, H1
Mecke, D1
Lippert, TH1
Shaw, IC1
Jones, HB1
Whysner, J1
Ross, PM1
Williams, GM1
Watanabe, T1
Sugie, S1
Okamoto, K1
Rahman, KM1
Ushida, J1
Mori, H1
Cavalieri, EL1
Li, KM1
Balu, N1
Saeed, M1
Devanesan, P1
Higginbotham, S1
Zhao, J1
Gross, ML1
Rogan, EG1
White, SJ1
McLean, AE2
Howland, C1
Pitot, HC2
Larson, SM1
Marx, JL1
Garattini, S1
Spreafico, F1
Driver, HE1
Sutherland, IA1
Shimada, T1
Yamazaki, H1
Shimura, H1
Tanaka, R1
Guengerich, FP1
Lutz, W1
Sułkowski, W1
Olsen, JH1
Boice, JD1
Jensen, JP1
Fraumeni, JF1
Okey, AB1
Roberts, EA1
Harper, PA1
Denison, MS1
Grosso, LE1
Goldsworthy, T1
Furue, H1
Akintonwa, DA1
Schmähl, D1
Trosko, JE1
Chang, CC1
Macmahon, B1
Wattenberg, LW1
Fuglsang-Frederiksen, V1
Plum, CM1
Schneiderman, MA1
Gelboin, HV2
Papillon, P1
Grossetete, JL1
Nakamura, M1

Reviews

19 reviews available for phenobarbital and Neoplasms

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia;

2000
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
    Brain : a journal of neurology, 2005, Volume: 128, Issue:Pt 1

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats

2005
State of the science: hot flashes and cancer. Part 2: management and future directions.
    Oncology nursing forum, 2005, Sep-01, Volume: 32, Issue:5

    Topics: Antidepressive Agents; Antineoplastic Agents; Belladonna Alkaloids; Cimicifuga; Combined Modality Th

2005
Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism.
    Current drug metabolism, 2006, Volume: 7, Issue:4

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Constitutive Androstane Receptor; Enzyme Induction; Neoplasm

2006
[Chemoprevention of carcinogenesis].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cyclic AMP; DNA, Neoplas

1983
Report of ICPEMC Task Group 5 on the differentiation between genotoxic and non-genotoxic carcinogens.
    Mutation research, 1984, Volume: 133, Issue:1

    Topics: Animals; Butylated Hydroxytoluene; Carcinogens; Cell Line; DDT; Dieldrin; Dioxins; Drug Evaluation,

1984
Tumor promotion--mechanisms and implication to risk estimation.
    Acta pharmacologica et toxicologica, 1984, Volume: 55 Suppl 2

    Topics: Animals; Carcinogens; Cell Communication; Cell Differentiation; Cocarcinogenesis; Humans; Mutagens;

1984
Problems in the chemotherapy of cancer in the neonate.
    The American journal of pediatric hematology/oncology, 1981,Fall, Volume: 3, Issue:3

    Topics: Age Factors; Antineoplastic Agents, Phytogenic; Blood Proteins; Glomerular Filtration Rate; Humans;

1981
Mechanisms of non-genotoxic carcinogenesis.
    Trends in pharmacological sciences, 1994, Volume: 15, Issue:3

    Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Division; Humans; Mutagens; Neoplasms; Phenobarbit

1994
Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion.
    Pharmacology & therapeutics, 1996, Volume: 71, Issue:1-2

    Topics: Animals; Biotransformation; Carcinogenicity Tests; Carcinogens; Cell Division; Enzyme Induction; Hum

1996
Mechanisms of localization of gallium-67 in tumors.
    Seminars in nuclear medicine, 1978, Volume: 8, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Gallium; Gallium Radioisotopes; G

1978
Some examples of interactions between drugs in cancer chemotherapy.
    Antibiotics and chemotherapy, 1978, Volume: 23

    Topics: Animals; Bacterial Vaccines; Cyclophosphamide; Daunorubicin; Doxorubicin; Drug Interactions; Drug Th

1978
Liver tumour promotion by phenobarbital: comparison of rat and human studies.
    Progress in clinical and biological research, 1992, Volume: 374

    Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Epilepsy; Humans; Liver Neoplasms; Liver Neoplasms,

1992
[Bioactivation of xenobiotics by cytochrome P-448 and its role in the process of carcinogenesis].
    Postepy higieny i medycyny doswiadczalnej, 1989, Volume: 43, Issue:5-6

    Topics: Acetaminophen; Cytochrome P-450 CYP1A2; Cytochromes; Free Radicals; Humans; Hydroxylation; Mixed Fun

1989
Induction of drug-metabolizing enzymes: mechanisms and consequences.
    Clinical biochemistry, 1986, Volume: 19, Issue:2

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Carcinogens; Chemical and Drug Induced Li

1986
Genetics and epigenetics of neoplasia: facts and theories.
    Carcinogenesis; a comprehensive survey, 1985, Volume: 10

    Topics: Age Factors; Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cul

1985
[Drug interactions with anticancer agents].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:12

    Topics: Allopurinol; Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Interact

1985
Studies on the mechanism of microsomal hydroxylase induction and its role in carcinogen action.
    Revue canadienne de biologie, 1972, Volume: 31, Issue:1

    Topics: Animals; Anthracenes; Benz(a)Anthracenes; Carbon Isotopes; Carcinogens; Cells, Cultured; Cricetinae;

1972
[6 Beta-hydroxycortisol].
    Horumon to rinsho. Clinical endocrinology, 1967, Volume: 15, Issue:8

    Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Chemical Phenomena; Che

1967

Trials

1 trial available for phenobarbital and Neoplasms

ArticleYear
A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital.
    Clinical pharmacology and therapeutics, 2004, Volume: 76, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; C

2004

Other Studies

40 other studies available for phenobarbital and Neoplasms

ArticleYear
Reduced Clearance of Phenobarbital in Advanced Cancer Patients near the End of Life.
    European journal of drug metabolism and pharmacokinetics, 2019, Volume: 44, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Female; Humans; Male; Metabolic Cl

2019
Influence of propofol, isoflurane and enflurance on levels of serum interleukin-8 and interleukin-10 in cancer patients.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:16

    Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Enflurane; Female; Humans; Inflammat

2014
A hemophagocytosis syndrome attributed to phenobarbital.
    Presse medicale (Paris, France : 1983), 2016, Volume: 45, Issue:3

    Topics: Anemia; Anticonvulsants; Autoimmune Diseases; Diagnosis, Differential; Drug Hypersensitivity Syndrom

2016
Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it.
    Bulletin of experimental biology and medicine, 2003, Volume: 135, Issue:3

    Topics: Animals; Anticonvulsants; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cimetidine

2003
The action exercised by the thymus and several neurotropic substances in experimental cancer.
    Acta - Unio Internationalis Contra Cancrum, 1957, Volume: 13, Issue:3

    Topics: Animals; Benzoates; Caffeine; Humans; Neoplasms; Neoplasms, Experimental; Phenobarbital; Thymus Extr

1957
[Clinical study of the use of a drug containing a combination of chlorpromazine, gardenal and theophylline-ethylenediamine in patients of malignant neoplasms].
    Rassegna internazionale di clinica e terapia, 1958, Jun-30, Volume: 38, Issue:12

    Topics: Aminophylline; Biomedical Research; Chlorpromazine; Electroencephalography; Humans; Neoplasms; Pheno

1958
[A STUDY ON THE SO-CALLED ATYPICAL LYMPHOCYTE WITH SPECIAL REFERENCE TO PHASE CONTRAST MICROSCOPY].
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1963, Volume: 26

    Topics: Anemia; Blood; Bone Marrow Diseases; Collagen Diseases; Coombs Test; Hodgkin Disease; Infectious Mon

1963
RENAL ISCHAEMIA DUE TO THROMBOSIS OF RENAL ARTERY RESULTING FROM METASTASES FROM PRIMARY CARCINOMA OF THE BRONCHUS.
    British medical journal, 1964, Oct-24, Volume: 2, Issue:5416

    Topics: Adrenal Gland Neoplasms; Angiography; Bronchi; Bronchial Neoplasms; Chlorthalidone; Diagnosis, Diffe

1964
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
    Obstetrics and gynecology, 1964, Volume: 24

    Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms;

1964
HYPERBARIC OXYGENATIN. THE SMALL PATIENT CHAMBER, RADIOTHERAPY.
    Annals of the New York Academy of Sciences, 1965, Jan-21, Volume: 117

    Topics: Anesthesia; Anesthesia, Intravenous; Equipment and Supplies; Humans; Hyperbaric Oxygenation; Meperid

1965
SEXUAL IMPOTENCE AND THE LIMBIC SYSTEM.
    The British journal of psychiatry : the journal of mental science, 1965, Volume: 111

    Topics: Astrocytoma; Brain Neoplasms; Diagnosis, Differential; Epilepsy; Epilepsy, Temporal Lobe; Erectile D

1965
[LYMPHADENOPATHIES AND BLOOD PROTEIN DISORDERS OR MEDICINAL ORIGIN, SIMULATING A MALIGNANT DISEASE].
    Arquivo de patologia, 1964, Volume: 36

    Topics: Blood Protein Disorders; Blood Protein Electrophoresis; Diagnosis, Differential; Drug Hypersensitivi

1964
THE STIMULATION OF DRUG METABOLISM IN VARIOUS RAT HEPATOMAS.
    The Journal of pharmacology and experimental therapeutics, 1965, Volume: 149

    Topics: Aminopyrine; Aniline Compounds; Benzoates; Blood; Carcinoma, Hepatocellular; Chlordan; Hexobarbital;

1965
Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:3

    Topics: Animals; Animals, Newborn; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Female; Gene Ex

2005
Differential display in rat livers treated for 13 weeks with phenobarbital implicates a role for metabolic and oxidative stress in nongenotoxic carcinogenicity.
    Toxicologic pathology, 2005, Volume: 33, Issue:1

    Topics: Animals; Gene Expression; Liver; Male; Models, Biological; Neoplasms; Oxidative Stress; Phenobarbita

2005
Drugs and environmental chemicals as promoters.
    IARC scientific publications, 1984, Issue:56

    Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Humans; Li

1984
Epidemiological studies of medically used drugs.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1980, Volume: 3

    Topics: 2-Naphthylamine; Brain Neoplasms; Epidemiologic Methods; Female; Humans; Isoniazid; Liver Neoplasms;

1980
[Approaches to the enhancement of anticancer activity in cancer chemotherapy].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1982, Volume: 57, Issue:4

    Topics: Angiotensin II; Antineoplastic Agents; Drug Therapy, Combination; Humans; Hypertension; Neoplasms; P

1982
Does phenobarbital cause intracranial tumors? A follow-up through 35 years.
    Ecotoxicology and environmental safety, 1981, Volume: 5, Issue:2

    Topics: Adult; Brain Neoplasms; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neoplasm

1981
Effects of inducer of liver drug-metabolizing enzyme on blood level of active metabolites of cyclophosphamide in rats and in cancer patients.
    The Tohoku journal of experimental medicine, 1981, Volume: 134, Issue:1

    Topics: Adult; Aged; Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Ther

1981
Hepatic hydroxylation of melatonin in the rat is induced by phenobarbital and 7,12-dimethylbenz[a]anthracene--implications for cancer etiology.
    Experientia, 1995, Apr-15, Volume: 51, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hydroxylation; Liver; Melatonin; Neoplasms; Pheno

1995
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:6

    Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce

2001
Catechol ortho-quinones: the electrophilic compounds that form depurinating DNA adducts and could initiate cancer and other diseases.
    Carcinogenesis, 2002, Volume: 23, Issue:6

    Topics: Apurinic Acid; Carcinogens; Catechols; DNA Adducts; Dopamine; Estrogens, Catechol; Horseradish Perox

2002
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1977, Volume: 13

    Topics: Acriflavine; Animals; Anthralin; Aurothioglucose; Carcinogens; Chloroquine; Diazepam; Ethanolamines;

1977
Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy.
    Lancet (London, England), 1979, Sep-01, Volume: 2, Issue:8140

    Topics: Adolescent; Adult; Brain Neoplasms; Child; England; Epilepsy; Female; Follow-Up Studies; Humans; Mal

1979
The stability of events in the natural history of neoplasia.
    The American journal of pathology, 1977, Volume: 89, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Humans; Liver; Liver Neoplasms; Mammary Neoplasms, Experimental;

1977
Statistical studies in the aetiology of malignant neoplasms. V. Trends and risks. Denmark 1943--72.
    Acta pathologica et microbiologica Scandinavica. Supplement, 1977, Issue:261

    Topics: Adolescent; Adult; Aged; Air Pollution; Animals; Carcinogens; Child; Child, Preschool; Denmark; Fema

1977
Tumor promoters: carcinogenesis gets more complicated.
    Science (New York, N.Y.), 1978, Aug-11, Volume: 201, Issue:4355

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro

1978
Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.
    Ecotoxicology and environmental safety, 1978, Volume: 1, Issue:4

    Topics: Anticonvulsants; Denmark; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neopla

1978
Metabolic deactivation of furylfuramide by cytochrome P450 in human and rat liver microsomes.
    Carcinogenesis, 1990, Volume: 11, Issue:1

    Topics: Animals; Benzoflavones; Cytochrome P-450 Enzyme System; Furylfuramide; Humans; Inactivation, Metabol

1990
Cancer among epileptic patients exposed to anticonvulsant drugs.
    Journal of the National Cancer Institute, 1989, May-10, Volume: 81, Issue:10

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Neoplasms; Child; Child, Preschool; Denmark;

1989
High-pressure liquid chromatography separation of phenobarbitone, thiourea, and thioacetamide of toxicological interest.
    Ecotoxicology and environmental safety, 1985, Volume: 10, Issue:2

    Topics: Abnormalities, Drug-Induced; Acetamides; Animals; Chromatography, High Pressure Liquid; Mice; Mutage

1985
Critical remarks on the validity of promoting effects in human carcinogenesis.
    Journal of cancer research and clinical oncology, 1985, Volume: 109, Issue:3

    Topics: Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Humans; Neoplasms; Phenobarbital

1985
Role of tumor promotion in affecting the multi-hit nature of carcinogenesis.
    Basic life sciences, 1985, Volume: 33

    Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Fema

1985
Phenobarbital: epidemiological evidence.
    IARC scientific publications, 1985, Issue:65

    Topics: Brain Neoplasms; Child; Female; Fetus; Follow-Up Studies; Humans; Lung Neoplasms; Male; Neoplasms; P

1985
The role of the portal of entry in inhibition of tumorigenesis.
    Progress in experimental tumor research, 1971, Volume: 14

    Topics: Animals; Azoles; Benzopyrenes; Biotransformation; Carcinogens; Diet; Dietary Fats; Environmental Pol

1971
Are anticonvulsants oncogenic?
    Lancet (London, England), 1974, Apr-20, Volume: 1, Issue:7860

    Topics: Anticonvulsants; Denmark; Epilepsy; Female; Humans; Male; Neoplasms; Phenobarbital; Phenytoin; Primi

1974
Letter: Phenobarbitone and liver tumours.
    Lancet (London, England), 1974, Nov-02, Volume: 2, Issue:7888

    Topics: Humans; Liver Neoplasms; Neoplasms; Phenobarbital

1974
Carcinogenesis and gene action. Franz Bielschowsky Memorial Lecture.
    The New Zealand medical journal, 1968, Volume: 67, Issue:426

    Topics: Animals; Azo Compounds; Carcinogens; Dactinomycin; DNA; Enzyme Induction; Genes; Liver; Methylcholan

1968
[Colchimax for control of the disturbing local reaction during antitumoral radiotherapy].
    Journal francais d'oto-rhino-laryngologie, audio-phonologie et chirurgie maxillo-faciale, 1970, Volume: 19, Issue:8

    Topics: Adult; Aged; Colchicine; Female; Humans; Male; Middle Aged; Neoplasms; Opium; Phenobarbital; Radiati

1970