phenobarbital has been researched along with Neoplasms, Nervous System in 2 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nervous system tumors were induced only in animals exposed to ENU." | 1.28 | Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea. ( Swenberg, JA; Walker, VE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naito, M | 1 |
| Naito, Y | 1 |
| Ito, A | 1 |
| Walker, VE | 1 |
| Swenberg, JA | 1 |
2 other studies available for phenobarbital and Neoplasms, Nervous System
| Article | Year |
|---|---|
Effect of phenobarbital on the development of tumors in mice treated neonatally with N-ethyl-N-nitrosourea.
Topics: Animals; Ethylnitrosourea; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neop | 1982 |
Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea.
Topics: Animals; Astrocytes; Ethylnitrosourea; Female; Gestational Age; Glioma; Male; Maternal-Fetal Exchang | 1989 |