phenobarbital has been researched along with Myasthenia Gravis in 2 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Myasthenia Gravis: A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Five years later she developed myasthenia gravis, and phenytoin was replaced by valproic acid and phenobarbital." | 3.68 | Epilepsy, myasthenia gravis, and effect of plasmapheresis on antiepileptic drug concentrations. ( Jenkins, DC; Lai, CW; Leppik, IE; Sood, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, CW | 1 |
| Leppik, IE | 1 |
| Jenkins, DC | 1 |
| Sood, P | 1 |
| Ravn-Jonsen, A | 1 |
| Lunding, M | 1 |
| Secher, O | 1 |
2 other studies available for phenobarbital and Myasthenia Gravis
| Article | Year |
|---|---|
Epilepsy, myasthenia gravis, and effect of plasmapheresis on antiepileptic drug concentrations.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Therapy, Combination; Epilepsy, Temporal Lob | 1990 |
Excretion of phenobarbitone in urine after intake of large doses.
Topics: Chromatography, Paper; Humans; Male; Methods; Middle Aged; Myasthenia Gravis; Phenobarbital; Spectro | 1969 |