phenobarbital has been researched along with Muscle Spasticity in 8 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GRAMSCH, H | 1 |
| OKUDA, O | 1 |
| SHINOHARA, S | 1 |
| Basmajian, JV | 1 |
| Turski, L | 2 |
| Schwarz, M | 2 |
| Turski, WA | 1 |
| Ikonomidou, C | 1 |
| Sontag, KH | 2 |
| Gerasimiuk, DL | 1 |
| Gusel', VA | 1 |
| Klimenko, VA | 1 |
| Korovin, AM | 1 |
| Ikonomidou-Turski, C | 1 |
| Lennox-Buchthal, MA | 1 |
| Cocchiarella, A | 1 |
| Downey, JA | 1 |
| Darling, RC | 1 |
1 review available for phenobarbital and Muscle Spasticity
| Article | Year |
|---|---|
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc | 1973 |
2 trials available for phenobarbital and Muscle Spasticity
| Article | Year |
|---|---|
Reflex cervical muscle spasm: treatment by diazepam, phenobarbital or placebo.
Topics: Adult; Clinical Trials as Topic; Diazepam; Double-Blind Method; Electromyography; Female; Humans; Ma | 1983 |
Evaluation of the effect of diazepam on spasticity.
Topics: Adult; Aged; Diazepam; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Middle Aged; Moto | 1967 |
5 other studies available for phenobarbital and Muscle Spasticity
| Article | Year |
|---|---|
[Contribution to the treatment of spastic obstipation].
Topics: Atropine; Constipation; Muscle Spasticity; Niacin; Nicotinic Acids; Phenobarbital; Procaine | 1958 |
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep | 1964 |
Effect of aminophylline on muscle relaxant action of diazepam and phenobarbitone in genetically spastic rats: further evidence for a purinergic mechanism in the action of diazepam.
Topics: Aminophylline; Animals; Carbolines; Diazepam; Drug Interactions; Electromyography; Female; Male; Mus | 1984 |
[The use of phenobarbital and carbamazepine (finlepsin) in children with epilepsy and cerebral spastic palsy with epileptic syndrome].
Topics: Adolescent; Carbamazepine; Cerebral Palsy; Child; Dose-Response Relationship, Drug; Drug Therapy, Co | 1990 |
Muscle relaxant action of phenobarbitone in genetically spastic rats: an electromyographic study.
Topics: Animals; Female; gamma-Aminobutyric Acid; Male; Muscle Spasticity; Muscle Tonus; Neuromuscular Block | 1986 |